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Bradley K Schniers et al.
The Biochemical journal, 478(20), 3757-3774 (2021-09-28)
PEPT1 is a proton-coupled peptide transporter that is up-regulated in PDAC cell lines and PDXs, with little expression in the normal pancreas. However, the relevance of this up-regulation to cancer progression and the mechanism of up-regulation have not been investigated.
Sarah E Tulk et al.
Journal of cellular biochemistry, 116(5), 711-720 (2015-02-03)
Vitamin D3 has emerged as an important regulator of the immune system. With metabolic enzymes for vitamin D3 activation and vitamin D receptors (VDR) now identified in a variety of immune cells, the active vitamin D3 metabolite 1,25(OH)2D3, is thought
Xingchu Gong et al.
International journal of pharmaceutics, 493(1-2), 208-213 (2015-08-01)
An analysis of data collected from 25 sets of diverse pharmaceutical powders has identified that an exponential growth function satisfactorily describes the relationship between tablet brittleness and tablet porosity while a power law function well describes the relationship between tablet
The second generation oral sulfonylureas: glyburide and glipizide.
T Kuhn
American pharmacy, NS28(10), 55-61 (1988-10-01)
Mariel Núñez et al.
BMC pharmacology & toxicology, 14, 6-6 (2013-01-15)
Glibenclamide (Gli) binds to the sulphonylurea receptor (SUR) that is a regulatory subunit of ATP-sensitive potassium channels (KATP channels). Binding of Gli to SUR produces the closure of KATP channels and the inhibition of their activity. This drug is widely
Ya-Jean Wang et al.
Toxicology letters, 223(2), 139-145 (2013-09-10)
Methamphetamine (MA), a highly abused amphetamine-like psychostimulant, has surged in popularity worldwide in the last decade. Repeated MA exposure has been shown to affect the alternative splice variant expression of large conductance Ca(2+)-activated K(+) (BK) channels. It remains unclear whether
Editorial: sulfonylureas differ in effects on ischemic preconditioning--is it time to retire glyburide?
Matthew C Riddle
The Journal of clinical endocrinology and metabolism, 88(2), 528-530 (2003-02-08)
Ke Ning et al.
BioMed research international, 2020, 3039184-3039184 (2020-11-03)
Inflammatory response during myocardial ischemia reperfusion injury (MIRI) is essential for cardiac healing, while excessive inflammation extends the infarction and promotes adverse cardiac remodeling. Understanding the mechanism of these uncontrolled inflammatory processes has a significant impact during the MIRI therapy.
Chunguang Wang et al.
International journal of molecular medicine, 44(2), 725-736 (2019-06-08)
The one‑lung ventilation (OLV) technique is vital in thoracic surgery. However, it can result in severe lung injury, which is difficult to manage. The main solution at present is the use of ventilation strategies, including continuous positive oxygen pressure, low
Carlo Marchetti et al.
Journal of cardiovascular pharmacology, 66(1), 1-8 (2015-04-29)
Sterile inflammation resulting from myocardial injury activates the NLRP3 inflammasome and amplifies the inflammatory response mediating further damage. We used 2 experimental models of ischemic injury (acute myocardial infarction [AMI] with and without reperfusion) and a model of nonischemic injury
[Diagnosis and treatment of type 2 diabetes from the perspective of guidelines].
M Kellerer
Deutsche medizinische Wochenschrift (1946), 139(21), 1114-1115 (2014-05-16)
Wei Liu et al.
EBioMedicine, 50, 306-316 (2019-11-30)
The understanding of the regulation of glucagon secretion by pancreatic islet α-cells remains elusive. We aimed to develop an in vitro model for investigating the function of human α-cells under direct influence of glucose and other potential regulators. Highly purified
D Saw et al.
Digestive diseases and sciences, 41(2), 322-325 (1996-02-01)
A wide variety of diseases and injuries can cause granulomatous hepatitis, and drug-induced granulomatous hepatitis is a well-described entity. Sulfonylurea derivatives, which are commonly used oral hypoglycemic agents in the treatment of non-insulin-dependent diabetes mellitus, have been implicated in liver
Yi-Ling Hsieh et al.
Journal of pharmaceutical sciences, 103(9), 2724-2735 (2014-02-08)
The aim of this study was to investigate the pH-induced precipitation behavior of four ionizable compounds (papaverine, dipyridamole, glyburide, and warfarin) in the absence and presence of polymers. Polymers selected included nonionic, anionic, and cationic polymers. Precipitates were analyzed immediately
Ryan Mathias et al.
American journal of physiology. Gastrointestinal and liver physiology, 304(6), G623-G634 (2013-01-01)
Mesenteric lymphatic vessels actively transport lymph, immune cells, fat, and other macromolecules from the intestine via a rhythmical contraction-relaxation process called lymphatic pumping. We have previously demonstrated that mesenteric lymphatic pumping was compromised in the guinea pig model of 2,4,6-trinitrobenzenesulfonic
Sherrie L Aspinall et al.
