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Bor-Show Tzang et al.
Journal of biomedical science, 16, 13-13 (2009-03-11)
Activity of secreted phospholipase A (sPLA2) has been implicated in a wide range of cellular responses. However, little is known about the function of human parvovirus B19-VP1 unique region (VP1u) with sPLA2 activity on macrophage. To investigate the roles of
Rong-Xin Chen et al.
Journal of experimental & clinical cancer research : CR, 29, 172-172 (2010-12-31)
Specific gene expression is tightly regulated by various transcription factors. Osteopontin (OPN) is a phosphoprotein that mediates hepatocellular carcinoma (HCC) progression and metastasis. However, the mechanism of OPN up-regulation in HCC metastasis remains to be clarified. Oligonucleotide array-based transcription factor
Susann Grosse et al.
Toxicology in vitro : an international journal published in association with BIBRA, 27(1), 305-313 (2012-09-08)
Silver nanoparticles (AgNPs) are among the most widely commercialised engineered nanomaterials, because of their antimicrobial properties. They are already commonly used in medical devices, household products and industry. Concerns have been raised about potential adverse health effects due to increasing
Cynthia K Hahn et al.
Cancer cell, 16(4), 281-294 (2009-10-06)
Cell-based screening can facilitate the rapid identification of compounds inducing complex cellular phenotypes. Advancing a compound toward the clinic, however, generally requires the identification of precise mechanisms of action. We previously found that epidermal growth factor receptor (EGFR) inhibitors induce
Yung-Ming Chang et al.
Evidence-based complementary and alternative medicine : eCAM, 2011, 395458-395458 (2009-10-08)
The earthworm, which has stasis removal and wound-healing functions, is a widely used Chinese herbal medicine in China. Schwann cell migration is critical for the regeneration of injured nerves. Schwann cells provide an essentially supportive activity for neuron regeneration. However
Ludovic Maertens et al.
PloS one, 9(9), e106976-e106976 (2014-09-16)
It is now well accepted that multipotent Bone-Marrow Mesenchymal Stem Cells (BM-MSC) contribute to cancer progression through several mechanisms including angiogenesis. However, their involvement during the lymphangiogenic process is poorly described. Using BM-MSC isolated from mice of two different backgrounds
Sarah J Young et al.
Cell reports, 33(3), 108289-108289 (2020-10-22)
MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of
Olga Koutsoni et al.
PloS one, 9(5), e97319-e97319 (2014-05-17)
The leishmaniases constitute neglected global public health problems that require adequate control measures, prophylactic clinical vaccines and effective and non-toxic drug treatments. In this study, we explored the potential of Leishmania infantum eukaryotic initiation factor (LieIF), an exosomal protein, as
Hui Tong et al.
Cancer management and research, 11, 1869-1879 (2019-03-19)
Hepatocellular carcinoma (HCC) is the third leading cause of death by malignancy worldwide. HCC has a poor prognosis due to tumor invasiveness and metastasis. There is substantial evidence that the epithelial-to-mesenchymal transition (EMT) plays a central role in cancer metastasis.
Man Zhang et al.
Biological trace element research, 166(2), 201-209 (2015-02-19)
The aim of the current study was to investigate the effect of excess iodine on rat aorta endothelial cells and the potential underlying mechanisms. Rat aorta endothelial cells were cultured with iodide ion (3506, 4076, 4647, 5218, 5789, 6360, 6931
Kan Shida et al.
Immunology, 128(1 Suppl), e858-e869 (2009-09-25)
We previously showed that Lactobacillus strains having a rigid cell wall resistant to intracellular digestion can stimulate macrophages to induce large a quantity of interleukin-12 (IL-12). In this study, we examined the influence of lactobacilli and bacterial cell wall components
Histophatologic Techniques null
Mollie Jurewicz et al.
Diabetes, 59(12), 3139-3147 (2010-09-16)
A number of clinical trials are underway to test whether mesenchymal stem cells (MSCs) are effective in treating various diseases, including type 1 diabetes. Although this cell therapy holds great promise, the optimal source of MSCs has yet to be
Cristina Cigana et al.
PloS one, 4(12), e8439-e8439 (2009-12-29)
Pseudomonas aeruginosa can establish life-long airways chronic infection in patients with cystic fibrosis (CF) with pathogenic variants distinguished from initially acquired strain. Here, we analysed chemical and biological activity of P. aeruginosa Pathogen-Associated Molecular Patterns (PAMPs) in clonal strains, including
Mohamad F Aslam et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3671-3678 (2014-04-30)
The ferritin core is composed of fine nanoparticulate Fe(3+) oxohydroxide, and we have developed a synthetic mimetic, nanoparticulate Fe(3+) polyoxohydroxide (nanoFe(3+)). The aim of this study was to determine how dietary iron derived in this fashion is absorbed in the
Carrie A Adelman et al.
