EHU081441

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Namal Perera et al.

International journal of biological sciences, 14(10), 1378-1388 (2018-08-21)

Antrodia cinnamomea (A. cinnamomea) is a medicinal fungus used in traditional Chinese medicine to treat different kinds of ailments, including liver diseases, abdominal pain, drug intoxication, diarrhea, itchy skin, hypertension, and cancer. Polysaccharides have been identified as one of the

Globular adiponectin acts as a melanogenic signal in human epidermal melanocytes.

Y Kim et al.

The British journal of dermatology, 179(3), 689-701 (2018-02-28)

Adiponectin is an adipocyte-derived cytokine that circulates as a full-length protein and a fragment containing the globular domain of adiponectin (gAd). A recent study has reported the antimelanogenic effects of full-length adiponectin. To examine the involvement of gAd in melanogenesis

TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms.

George Coricor et al.

Scientific reports, 6, 38616-38616 (2016-12-09)

Members of the TGF-β superfamily are important regulators of chondrocyte function. Sox9, a key transcriptional regulator of chondrogenesis, is required for TGF-β-mediated regulation of specific cartilage genes. TGF-β can signal through a canonical, Smad-mediated pathway or non-conical pathways, including p38.

p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging.

Ana M Tormos et al.

PloS one, 12(2), e0171738-e0171738 (2017-02-07)

Hepatocyte poliploidization is an age-dependent process, being cytokinesis failure the main mechanism of polyploid hepatocyte formation. Our aim was to study the role of p38α MAPK in the regulation of actin cytoskeleton and cytokinesis in hepatocytes during development and aging.

Ursolic acid inhibits the invasive phenotype of SNU-484 human gastric cancer cells.

Eun-Sook Kim et al.

Oncology letters, 9(2), 897-902 (2015-01-27)

Metastasis is a major cause of cancer-related mortality in patients with gastric cancer. Ursolic acid, a pentacyclic triterpenoid compound derived from medicinal herbs, has been demonstrated to exert anticancer effects in various cancer cell systems. However, to the best of

PD169316, a specific p38 inhibitor, shows antiviral activity against Enterovirus71.

Zhe Zhang et al.

Virology, 508, 150-158 (2017-05-26)

Enterovirus71 (EV71) is the major causative agent of hand, foot and mouth disease, which threatens the health of infants and young children. The expression of inflammatory cytokines induced by this viral infection aggravate the illness. Here, we describe the anti-EV71

Peroxiredoxin 1 suppresses apoptosis via regulation of the apoptosis signal-regulating kinase 1 signaling pathway in human oral leukoplakia.

Min Zhang et al.

Oncology letters, 10(3), 1841-1847 (2015-12-02)

Peroxiredoxin 1 (Prx1) has a significant role in several malignant types of tumor. However, the role of Prx1 in oral leukoplakia (OLK) has remained to be elucidated. OLK is a common precancerous lesion of the oral mucosa that has a

Crosstalk between p38 MAPK and caspase-9 regulates mitochondria-mediated apoptosis induced by tetra-α-(4-carboxyphenoxy) phthalocyanine zinc photodynamic therapy in LoVo cells.

Yu Wang et al.

Oncology reports, 39(1), 61-70 (2017-11-09)

Photodynamic therapy (PDT) is considered to be an advancing antitumor technology. PDT using hydrophilic/lipophilic tetra‑α-(4-carboxyphenoxy) phthalocyanine zinc (TαPcZn-PDT) has exhibited antitumor activity in Bel-7402 hepatocellular cancer cells. However, the manner in which p38 MAPK and caspase-9 are involved in the regulation

Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways.

Vladimir N Ivanov et al.

Oncotarget, 8(43), 74068-74095 (2017-11-02)

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The challenging problem in cancer treatment is to find a way to upregulate radiosensitivity of GBM while protecting neurons and neural stem/progenitor cells in the brain. The goal

Inhibiting MAPK14 showed anti-prolactinoma effect.

Qiao-Yan Ding et al.

BMC endocrine disorders, 20(1), 138-138 (2020-09-08)

The specific underlying pathogenesis of prolactinoma has not been clarified yet, to the best of our knowledge. p38 mitogen-activated protein kinase (MAPK) signaling including p38α MAPK (MAPK14), p38β (MAPK11), p38γ (MAPK12) and p38δ (MAPK13) is associated with the development and

Monomeric C-reactive protein affects cell injury and apoptosis through activation of p38 mitogen-activated protein kinase in human coronary artery endothelial cells.

