Fluorination

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facet applications:Fluorination

facet content type:Technical Article

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Fluoroamidinium salts advance acid halogenation with greater stability and no oxazolones conversion compared to chlorides.

AlPhos and [(AlPhosPd)₂•COD] for Pd-Catalyzed Fluorination

Fluorine containing aromatics (ArF) are desirable compounds with applications in medicinal chemistry and the agricultural industry.

Deoxyfluorination with 2-Pyridinesulfonyl Fluoride (PyFluor)

The prevalence of organofluorine compounds in industry and drug design necessitates the ability to introduce C–F bonds to molecules.

Diethylaminosulfur Trifluoride (DAST)

Diethylaminosulfur trifluoride (DAST) facilitates nucleophilic fluorination in selective reactions with alcohols, ketones, and other compounds.

Fluoroalkylation: Expansion of Togni Reagents

Fluoroalkylation toolbox expands with various reagents for late-stage fluoroalkylation in organic synthesis and medicinal chemistry.

Fluorinated Azides: Click Chemistry Meets Fluorine

Fluorinated azides are a new tool that can be used to introduce fluorinated groups to molecules. These molecules can utilize click chemistry to easily add fluorinated groups.

PhenoFluor™ Deoxyfluorination Solution

PhenoFluor™ enables one-step conversion of phenols to aryl fluorides, facilitating fluorination without pre-activation.

Selectfluor™

Selectfluor™ (F-TEDA) is a mild, stable reagent for electrophilic fluorination, enhancing user-friendly fluorination reactions.

AISF: A Solid Alternative to Sulfuryl Fluoride Gas

ASIF provides bench-stable alternative to sulfuryl fluoride gas for installing SO2F functional group in organic synthesis.

Sulfonyl Chlorides and Sulfonamides

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

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