The American journal of geriatric pharmacotherapy, 9(1), 58-68 (2011-04-05)
The objectives of this study were to describe changes in glyburide prescribing in cohorts that were and were not targeted by a risk reduction project, assess factors associated with glyburide discontinuation, and evaluate changes in glycated hemoglobin (ie, HbA(1c)) levels
Xiafei Wu et al.
IUBMB life, 67(4), 312-321 (2015-04-08)
Hepatic fibrosis is concomitant with liver inflammation, which has been highlighted as significant treatment of chronic liver disease. We previously demonstrated that tetramethylpyrazine (TMP), the effective component of Ligusticum chuanxiong Hort, can inhibit the activation of HSCs and consequential anti-hepatic
McGuinness OP; discussion 51S-53S et al.
The American journal of medicine, 89(2A), 26S-37S (1990-08-20)
Glyburide, along with the other second-generation oral hypoglycemic agent glipizide, has been used as adjunctive therapy for the treatment of non-insulin-dependent diabetes mellitus. After glyburide therapy, basal glycemia and glucose response to a meal are greatly improved. The mechanism for
Colleen M Bartman et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12991-13004 (2020-08-11)
Preterm infants can develop airway hyperreactivity and impaired bronchodilation following supplemental O2 (hyperoxia) in early life, making it important to understand mechanisms of hyperoxia effects. Endogenous hydrogen sulfide (H2 S) has anti-inflammatory and vasodilatory effects with oxidative stress. There is
A Ahmadi et al.
Drug research, 63(12), 614-619 (2013-07-06)
In this study, new glibenclamide analogues (5a-d) with substituted pharmacological triethoxysilyl propan, allyl and ethoxyphenyl groups for cyclohexyl moiety have been synthesized by condensing sulfonamide (4) with related isocyanate or isothiocyanate's compounds. The newly synthesized drugs were evaluated for their
Séverin Slove et al.
Hypertension (Dallas, Tex. : 1979), 62(4), 794-801 (2013-08-07)
Hypertension is a cardiovascular disorder that appears in more than half of the patients with Williams-Beuren syndrome, hemizygous for the elastin gene among 26 to 28 other genes. It was shown that the antihypertensive drug minoxidil, an ATP-dependent potassium channel
Anne Skakkebæk et al.
Scientific reports, 13(1), 12089-12089 (2023-07-27)
The genetic architecture of the QT interval, defined as the period from onset of depolarisation to completion of repolarisation of the ventricular myocardium, is incompletely understood. Only a minor part of the QT interval variation in the general population has
Jaime Salazar et al.
Journal of pharmaceutical sciences, 102(5), 1636-1649 (2013-02-26)
The nanosizing of poorly soluble drugs as a formulation strategy can eventually enhance their dissolution rate and bioavailability. Standard comminution techniques such as high-pressure homogenization (HPH) or wet bead milling have limitations in reaching the desired mean particle size. Combinative
Wenli Yang et al.
Journal of pediatric endocrinology & metabolism : JPEM, 26(5-6), 591-594 (2013-05-04)
The ATP-sensitive K+ channel controls insulin secretion from the islet. Mutations in KCNJ11 can cause permanent and transient neonatal diabetes. To date, more than 30 KCNJ11 mutations have been revealed as related to the onset of neonatal diabetes mellitus (NDM)
Glucocorticoids distinctively modulate the CFTR channel with possible implications in lung development and transition into extrauterine life
Laube M, et al.
Testing, 10(4), e0124833-e0124833 (2015)
A E Boyd et al.
The American journal of medicine, 89(2A), 3S-10S (1990-08-20)
A high-affinity sulfonylurea receptor has been identified on the plasma membrane of the beta cell. The potent second-generation sulfonylureas, glyburide and glipizide, saturate the receptor in the low nM concentration range, whereas first-generation drugs bind to and saturate the receptor
Gary N Fox et al.
Cutis, 76(1), 41-45 (2005-09-08)
Lichenoid reactions to sulfonylurea drugs have been reported, albeit infrequently. To our knowledge, this is the first case of a generalized lichenoid dermatitis likely induced by the third-generation sulfonylurea hypoglycemic drug glyburide.
Eun-Seon Yoo et al.
Cell reports, 37(7), 109997-109997 (2021-11-18)
The anorexigenic effect of serotonergic compounds has largely been attributed to activation of serotonin 2C receptors (Htr2cs). Using mouse genetic models in which Htr2c can be selectively deleted or restored (in Htr2c-null mice), we investigate the role of Htr2c in
Huifang Lian et al.
Frontiers in medicine, 9, 845129-845129 (2022-04-26)
Fungal keratitis is a sight-threatening corneal infection caused by fungal pathogens, and the pathogenic mechanisms have not been fully elucidated. The aim of this study was to determine whether NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-mediated pyroptosis contributes
Hiroe Honda et al.
Journal of leukocyte biology, 96(6), 1087-1100 (2014-09-12)
Inflammasome activation initiates the development of many inflammatory diseases, including obesity and type 2 diabetes. Therefore, agents that target discrete activation steps could represent very important drugs. We reported previously that ILG, a chalcone from Glycyrrhiza uralensis, inhibits LPS-induced NF-κB
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