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显示 31-60 共 101 条结果 关于 "G5172" 范围 论文
Cinzia Giordano et al.
Scientific reports, 6, 21782-21782 (2016-02-24)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, the cytokine leptin has been associated to breast
Jinxin Liu et al.
Pharmacological research, 152, 104631-104631 (2020-01-09)
Hypercholesterolemia is the main risk factor to threaten human health and geniposide has been found to have hypolipidemic functions. However, its underlying mechanism is not clear. In this study, we firstly confirmed the hypolipidemic functions of geniposide in C57BL/6 and
Faten A Al-Aqil et al.
Biochimica et biophysica acta. Molecular basis of disease, 1864(9 Pt B), 2927-2937 (2018-06-09)
At high doses, glucocorticoids (GC) have been associated with enhanced serum bile acids and liver injury. We have evaluated the effect of GC, in the absence of hepatotoxicity, on FXR/FGF91(Fgf15)/FGF21-mediated ileum-liver crosstalk. Rats and mice (wild type and Fxr-/-, Fgf15-/-
Lihua Jin et al.
Scientific reports, 5, 17288-17288 (2015-12-02)
Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work
Pengfei Qiao et al.
Oncology reports, 40(4), 2067-2078 (2018-08-15)
Colorectal cancer (CRC) is among the most common malignancies of the digestive system. Dysregulation of miRNAs and the farnesoid X receptor (FXR) are involved in the progression of CRC. In the present study, the effects of FXR and miR‑135A1 in
Amar Bahadur Singh et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1864(3), 358-371 (2018-12-24)
Long-chain acyl-CoA synthetase 1 (ACSL1) plays a pivotal role in fatty acid β‑oxidation in heart, adipose tissue and skeletal muscle. However, key functions of ACSL1 in the liver remain largely unknown. We investigated acute effects of hepatic ACSL1 deficiency on
Tomofumi Fujino et al.
The Journal of toxicological sciences, 45(1), 25-35 (2020-01-15)
In this study, we found that nuclear receptors FXR and LXR (originally characterized as regulatory factors involved in cholesterol/bile acid homeostasis) regulate the expression of Oct3/4, a marker for cell differentiation, in both normal renal-derived cell line HK-2 and renal
Xiao-Min Xin et al.
World journal of gastroenterology, 20(42), 15727-15735 (2014-11-18)
To investigate the effect of GW4064 on the expression of adipokines and their receptors during differentiation of 3T3-L1 preadipocytes and in HepG2 cells. The mRNA expression of farnesoid X receptor (FXR), peroxisome proliferator-activated receptor-gamma 2 (PPAR-γ2), adiponectin, leptin, resistin, adiponectin
Thomas A Kerr et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 44(10), E218-E228 (2013-09-17)
Bile acid synthesis is regulated by nuclear receptors including farnesoid X receptor (FXR) and small heterodimer partner (SHP), and by fibroblast growth factor 15/19 (FGF15/19). We hypothesized that hepatic cysteine sulfinic acid decarboxylase (CSAD) (a key enzyme in taurine synthesis)
Teruo Miyazaki et al.
Journal of clinical biochemistry and nutrition, 64(2), 112-123 (2019-04-03)
Nuclear receptor farnesoid X receptor activation inhibits fatty acid synthesis through the liver X receptor-α-sterol regulatory element binding protein-1c pathway universally in animals, but also has human-specific crosstalk with the peroxisome proliferator-activated receptor-α. The effects of farnesoid X receptor-ligands on
Chunfeng Lu et al.
IUBMB life, 67(8), 645-658 (2015-08-26)
Alcoholic liver disease (ALD) is a common health problem worldwide, characterized by aberrant accumulation of lipid in hepatocytes. Inhibition of lipid accumulation has been well recognized as a promising strategy for ALD. Previous studies showed that curcumin has potential effect
Hailiang Liu et al.
Journal of lipid research, 57(10), 1831-1844 (2016-08-19)
Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in control of bile acid and cholesterol homeostasis. Bile acids activate farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) to regulate lipid, glucose, and energy metabolism. However, the role of
Meijing Liu et al.
Antioxidants & redox signaling, 33(2), 87-116 (2020-02-11)
Aims: Acetaminophen (APAP) overdose leads to acute liver injury by inducing hepatic mitochondrial oxidative stress and inflammation. However, the
Kristoffer Niss et al.
Molecular and cellular endocrinology, 517, 110923-110923 (2020-07-24)
Activated transcription factor (TF) farnesoid X receptor (FXR) represses glucagon-like peptide-1 (GLP-1) secretion in enteroendocrine L cells. This, in turn, reduces insulin secretion, which is triggered when β cells bind GLP-1. Preventing FXR activation could boost GLP-1 production and insulin
Rebekka Pohl et al.
European journal of clinical investigation, 47(1), 7-18 (2016-11-01)
Chemerin is associated with insulin resistance and is expressed in the liver. Nonalcoholic fatty liver disease (NAFLD) is related to impaired insulin sensitivity, but studies evaluating hepatic and serum chemerin in NAFLD resulted in discordant data. Chemerin mRNA was determined
Bi Chen et al.
