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Kenji Kishimoto et al.
Clinical immunology (Orlando, Fla.), 153(1), 17-22 (2014-04-03)
Hereditary folate malabsorption (HFM) is a rare autosomal recessive disorder. Severe folate deficiency in HFM can result in immunodeficiency. We describe a female infant with HFM who acquired severe Pneumocystis pneumonia. The objective of the present study was to elucidate
Diep Ngoc Thi Pham et al.
The American journal of clinical nutrition, 98(2), 413-422 (2013-06-28)
β,β-Carotene 15,15'-monooxygenase (BCMO1) converts β-carotene to retinaldehyde. Increased β-carotene consumption is linked to antitumor effects. Retinoic acid reduces the invasiveness in cancer, through inhibition of matrix metalloproteinases (MMPs). In our studies of a mouse model that develops intestinal tumors after
Young-Min Kim et al.
Biomaterials, 35(27), 7970-7977 (2014-06-22)
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to
Maternal prenatal folic acid supplementation is associated with a reduction in development of autistic disorder.
Robert J Berry
The Journal of pediatrics, 163(1), 303-304 (2013-06-26)
Rocío Pérez-Masiá et al.
Food chemistry, 168, 124-133 (2014-08-31)
In this work, two different technologies (electrospraying and nanospray drying) were evaluated for the encapsulation of folic acid using both a whey protein concentrate (WPC) matrix and a commercial resistant starch. The morphology of the capsules, molecular organization of the
Birgit Hoeft et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 316-320 (2013-06-26)
The link between a sufficient intake of vitamins and long term health, cognition, healthy development and aging is increasingly supported by experimental animal, human and epidemiology studies. In low income countries billions of people still suffer from the burden of
Hadi Hassani Nadiki et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 30(9), 911-918 (2014-09-13)
A glassy carbon electrode modified with ruthenium red and functionalized multi-walled carbon nanotube has been developed. The electrochemical response characteristics of the modified electrode toward epinephrine (EP) and acetaminophen (AC) was investigated by differential pulse voltammetry (DPV). Linear calibration plots
Gui Ling Huang et al.
Biomedical and environmental sciences : BES, 26(12), 1008-1012 (2014-01-08)
This study examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions (EPL) and esophageal squamous cell carcinoma (ESCC). The highest quartile of serum folate concentration significantly decreased the risk of ESCC compared
Niels Grarup et al.
PLoS genetics, 9(6), e1003530-e1003530 (2013-06-12)
Genome-wide association studies have mainly relied on common HapMap sequence variations. Recently, sequencing approaches have allowed analysis of low frequency and rare variants in conjunction with common variants, thereby improving the search for functional variants and thus the understanding of
K L Lindsay et al.
Public health, 128(7), 647-653 (2014-07-30)
The aim of the study is to explore the dietary intakes of a prominent ethnic minority group of women from Sub-Saharan Africa during pregnancy, in order to identify nutritional issues of concern which may impact on pregnancy outcomes and whether
Federico Cacciapuoti
Journal of thrombosis and thrombolysis, 36(3), 258-262 (2012-12-12)
Inheired or acquired hyperhomocysteinemia (HHcy) is associated with several impairments, as certain tumors, deep venous thrombosis, tube neural defects, osteoporosis, early atherosclerosis and vascular acute events (IMA, stroke, PVD), mild cognitive impairments till Alzheimer's disease (AD). But, vascular and neuronal
Jennifer Williams et al.
MMWR. Morbidity and mortality weekly report, 64(1), 1-5 (2015-01-16)
In 1992, the U.S. Public Health Service recommended that all women capable of becoming pregnant consume 400 µg of folic acid daily to prevent neural tube defects (NTDs). NTDs are major birth defects of the brain and spine that occur
Veysi Akpolat et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(3), 403-409 (2013-07-06)
In the current study, the risk coefficients of nitric oxide (NO), folate, homocysteine levels and lipid peroxidation in postmenopausal osteoporotic women were determined. Bone mineral density was determined by dual-energy X-ray absorptiometry. The levels of serum lipid peroxidation products such
N Lavanya et al.
Nanotechnology, 25(29), 295501-295501 (2014-07-02)
A novel folic acid biosensor has been fabricated using Cu doped SnO2 nanoparticles (NPs) synthesized by a simple microwave irradiation method. Powder XRD and TEM studies confirmed that both the pure and Cu doped SnO2 (Cu: 0, 10, 20wt%) crystallized
Agnieszka Seremak-Mrozikiewicz
Ginekologia polska, 84(5), 377-384 (2013-07-04)
Proper metabolism of folates has a crucial role for body homeostasis. Folate metabolism regulates changing of amino acids (homocysteine and methionine), purine and pyrimidine synthesis and DNA methylation. These whole biochemical processes have significant influence on hematopoietic, cardiovascular and nervous
Bingyang Shi et al.
