搜索范围
F4679
应用筛选条件
关键词:'F4679'
显示 1-30 #N/A 285 条结果 关于 "F4679" 范围 论文
Susann Schulz et al.
Applied microbiology and biotechnology, 107(9), 2871-2886 (2023-03-24)
FK-506 is a potent immunosuppressive macrocyclic polyketide with growing pharmaceutical interest, produced by Streptomyces tsukubaensis. However, due to low levels synthesized by the wild-type strain, biotechnological production of FK-506 is rather limited. Optimization strategies to enhance the productivity of S.
LiQin Zhu et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(9), 840-846 (2015-04-15)
1. The purpose of this study was to establish a population pharmacokinetic (PK) model of tacrolimus and evaluate the influence of clinical covariates, including the genetic polymorphisms of the cytochrome P450 3A5 gene (CYP3A5) and gene-encoding P-glycoprotein (ABCB1), on the PK
Sarra Ait Djebbara et al.
Frontiers in immunology, 14, 1180900-1180900 (2023-06-12)
We previously identified the recombinant (r) macrophage (M) infectivity (I) potentiator (P) of the protozoan parasite Trypanosoma cruzi (Tc) (rTcMIP) as an immuno-stimulatory protein that induces the release of IFN-γ, CCL2 and CCL3 by human cord blood cells. These cytokines
Harry M Gallagher et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 34(11), 1442-1448 (2015-07-19)
Erratic tacrolimus blood levels are associated with liver and kidney graft failure. We hypothesized that erratic tacrolimus exposure would similarly compromise lung transplant outcomes. This study assessed the effect of tacrolimus mean and standard deviation (SD) levels on the risk
Jennifer Grossman et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 20(12), 1940-1948 (2014-08-12)
We treated 14 patients with GATA2 deficiency using a nonmyeloablative allogeneic hematopoietic stem cell transplantation regimen. Four patients received peripheral blood stem cells from matched related donors (MRD), 4 patients received peripheral blood stem cells from matched unrelated donors (URD)
Jesus Ruiz et al.
International journal of molecular sciences, 16(9), 20168-20182 (2015-08-27)
Lung transplant patients present important variability in immunosuppressant blood concentrations during the first months after transplantation. Pharmacogenetics could explain part of this interindividual variability. We evaluated SNPs in genes that have previously shown correlations in other kinds of solid organ
Mats Brännström et al.
Lancet (London, England), 385(9968), 607-616 (2014-10-11)
Uterus transplantation is the first available treatment for absolute uterine infertility, which is caused by absence of the uterus or the presence of a non-functional uterus. Eleven human uterus transplantation attempts have been done worldwide but no livebirth has yet
Kyung Eun Jung et al.
International immunopharmacology, 26(2), 432-438 (2015-03-22)
Rapamycin (RPM) and mycophenolic acid (MPA) are immunosuppressive drugs approved for use in preventing transplant rejection. These drugs have also been used in the field of dermatology as glucocorticoid sparing agents for autoimmune and inflammatory disorders such as atopic dermatitis
Dan Li et al.
Autophagy, 17(4), 872-887 (2020-03-07)
Oxidative stress underlies a number of pathological conditions, including cancer, neurodegeneration, and aging. Antioxidant-rich foods help maintain cellular redox homeostasis and mitigate oxidative stress, but the underlying mechanisms are not clear. For example, sulforaphane (SFN), an electrophilic compound that is
Frank Stifft et al.
British journal of clinical pharmacology, 78(5), 996-1004 (2014-05-09)
The immunosuppressant tacrolimus is usually administered orally. When this is not feasible, other routes of administration may be useful. Previous research suggested that tacrolimus may be applied sublingually or rectally. Pharmacokinetic data are sparse. The aim of this study was
Alessio Provenzani et al.
World journal of gastroenterology, 19(48), 9156-9173 (2014-01-11)
The introduction of tacrolimus in clinical practice has improved patient survival after organ transplant. However, despite the long use of tacrolimus in clinical practice, the best way to use this agent is still a matter of intense debate. The start
Reversible cerebral vasoconstriction syndrome resulted in cerebral infarction after allogeneic stem cell transplantation: a case report.
Osamu Imataki et al.
Annals of hematology, 93(5), 895-896 (2013-09-26)
Ashok Thorat et al.
BioMed research international, 2014, 265658-265658 (2014-08-15)
Typically, tacrolimus is administrated twice daily. Prolonged-release tacrolimus is the once-daily formulation and may be more convenient for patients. Experience with the administration of the once-daily formulation is still limited. This study enrolled 210 liver transplant recipients who had stable
Daisuke Imai et al.
Journal of the American College of Surgeons, 219(6), 1134-1142 (2014-12-03)
Thoracic fluid retention after living donor liver transplantation (LDLT) has various negative consequences, including atelectasis, pneumonia, and respiratory distress or failure. We analyzed the clinical impact of preemptive thoracic drainage in 177 patients undergoing adult-to-adult LDLT for chronic liver diseases
Khyati Kapoor et al.
The Journal of biological chemistry, 288(45), 32622-32636 (2013-09-26)
P-glycoprotein (P-gp) is an ATP binding cassette transporter that effluxes a variety of structurally diverse compounds including anticancer drugs. Computational models of human P-gp in the apo- and nucleotide-bound conformation show that the adenine group of ATP forms hydrogen bonds
R B Friedrich et al.
