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[Tacrolimus therapy for patients with ulcerative colitis].
Hiroshi Nakase
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 110(11), 1916-1921 (2013-11-06)
A Argudo et al.
Transplantation proceedings, 47(8), 2388-2392 (2015-11-01)
The aim of this work was to evaluate the CYP3A5:CYP3A5*1/CYP3A5*3 (6986A>G) polymorphism related to the pharmacokinetic characteristics of tacrolimus during the first 3 months after transplantation, analyzing both donor and recipient genotype, in liver transplant patients. This retrospective, single-center, cohort
Binta Diémé et al.
Transplantation, 98(2), 195-201 (2014-03-07)
Biomarkers that can predict graft function and/or renal side effects of calcineurin inhibitors (CNI) at each stage of treatment in kidney transplantation are still lacking. We report the first untargeted GC-MS-based metabolomic study on urines of renal transplant patients. This
Ahmad Sharanek et al.
Toxicological sciences : an official journal of the Society of Toxicology, 141(1), 244-253 (2014-06-29)
Mechanisms involved in drug-induced cholestasis in humans remain poorly understood. Although cyclosporine A (CsA) and tacrolimus (FK506) share similar immunosuppressive properties, only CsA is known to cause dose-dependent cholestasis. Here, we have investigated the mechanisms implicated in early cholestatic effects
Ehren N Rudolph et al.
Transplantation, 99(2), 367-374 (2015-01-17)
Pancreas retransplantation is associated with increased rates of technical failure and rejection compared to other organ transplants. As such, it is not routinely done, and outcomes are mostly known through registry data. Here we analyze the outcomes of primary versus
Guillaume Margaillan et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1331-1335 (2015-06-17)
Phase II metabolism is prominently governed by UDP-glucuronosyltransferases (UGTs) in humans. These enzymes regulate the bioactivity of many drugs and endogenous small molecules in many organs, including the liver, a major site of regulation by the glucuronidation pathway. This study
Sarah König et al.
American journal of physiology. Heart and circulatory physiology, 305(11), H1646-H1657 (2013-09-24)
Sirolimus (rapamycin) is used in drug-eluting stent strategies and proved clearly superior in this application compared with other immunomodulators such as pimecrolimus. The molecular basis of this action of sirolimus in the vascular system is still incompletely understood. Measurements of
Deana Funaro et al.
Journal of the American Academy of Dermatology, 71(1), 84-91 (2014-04-08)
Vulvar lichen sclerosus is a chronic condition usually responsive to topical corticosteroids. We sought to evaluate the efficacy (reduction of signs and symptoms) and safety of clobetasol propionate 0.05% and tacrolimus 0.1% in the treatment of vulvar lichen sclerosus. This
Rania Rabie et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 19(1), 36-48 (2012-07-24)
Cyclosporine A (CSA), but not tacrolimus (TAC), inhibits hepatitis C virus (HCV) replication in vitro. Clinical reports on the efficacy of interferon-α (IFNα)-based antiviral therapy (AVT) for recurrent HCV after liver transplantation (LT) with CSA and TAC are conflicting. Our
Qing-Jie Chen et al.
Renal failure, 37(4), 601-606 (2015-02-04)
New Onset Diabetes after Transplantation (NODAT) is defined as sustained hyperglycemia developing in patients without diabetes history before transplantation. A cohort study was performed to access the effects of tacrolimus on insulin secretion and insulin sensitivity and consequently in the
Khawar Abbas et al.
Clinical transplantation, 29(9), 835-841 (2015-07-15)
Acute rejections (ARs) with plasma cell-rich infiltrates (PCARs) are associated with poor outcomes. Between February 2012 and December 2013, 1630 dysfunctional renal graft biopsies were performed. Of these, 50 (3%) showed PCAR. ARs with >10% plasma cells were defined as
Dirk R J Kuypers et al.
Pharmacogenetics and genomics, 24(12), 597-606 (2014-10-17)
In a cohort of 298 de-novo renal recipients treated with a standard tacrolimus loading dose of 0.2 mg/kg, the combined effects of the CYP3A5*1, POR*28, and CYP3A4*22 genotypes on early tacrolimus exposure (C0), dose requirements, and achievement of the therapeutic target
Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
Rajat Puri et al.
Nature communications, 10(1), 3645-3645 (2019-08-15)
Chronic mitochondrial stress associates with major neurodegenerative diseases. Recovering stressed mitochondria constitutes a critical step of mitochondrial quality control and thus energy maintenance in early stages of neurodegeneration. Here, we reveal Mul1-Mfn2 pathway that maintains neuronal mitochondrial integrity under stress
Luis E Rojas et al.
Pharmacogenetics and genomics, 23(10), 509-517 (2013-07-23)
A meta-analysis was carried out of published studies on the effect of the CYP3A5 6986A>G polymorphism in liver donors and transplant recipients on tacrolimus pharmacokinetics. Cohort studies that evaluated the relationship between the CYP3A5 polymorphism in liver donors and transplant
Silvia Biggi et al.
