搜索范围
F2442
应用筛选条件
关键词:'F2442'
显示 1-30 #N/A 612 条结果 关于 "F2442" 范围 论文
Microcantilever based disposable viscosity sensor for serum and blood plasma measurements.
Cakmak, et al.
Methods, 63, 225-232 (2013)
Yina Zhang et al.
Autophagy, 16(9), 1697-1710 (2019-12-31)
Macroautophagy/autophagy is a host natural defense response. Viruses have developed various strategies to subvert autophagy during their life cycle. Recently, we revealed that autophagy was activated by binding of Avibirnavirus to cells. In the present study, we report the inhibition
D G Roy et al.
Nature communications, 12(1), 2626-2626 (2021-05-13)
By conferring systemic protection and durable benefits, cancer immunotherapies are emerging as long-term solutions for cancer treatment. One such approach that is currently undergoing clinical testing is a therapeutic anti-cancer vaccine that uses two different viruses expressing the same tumor
Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system.
Mahmoudi Azar, et al.
BMC biotechnology, 23, 15-15 (2023)
Maria Fasolino et al.
Immunity, 52(2), 257-274 (2020-02-13)
Genetics is a major determinant of susceptibility to autoimmune disorders. Here, we examined whether genome organization provides resilience or susceptibility to sequence variations, and how this would contribute to the molecular etiology of an autoimmune disease. We generated high-resolution maps
Wenzhu Lu et al.
International journal of biological sciences, 16(6), 1071-1085 (2020-03-07)
The transcription factor c-Myc and two cullin family members CUL4A/4B function as oncogenes in colorectal cancer. Our recent publication reveals that c-Myc specifically activates the expression of CUL4A/4B through binding to their promoters. However, the underlying mechanism of how c-Myc
Sang Bae Lee et al.
Molecular cell, 79(3), 376-389 (2020-07-09)
Activation of dual-specificity tyrosine-phosphorylation-regulated kinases 1A and 1B (DYRK1A and DYRK1B) requires prolyl hydroxylation by PHD1 prolyl hydroxylase. Prolyl hydroxylation of DYRK1 initiates a cascade of events leading to the release of molecular constraints on von Hippel-Lindau (VHL) ubiquitin ligase
Ruijie Zhang et al.
Oncology reports, 44(3), 1224-1232 (2020-07-25)
Ovarian cancer is one of the most lethal cancer types in American women. The platinum agent cisplatin, and/or paclitaxel, remains the first‑line chemotherapy for ovarian cancer, but the treatment success is severely limited by chemoresistance. As previously reported, persistent STAT3
Catríona M Dowling et al.
Science advances, 7(3) (2021-02-02)
Triple-negative breast cancer (TNBC) is a subtype of breast cancer without a targeted form of therapy. Unfortunately, up to 70% of patients with TNBC develop resistance to treatment. A known contributor to chemoresistance is dysfunctional mitochondrial apoptosis signaling. We set
Eleonora Dal Sasso et al.
ACS biomaterials science & engineering, 6(10), 5493-5506 (2020-12-16)
Heart failure is the worst outcome of all cardiovascular diseases and still represents nowadays the leading cause of mortality with no effective clinical treatments, apart from organ transplantation with allogeneic or artificial substitutes. Although applied as the gold standard, allogeneic
Andrew VonHandorf et al.
Epigenetics, 13(4), 363-375 (2018-03-22)
Hexavalent chromium compounds are well-established respiratory carcinogens used in industrial processes. While inhalation exposure constitutes an occupational risk affecting mostly chromium workers, environmental exposure from drinking water is a widespread gastrointestinal cancer risk, affecting millions of people throughout the world.
Tatiana Ilchibaeva et al.
Biomedicines, 11(5) (2023-05-27)
Disturbances in neuroplasticity undoubtedly play an important role in the development of autism spectrum disorders (ASDs). Brain neurotransmitters and brain-derived neurotrophic factor (BDNF) are known as crucial players in cerebral and behavioral plasticity. Such an important neurotransmitter as dopamine (DA)
S R Mishra et al.
Reproduction in domestic animals = Zuchthygiene, 51(6), 855-869 (2016-08-30)
The objective of this study was to document the expression and localization of angiopoietin (ANGPT) family members comprising of angiopoietin (ANGPT1 and ANGPT2), and their receptors (Tie1 and Tie2) in buffalo corpus luteum (CL) obtained from different stages of the
Theodore A Slotkin et al.
Environmental health perspectives, 116(6), 716-722 (2008-06-19)
The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants. We evaluated perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorooctane
Kevin Klann et al.
Molecular cell, 80(1), 164-174 (2020-09-03)
SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of therapies is of major importance. However, our lack of understanding of the molecular processes and host cell signaling events underlying SARS-CoV-2 infection hinders therapy development. We use a
Young Ik Koh et al.