Yong Zhang et al.

Bosnian journal of basic medical sciences, 20(4), 487-494 (2020-05-03)

C-reactive protein (CRP) is an important predictor of cardiovascular events and plays a role in vascular inflammation and vessel damage. The aim of this study was to investigate the effect of pentameric CRP (pCRP) and monomeric CRP (mCRP) on the

Seno-destructive smooth muscle cells in the ascending aorta of patients with bicuspid aortic valve disease.

Brittany Balint et al.

EBioMedicine, 43, 54-66 (2019-05-13)

Ascending aortic aneurysms constitute an important hazard for individuals with a bicuspid aortic valve (BAV). However, the processes that degrade the aortic wall in BAV disease remain poorly understood. We undertook in situ analysis of ascending aortas from 68 patients

Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells.

Jolie R Schafer et al.

The Journal of allergy and clinical immunology, 143(1), 346-358 (2018-08-11)

The mechanism by which natural killer (NK) cell education results in licensed NK cells with heightened effector function against missing self-targets is not known. We sought to identify potential mechanisms of enhanced function in licensed human NK cells. We used

LIMD1 Increases the Sensitivity of Lung Adenocarcinoma Cells to Cisplatin via the GADD45α/p38 MAPK Signaling Pathway.

Xiaofei Zeng et al.

Frontiers in oncology, 10, 969-969 (2020-08-06)

Objective: To investigate the effect of LIM domain-containing protein 1 (LIMD1) on the sensitivity of lung adenocarcinoma cells to cisplatin and explore the mechanism. Methods: A549 and H1299 cells were transfected with lentivirus to establish LIMD1-overexpressing cell lines and their

Flavopereirine Inhibits Autophagy via the AKT/p38 MAPK Signaling Pathway in MDA-MB-231 Cells.

Ming-Shan Chen et al.

International journal of molecular sciences, 21(15) (2020-08-01)

Autophagy is a potential target for the treatment of triple negative breast cancer (TNBC). Because of a lack of targeted therapies for TNBC, it is vital to find optimal agents that avoid chemoresistance and metastasis. Flavopereirine has anti-proliferation ability in

Identification of a clinical compound losmapimod that blocks Lassa virus entry.

Xiaoyu Zhang et al.

Antiviral research, 167, 68-77 (2019-04-07)

Lassa virus (LASV) causes Lassa hemorrhagic fever in humans and poses a significant threat to public health in West Africa. Current therapeutic treatments for Lassa fever are limited, making the development of novel countermeasures an urgent priority. In this study

Klotho Alleviates Lung Injury Caused by Paraquat via Suppressing ROS/P38 MAPK-Regulated Inflammatory Responses and Apoptosis.

Zhiqiang Zhang et al.

Oxidative medicine and cellular longevity, 2020, 1854206-1854206 (2020-06-09)

Acute lung injury (ALI) induced by paraquat (PQ) progresses rapidly with high mortality; however, there is no effective treatment, and the specific mechanism is not well understood. The antiaging protein klotho (KL) has multiple functions and exerts significant influences on

Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons.

Rong Tan et al.

International journal of molecular medicine, 42(2), 919-925 (2018-05-23)

Tumor necrosis factor-α (TNF-α) is an established pain modulator in the peripheral nervous system. Elevated levels of TNF-α in dorsal root ganglion (DRG) neurons reportedly is critical for neuropathic pain processing. It has been shown that the production of nitric

Coronin 1B serine 2 phosphorylation by p38α is critical for vascular endothelial growth factor-induced migration of human umbilical vein endothelial cells.

Geun-Young Kim et al.

Cellular signalling, 28(12), 1817-1825 (2016-09-07)

Coronin 1B is an actin-binding protein that regulates various cellular processes including cell motility. However, the role of coronin 1B in vascular cell migration remains controversial. Here, we examined the function of coronin 1B in vascular endothelial growth factor (VEGF)-induced

A new role for cofilin in retinal neovascularization.

Raj Kumar et al.

Journal of cell science, 129(6), 1234-1249 (2016-02-10)

Pak1 plays an important role in several cellular processes, including cell migration, but its role in pathological angiogenesis is not known. Here, we have determined its role in pathological retinal angiogenesis using an oxygen-induced retinopathy (OIR) model. VEGFA induced phosphorylation

Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.

