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Baowei Lu et al.
PeerJ, 8, e8895-e8895 (2020-04-29)
The herbaceous peony (Paeonia lactiflora Pall.) is a perennial flowering plant of the Paeoniaceae species that is widely cultivated for medical and ornamental uses. The monoterpene glucoside paeoniflorin and its derivatives are the active compounds of the P. lactiflora roots.
Jieyang Jin et al.
International journal of molecular sciences, 21(2) (2020-01-23)
Terpenoids play vital roles in tea aroma quality and plants defense performance determination, whereas the scenarios of genes to metabolites of terpenes pathway remain uninvestigated in tea plants. Here, we report the use of an integrated approach combining metabolites, target
Subijanto Marto Sudarmo et al.
Gut pathogens, 7, 3-3 (2015-03-21)
Rotavirus infections are a major cause of diarrhea in children in both developed and developing countries. Rotavirus genetics, patient immunity, and environmental factors are thought to be related to the severity of acute diarrhea due to rotavirus in infants and
W E Hotham et al.
Bone & joint research, 7(5), 336-342 (2018-06-21)
This systematic review examines the current literature regarding surgical techniques for restoring articular cartilage in the hip, from the older microfracture techniques involving perforation to the subchondral bone, to adaptations of this technique using nanofractures and scaffolds. This review discusses
Piao-Yi Wang et al.
Plant physiology and biochemistry : PPB, 155, 716-724 (2020-08-31)
Typical plant terpene synthases (TPSs) are responsible for the production of terpenes, a major class of plant secondary metabolites. However, various nonseed plants also harbor genes encoding microbial terpene synthase-like (MTPSL) enzymes. Here, a scan of 31 ferns transcriptomes revealed
Sarma Rajeev Kumar et al.
The Plant journal : for cell and molecular biology, 103(1), 248-265 (2020-02-18)
In plants, geranylgeranyl diphosphate (GGPP, C20 ) synthesized by GGPP synthase (GGPPS) serves as precursor for vital metabolic branches including specialized metabolites. Here, we report the characterization of a GGPPS (CrGGPPS2) from the Madagascar periwinkle (Catharanthus roseus) and demonstrate its
Zhendong Wu et al.
Scientific reports, 9(1), 3367-3367 (2019-03-06)
Carbon storage dynamics in vegetation and soil are determined by the balance of carbon influx and turnover. Estimates of these opposing fluxes differ markedly among different empirical datasets and models leading to uncertainty and divergent trends. To trace the origin
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Tingting Bao et al.
Plant & cell physiology, 61(10), 1733-1749 (2020-07-30)
Lathyrus odoratus (sweet pea) is an ornamental plant with exceptional floral scent, previously used as an experimental organism in the early development of Mendelian genetics. However, its terpene synthases (TPSs), which act as metabolic gatekeepers in the biosynthesis of volatile
Guo-Feng Liu et al.
Plant, cell & environment, 41(1), 176-186 (2017-10-01)
Volatile terpenoids produced in tea plants (Camellia sinensis) are airborne signals interacting against other ecosystem members, but also pleasant odorants of tea products. Transcription regulation (including transcript processing) is pivotal for plant volatile terpenoid production. In this study, a terpene
Farhat Abbas et al.
Phytochemistry, 173, 112294-112294 (2020-02-15)
Lilies are a commercially significant cut flower worldwide due not only to their elegant shape but also to their appealing scent. Among Lilium varieties, Lilium 'Siberia' is a cultivar that is prominent and highly favored by consumers due to its
Hiroyuki Kajiura et al.
Biochimie, 139, 95-106 (2017-05-10)
Farnesyl diphosphate synthase (FPS) is an essential enzyme in the biosynthesis of prenyl precursors for the production of primary and secondary metabolites, including sterols, dolichols, carotenoids and ubiquinones, and for the modification of proteins. Here we identified and characterized two
Hang Fan et al.
BMC plant biology, 19(1), 82-82 (2019-02-21)
There exist differences in morphological traits and phytochemical compositions between field- and mountain-cultivated Panax ginseng (FCG and MCG), which might be attributed to variations of terpenoids metabolism adapting to different growth conditions. The present work aims to uncover these variations.
Y Zboromyrska et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(10), O753-O759 (2014-03-14)
Traveller's diarrhoea (TD) is the most common illness reported in international travellers. TD is caused by a wide range of pathogens, including bacteria, viruses and parasites. Multiplex PCR assays can be especially useful for studying the aetiology of TD. The
Dandan Xu et al.
Molecular carcinogenesis, 58(11), 2052-2064 (2019-08-10)
Recent studies have indicated that using statins to inhibit the mevalonate pathway induces mutant p53 degradation by impairing the interaction of mutant p53 with DnaJ subfamily A member 1 (DNAJA1). However, the role of the C-terminus of DNAJA1 with a
Jianling Xie et al.