Autophagy, 18(11), 2593-2614 (2022-03-08)
Intracellular accumulation of mutant proteins causes proteinopathies, which lack targeted therapies. Autosomal dominant hearing loss (DFNA67) is caused by frameshift mutations in OSBPL2. Here, we show that DFNA67 is a toxic proteinopathy. Mutant OSBPL2 accumulated intracellularly and bound to macroautophagy/autophagy
Caitlin C Murdoch et al.
PLoS pathogens, 15(3), e1007381-e1007381 (2019-03-08)
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced
Venkatesha Narayanaswamy et al.
International journal of molecular sciences, 20(13) (2019-07-22)
The study presented in this work consists of two parts: The first part is the synthesis of Graphene oxide-Fe3O4 nanocomposites by a mechanochemical method which, is a mechanical process that is likely to yield extremely heterogeneous particles. The second part
Moona Roshanfekr Rad et al.
Iranian journal of pharmaceutical research : IJPR, 19(2), 242-250 (2020-11-24)
The present study was done to uncover the possible beneficial and/or detrimental effect(s) of nano-micelle curcumin (NMC) on oocyte in-vitro maturation and pre-implantation embryo development. Forty-eight mature female Wistar rats were assigned to control, 7.5, 15, and 30 mg/kg-1 NMC-receiving
Christopher C Nguyen et al.
Journal of virology, 92(18) (2018-07-13)
UL148 is a viral endoplasmic reticulum (ER)-resident glycoprotein that contributes to human cytomegalovirus (HCMV) cell tropism. The influence of UL148 on tropism correlates with its potential to promote the expression of glycoprotein O (gO), a viral envelope glycoprotein that participates
TrpA1 is a shear stress mechanosensing channel regulating intestinal stem cell proliferation in Drosophila.
Gong, et al.
Science Advances, 9, eadc9660-eadc9660 (2023)
Farooq Z Rahman et al.
Immunology, 128(2), 253-259 (2009-09-11)
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is critical for phagocyte anti-microbial activity and plays a major role in innate immunity. Defects in genes coding for components of the NADPH oxidase enzyme system are responsible for chronic granulomatous disease (CGD), a
Alexandra D'Oto et al.
Nature communications, 12(1), 7204-7204 (2021-12-12)
The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We demonstrate that inhibition of KDM6B activity 1) reduces the chromatin accessibility of E2F target genes and MYCN, 2) selectively
Tamar Barbakadze et al.
Cell journal, 25(4), 247-254 (2023-05-21)
Thyroid hormones are involved in the pathogenesis of various neurological disorders. Ischemia/hypoxia that induces rigidity of the actin filaments, which initiates neurodegeneration and reduces synaptic plasticity. We hypothesized that thyroid hormones via alpha-v-beta-3 (αvβ3) integrin could regulate the actin filament
Promoter methylation of Wnt/β-Catenin signal inhibitor
Rongna Ma et al.
Cancer biology & medicine, 14(4), 377-386 (2018-01-27)
Effects of Gallic Acid on Endometrial Cancer Cells in Two and Three Dimensional Cell Culture Models.
Muhammet Volkan Bulbul et al.
Asian Pacific journal of cancer prevention : APJCP, 22(6), 1745-1751 (2021-06-29)
Cell culture studies are an indispensable tools used to understand basic physiological, biophysical and biomolecular mechanisms. Although traditional two-dimensional (2D) cell culture models are more preferred in experimental studies, three-dimensional (3D) cell culture models, attract more attention due to several
Xiaoming Liu et al.
Journal for immunotherapy of cancer, 10(4) (2022-04-29)
Anti-GD2 monoclonal antibody immunotherapy has significantly improved the overall survival rate for high-risk neuroblastoma patients. However, 40% of patients fail to respond or develop resistance to treatment, and the molecular mechanisms by which this occurs remain poorly understood. Tumor-derived small
Seetharam Deepa et al.
Nanotoxicology, 13(2), 240-257 (2019-01-22)
The present study analyzed the effects of zinc oxide nanoparticles (ZnO-NPs) and zinc sulfate (ZnSO4) in the testis of six-month-old common carp Cyprinus carpio exposed to three different doses, viz., 10, 50, and 100 μg/L for 21 days. Characterization of ZnO-NPs was
Chen Benkler et al.
Scientific reports, 8(1), 16393-16393 (2018-11-08)
Most human neurodegenerative diseases share a phenotype of neuronal protein aggregation. In Amyotrophic Lateral Sclerosis (ALS), the abundant protein superoxide dismutase (SOD1) or the TAR-DNA binding protein TDP-43 can aggregate in motor neurons. Recently, numerous studies have highlighted the ability
Fatu Badiane Markey et al.
Cells, 10(6) (2021-06-03)
Ewing's sarcoma (ES) is caused by a chromosomal translocation leading to the formation of the fused EWSFLI1 gene, which codes for an aberrant transcription factor EWSFLI1. The transcriptional targets of EWSFLI1 have been viewed as promising and novel drug targets
1/21