F0300000

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Folate/NIR 797-conjugated albumin magnetic nanospheres: synthesis, characterisation, and in vitro and in vivo targeting evaluation.

Qiusha Tang et al.

PloS one, 9(9), e106483-e106483 (2014-09-05)

A practical and effective strategy for synthesis of Folate-NIR 797-conjugated Magnetic Albumin Nanospheres (FA-NIR 797-MAN) was developed. For this strategy, Magnetic Albumin Nanospheres (MAN), composed of superparamagnetic iron oxide nanoparticles (SPIONs) and bovine serum albumin (BSA), were covalently conjugated with

Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology.

Jacob Joseph et al.

Nutrients, 5(8), 3235-3256 (2013-08-21)

Over the last four decades, abnormalities in the methionine-homocysteine cycle and associated folate metabolism have garnered great interest due to the reported link between hyperhomocysteinemia and human pathology, especially atherothrombotic cardiovascular disease. However, clinical trials of B-vitamin supplementation including high

[History of the therapy of pernicious anemia].

András Jeney

Orvosi hetilap, 154(44), 1754-1758 (2013-10-29)

Increased blood cell regeneration in exsanguinated experimental animals treated either with liver or with aqueous liver extracts was reported by Whipple and by Jeney and Jobling, respectively. These findings stimulated Minot and Murphy to provide evidence for the efficacy of

Expression of functional folate receptors by human parathyroid cells.

Collin J Weber et al.

Surgery, 154(6), 1385-1393 (2013-11-12)

Human pituitary adenomas express folate receptors (FR); therefore, we hypothesized that parathyroid (PT) tumors also might express FR, whereas normal human thyroids might not. The purpose of our study was to characterize the functionality of FRs on human PT tumors

Development and in vitro characterization of docetaxel-loaded ligand appended solid fat nanoemulsions for potential use in breast cancer therapy.

Sachin Yadav et al.

Artificial cells, nanomedicine, and biotechnology, 43(2), 93-102 (2013-11-08)

Breast cancer accounts for 23% of all newly occurring cancers in women worldwide and represents 13.7% of all cancer deaths. Available chemotherapeutic agents are limited largely due to the low accumulation of chemotherapeutics at the tumors relative to their accumulation

Promises of cyclotron-produced 44Sc as a diagnostic match for trivalent β--emitters: in vitro and in vivo study of a 44Sc-DOTA-folate conjugate.

Cristina Müller et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(12), 2168-2174 (2013-11-08)

In recent years, implementation of (68)Ga-radiometalated peptides for PET imaging of cancer has attracted the attention of clinicians. Herein, we propose the use of (44)Sc (half-life = 3.97 h, average β(+) energy [Eβ(+)av] = 632 keV) as a valuable alternative

Effect of epigallocatechin gallate on drug transport mediated by the proton-coupled folate transporter.

Maika Kissei et al.

Drug metabolism and pharmacokinetics, 29(5), 367-372 (2014-04-04)

Folic acid (FA) is a water-soluble vitamin, and orally ingested FA is absorbed from the small intestine by the proton-coupled folate transporter (PCFT). In the present study, we investigated whether epigallocatechin gallate (EGCG), one of the tea catechins, affects the

Bioavailability of enteric-coated microencapsulated calcium during pregnancy: a randomized crossover trial in Bangladesh.

Daniel E Roth et al.

The American journal of clinical nutrition, 100(6), 1587-1595 (2014-11-21)

Prenatal calcium and iron supplements are recommended in settings of low dietary calcium intake and high prevalence of anemia. However, calcium administration may inhibit iron absorption. To overcome calcium-iron interactions, we developed a multi-micronutrient powder containing iron (60 mg), folic

The direction of the difference between Canadian and American erythrocyte folate concentrations is dependent on the assay method employed: a comparison of the Canadian Health Measures Survey and National Health and Nutrition Examination Survey.

Cynthia K Colapinto et al.

The British journal of nutrition, 112(11), 1873-1881 (2014-10-09)

Fortification of select grain products with folic acid and periconceptional supplementation recommendations in Canada and the USA have improved folate status, and have been associated with a reduced risk of neural tube defects. In the present study, we aimed to

Targeted molecular therapy for lung cancer: exuberance reestablished.

