E7889

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Reclamation of copper-contaminated soil using EDTA or citric acid coupled with dissolved organic matter solution extracted from distillery sludge.

Cheng-Chung Liu et al.

Environmental pollution (Barking, Essex : 1987), 178, 97-101 (2013-04-03)

Soil washing using a strong chelating agent is a common practice for restoring contaminated soils, but significant soil fertility degradation and high operation costs are the major disadvantages. Washing soil with a dissolved organic matter (DOM) solution has been identified

Proteogenomic Characterization of Endometrial Carcinoma.

Yongchao Dou et al.

Cell, 180(4), 729-748 (2020-02-16)

We undertook a comprehensive proteogenomic characterization of 95 prospectively collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This analysis revealed possible new consequences of perturbations to the p53 and Wnt/β-catenin pathways, identified a potential role for circRNAs in

Enzymatic activity of a subtilisin homolog, Tk-SP, from Thermococcus kodakarensis in detergents and its ability to degrade the abnormal prion protein.

Azumi Hirata et al.

BMC biotechnology, 13, 19-19 (2013-03-02)

Tk-SP is a member of subtilisin-like serine proteases from a hyperthermophilic archaeon Thermococcus kodakarensis. It has been known that the hyper-stable protease, Tk-SP, could exhibit enzymatic activity even at high temperature and in the presence of chemical denaturants. In this

Eva Garcia-Alegria et al.

STAR protocols, 2(1), 100367-100367 (2021-03-16)

Little is known about the emergence of blood progenitors during human embryogenesis due to ethical reasons and restricted embryo access. The use of human embryonic stem cells (hESCs) as a model system offers unique opportunities to dissect human blood cell

Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner.

Q Chu et al.

Cell proliferation, 46(3), 254-262 (2013-05-23)

Human CAP10-like protein 46 kDa (hCLP46), also known as Poglut1, has been shown to be an essential regulator of Notch signalling. hCLP46 is overexpressed in primary acute myelogenous leukaemia, T-acute lymphoblastic leukaemia samples and other leukaemia cell lines. However, effects

Oxime-based linker libraries as a general approach for the rapid generation and screening of multidentate inhibitors.

Medhanit Bahta et al.

Nature protocols, 7(4), 686-702 (2012-03-17)

The described oxime-based library protocol provides detailed procedures for the linkage of aminooxy functionality with aldehyde building blocks that result in the generation of libraries of multidentate inhibitors. Synthesis of inhibitors for protein tyrosine phosphatases (PTPs) and antagonists directed against

Effective estimation of correct platelet counts in pseudothrombocytopenia using an alternative anticoagulant based on magnesium salt.

Peter Schuff-Werner et al.

British journal of haematology, 162(5), 684-692 (2013-07-03)

Pseudothrombocytopenia remains a challenge in the haematological laboratory. The pre-analytical problem that platelets tend to easily aggregate in vitro, giving rise to lower platelet counts, has been known since ethylenediamine-tetra acetic acid EDTA and automated platelet counting procedures were introduced

Single nucleotide polymorphisms in premature ovarian failure-associated genes in a Chinese Hui population.

Lili Ma et al.

Molecular medicine reports, 12(2), 2529-2538 (2015-05-09)

Premature ovarian failure (POF) is an ovarian defect characterized by the premature depletion of ovarian follicles in individuals <40 years old, and is a major cause of infertility in females. Genetic factors are considered to be responsible for the development

Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models.

Mingqiang Li et al.

Biomaterials, 51, 161-172 (2015-03-17)

As a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-based nanoparticles (Dex-SA-DOX-CDDP) have demonstrated enhanced antitumor efficacy and reduced systemic toxicity via optimized biodistribution, controlled drug release, prolonged blood circulation, and improved tolerability, compared to the non-crosslinked nanoparticles or free doxorubicin.

Development of a universal internal positive control.

Mark F Kavlick

BioTechniques, 65(5), 275-280 (2018-11-06)

Described here is a novel, universal exogenous internal positive control (IPC), which is fully synthetic for unparalleled quality control. The IPC was rationally designed, is small and efficiently amplified, has been successfully utilized alone or in triplex qPCR reactions, and

Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells.

Matej Adámik et al.

