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Michael D Perry et al.
Journal of medical microbiology, 63(Pt 11), 1419-1426 (2014-08-12)
Infectious gastrointestinal disease is caused by a diverse array of pathogens, and is a challenging syndrome to correctly diagnose and manage. Conventional laboratory diagnostic methods are often time-consuming and frequently suffer from low detection rates. Two commercial multiplex nucleic acid
Tamara Rodríguez-Castillo et al.
The Science of the total environment, 599-600, 1108-1118 (2017-05-18)
Sewage inputs on fluvial ecosystems affect benthic communities and alter trophic networks resulting in changes on river functioning. Functional indicators (e.g. river metabolism) have been proposed as a valuable tool to evaluate ecosystem impairment. In the present study we monitored
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Lipids.
Alexandre Lapillonne et al.
Clinical nutrition (Edinburgh, Scotland), 37(6 Pt B), 2324-2336 (2018-08-26)
Orapin Ariyawutthiphan et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 67(Pt 3), 417-420 (2011-03-12)
The biosynthetic pathway of the off-flavour terpenoid alcohol 2-methylisoborneol (2-MIB) requires geranyl pyrophosphate methyltransferase (GPPMT) to methylate GPP before the cyclization reaction. GPPMT is the first example of an S-adenosyl-L-methionine-dependent methyltransferase that acts on general intermediates such as geranyl pyrophosphate
C Browne et al.
Letters in applied microbiology, 64(1), 2-7 (2016-10-21)
Porcine enzootic pneumonia (EP) caused by Mycoplasma hyopneumoniae adversely affects pig welfare and is associated with major economic losses in the pig industry worldwide. Transmission is predominantly by direct contact, but the role of indirect transmission remains poorly understood. This
Sijia Kong et al.
Enzyme and microbial technology, 140, 109614-109614 (2020-09-12)
Linalool is an important terpenoids of floral scents and has wide applications. In the past, several groups reported on a strategy to establish biosynthesis of linalool in yeast based on co-expression of Saccharomyces cerevisiae farnesyl diphosphate synthase ERG20 and Actinidia
P D Wagner et al.
The Journal of biological chemistry, 275(45), 35570-35576 (2000-08-23)
The biochemical mechanism(s) by which Nm23 proteins/nucleoside diphosphate kinases suppress tumor metastasis, inhibit cell motility, and affect cellular differentiation are not known. Here we report that Nm23 proteins can phosphorylate geranyl and farnesyl pyrophosphates to give triphosphates. Wild type Nm23-H1
Xuewen Wang et al.
International journal of molecular sciences, 20(17) (2019-08-28)
Herbivore-induced plant volatiles (HIPVs) play important ecological roles in defense against stresses. In contrast to model plants, reports on HIPV formation and function in crops are limited. Tea (Camellia sinensis) is an important crop in China. α-Farnesene is a common
Takuya Ogawa et al.
The FEBS journal, 281(14), 3165-3176 (2014-05-23)
Saturation of a prenyl group to various levels is a frequently observed modification of isoprenoids. The members of the geranylgeranyl reductase family, however, are the only known enzymes responsible for such reductive modifications in archaea. A methanogenic archaeon, Methanosarcina acetivorans
Qingzhu Liu et al.
European journal of medicinal chemistry, 186, 111905-111905 (2019-12-02)
Farnesyl pyrophosphate synthase (FPPS) is known to participate in a variety of disease-related cell signaling pathway and bisphosphonates (BPs) are served as FPPS inhibitors. However, the high polarity of BPs often induces a series of side effects, limiting their applications.
Axel Schmidt et al.
Plant physiology, 152(2), 639-655 (2009-11-27)
The conifer Picea abies (Norway spruce) defends itself against herbivores and pathogens with a terpenoid-based oleoresin composed chiefly of monoterpenes (C(10)) and diterpenes (C(20)). An important group of enzymes in oleoresin biosynthesis are the short-chain isoprenyl diphosphate synthases that produce
Grégory Guirimand et al.
Plants (Basel, Switzerland), 9(4) (2020-04-11)
The Madagascar periwinkle (Catharanthus roseus) synthesizes the highly valuable monoterpene indole alkaloids (MIAs) through a long metabolic route initiated by the 2C-methyl-D-erythritol 4-phosphate (MEP) pathway. In leaves, a complex compartmentation of the MIA biosynthetic pathway occurs at both the cellular
Elias Orouji et al.
Cancers, 12(4) (2020-04-30)
Merkel cell carcinoma (MCC) is a deadly skin cancer, and about 80% of its cases have been shown to harbor integrated Merkel polyomavirus in the tumor cell genome. Viral oncoproteins expressed in the tumor cells are considered as the oncogenic
Xuemei Mao et al.
Biotechnology for biofuels, 13, 73-73 (2020-04-24)
Chromochloris zofingiensis, a freshwater alga capable of synthesizing both triacylglycerol (TAG) and astaxanthin, has been receiving increasing attention as a leading candidate producer. While the mechanism of oleaginousness and/or carotenogenesis has been studied under such induction conditions as nitrogen deprivation
Keven Hoerster et al.