Journal of biomedical nanotechnology, 10(8), 1599-1609 (2014-07-16)
Tacrolimus is widely used in the prophylaxis of solid-organ transplant rejection. Several studies have reported that tacrolimus has variable and poor bioavailability after oral administration, apart from adverse effects such as gastrointestinal disorders, hyperglycemia, nephro- and neurotoxicity. The aim of
Jamil R Azzi et al.
Journal of immunology (Baltimore, Md. : 1950), 191(12), 5785-5791 (2013-12-10)
Calcineurin inhibitors (CNIs) revolutionized the field of organ transplantation and remain the standard of care 40 years after the discovery of cyclosporine. The early impressive results of cyclosporine in kidney transplant recipients led to its subsequent use in other organ
Baolian Wang et al.
Journal of ethnopharmacology, 155(3), 1473-1482 (2014-08-06)
Schisandra chinensis (SC), officially listed as a sedative and tonic in the Chinese Pharmacopoeia, has been used as a common component in various prescriptions in Traditional Chinese Medicine (TCM) and more recently in western medicine for its antihepatotoxic effect. To
Robert Caiazzo et al.
Transplantation, 99(5), 979-984 (2014-11-14)
Pancreatic islet transplantation offers a promising biotherapy for the treatment of type 1 diabetes, but this procedure has met significant challenges over the years. One such challenge is to address why primary graft function still remains inconsistent after islet transplantation.
Martijn W H J Demmers et al.
Transplantation, 97(11), 1110-1118 (2014-04-08)
Although CD8+ T cell-mediated and natural killer (NK) cell-mediated cytotoxicity against renal tubular epithelial cells (TECs) plays a crucial role during rejection, the degree of inhibition of these lytic immune responses by immunosuppressive drugs is unknown. We investigated the CD8
Ryota Inoue et al.
iScience, 25(7), 104603-104603 (2022-07-09)
Uncoupling protein 2 (UCP2), a mitochondrial protein, is known to be upregulated in pancreatic islets of patients with type 2 diabetes (T2DM); however, the pathological significance of this increase in UCP2 expression is unclear. In this study, we highlight the
Arteriosclerosis in zero-time biopsy is a risk factor for tacrolimus-induced chronic nephrotoxicity.
Takafumi Yagisawa et al.
Nephrology (Carlton, Vic.), 20 Suppl 2, 51-57 (2015-06-03)
Calcineurin inhibitors reduce the acute rejection rate and greatly improve renal allograft survival. However, they are associated with some adverse events, including nephrotoxicity, a risk factor for allograft failure. Chronic calcineurin inhibitor-induced nephrotoxicity causes irreversible damage to renal components, such
Sayako Yuda et al.
[Rinsho ketsueki] The Japanese journal of clinical hematology, 54(12), 2187-2191 (2014-01-24)
A 39-year-old woman (Case 1) and a 57-year-old woman (Case 2) underwent allogeneic bone marrow transplantation for acute lymphoblastic leukemia and follicular lymphoma, respectively. Both patients had received tacrolimus orally for treatment of or prophylaxis against graft-versus-host disease. Seventeen months
Nikola Z Stefanović et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 70, 132-139 (2015-02-07)
The main goal of this study was to evaluate the influence of tacrolimus daily dose (TDD) as well as cytochrome P450 (CYP) 3A5 6986A>G and ABCB1 3435C>T polymorphisms on the erythrocytes' oxidative stress parameters in long-term period after renal transplantation
Takashi Namba et al.
Neuron, 105(5), 867-881 (2019-12-31)
The human-specific gene ARHGAP11B is preferentially expressed in neural progenitors of fetal human neocortex and increases abundance and proliferation of basal progenitors (BPs), which have a key role in neocortex expansion. ARHGAP11B has therefore been implicated in the evolutionary expansion
César Díaz-García et al.
Fertility and sterility, 102(6), 1545-1552 (2014-12-03)
To investigate whether allogeneic uterine grafts in a rat model, with tacrolimus immunosuppression, can harbor pregnancies that result in offspring with normal postnatal growth. Experimental animal study. University hospital. Lewis rats as uterus donors and Piebald-Virol-Glaxo rats as recipients. Animals
Magdalena Bodnar-Broniarczyk et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1104, 220-227 (2018-12-12)
The aim of this work was to develop and to validate LC-MS/MS method for tacrolimus (TAC) determination in whole blood samples using two different types of internal standards (IS): an isotope-labeled TAC13C,D2 and a structural analog ascomycin (ASC). Matrix effects
Flavia D Toledo et al.
Archives of toxicology, 88(9), 1695-1709 (2014-03-13)
Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive role in these events
Radim Vrzal et al.
Toxicology in vitro : an international journal published in association with BIBRA, 29(5), 1088-1099 (2015-05-02)
In this paper we investigated the effects of several drugs used in transplant medicine, i.e. cyclosporine A, tacrolimus, rapamycin, everolimus, mycophenolate mofetil, fluvastatin and rosuvastatin, on the expression of major drug-metabolizing enzymes in human hepatocytes. Moreover, we tested the ability
Johann K Hitzler et al.
Pediatric blood & cancer, 61(6), 1126-1128 (2014-01-07)
We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received myeloablative conditioning and 52% underwent transplantation in second remission. Disease-free
1/10