Biochemical and biophysical research communications, 456(1), 29-34 (2014-12-03)

Site-specific DNA recognition and binding activity belong to common attributes of all three members of tumor suppressor p53 family proteins: p53, p63 and p73. It was previously shown that heavy metals can affect p53 conformation, sequence-specific binding and suppress p53

Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition.

Balázs Bálint et al.

ChemMedChem, 12(12), 932-939 (2017-03-07)

Dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) is an emerging biological target with implications in diverse therapeutic areas such as neurological disorders (Down syndrome, in particular), metabolism, and oncology. Harmine, a natural product that selectively inhibits DYRK1A amongst kinases, could serve as a

Gestational and lactational exposure to atrazine via the drinking water causes specific behavioral deficits and selectively alters monoaminergic systems in C57BL/6 mouse dams, juvenile and adult offspring.

Zhoumeng Lin et al.

Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 90-102 (2014-06-11)

Atrazine (ATR) is one of the most frequently detected pesticides in the U.S. water supply. This study aimed to investigate neurobehavioral and neurochemical effects of ATR in C57BL/6 mouse offspring and dams exposed to a relatively low (3 mg/l, estimated

Cellular fluid shear stress on implant surfaces-establishment of a novel experimental set up.

P W Kämmerer et al.

International journal of implant dentistry, 3(1), 22-22 (2017-06-02)

Mechanostimuli of different cells can affect a wide array of cellular and inter-cellular biological processes responsible for dental implant healing. The purpose of this in vitro study was to establish a new test model to create a reproducible flow-induced fluid

Effect of Relative Arrangement of Cationic and Lipophilic Moieties on Hemolytic and Antibacterial Activities of PEGylated Polyacrylates.

Ashish Punia et al.

International journal of molecular sciences, 16(10), 23867-23880 (2015-10-17)

Synthetic amphiphilic polymers have been established as potentially efficient agents to combat widespread deadly infections involving antibiotic resistant superbugs. Incorporation of poly(ethylene glycol) (PEG) side chains into amphiphilic copolymers can reduce their hemolytic activity while maintaining high antibacterial activity. Our

Brand of dipotassium EDTA vacuum tube as a new source of pre-analytical variability in routine haematology testing.

G Lima-Oliveira et al.

British journal of biomedical science, 70(1), 6-9 (2013-04-27)

This study assesses the use of different dry K2 (dipotassium) EDTA vacuum tubes and whether or not they might represent a bias in haematological testing. Blood was collected in three dipotassium EDTA vacuum tubes from different manufacturers: Venosafe, Vacuette and

Heat stress during the luteal phase decreases luteal size but does not affect circulating progesterone in gilts1.

Katie L Bidne et al.

Journal of animal science, 97(10), 4314-4322 (2019-08-03)

Heat stress (HS) occurs when heat dissipation mechanisms are insufficient to maintain euthermia, and it is associated with seasonal infertility (SI), which manifests as smaller litters, longer wean-to-estrus interval, increased abortions, and reduced conception rates. To understand HS-induced mechanisms underlying

Effects of Mn-DPDP and manganese chloride on hemodynamics and glucose tolerance in anesthetized rats.

Xiang Gao et al.

Acta radiologica (Stockholm, Sweden : 1987), 55(3), 328-334 (2013-08-22)

Previous studies have demonstrated that magnetic resonance imaging may be a method of choice to visualize transplanted pancreatic islets. However, contrast agents may interfere with microcirculation and affect graft function. To evaluate the effects manganese-containing contrast media on regional blood

Effect of N-acyl-dopamines on beta cell differentiation and wound healing in diabetic mice.

Carla Jiménez-Jiménez et al.

Biochimica et biophysica acta. Molecular cell research, 1865(11 Pt A), 1539-1551 (2018-10-18)

N-acyl-dopamines are endolipids with neuroprotective, antiinflammatory and immunomodulatory properties. Previously, we showed the ability of these compounds to induce HIF-1α stabilization. Hypoxia and HIF-1α play an important role in the most relevant stages of diabetic pathogenesis. This work analyzes the

Intracellular MMP-2 activity in skeletal muscle is associated with type II fibers.

Elin Hadler-Olsen et al.

