F2003

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Rapid prediction of chlorophylls and carotenoids content in tea leaves under different levels of nitrogen application based on hyperspectral imaging.

Yujie Wang et al.

Journal of the science of food and agriculture, 99(4), 1997-2004 (2018-10-10)

Photosynthetic pigments perform critical physiological functions in tea plants. Their content is an essential indicator of photosynthetic efficiency and nutritional status. The present study aimed to predict chlorophyll a (Chl a), chlorophyll b (Chl b), total chlorophyll (total Chl), and

Transciptome analysis reveals flavonoid biosynthesis regulation and simple sequence repeats in yam (Dioscorea alata L.) tubers.

Zhi-Gang Wu et al.

BMC genomics, 16, 346-346 (2015-05-01)

Yam (Dioscorea alata L.) is an important tuber crop and purple pigmented elite cultivar has recently become popular because of associated health benefits. Identifying candidate genes responsible for flavonoid biosynthesis pathway (FBP) will facilitate understanding the molecular mechanism of controlling

Leidy Lagos et al.

Frontiers in immunology, 11, 1924-1924 (2020-10-06)

Supplying novel feed ingredients for pig production is crucial to enhance food security and decrease the environmental impact of meat production. Several studies have focused on evaluating the beneficial health effects of yeast in pigs. However, its use as a

Inhibitory Effect of Synthetic Flavone Derivatives on Pan-Aurora Kinases: Induction of G2/M Cell-Cycle Arrest and Apoptosis in HCT116 Human Colon Cancer Cells.

Soon Young Shin et al.

International journal of molecular sciences, 19(12) (2018-12-20)

Members of the aurora kinase family are Ser/Thr kinases involved in regulating mitosis. Multiple promising clinical trials to target aurora kinases are in development. To discover flavones showing growth inhibitory effects on cancer cells, 36 flavone derivatives were prepared, and

Plasma protein binding of dietary polyphenols to human serum albumin: A high performance affinity chromatography approach.

Hui Cao et al.

Food chemistry, 270, 257-263 (2018-09-04)

Herein, the protein binding rates of structurally different flavonoids to human serum albumin (HSA) were elucidated by applying the high performance affinity chromatography (HPAC). The flavonoids with hydroxyl groups on ring A showed a higher protein binding rate compared with

The risk of lung cancer related to dietary intake of flavonoids.

Krista Yorita Christensen et al.

Nutrition and cancer, 64(7), 964-974 (2012-10-16)

It has been hypothesized that flavonoids in foods and beverages may reduce cancer risk through antioxidation, inhibition of inflammation, and other antimutagenic and antiproliferative properties. We examined associations between intake of 5 flavonoid subclasses (anthocyanidins, flavan-3-ols, flavones, flavonols, and flavanones)

Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.

Gugan Kothandan et al.

European journal of medicinal chemistry, 46(9), 4078-4088 (2011-07-05)

In order to explore the interactions between flavones and P-gp, in silico methodologies such as docking and 3D-QSAR were performed. CoMFA and CoMSIA analyses were done using ligand based and receptor guided alignment schemes. Validation statistics include leave-one-out cross-validated R(2)

Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.

Michelle Alonso et al.

Molecular cancer therapeutics, 2(2), 139-150 (2003-02-18)

Flavopiridol is a synthetic flavone, which inhibits growth in vitro and in vivo of several solid malignancies such as renal, prostate, and colon cancers. It is a potent cyclin-dependent kinase inhibitor presently in clinical trials. In this study, we examined

Fall armyworm (Spodoptera frugiperda Smith) feeding elicits differential defense responses in upland and lowland switchgrass.

Nathan A Palmer et al.

PloS one, 14(6), e0218352-e0218352 (2019-06-14)

Switchgrass (Panicum virgatum L.) is a low input, high biomass perennial grass being developed for the bioenergy sector. Upland and lowland cultivars can differ in their responses to insect herbivory. Fall armyworm [FAW; Spodoptera frugiperda JE Smith (Lepidoptera: Noctuidae)] is

Fast sensing of imidacloprid residue in tea using surface-enhanced Raman scattering by comparative multivariate calibration.

Quansheng Chen et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 211, 86-93 (2018-12-07)

This study focused on the fabrication of a rapid, highly sensitive and inexpensive technique for the quantification of imidacloprid residue in green tea, based on surface-enhanced Raman scattering (SERS) using highly roughned surface flower shaped silver nanostructure (as SERS substrate)

New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer's Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase.

Shaik Jeelan Basha et al.