Journal of clinical microbiology, 57(6) (2019-04-05)
Data are lacking regarding the impact of visible pigment on rectal swab diagnostic accuracy. We describe the test characteristics of rectal swabs with and without pigment in children with gastroenteritis. Between December 2014 and September 2017, children (age, <18 years) with
Shigetoshi Sano et al.
The Journal of dermatology, 45(5), 529-539 (2018-03-24)
Generalized pustular psoriasis (GPP) and erythrodermic psoriasis (EP) are the rare and severe subtypes of psoriasis, which are often difficult to treat. The aim of this phase 3, open-label study was to evaluate efficacy and safety of guselkumab, a human
Jason Lancaster et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(37), E8634-E8641 (2018-08-25)
Insects use a diverse array of specialized terpene metabolites as pheromones in intraspecific interactions. In contrast to plants and microbes, which employ enzymes called terpene synthases (TPSs) to synthesize terpene metabolites, limited information from few species is available about the
Wei Zhang et al.
Genes & development, 34(7-8), 580-597 (2020-03-03)
Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders. However, the mechanism underlying this dysregulation, particularly in human cells, remains poorly understood. Mutations in the small GTPase gene RAB39b are associated with X-linked macrocephaly, autism spectrum disorder (ASD), and intellectual
Charles Burke et al.
The Journal of biological chemistry, 277(5), 3141-3149 (2001-12-26)
Geranyl diphosphate synthase belongs to a subgroup of prenyltransferases, including farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase, that catalyzes the specific formation, from C(5) units, of the respective C(10), C(15), and C(20) precursors of monoterpenes, sesquiterpenes, and diterpenes. Unlike farnesyl
Matthew Edwards et al.
PloS one, 15(3), e0226173-e0226173 (2020-03-05)
Trophic interactions can result in changes to the abundance and distribution of habitat-forming species that dramatically reduce ecosystem functioning. In the coastal zone of the Aleutian Archipelago, overgrazing by herbivorous sea urchins that began in the 1990s resulted in widespread
G F Barnard et al.
Biochimica et biophysica acta, 661(1), 87-99 (1981-09-15)
Prenyltransferase (dimethylallydiphosphate: isopentenyldiphosphate dimethylallytransferase, EC 2.5.1.1) has been purified to homogeneity from human liver obtained at autopsy. The enzyme is a dimer with a native molecular weight of 74 000 +/- 1 400. The amino acid composition is reported. the
Yoshihisa Hirota et al.
PloS one, 10(4), e0125737-e0125737 (2015-04-16)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis. We investigated the enzymological properties of UBIAD1 using microsomal fractions from Sf9 cells expressing UBIAD1 by analysing MK-4 biosynthetic activity. With regard to UBIAD1 enzyme
Indrajyoti Indra et al.
Cell reports, 30(8), 2820-2833 (2020-02-27)
We study punctate adherens junctions (pAJs) to determine how short-lived cadherin clusters and relatively stable actin bundles interact despite differences in dynamics. We show that pAJ-linked bundles consist of two distinct regions-the bundle stalk (AJ-BS) and a tip (AJ-BT) positioned
Paramita Bera et al.
Plant science : an international journal of experimental plant biology, 256, 25-38 (2017-02-09)
Floral scent composed of low molecular weight volatile organic compounds. The sweet fragrance of any evening blooming flower is dominated by benzenoid and terpenoid volatile compounds. Floral scent of Jasminum sambac (Oleaceae) includes three major benzenoid esters - benzylacetate, methylbenzoate
Xu Yue et al.
Global change biology, 22(11), 3750-3759 (2016-10-21)
Ozone (O
Mohammad N Mhaissen et al.
Journal of the Pediatric Infectious Diseases Society, 6(3), 275-280 (2016-09-01)
Diarrhea is common in children with cancer, but this has not been systematically studied to date. Remnant stool samples collected between January 2010 and June 2011 from pediatric oncology patients with diarrhea were tested for bacterial, viral, and parasitic enteropathogens
Kathryn L Kavanagh et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(20), 7829-7834 (2006-05-11)
Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting >50% of the female population over the age of 50. Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of
Koh-Ichi Emi et al.
Biochemical and biophysical research communications, 520(2), 291-296 (2019-10-09)
Cis-prenyltransferases are enzymes responsible for the biosynthesis of glycosyl carrier lipids, natural rubber, and some secondary metabolites. Certain organisms, including some archaeal species, possess multiple genes encoding cis-prenyltransferase homologs, and the physiological roles of these seemingly-redundant genes are often obscure.
Bharati Lalhal Barsain et al.
Plant physiology and biochemistry : PPB, 154, 115-128 (2020-06-20)
Geranyl geranyl pyrophosphate synthase (GGPPS) is known to form an integral subunit of the heteromeric GPPS (geranyl pyrophosphate synthase) complex and catalyzes the biosynthesis of monoterpene in plants. Picrorhiza kurrooa Royle ex Benth., a medicinally important high altitude plant is
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