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C Vocale et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 34, 33-37 (2015-03-10)
Gastroenteritis caused by a single pathogen or multiple pathogens remains a major diagnostic challenge for the laboratory. The treatment of diarrhoea is based on microbiological results. Diagnosis is achieved using different laboratory techniques that have variable sensitivity and specificity. xTAG
Savitha Dhandapani et al.
BMC genomics, 18(1), 463-463 (2017-06-16)
Magnolia champaca, commonly known as champak is a well-known tree due to its highly fragrant flowers. Champak floral scent is attributed to a complex mix of volatile organic compounds (VOCs). These aromatic flowers are widely used in flavors and fragrances
Akira Saito et al.
Melanoma research, 18(2), 85-94 (2008-03-14)
Competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase (the statins) that inhibit the synthesis of mevalonic acid are in wide use for treatment of hypercholesterolemia. Although antitumor effects on a variety of cell types have been reported for statins, the effect
Xavier Waltz et al.
The Journal of physiology, 594(23), 7089-7104 (2016-09-21)
Altered cerebral autoregulation (CA) in obstructive sleep apnoea (OSA) patients may contribute to increased stroke risk in this population; the gold standard treatment for OSA is continuous positive airway pressure, which improves cerebrovascular regulation and may decrease the risk of
Zichao Wang et al.
International journal of biological macromolecules, 126, 209-214 (2018-12-28)
In current study, a polysaccharide (GPP) was successfully extracted from Gynostemma pentaphyllum herb. Monosaccharide composition of GPP was rhamnose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 4.11: 7.34: 13.31: 20.99: 1.07: 0.91:
Shilpa Bhardwaj et al.
Clinical interventions in aging, 8, 47-59 (2013-01-29)
Statins have demonstrated substantial benefits in supporting cardiovascular health. Older individuals are more likely to experience the well-known muscle-related side effects of statins compared with younger individuals. Elderly females may be especially vulnerable to statin-related muscle disorder. This review will
Morgan T Gallagher et al.
The Science of the total environment, 706, 135728-135728 (2020-01-17)
Pharmaceuticals and personal care products (PPCPs), such as the commonly prescribed antibiotic ciprofloxacin, are present and persistent in freshwaters, yet their effects on aquatic ecosystem functions at environmentally-relevant concentrations are rarely explored. Stream biofilms provide multiple functions in stream ecosystems
E Micali et al.
Biochemistry, 40(41), 12254-12265 (2001-10-10)
Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase). We synthesized the benzyloxyisoprenyl pyrophosphate (BnPP) series of
Hayato Ueoka et al.
Plant physiology, 182(4), 1933-1945 (2020-01-25)
Geranyl diphosphate (GPP) is the direct precursor of all monoterpenoids and is the prenyl source of many meroterpenoids, such as geranylated coumarins. GPP synthase (GPPS) localized in plastids is responsible for providing the substrate for monoterpene synthases and prenyltransferases for
Lawrence W Harding et al.
Scientific reports, 10(1), 2019-2019 (2020-02-08)
Estuarine-coastal ecosystems are rich areas of the global ocean with elevated rates of organic matter production supporting major fisheries. Net and gross primary production (NPP, GPP) are essential properties of these ecosystems, characterized by high spatial, seasonal, and inter-annual variability
Kazutake Hirooka et al.
Bioscience, biotechnology, and biochemistry, 84(2), 347-357 (2019-11-02)
Bacillus ComQ participates in the biosynthesis of a quorum-sensing signaling molecule (ComX pheromone) through catalyzing the prenylation at a Trp residue of the precursor peptide (pre-ComX) with geranyl diphosphate (C10 type) or farnesyl diphosphate (C15 type). We hypothesized that several
Sophie Twelves et al.
The Journal of allergy and clinical immunology, 143(3), 1021-1026 (2018-07-24)
The term pustular psoriasis indicates a group of severe skin disorders characterized by eruptions of neutrophil-filled pustules. The disease, which often manifests with concurrent psoriasis vulgaris, can have an acute systemic (generalized pustular psoriasis [GPP]) or chronic localized (palmoplantar pustulosis
Garret P Miller et al.
The Plant journal : for cell and molecular biology, 104(3), 693-705 (2020-08-11)
Serrulatane diterpenoids are natural products found in plants from a subset of genera within the figwort family (Scrophulariaceae). Many of these compounds have been characterized as having anti-microbial properties and share a common diterpene backbone. One example, leubethanol from Texas
Giuseppe Tringali et al.
Neuroscience letters, 354(2), 107-110 (2003-12-31)
Statins were recently shown to possess anti-inflammatory activities, which might be responsible for their favourable effects in cardiovascular or CNS disorders independently from the inhibition of hydroxy-methyl-glutaryl CoA reductase. Here we investigated the effects of the statins lovastatin and mevastatin
Sophia Hasenjäger et al.
ACS synthetic biology, 8(5), 1026-1036 (2019-04-09)
Optogenetic control of protein activity is a versatile technique to gain control over cellular processes, for example, for biomedical and biotechnological applications. Among other techniques, the regulation of protein abundance by controlling either transcription or protein stability found common use
Tengxun Zhang et al.