Molecular pharmaceutics, 15(6), 2206-2223 (2018-05-11)

In line with the modern multi-target-directed ligand paradigm of Alzheimer's disease (AD), a series of 19 compounds composed of flavone and cyanoacetamide groups have been synthesized and evaluated as multifunctional agents against AD. Biological evaluation demonstrated that compounds 7j, 7n

Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

Daniela Schuster et al.

Journal of medicinal chemistry, 51(14), 4188-4199 (2008-06-07)

17Beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) plays a pivotal role in the local synthesis of the most potent estrogen estradiol. Its expression is a prognostic marker for the outcome of patients with breast cancer and inhibition of 17beta-HSD1 is currently under

High-yield production of multiple O-methylated phenylpropanoids by the engineered Escherichia coli-Streptomyces cocultivation system.

Heqing Cui et al.

Microbial cell factories, 18(1), 67-67 (2019-04-12)

O-Methylated phenylpropanoids, which are generally present in small amounts in plants, have improved or distinct biological activities and pharmacological properties as opposed to their unmethylated counterparts. Although microbial production could be a useful tool for the efficient and environment-friendly production

Evolutionary and ecological drivers of plant flavonoids across a large latitudinal gradient.

Erin A Tripp et al.

Molecular phylogenetics and evolution, 128, 147-161 (2018-07-19)

Flavonoids are important secondary metabolites that play an integral role in protecting plants against UV radiation and other forms of environmental stress. Given widespread impacts of environmental effects associated with latitude on a multitude of biological systems and a well-documented

The Reference Genome Sequence of Scutellaria baicalensis Provides Insights into the Evolution of Wogonin Biosynthesis.

Qing Zhao et al.

Molecular plant, 12(7), 935-950 (2019-04-19)

Scutellaria baicalensis Georgi is important in Chinese traditional medicine where preparations of dried roots, "Huang Qin," are used for liver and lung complaints and as complementary cancer treatments. We report a high-quality reference genome sequence for S. baicalensis where 93%

Chemical profiling of infusions and decoctions of Helichrysum italicum subsp. picardii by UHPLC-PDA-MS and in vitro biological activities comparatively with green tea (Camellia sinensis) and rooibos tisane (Aspalathus linearis).

Catarina Guerreiro Pereira et al.

Journal of pharmaceutical and biomedical analysis, 145, 593-603 (2017-08-09)

Several medicinal plants are currently used by the food industry as functional additives, for example botanical extracts in herbal drinks. Moreover, the scientific community has recently begun focusing on halophytes as sources of functional beverages. Helichrysum italicum subsp. picardii (everlasting)

Transcriptome analysis reveals the tolerant mechanisms to cobalt and copper in barley.

Jonas Lwalaba Wa Lwalaba et al.

Ecotoxicology and environmental safety, 209, 111761-111761 (2020-12-18)

Cobalt (Co) and copper (Cu) co-exist commonly in the contaminated soils and at excessive levels, they are toxic to plants. However, their joint effect and possible interaction have not been fully addressed. In this work, a hydroponic experiment was performed

Identification of anthocyanin and other flavonoids from the green-blue petals of Puya alpestris (Bromeliaceae) and a clarification of their coloration mechanism.

Takayuki Mizuno et al.

Phytochemistry, 181, 112581-112581 (2020-11-28)

To understand the unique green-blue color of Puya alpestris (Bromeliaceae) flowers, we investigated their constituent anthocyanin and related compounds. An anthocyanin, two undescribed flavonols, and two flavones were isolated and identified as delphinidin 3,3',5'-tri-O-β-glucopyranoside, myricetin 3-O-[α-rhamnopyranosyl-(1 → 6)-β-glucopyranoside]-3',5'-di-O-β-glucopyranoside, myricetin 3,3',5'-tri-O-β-glucopyranoside, luteolin 4'-O-glucoside

Changes in Beneficial C-glycosylflavones and Policosanol Content in Wheat and Barley Sprouts Subjected to Differential LED Light Conditions.

Muthusamy Muthusamy et al.

Plants (Basel, Switzerland), 9(11) (2020-11-12)

The spectral quality and intensity of light, photoperiodism, and other environmental factors have profound impacts on the metabolic composition of light-dependent higher plants. Hence, we investigate the effects of fluorescent light (96 μmol m-2s-1) and white (100 μmol m-2s-1), blue

Flavone ingredients can synergistically inhibit NDV infecting cell and improve ND vaccine's protective rate.

Zhang Yuqing et al.

