Cell culture in 3D systems: moving from 2D to 3D cell culture? It’s now well accepted by the scientific community that the 3D cell culture condition better recapitulate the in vivo environment and behaviours of cells.

Create a 3D kidney nephrotoxicity model on the AIM Biotech 3D cell culture chip

AIM Biotech’s easy-to-use modular platform for conducting 3D cell culture into your research. The AIM Biotech organ-on-a-chip enables you to run simple assays or create more complex microphysiological systems. The versatile platform is suitable for a wide variety of cell

Utilization of TrueGel3D™ Hydrogels to Study Fibroblast Spreading

Fibroblasts that are present in the stroma secrete glycoproteins and polysaccharides to form extracellular matrix. They maintain the structural integrity within the connective tissue and play a key role in cancer, chronic obstructive pulmonary diseases, idiopathic pulmonary fibrosis, scleroderma and

Fibronectin

Fibronectin (FN) is a multifunctional, extracellular plasma glycoprotein produced by hepatocytes that circulates at near micromolar concentration and assembles into extracellular matrix fibrils at cell surfaces along with locally produced cellular FN.

3D Imaging of Optically Cleared Spheroids in Corning® Spheroid Microplates

Discover how Corning® Spheroid Microplates played a key role in the use of use of 3D cell cultures for in vitro drug discovery assay.

High-Throughput Drug Screening using TrueGel3D® HTS Hydrogel Plates

Compound cytotoxicity screening assays with 3D cell cultures using TrueGel3D® HTS Hydrogel Plates including dose response curves, IC50 determination, and spheroid killing assay data.

Organoid Culture Frequently Asked Questions

Organoid culture FAQs. Learn how to culture and analyze organoids following established 3D cell culture protocols. Tips and tricks.

Using Human iPS Cell-derived Colon Organoids for Cytotoxicity Screening of Drug Compounds

Human epithelial intestinal colonic organoids can be used as an alternative to Caco-2 drug permeability assays for drug screening and compound toxicity testing.

Barrier Formation and Permeability Assays using Millicell^® Hanging Cell Culture Inserts

How to set up barrier formation and permeability assays using cell culture inserts and TEER measurements.

Millicell^® Microwell Plates Frequently Asked Questions (FAQs)

Explore answers to your frequency asked questions about Millicell® Microwell plates. Our plates support reliable organoid culture with array of ultra-dense microwells in hydrogel for immunology, drug development, and cell therapy applications.

Evaluation of Spheroid Formation and Robustness using Millicell^® Ultra-low Attachment Plates

Learn how to quantify spheroid formation, roundness, and circularity. Discover Millicell® Ultra-low Attachment plates, an ideal 3D cell culture model for uniform spheroid formation.

3D Bioprinting: Bioink Selection Guide

Bioinks can be 3D bioprinted into functional tissue constructs for drug screening, disease modeling, and in vitro transplantation. Choose the Bioinks and method for specific tissues engineering applications.

What is Hyaluronan?

Hyaluronan is a major component of the extracellular matrix. It’s the simplest glycosaminoglycan, and it plays several biological roles.

Tissue-Specific Decellularized Extracellular Matrix (dECM) Hydrogels for Enhanced 3D Cell Cultures

To isolate the native extracellular matrix of a tissue from its inhabiting cells, a decellularization process is employed.

ECM Gel Matrix: Protocols Using EHS Basement Membrane Extracts

Cell culture protocols using ECM Gel Matrix EHS basement membrane extract (BME) for neurite outgrowth, cell invasion and angiogenesis tube formation assays.

True Gel3D™ Hydrogel Troubleshooting Guide

The TrueGel3D™ hydrogel is formed by crosslinking RGD (arginylglycylaspartic acid) degradable polymer with CD cell-degradable crosslinker. Troubleshoot hydrogel formation and cell viability with this article.

3D Pluripotent Stem Cells: Simplified Culture and Realistic Differentiation

This white paper illustrates the importance of three-dimensional (3D) cell culture in the production of pluripotent stem cell (PSC)-derived models of embryo development and differentiation. It contains a general overview of embryoid bodies (EBs) and a comparison between the various

Advanced Cell Culture Technology for Generation of In Vivo-like Tissue Models

Sophisticated models are developing as 3D cell culture technology becomes established and accepted as a means of creating more physiologically relevant cell-based assays.

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