Journal of thoracic disease, 8(11), 3063-3074 (2017-01-10)
Epithelial-mesenchymal transition (EMT) and cyclooxygenase-2 (COX-2) contribute to airway remodelling and inflammation in chronic obstructive pulmonary disease (COPD). Recent data suggest that the farnesoid X receptor (FXR), a nuclear receptor traditionally considered as bile acid-activated receptor, is also expressed in
Fei Guo et al.
Oncotarget, 6(33), 34606-34616 (2015-09-30)
Suppressor of cytokine signaling 3 (SOCS3) is regarded as a vital repressor in the liver carcinogenesis mainly by inhibiting signal transducer and activator of transcription 3 (STAT3) activity. Farnesoid X Receptor (FXR), highly expressed in liver, has an important role
Bing Wang et al.
Experimental cell research, 390(1), 111949-111949 (2020-03-08)
Farnesoid X receptor (FXR) is a metabolic nuclear receptor, which protects liver from many endogenous and exogenous injuries. Metallothioneins (MTs) belong to a low-molecular-weight protein family involved in metal homeostasis and the regulation of hepatic oxidative stress. In the present
Stefanie Albrecht et al.
Journal of neuroinflammation, 14(1), 66-66 (2017-03-30)
The nuclear receptor farnesoid-X-receptor (FXR; NR1H4) is expressed not only in the liver, gut, kidney and adipose tissue but also in the immune cells. FXR has been shown to confer protection in several animal models of inflammation, including experimental autoimmune
Joanne M Donkers et al.
Cellular and molecular gastroenterology and hepatology, 10(3), 451-466 (2020-04-25)
Bile acids are important metabolic signaling molecules. Bile acid receptor activation promotes body weight loss and improves glycemic control. The incretin hormone GLP-1 and thyroid hormone activation of T4 to T3 have been suggested as important contributors. Here, we identify
Ling Li et al.
Journal of translational medicine, 17(1), 418-418 (2019-12-15)
Tacrolimus (FK506)-induced diabetes mellitus is one of the most important factors of post-transplant diabetes mellitus (PTDM). However, the detailed mechanisms underlying PTDM are still unclear. Farnesoid X receptor (FXR) regulates glycolipid metabolism. The objective of this study was to explore
Xiang Jiang et al.
Journal of autoimmunity, 90, 64-75 (2018-02-13)
Mucosal-associated invariant T (MAIT) cells are novel innate-like T cells constituting a significant proportion of circulating and hepatic T cells. Herein, we extensively examine the phenotypical and functional alterations of MAIT cells and their regulation in a cohort of 56
Kevin S Baker et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(10), 2038-2048 (2019-08-16)
Regulation of TF (tissue factor):FVIIa (coagulation factor VIIa) complex procoagulant activity is especially critical in tissues where plasma can contact TF-expressing cells. One example is the liver, where hepatocytes are routinely exposed to plasma because of the fenestrated sinusoidal endothelium.
Banrida Wahlang et al.
Toxicological sciences : an official journal of the Society of Toxicology, 140(2), 283-297 (2014-05-09)
Polychlorinated biphenyls (PCBs) are persistent environmental toxicants, present in 100% of U.S. adults and dose-dependently associated with obesity and non-alcoholic fatty liver disease (NAFLD). PCBs are predicted to interact with receptors previously implicated in xenobiotic/energy metabolism and NAFLD. These receptors include
Shujun Xie et al.
FEBS letters, 591(18), 2836-2847 (2017-08-09)
GW4064 is a small molecule known to be an agonist of the nuclear farnesoid X receptor (FXR). We found that GW4064 inhibits the NLR family CARD domain containing 3 (NLRP3) inflammasome activation in an FXR-independent manner as evidenced by its
Haojun Xiong et al.
Oncotarget, 8(38), 64083-64094 (2017-10-04)
Liver X receptor (LXR), a member of nuclear receptor superfamily, is involved in the regulation of glucose, lipid and cholesterol metabolism. Recently, it has been reported that LXR suppress different kinds of cancers including hepatocellular carcinoma (HCC). However, the corresponding
Kosuke Murakami et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(3), 1700-1710 (2020-01-04)
Human noroviruses (HuNoVs) cause sporadic and epidemic outbreaks of gastroenteritis in all age groups worldwide. We previously reported that stem cell-derived human intestinal enteroid (HIE) cultures support replication of multiple HuNoV strains and that some strains (e.g., GII.3) replicate only
Abdullah Mayati et al.
Scientific reports, 8(1), 16115-16115 (2018-11-02)
HepaRG is an original human hepatoma cell line, acquiring highly differentiated hepatic features when exposed to dimethylsulfoxide (DMSO). To search alternatives to DMSO, which may exert some toxicity, we have analyzed the effects of forskolin (FSK), a cAMP-generating agent known
Sanae Haga et al.
BMC gastroenterology, 17(1), 9-9 (2017-01-15)
Liver injury and regeneration involve complicated processes and are affected by various physio-pathological conditions. Surgically, severe liver injury after surgical resection often leads to fatal liver failure, especially with some underlying pathological conditions such as steatosis. Therefore, protection from the
Qixiao Zhai et al.
Journal of agricultural and food chemistry, 67(14), 3956-3965 (2019-03-25)
The heavy metal cadmium (Cd) is a contaminant widely distributed in the food chain. In the present study, 8-week oral administration of a probiotic strain, Lactobacillus plantarum CCFM8610, markedly decreased blood Cd levels in volunteers. Further animal study showed that
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