Timothy Craig Allen

Archives of pathology & laboratory medicine, 137(6), 747-747 (2013-06-01)

Preparation and characterization of thermosensitive and folate functionalized Pluronic micelles.

Cheng Yang et al.

Journal of nanoscience and nanotechnology, 13(10), 6553-6559 (2013-11-20)

In this study, thermosensitive and folate functionalized poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-ploy(N-isopropylacrylamide-co-hydroxyethyl methacrylate) (FA-Pluronic-PNH) copolymer was synthesized. The structure and molecular weight of the copolymer were confirmed by 1H NMR, FT-IR and GPC, respectively. The lower critical solution temperature (LCST) of

Knowledge of periconceptional folic acid use among pregnant women at Ain Shams University Hospital, Cairo, Egypt.

W Al-Darzi et al.

Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit, 20(9), 561-568 (2014-10-25)

Egypt has a high incidence of neural tube defects. Folic acid supplementation in the periconceptional period is known to lower the risk of such defects. This cross-sectional study aimed to measure the level of knowledge about periconceptional folic acid use

Interaction between the SLC19A1 gene and maternal first trimester fever on offspring neural tube defects.

Lijun Pei et al.

Birth defects research. Part A, Clinical and molecular teratology, 103(1), 3-11 (2014-06-12)

Many studies have indicated that the reduced folate carrier gene (SLC19A1) is associated with an increased risk of neural tube defects (NTDs). However, the interaction between the SLC19A1 gene variant and maternal fever exposure and NTD risk remains unknown. The

Circulating biomarkers of one-carbon metabolism in relation to renal cell carcinoma incidence and survival.

Mattias Johansson et al.

Journal of the National Cancer Institute, 106(12), doi:10-doi:10 (2014-11-08)

The etiology of renal cell carcinoma (RCC) is only partially understood, but a metabolic component appears likely. We investigated biomarkers of one-carbon metabolism and RCC onset and survival. The European Prospective Investigation into Cancer and Nutrition (EPIC) recruited 385747 participants

Results of 2-year vitamin B treatment on cognitive performance: secondary data from an RCT.

Nikita L van der Zwaluw et al.

Neurology, 83(23), 2158-2166 (2014-11-14)

We investigated the effects of 2-year folic acid and vitamin B12 supplementation on cognitive performance in elderly people with elevated homocysteine (Hcy) levels. This multicenter, double-blind, randomized, placebo-controlled trial included 2,919 elderly participants (65 years and older) with Hcy levels

Dietary L-arginine modulates immunosuppression in broilers inoculated with an intermediate strain of infectious bursa disease virus.

Jian-Zhuang Tan et al.

Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)

The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:

Genetic variant in folate homeostasis is associated with lower warfarin dose in African Americans.

Roxana Daneshjou et al.

Blood, 124(14), 2298-2305 (2014-08-01)

The anticoagulant warfarin has >30 million prescriptions per year in the United States. Doses can vary 20-fold between patients, and incorrect dosing can result in serious adverse events. Variation in warfarin pharmacokinetic and pharmacodynamic genes, such as CYP2C9 and VKORC1

Impact of folate intake on prostate cancer recurrence following definitive therapy: data from CaPSURE™.

Jeffrey J Tomaszewski et al.

The Journal of urology, 191(4), 971-976 (2013-10-08)

A randomized, placebo controlled clinical trial of folic acid supplementation for the chemoprevention of colorectal adenoma revealed an increased incidence of prostate cancer in the treatment group. Limited data exist on postdiagnostic folate/folic acid intake and the risk of prostate

Prolonged blood circulation and enhanced tumor accumulation of folate-targeted dendrimer-polymer hybrid nanoparticles.

Suhair Sunoqrot et al.

Journal of controlled release : official journal of the Controlled Release Society, 191, 115-122 (2014-05-20)

Nanoparticle (NP)-based drug delivery platforms have received a great deal of attention over the past two decades for their potential in targeted cancer therapies. Despite the promises, passive targeting approaches utilizing relatively larger NPs (typically 50-200nm in diameter) allow for

PRECEDENT: a randomized phase II trial comparing vintafolide (EC145) and pegylated liposomal doxorubicin (PLD) in combination versus PLD alone in patients with platinum-resistant ovarian cancer.