Journal of neurochemistry, 152(1), 136-150 (2019-07-03)
The vast majority of therapeutic approaches tested so far for prion diseases, transmissible neurodegenerative disorders of human and animals, tackled PrPSc , the aggregated and infectious isoform of the cellular prion protein (PrPC ), with largely unsuccessful results. Conversely, targeting
Xiaofan Guo et al.
Nature communications, 11(1), 2177-2177 (2020-05-03)
Brain tumors (gliomas) are heterogeneous cellular ecosystems, where non-neoplastic monocytic cells have emerged as key regulators of tumor maintenance and progression. However, relative to macrophages/microglia, comparatively less is known about the roles of neurons and T cells in glioma pathobiology.
Hao Guo et al.
Cellular immunology, 295(1), 19-28 (2015-03-04)
We expanded flow-sorted Foxp3(+) cynomolgus monkey regulatory T cells (Treg) >1000-fold after three rounds of stimulation with anti-CD3 mAb-loaded artificial antigen-presenting cells, rapamycin (first round only) and IL-2. The expanded Treg maintained their expression of Treg signature markers, CD25, CD27
K Kasutani et al.
British journal of pharmacology, 171(22), 5049-5058 (2014-06-20)
IL-31, which is described as a pruritogenic cytokine, is linked to the itching that is associated with allergic and non-allergic eczema, but the precise pruritogenic mechanism of IL-31 and its potential as a therapeutic target for atopic dermatitis (AD) have
M Rodríguez-Perálvarez et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 12(10), 2797-2814 (2012-06-19)
We hypothesized that current trough concentrations of tacrolimus after liver transplantation are set too high, considering that clinical consequences of rejection are not severe while side effects are increased.We systematically reviewed 64 studies (32 randomized controlled trials and 32 observational
K McSharry et al.
Alimentary pharmacology & therapeutics, 34(11-12), 1282-1294 (2011-10-18)
BACKGROUND Several published studies have evaluated the efficacy of tacrolimus in the management of Crohn's disease with variable conclusions. AIM To review systematically the evidence examining the efficacy and safety of tacrolimus in treating Crohn's disease. METHODS The Cochrane Central
Ida Robertsen et al.
Transplantation, 99(3), 528-532 (2014-08-26)
Proper bioequivalence studies comparing original with generic immunosuppressive drugs in patients are limited, especially in the increasing population of elderly renal transplant recipients. We performed an open-label, single-center, prospective, randomized, cross-over study and compared steady-state pharmacokinetics (PK) of a generic
Successful multitarget therapy using mizoribine and tacrolimus for refractory Takayasu arteritis.
Masaki Shimizu et al.
Rheumatology (Oxford, England), 53(8), 1530-1532 (2014-03-13)
D J R Dall'Agnol et al.
Transplantation proceedings, 46(6), 1872-1874 (2014-08-19)
Triple immunosuppressive therapy after organ transplantation may cause several gastrointestinal disturbances. It is difficult to identify which drug causes more complications, requiring an appropriate animal model. The aim was to compare the gastrointestinal transit in immunosuppressed rats under triple immunosuppressive
M W F van den Hoogen et al.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 15(2), 407-416 (2015-01-24)
We evaluated the efficacy and safety of rituximab as induction therapy in renal transplant patients. In a double-blind, placebo-controlled study, 280 adult renal transplant patients were randomized between a single dose of rituximab (375 mg/m(2)) or placebo during transplant surgery. Patients
Susann Schulz et al.
Applied microbiology and biotechnology, 107(9), 2871-2886 (2023-03-24)
FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is rather limited. Optimization strategies to enhance the productivity of S.
Jesus Ruiz et al.
International journal of molecular sciences, 16(9), 20168-20182 (2015-08-27)
Lung transplant patients present important variability in immunosuppressant blood concentrations during the first months after transplantation. Pharmacogenetics could explain part of this interindividual variability. We evaluated SNPs in genes that have previously shown correlations in other kinds of solid organ
Kyung Eun Jung et al.
International immunopharmacology, 26(2), 432-438 (2015-03-22)
Rapamycin (RPM) and mycophenolic acid (MPA) are immunosuppressive drugs approved for use in preventing transplant rejection. These drugs have also been used in the field of dermatology as glucocorticoid sparing agents for autoimmune and inflammatory disorders such as atopic dermatitis
Mats Brännström et al.
Lancet (London, England), 385(9968), 607-616 (2014-10-11)
Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet
Harry M Gallagher et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 34(11), 1442-1448 (2015-07-19)
Erratic tacrolimus blood levels are associated with liver and kidney graft failure. We hypothesized that erratic tacrolimus exposure would similarly compromise lung transplant outcomes. This study assessed the effect of tacrolimus mean and standard deviation (SD) levels on the risk
Jennifer Grossman et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(12), 1940-1948 (2014-08-12)
We treated 14 patients with GATA2 deficiency using a nonmyeloablative allogeneic hematopoietic stem cell transplantation regimen. Four patients received peripheral blood stem cells from matched related donors (MRD), 4 patients received peripheral blood stem cells from matched unrelated donors (URD)
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