Journal of cellular physiology, 230(1), 160-169 (2014-06-07)

Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to

Small expression tags enhance bacterial expression of the first three transmembrane segments of the apelin receptor.

Aditya Pandey et al.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 92(4), 269-278 (2014-06-20)

G-protein coupled receptors (GPCRs) are inherently dynamic membrane protein modulators of various important cellular signaling cascades. The apelin receptor (AR or APJ) is a class A GPCR involved in numerous physiological processes, implicated in angiogenesis during tumour formation and as

Modified Fenton oxidation of diesel fuel in arctic soils rich in organic matter and iron.

Mary K Sherwood et al.

Chemosphere, 113, 56-61 (2014-07-30)

Modified Fenton (MF) chemistry was tested in the laboratory to treat three diesel fuel-contaminated soils from the Canadian arctic rich in soil organic matter (SOM) and Fe oxides. Reactors were dosed with hydrogen peroxide (HP), and treatment was compared in

Percentage exposure of root dentin collagen after application of two irrigation protocols with manual or rotary instrumentation and two methacrylate resin-based sealers.

Santiago González-López et al.

The journal of adhesive dentistry, 15(5), 481-489 (2013-04-18)

To compare the percentage of collagen exposed in dentin root thirds after two irrigation protocols with manual or rotary instrumentation using two methacrylate resin-based sealers. Forty-eight single-root human teeth were prepared with manual (n = 24) or nickeltitanium ProFile rotary

Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs.

Katie L Bidne et al.

Journal of animal science, 96(9), 3622-3634 (2018-07-10)

Increased circulating lipopolysaccharide (LPS) results from heat stress (HS) and bacterial infection, both of which are associated with reduced female fertility. Specific effects of low-level, repeated LPS exposure on the ovary are unclear, as many studies utilize a bolus model

Getting on target: Development of the novel, prozone-resistant, dual antibody rapid test (DART) for the LABScreen single antigen bead (SAB) assay.

Anna Greenshields et al.

Human immunology, 80(7), 468-477 (2019-05-02)

A major limitation of the single antigen bead (SAB) assay is the so called prozone effect, whereby the detection of high titer complement fixing HLA antibodies is compromised due to complement split product (from C3 and C4 components) deposition and

Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection.

Lynnae D Hyatt et al.

PloS one, 9(10), e109072-e109072 (2014-10-10)

Zinc finger protein 36, C3H type-like 1 (ZFP36L1) is one of several Zinc Finger Protein 36 (Zfp36) family members, which bind AU rich elements within 3' untranslated regions (UTRs) to negatively regulate the post-transcriptional expression of targeted mRNAs. The prototypical

Evaluation of p-phenylenediamine, o-phenylphenol sodium salt, and 2,4-diaminotoluene in the rat comet assay as part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay.

Marlies De Boeck et al.

Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 151-157 (2015-07-28)

As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiated international validation study of in vivo rat alkaline comet assay (comet assay), p-phenylenediamine dihydrochloride (PPD), o-phenylphenol sodium salt (OPP), and 2,4-diaminotoluene (2,4-DAT), were analyzed in this laboratory

Sambrook, J., et al.

Molecular Cloning: A Laboratory Manual, B-B (1989)

Monitoring the effects of chelating agents and electrical fields on active forms of Pb and Zn in contaminated soil.

Iman Tahmasbian et al.

Environmental monitoring and assessment, 185(11), 8847-8860 (2013-05-21)

The application of electrical fields and chelating agents is an innovative hybrid technology used for the decontamination of soil polluted by heavy metals. The effects of four center-oriented electrical fields and chelating agents on active fractions of lead and zinc

EDTA-dependent pseudothrombocytopenia complicated by eosinophilic pneumonia.

Naoko Ohashi et al.

The American journal of emergency medicine, 31(7), 1157-1157 (2013-05-25)

EDTA-dependent pseudothrombocytopenia (EDTA-PTCP) is a phenomenon that occurs in vitro when EDTA reacts with harvested blood. EDTA-dependent pseudothrombocytopenia usually does not indicate thrombocytopenia in vivo. Here, we report the first case of EDTA-PTCP complicated by eosinophilic pneumonia. A 70-year-old man

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