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Federica Castelletti et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2538-2543 (2008-02-13)
Glomerulopathy with fibronectin (FN) deposits (GFND) is an autosomal dominant disease with age-related penetrance, characterized by proteinuria, microscopic hematuria, hypertension, and massive glomerular deposits of FN that lead to end-stage renal failure. The genetic abnormality underlying GFND was still unknown.
Generation of an induced pluripotent stem cell line from chorionic villi of a Turner syndrome spontaneous abortion.
Parveen S, et al.
Stem Cell Research, 19, 12-16 (2017)
Denise Gay et al.
Science advances, 6(12), eaay3704-eaay3704 (2020-03-29)
Human and murine skin wounding commonly results in fibrotic scarring, but the murine wounding model wound-induced hair neogenesis (WIHN) can frequently result in a regenerative repair response. Here, we show in single-cell RNA sequencing comparisons of semi-regenerative and fibrotic WIHN
Laurin Marie Pacheco et al.
Aging, 6(12), 1049-1063 (2015-01-09)
Vascular disease is one of the leading causes of death worldwide. Vascular repair, essential for tissue maintenance, is critically reduced during vascular disease and aging. Efficient vascular repair requires functional adult stem cells unimpaired by aging or mutation. One protein
Bin Xu et al.
Journal of neuroinflammation, 20(1), 11-11 (2023-01-18)
Ischemic stroke in white matter of the brain induces not only demyelination, but also neuroinflammation. Peripheral T lymphocytes, especially regulatory T cells (Tregs), are known to infiltrate into ischemic brain and play a crucial role in modulation of inflammatory response
Ursula Fürnkranz et al.
Acta veterinaria Scandinavica, 55, 63-63 (2013-09-10)
The cell invasiveness of Mycoplasma gallisepticum, the causative agent of respiratory disease in chickens and infectious sinusitis in turkeys, may be a substantial factor in the well-known chronicity of these diseases and in the systemic spread of infection. To date
Nathan Kumar et al.
eLife, 4 (2015-11-12)
The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations. However, these cells harbor significant
Prem Prakash et al.
Blood, 125(20), 3164-3172 (2015-02-24)
Cellular fibronectin containing extra domain A (Fn-EDA+), which is produced in response to tissue injury in several disease states, has prothrombotic activity and is known to interact with Toll-like-receptor 4 (TLR4). The underlying mechanism and cell types involved in mediating
Anthony R Flores et al.
Infection and immunity, 83(3), 1122-1129 (2015-01-07)
Group A Streptococcus (GAS) predominantly exists as a colonizer of the human oropharynx that occasionally breaches epithelial barriers to cause invasive diseases. Despite the frequency of GAS carriage, few investigations into the contributory molecular mechanisms exist. To this end, we
Regulation of matrix Accumulation (2012)
Ulvi K Gursoy et al.
Cytotechnology, 68(6), 2345-2354 (2016-10-19)
In construction of epithelial cells as multilayers, the cells are grown submerged to confluence on fibroblast-embedded collagen gels and, then, lifted to air to promote their stratification. We recently demonstrated that gingival epithelial cells form uniform monolayers on semi-permeable nitrocellulose
Ail binding to fibronectin facilitates Yersinia pestis binding to host cells and Yop delivery.
Tsang T M, et al.
Infection and Immunity, 78(8), 3358-3368 (2010)
Fibronectin
Fabrizio M and Angela S
Encyclopedia of Immunology, 909-913 (1998)
Prabhavathi Maddineni et al.
International journal of molecular sciences, 22(18) (2021-09-29)
Ocular hypertension (OHT) is a serious adverse effect of the widely prescribed glucocorticoid (GC) therapy and, if left undiagnosed, it can lead to glaucoma and complete blindness. Previously, we have shown that the small chemical chaperone, sodium-4-phenylbutyrate (PBA), rescues GC-induced
Sangam Rajak et al.
Scientific reports, 10(1), 9102-9102 (2020-06-06)
We determined the role of cellular fibronectin (CFN) containing the alternatively spliced extra domain A (FN-EDA) in causing insulin resistance (IR) through toll-like receptor 4 (TLR4). Circulating FN-EDA level was evaluated in mouse and rat IR models. Specific anti-FN-EDA antibody
Xia Wang et al.