PLoS genetics, 4(3), e1000042-e1000042 (2008-03-29)
We have recently shown that hypomorphic Mre11 complex mouse mutants exhibit defects in the repair of meiotic double strand breaks (DSBs). This is associated with perturbation of synaptonemal complex morphogenesis, repair and regulation of crossover formation. To further assess the
Chrysoula Christou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 964, 195-201 (2014-02-01)
In the current paper the analytical conditions for the determination of ten free organic acids by GC-MS are studied with the aim to establish a method for organic acid profiling in human urine to be used as a tool for
Analysis and testing of biological stains--the Biological Stain Commission Procedures.
D P Penney et al.
Biotechnic & histochemistry : official publication of the Biological Stain Commission, 77(5-6), 237-275 (2003-02-05)
Jennifer Hein et al.
Journal of virology, 83(1), 117-127 (2008-10-17)
Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is important for viral replication and oncogenic transformation. Previously, infection of monkey or human cells with SV40 was shown to lead to the induction of DNA damage
Joseph A Majdi et al.
Investigative ophthalmology & visual science, 56(1), 587-597 (2014-12-20)
We developed a novel technique for accelerated drug screening and retinotoxin characterization using time-lapse optical coherence tomography (OCT) and a drug microapplication device. Using an ex vivo rabbit eyecup preparation, we studied retinotoxin effects in real-time by microperfusing small retinal
Hiroyuki Yamashita et al.
Pharmaceutical research, 31(8), 1946-1957 (2014-02-14)
The advent of cocrystals has demonstrated a growing need for efficient and comprehensive coformer screening in search of better development forms, including salt forms. Here, we investigated a coformer screening system for salts and cocrystals based on binary phase diagrams
Hong-Fei Wang et al.
Antonie van Leeuwenhoek, 107(3), 835-843 (2015-01-09)
A white bacterial strain, designated EGI 650022(T), was isolated from the roots of Salsola affinis C. A. Mey, collected from Urumqi City, Xinjiang, north-western China. The strain was found to be aerobic, Gram-stain positive, oxidase-positive and catalase-positive. Cells were non-motile
Xianhua Yin et al.
Applied and environmental microbiology, 75(18), 5779-5786 (2009-07-28)
O island 48 (OI-48) of Escherichia coli consists of three functional gene clusters that encode urease, tellurite resistance (Te(r)), and putative adhesins Iha and AIDA-1. The functions of these clusters in enterohemorrhagic E. coli (EHEC) O157:H7 infection are unknown. Deletion
Koji Mizuhashi et al.
Human molecular genetics, 23(11), 2953-2967 (2014-01-18)
Mutations of Filamin genes, which encode actin-binding proteins, cause a wide range of congenital developmental malformations in humans, mainly skeletal abnormalities. However, the molecular mechanisms underlying Filamin functions in skeletal system formation remain elusive. In our screen to identify skeletal
E Maria Donner et al.
Mutagenesis, 25(1), 49-55 (2009-11-04)
Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week). Animals were sacrificed at 6, 12, 24 and 48 weeks after
Lee M Bergman et al.
Molecular and cellular biology, 29(16), 4539-4551 (2009-06-10)
CtBPs (CtBP1 and CtBP2) act in the nucleus as transcriptional corepressors and in the cytoplasm as regulators of Golgi apparatus fission. Studies in which the expression or function of CtBPs has been inhibited have independently identified roles for CtBPs in
Elena Canellas et al.
Analytical and bioanalytical chemistry, 407(22), 6781-6790 (2015-07-04)
Biodegradable packagings are made by combination of several materials creating a multilayer with the properties needed. Each material, including the adhesive, could contain substances that could migrate to the food. In this work, gas chromatography coupled with mass spectrometry and
Ritesh Tandon et al.
Journal of virology, 83(20), 10797-10807 (2009-07-31)
The endosomal sorting complex required for transport (ESCRT) machinery controls the incorporation of cargo into intraluminal vesicles of multivesicular bodies. This machinery is used during envelopment of many RNA viruses and some DNA viruses, including herpes simplex virus type 1.
Kwi Young Kang et al.
The Journal of rheumatology, 42(11), 2003-2011 (2015-09-04)
Synovial fluid (SF) is one of the most important materials that reflect the pathophysiological process of arthritis. A metabolomic and lipidomic study of SF was performed with the aim of identifying tentative diagnostic markers or therapeutic candidates for rheumatoid arthritis
Marta Worzakowska
Molecules (Basel, Switzerland), 20(6), 10594-10603 (2015-06-11)
Cinnamyl long chain aroma esters were prepared by using the conventional and microwave-assisted methods. The esterification reaction of naturally occurring 3-phenyl-prop-2-en-1-ol and different chain lengths acidic and diol reagents was carried out at the temperature of 140 °C under solvent
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