Hye Jeong Lee et al.

Molecular endocrinology (Baltimore, Md.), 29(6), 873-881 (2015-04-01)

Irisin is a novel myokine produced by skeletal muscle. However, its metabolic role is poorly understood. In the present study, irisin induced glucose uptake in differentiated skeletal muscle cells. It increased AMP-activated protein kinase (AMPK) phosphorylation and the inhibition of

Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation.

Xi-Xi Lin et al.

Toxicology mechanisms and methods, 24(8), 575-583 (2014-08-20)

Cigarette smoke contains reactive oxygen (ROS) that can cause oxidative stress. It increases the number of apoptotic and necrotic lung cells and further induces the development of chronic airway disease. In this study, we investigated the effects of cigarette smoke

P38 MAPK Promotes Migration and Metastatic Activity of BRAF Mutant Melanoma Cells by Inducing Degradation of PMCA4b.

Randa Naffa et al.

Cells, 9(5) (2020-05-18)

Metastatic melanoma is the most aggressive type of skin cancer. Previously, we identified the plasma membrane Ca2+ pump isoform 4b (PMCA4b or ATP2B4) as a putative metastasis suppressor in BRAF mutant melanoma cells. Metastasis suppressors are often downregulated in cancer

Alisertib promotes apoptosis and autophagy in melanoma through p38 MAPK-mediated aurora a signaling.

Yuan-Yuan Shang et al.

Oncotarget, 8(63), 107076-107088 (2018-01-02)

We investigated the efficacy of Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, in melanoma. We found that ALS exerts anti-proliferative, pro-apoptotic, and pro-autophagic effects on A375 and skmel-5 melanoma cells by inhibiting p38 MAPK signaling. SB202190, a p38

High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation.

Wei He et al.

Nature communications, 11(1), 1732-1732 (2020-04-09)

High-salt diets are associated with an elevated risk of autoimmune diseases, and immune dysregulation plays a key role in cancer development. However, the correlation between high-salt diets (HSD) and cancer development remains unclear. Here, we report that HSD increases the

Autophagy and TrkC/NT-3 signaling joined forces boost the hypoxic glioblastoma cell survival.

Soha Jawhari et al.

Carcinogenesis, 38(6), 592-603 (2017-04-13)

Glioblastoma multiform (GBM), the most common and aggressive primary brain tumor, is characterized by a high degree of hypoxia and resistance to therapy because of its adaptation capacities, including autophagy and growth factors signaling. In this study, we show an

Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase.

Nirmita J Patel et al.

Oncotarget, 7(51), 84608-84622 (2016-10-06)

Heparan sulfate (HS) plays a role in the majority of essential hallmarks of cancer, yet its ability to modulate self-renewal, especially of cancer stem cells (CSCs), remains unknown. We have discovered that a non-anticoagulant HS hexasaccharide (HS06) sequence, but not

M1 macrophages accelerate renal glomerular endothelial cell senescence through reactive oxygen species accumulation in streptozotocin-induced diabetic mice.

Songyan Yu et al.

International immunopharmacology, 81, 106294-106294 (2020-02-18)

Cellular senescence is a fundamental aging mechanism leading to tissue dysfunction. Accumulation of senescent cells is observed in the context of diabetes, which plays an important role in the pathogenesis of diabetes and its complications. Macrophages, the most prevalent leucocytes

p38 mitogen-activated protein kinase gene silencing rescues rat hippocampal neurons from ketamine-induced apoptosis: An in vitro study.

Xiao-Qian Guo et al.

International journal of molecular medicine, 42(3), 1401-1410 (2018-07-24)

Ketamine (KTM) is an anesthetic drug with several advantages, including the elevation of cardiac output and blood pressure. However, KTM may also induce the apoptosis of hippocampal neurons. Notably, p38 mitogen‑activated protein kinase (p38MAPK) has previously been studied for its role

Molecular signaling underlying bulleyaconitine A (BAA)-induced microglial expression of prodynorphin.

Teng-Fei Li et al.

Scientific reports, 7, 45056-45056 (2017-03-23)

Bulleyaconitine (BAA) has been shown to possess antinociceptive activities by stimulation of dynorphin A release from spinal microglia. This study investigated its underlying signal transduction mechanisms. The data showed that (1) BAA treatment induced phosphorylation of CREB (rather than NF-κB)

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