International journal of biological macromolecules, 51(3), 201-208 (2012-05-12)

In order to screen better flavone prescriptions of anti-Newcastle disease virus (NDV), four flavone ingredients of epimedium flavones (EF), baikal skullcap root flavones (BSRF), wild dendranthema flower flavones (WDFF), and sanchi flavones (SF) screened in previous experiments and their prescriptions

Nanoparticles Containing Curcumin Useful for Suppressing Macrophages In Vivo in Mice.

Chie Amano et al.

PloS one, 10(9), e0137207-e0137207 (2015-09-12)

To explore a novel method using liposomes to suppress macrophages, we screened food constituents through cell culture assays. Curcumin was one of the strongest compounds exhibiting suppressive effects on macrophages. We subsequently tried various methods to prepare liposomal curcumin, and

Dynamic Changes in Metabolite Accumulation and the Transcriptome during Leaf Growth and Development in Eucommia ulmoides.

Long Li et al.

International journal of molecular sciences, 20(16) (2019-08-21)

Eucommia ulmoides Oliver is widely distributed in China. This species has been used mainly in medicine due to the high concentration of chlorogenic acid (CGA), flavonoids, lignans, and other compounds in the leaves and barks. However, the categories of metabolites

Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

Roger J Griffin et al.

Journal of medicinal chemistry, 48(2), 569-585 (2005-01-22)

A diverse range of chromen-2-one, chromen-4-one and pyrimidoisoquinolin-4-one derivatives was synthesized and evaluated for inhibitory activity against the DNA repair enzyme DNA-dependent protein kinase (DNA-PK), with a view to elucidating structure-activity relationships for potency and kinase selectivity. DNA-PK inhibitory activity

Screening of Inhibitory Effects of Polyphenols on Akt-Phosphorylation in Endothelial Cells and Determination of Structure-Activity Features.

Stoyan Dirimanov et al.

Biomolecules, 9(6) (2019-06-15)

Polyphenols exert beneficial effects in type 2 diabetes mellitus (T2DM). However, their mechanism of action remains largely unknown. Endothelial Akt-kinase plays a key role in the pathogenesis of cardiovascular complications in T2DM and therefore the modulation of its activity is

Analysis of the erythroid differentiation effect of flavonoid apigenin on K562 human chronic leukemia cells.

Hiroko Isoda et al.

Chemico-biological interactions, 220, 269-277 (2014-07-25)

The erythroid differentiation-inducing effect of apigenin and its derivatives on human chronic myeloid leukemia K562 has been reported but the functional group in its structure responsible for the effect has not yet been elucidated. Here, we determined the moiety responsible

Flavonoids with Vicinal Hydroxyl Groups Inhibit Human Calcitonin Amyloid Formation.

Richard Lantz et al.

Chemistry (Weinheim an der Bergstrasse, Germany), 26(57), 13063-13071 (2020-05-28)

Human calcitonin (hCT) is a 32-residue peptide hormone that can aggregate into amyloid fibrils and cause cellular toxicity. In this study, we investigated the inhibition effects of a group of polyphenolic molecules on hCT amyloid formation. Our results suggest that

The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling.

Min-Jung Seo et al.

The Journal of nutritional biochemistry, 26(11), 1308-1316 (2015-08-19)

Quercetin is a flavonoid found in fruits, vegetables, leaves and grains. It has inhibitory, antiviral, antiasthma, anticancer and antiinflammatory effects. Research has suggested that obesity is linked to metabolic disorders. In this study, we examined the inhibitory effect of quercetin

A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.

Mariana Torres-Piedra et al.

European journal of medicinal chemistry, 45(6), 2606-2612 (2010-03-30)

The aim of the current study was to investigate the oral antidiabetic activity of six structurally related flavonoids: flavone (1), 3-hydroxyflavone (2), 6-hydroxyflavone (3), 7-hydroxyflavone (4), chrysin (5) and quercetin (6). Normoglycemic and STZ-nicotinamide diabetic rats were treated with these

QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

Pablo R Duchowicz et al.

European journal of medicinal chemistry, 43(8), 1593-1602 (2007-12-26)

Experimentally assigned values to binding affinity constants of flavonoid ligands towards the benzodiazepine site of the GABA(A) receptor complex were compiled from several publications, and enabled to perform a predictive analysis based on Quantitative Structure-Activity Relationships (QSAR). The best linear

Quantitative high-throughput identification of drugs as modulators of human constitutive androstane receptor.

Caitlin Lynch et al.

Scientific reports, 5, 10405-10405 (2015-05-21)

The constitutive androstane receptor (CAR, NR1I3) plays a key role in governing the transcription of numerous hepatic genes that involve xenobiotic metabolism/clearance, energy homeostasis, and cell proliferation. Thus, identification of novel human CAR (hCAR) modulators may not only enhance early

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