Development (Cambridge, England), 143(1), 88-100 (2015-11-11)
The chemical and mechanical properties of extracellular matrices (ECMs) modulate diverse aspects of cellular fates; however, how regional heterogeneity in ECM composition regulates developmental programs is not well understood. We discovered that fibronectin 1 (Fn1) is expressed in strikingly non-uniform
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Sapkota Y, et al.
Nature Communications, 8, 15539-15539 (2017)
Caroline Chagnot et al.
PloS one, 8(3), e59386-e59386 (2013-03-22)
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 are responsible for repeated food-poisoning cases often caused by contaminated burgers. EHEC infection is predominantly a pediatric illness, which can lead to life-threatening diseases. Ruminants are the main natural reservoir for EHEC and food contamination
Natural variant of collagen-like protein A in serotype M3 group A Streptococcus increases adherence and decreases invasive potential.
Flores A R, et al.
Infection and Immunity (2015)
Ricardo Monteiro et al.
Cells, 12(12) (2023-06-28)
Escherichia coli is a versatile commensal species of the animal gut that can also be a pathogen able to cause intestinal and extraintestinal infections. The plasticity of its genome has led to the evolution of pathogenic strains, which represent a
Konrad Schwefel et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(7), 9018-9033 (2020-06-10)
Loss-of-function variants in CCM1/KRIT1, CCM2, and CCM3/PDCD10 are associated with autosomal dominant cerebral cavernous malformations (CCMs). CRISPR/Cas9-mediated CCM3 inactivation in human endothelial cells (ECs) has been shown to induce profound defects in cell-cell interaction as well as actin cytoskeleton organization.
Mootaz M Salman et al.
Frontiers in bioengineering and biotechnology, 8, 573775-573775 (2020-10-30)
We describe here the design and implementation of an in vitro microvascular open model system using human brain microvascular endothelial cells. The design has several advantages over other traditional closed microfluidic platforms: (1) it enables controlled unidirectional flow of media
Nirav Dhanesha et al.
Journal of thrombosis and haemostasis : JTH, 19(3), 814-821 (2020-12-11)
Overweight and obesity are significant risk factors for deep vein thrombosis (DVT). Cellular fibronectin containing extra domain A (Fn-EDA), an endogenous ligand for toll-like-receptor 4 (TLR4), contributes to thrombo-inflammation. The role of Fn-EDA in the modulation of DVT is not
Felipe José Passalia et al.
Frontiers in cellular and infection microbiology, 11, 708739-708739 (2021-07-20)
Leptospirosis is a neglected zoonosis, caused by pathogenic spirochetes bacteria of the genus Leptospira. The molecular mechanisms of leptospirosis infection are complex, and it is becoming clear that leptospires express several functionally redundant proteins to invade, disseminate, and escape the
Ramesh B Kasetti et al.
Scientific reports, 7(1), 14951-14951 (2017-11-04)
Increased synthesis and deposition of extracellular matrix (ECM) proteins in the trabecular meshwork (TM) is associated with TM dysfunction and intraocular pressure (IOP) elevation in glaucoma. However, it is not understood how ECM accumulation leads to TM dysfunction and IOP
Xiaonan Su et al.
Cell death discovery, 6(1), 140-140 (2020-12-10)
Pathological angiogenesis is an important component of hepatic fibrosis along with fibrous deposition, but its role is not well understood. Here, we demonstrated that fibronectin containing extra domain A(FN-EDA), a fibronectin splice variant highly expressed in hepatic fibrosis, mediated angiogenesis
Humberto Hernandez et al.
Experimental eye research, 191, 107920-107920 (2020-01-11)
A major risk for the development of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP). Elevated IOP is caused by increased outflow resistance due in part to excessive extracellular matrix (ECM) deposition in the trabecular meshwork (TM). The role
Giulia Mana et al.
Nature communications, 7, 13546-13546 (2016-11-24)
Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling. However, mechanisms coordinating α5β1 integrin-mediated extracellular FN endocytosis and exocytosis of newly synthesized FN remain elusive. Here we show that, on Rab21-elicited internalization
Artificial biomaterials for urological tissue engineering
Farhat WA and Geutjes, PJ
Journal of Separation Science (2009)
Fibronectin binds and enhances the activity of bone morphogenetic protein 1.
Huang G, et al.
The Journal of Biological Chemistry (2009)
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