Colloids and surfaces. B, Biointerfaces, 119, 55-65 (2014-06-02)
Treatment of human diseases at gene level is always limited by effective gene delivery vectors. In this study, we designed and developed an endosomal pH sensitive targeted gene delivery system, folic acid functionalized Schiff-base linked imidazole chitosan (FA-SLICS), for cancer
Vanessa R da Silva et al.
American journal of physiology. Endocrinology and metabolism, 307(1), E93-101 (2014-05-16)
Low vitamin B-6 nutritional status is associated with increased risk for cardiovascular disease and certain cancers. Pyridoxal 5'-phosphate (PLP) serves as a coenzyme in many cellular processes, including several reactions in one-carbon (1C) metabolism and the transsulfuration pathway of homocysteine
Mariano Licciardi et al.
Journal of biomedical nanotechnology, 9(6), 949-964 (2013-07-19)
Dual targeted drug delivery systems represent a potential platform for developing efficient vector to tumor sites. In this study we evaluated a folate- and magnetic-targeted nanocarriers based on 10 nm iron oxide nanodomais coated with the properly synthesized and characterized
Helene McNulty et al.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 348-354 (2013-06-26)
Scientific evidence supports a number of roles for folate in maintaining health from early life to old age. Folate is required for one-carbon metabolism, including the remethylation of homocysteine to methionine; thus elevated plasma homocysteine reflects functional folate deficiency. Optimal
Shougang Jiang et al.
Drug delivery, 22(2), 206-213 (2014-01-30)
Docetaxel is now a major antitumor drug in clinical use for the treatment of a variety of tumors. The ethanol/Tween 80 solvent required in the formulation to increase the docetaxel solubility is at least partly responsible for the hypersensitivity reaction
Katsumi Shibata et al.
Bioscience, biotechnology, and biochemistry, 78(12), 2102-2109 (2014-08-15)
We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season. In this study, we investigated the levels of B-group vitamins in the
Karine Meisser-Redeuil et al.
Journal of AOAC International, 97(4), 1121-1126 (2014-08-26)
A UHPLC-MS/MS method for the determination of folate (vitamin B9) in infant formula and adult/pediatric nutritional formula was assessed for compliance with standard method performance requirements set forth by the AOAC INTERNATIONAL Stakeholder Panel for Infant Formula and Adult Nutritionals
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Beverley Shea
Journal of evidence-based medicine, 6(3), 202-203 (2013-12-12)
Mingjun Xuan et al.
Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2255-2260 (2014-04-18)
The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and
Wen-Ni Chang et al.
Biochimica et biophysica acta, 1840(7), 2340-2350 (2014-04-22)
Folate is an essential nutrient for cell survival and embryogenesis. 10-Formyltetrahydrofolate dehydrogenase (FDH) is the most abundant folate enzyme in folate-mediated one-carbon metabolism. 10-Formyltetrahydrofolate dehydrogenase converts 10-formyltetrahydrofolate to tetrahydrofolate and CO2, the only pathway responsible for formate oxidation in methanol
Patrick O'Donoghue et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(48), 17206-17211 (2014-11-19)
Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes long ago over the course of evolution. Less than 1% of all sequenced genomes encode an operon that reassigns the stop
Arnold L M Dekkers et al.
The Journal of nutrition, 144(12), 2083-2091 (2014-10-17)
For the evaluation of both the adequacy of intakes and the risk of excessive intakes of micronutrients, all potential sources should be included. In addition to micronutrients naturally present in foods, micronutrients can also be derived from fortified foods and
Barbara Anne Jennings et al.
Cancer letters, 356(2 Pt A), 224-230 (2014-03-13)
Folate was identified as an essential micronutrient early in the twentieth century and anti-folate chemotherapy such as 5-fluorouracil (5-FU) has been central to the medical management of solid tumours including colorectal cancer for more than five decades. In the intervening
Donghong Zhang et al.
Arteriosclerosis, thrombosis, and vascular biology, 35(1), 71-78 (2014-11-02)
Homocysteine can accelerate the senescence of endothelial progenitor cells or endothelial cells (ECs) via telomerase inactivation and length shortening. However, the underlying mechanism is unclear. Here, we investigated whether homocysteine promotes endothelial senescence by reducing the expression and activity of
Priscila B Rosa et al.
Pharmacology, biochemistry, and behavior, 127, 1-6 (2014-10-16)
The objective of this study was to investigate the effects of folic acid on depressive-like behavior induced by chronic administration of corticosterone in mice. Corticosterone (20mg/kg, p.o.) was administered once a day for 21days. Folic acid (30mg/kg, p.o.) or fluoxetine
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