Frontiers in immunology, 11, 586168-586168 (2021-02-16)
Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells. However, harvesting sufficient numbers of T cells is often challenging in heavily pre-treated patients with malignancies and perturbed
J Xie et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 25(4), 454-461 (2018-07-03)
To evaluate the relationship between individual bacterial and viral pathogens and disease severity. Children <18 years with three or more episodes of vomiting and/or diarrhoea were enrolled in two Canadian paediatric emergency departments between December 2014 and August 2016. Specimens were
Taojun He et al.
The Journal of molecular diagnostics : JMD, 19(6), 836-842 (2017-08-16)
In immunocompromised patients with norovirus (NoV) gastroenteritis, the relationship between fecal NoV load and clinical complications has not been examined. In this study, a validated real-time quantitative PCR assay was used to determine viral loads for NoV genogroup I and
Lei Cheng et al.
Nature communications, 8(1), 110-110 (2017-07-26)
Quantifying the responses of the coupled carbon and water cycles to current global warming and rising atmospheric CO
Jordan J Zager et al.
Plant physiology, 180(4), 1877-1897 (2019-05-30)
Glandular trichomes are specialized anatomical structures that accumulate secretions with important biological roles in plant-environment interactions. These secretions also have commercial uses in the flavor, fragrance, and pharmaceutical industries. The capitate-stalked glandular trichomes of Cannabis sativa (cannabis), situated on the
Shuai Shao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(6), 6813-6828 (2019-02-28)
Generalized pustular psoriasis (GPP) is a rare and severe inflammatory skin disease that can be life-threatening. Gene mutations are found in some cases, but its immune pathogenesis is largely unknown. Here, we observed that the neutrophil:lymphocyte ratio in patients with
Jen-Wei Huang et al.
Nature communications, 11(1), 2948-2948 (2020-06-13)
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially
Joris W De Schutter et al.
Bioorganic & medicinal chemistry letters, 20(19), 5781-5786 (2010-08-31)
A structure-based approach was pursued in designing novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase (hFPPS). Preliminary SAR and structural evidence for the simultaneous binding of these inhibitors into the isopentenyl pyrophosphate (IPP) and the geranyl pyrophosphate (GPP) substrate
Emil Aagaard Thomsen et al.
Molecular oncology, 14(9), 1978-1997 (2020-06-26)
Diffuse large B-cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable responses to the current treatment, R-CHOP, which consists of a cancer drug combination supplemented with the humanized CD20-targeting monoclonal antibody rituximab. Despite improvements in
Anthony L Schilmiller et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(26), 10865-10870 (2009-06-03)
We identified a cis-prenyltransferase gene, neryl diphosphate synthase 1 (NDPS1), that is expressed in cultivated tomato (Solanum lycopersicum) cultivar M82 type VI glandular trichomes and encodes an enzyme that catalyzes the formation of neryl diphosphate from isopentenyl diphosphate and dimethylallyl
M Águila Ruiz-Sola et al.
Plant physiology, 172(3), 1393-1402 (2016-10-21)
A wide diversity of isoprenoids is produced in different plant compartments. Most groups of isoprenoids synthesized in plastids, and some produced elsewhere in the plant cell derive from geranylgeranyl diphosphate (GGPP) synthesized by GGPP synthase (GGPPS) enzymes. In Arabidopsis (Arabidopsis
J Fraser Glickman et al.
Assay and drug development technologies, 5(2), 205-214 (2007-05-05)
A mix-and-read FlashPlate (PerkinElmer, Waltham, MA) assay for the enzyme farnesyl pyrophosphate (FPP) synthase (FPPS) was developed to rapidly measure both steps in the synthesis of FPP from dimethylallyl pyrophosphate (DMAPP). The assay used either DMAPP or geranyl pyrophosphate (GPP)
Bei-Bei He et al.
ACS synthetic biology, 7(9), 2094-2104 (2018-08-15)
Prenylated aromatic compounds are important intermediates in the biosynthesis of bioactive molecules such as 3-chromanols from plants, ubiquinones from prokaryotes and meroterpenoids from sponges. Biosynthesis of prenylated aromatic compounds using prokaryotic microorganisms has attracted increasing attention in the field of
Frederick G B Goddard et al.
International journal of environmental research and public health, 17(9) (2020-05-01)
Characterizing child immunological responses to enteric infections with antibody detection in serum can be challenging in resource-constrained field settings, because sample collection requires trained individuals and its invasive procedure may lead to low response rates, especially among children. Saliva may
Mosaab Yahyaa et al.
Journal of agricultural and food chemistry, 63(19), 4870-4878 (2015-05-01)
Plants produce an excess of volatile organic compounds, which are important in determining the quality and nutraceutical properties of fruit and root crops, including the taste and aroma of carrots (Daucus carota L.). A combined chemical, biochemical, and molecular study
Jaeok Park et al.
Nature communications, 8, 14132-14132 (2017-01-18)
Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable pocket near the enzyme's active site. Pharmacological exploitation of this pocket is deemed promising; however
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