R Wendel Naumann et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(35), 4400-4406 (2013-10-16)

Vintafolide (EC145) is a folic acid-desacetylvinblastine conjugate that binds to the folate receptor (FR), which is expressed on the majority of epithelial ovarian cancers. This randomized phase II trial evaluated vintafolide combined with pegylated liposomal doxorubicin (PLD) compared with PLD

Gene delivery with active targeting to ovarian cancer cells mediated by folate receptor alpha.

Zhiyao He et al.

Journal of biomedical nanotechnology, 9(5), 833-844 (2013-06-28)

Folate receptor alpha (FRalpha) is overexpressed on ovarian cancer cells and is a promising molecular target for ovarian cancer gene therapy, but there was still no related report. In this study, folate modified cationic liposomes (F-PEG-CLPs) for ovarian cancer gene

Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.

Reiko Nishihara et al.

The American journal of clinical nutrition, 100(6), 1479-1488 (2014-11-21)

Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood. We hypothesized that excess alcohol consumption might increase risk of colorectal carcinoma with hypomethylation of insulin-like growth factor

Valproate and folic acid in pregnancy: associations with autism.

Peter Baxter

Developmental medicine and child neurology, 56(7), 604-604 (2014-06-14)

Haematological implications of folate food fortification.

Jack Metz

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 103(12 Suppl 1), 978-981 (2013-12-05)

Reports from some Western countries indicate that mandatory folate food fortification (FFF) has substantially reduced the prevalence of folate deficiency, leading to calls for folate testing following FFF to be limited to specific indications such as macrocytic anaemia. This is

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.

P M Tedeschi et al.

Cell death & disease, 4, e877-e877 (2013-10-26)

Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis. We have predicted that a fraction of the synthesized serine is routed to a pathway for ATP production. The pathway is composed

Effect of folic acid, vitamin B6 and vitamin B12 supplementation on mortality and cardiovascular complication among patients with chronic kidney disease: an evidence-based case report.

Alvin Nursalim et al.

Acta medica Indonesiana, 45(2), 150-156 (2013-06-19)

to determine whether the administration of folic acid, vitamin B6 and vitamin B12 would lead to reduction of cardiovascular complication and mortality among CKD patients. a search was conducted on PubMed and Google. The selection of title and abstract was

Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells.

Vanessa R da Silva et al.

American journal of physiology. Endocrinology and metabolism, 307(1), E93-101 (2014-05-16)

Low vitamin B-6 nutritional status is associated with increased risk for cardiovascular disease and certain cancers. Pyridoxal 5'-phosphate (PLP) serves as a coenzyme in many cellular processes, including several reactions in one-carbon (1C) metabolism and the transsulfuration pathway of homocysteine

Nutrition throughout life: folate.

Helene McNulty et al.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 82(5), 348-354 (2013-06-26)

Scientific evidence supports a number of roles for folate in maintaining health from early life to old age. Folate is required for one-carbon metabolism, including the remethylation of homocysteine to methionine; thus elevated plasma homocysteine reflects functional folate deficiency. Optimal

Self-propelled Janus mesoporous silica nanomotors with sub-100 nm diameters for drug encapsulation and delivery.

Mingjun Xuan et al.

Chemphyschem : a European journal of chemical physics and physical chemistry, 15(11), 2255-2260 (2014-04-18)

The synthesis of an innovative self-propelled Janus nanomotor with a diameter of about 75 nm that can be used as a drug carrier is described. The Janus nanomotor is based on mesoporous silica nanoparticles (MSNs) with chromium/platinum metallic caps and

Development of optical probes for in vivo imaging of polarized macrophages during foreign body reactions.

David W Baker et al.

Acta biomaterialia, 10(7), 2945-2955 (2014-04-15)

Plasticity of macrophage (MΦ) phenotypes exist in a spectrum from classically activated (M1) cells, to alternatively activated (M2) cells, contributing to both the normal healing of tissues and the pathogenesis of implant failure. Here, folate- and mannose-based optical probes were

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