Plant physiology and biochemistry : PPB, 151, 391-399 (2020-04-12)
Lily, a famous cut flower with highly fragrance, has high ornamental and economic values. Monoterpenes are the main components contributing to its fragrance, and terpene synthase (TPS) genes play critical roles in the biosynthesis of monoterpenoids. To understand the function
Bin Liu et al.
Plant, cell & environment, 44(1), 257-274 (2020-08-25)
Pine wood nematode (PWN; Bursaphelenchus xylophilus), a destructive pest of Pinus massoniana, is causing a severe epidemic of pine wilt disease in China. When invaded by PWN, resistant P. massoniana secretes an abundance of oleoresin terpenoids as a defensive strategy.
Giulia Opassi et al.
Protein science : a publication of the Protein Society, 29(4), 991-1003 (2020-01-30)
Procedures for producing and exploring Trypanosoma cruzi farnesyl pyrophosphate synthase (tcFPPS) for surface plasmon resonance (SPR) biosensor-driven fragment-based discovery have been established. The method requires functional sensor surfaces with high sensitivity for extended times and appropriate controls. Initial problems with
Olatz Pereda et al.
Environmental pollution (Barking, Essex : 1987), 258, 113719-113719 (2019-12-16)
The ecological effects of wastewater treatment plant (WWTP) effluents on stream ecosystems cause growing concern. However, it is difficult to assess these effects as most streams receiving WWTP effluents are also affected by other stressors. We performed a whole-ecosystem manipulation
Annie P-C Chen et al.
The Biochemical journal, 386(Pt 1), 169-176 (2004-09-28)
UPPS (undecaprenyl pyrophosphate synthase) catalyses consecutive condensation reactions of FPP (farnesyl pyrophosphate) with eight isopentenyl pyrophosphates to generate C55 UPP, which serves as a lipid carrier for bacterial peptidoglycan biosynthesis. We reported the co-crystal structure of Escherichia coli UPPS in
Parvaneh Keshavarz et al.
Topics in stroke rehabilitation, 23(4), 254-260 (2016-04-15)
Genetic factors like the allele for Brain-Derived Neurotrophic Factor (BDNF) are associated with the outcome of ischemic stroke most likely through affecting neural differentiation and synaptic plasticity. Studies of the association of BDNF G196A gene polymorphism and long-term ischemic stroke
Janire De-La-Torre et al.
Revista iberoamericana de micologia, 35(3), 134-139 (2018-08-08)
Candida can be implicated in the pathology of chronic periodontitis. To analyze the oral Candida carriage in patients suffering from chronic periodontitis (CP) and its correlation with the severity of this condition. Microbiological samples were taken from 155 patients using
Liwei Ma
Carbon balance and management, 15(1), 3-3 (2020-03-21)
Annual total Gross Primary Production (GPP) and Net Primary Production (NPP) and the annual total stored GPP and NPP are tightly coupled to land cover distributions because the distinct vegetation conditions of different land cover classes strongly affect GPP and
Nadja A Henke et al.
International journal of molecular sciences, 21(15) (2020-08-06)
Carotenoid biosynthesis in Corynebacteriumglutamicum is controlled by the MarR-type regulator CrtR, which represses transcription of the promoter of the crt operon (PcrtE) and of its own gene (PcrtR). Geranylgeranyl pyrophosphate (GGPP), and to a lesser extent other isoprenoid pyrophosphates, interfere
Jacob Schewe et al.
Nature communications, 10(1), 1005-1005 (2019-03-03)
Global impact models represent process-level understanding of how natural and human systems may be affected by climate change. Their projections are used in integrated assessments of climate change. Here we test, for the first time, systematically across many important systems
Fu-Lien Hsieh et al.
Journal of molecular biology, 404(5), 859-873 (2010-10-23)
Isoprenoids, most of them synthesized by prenyltransferases (PTSs), are a class of important biologically active compounds with diverse functions. The mint geranyl pyrophosphate synthase (GPPS) is a heterotetramer composed of two LSU·SSU (large/small subunit) dimers. In addition to C(10)-GPP, the
Wojciech Siwek et al.
Molecular cell, 80(3), 396-409 (2020-10-28)
Cytokine activation of cells induces gene networks involved in inflammation and immunity. Transient gene activation can have a lasting effect even in the absence of ongoing transcription, known as long-term transcriptional memory. Here we explore the nature of the establishment
Batika M J Rana et al.
The Journal of experimental medicine, 216(9), 1999-2009 (2019-06-30)
Group-2 innate lymphoid cells (ILC2), type-2 cytokines, and eosinophils have all been implicated in sustaining adipose tissue homeostasis. However, the interplay between the stroma and adipose-resident immune cells is less well understood. We identify that white adipose tissue-resident multipotent stromal
Si Cheng et al.
ACS synthetic biology, 8(5), 968-975 (2019-05-08)
Limonene, a plant-derived natural cyclic monoterpene, is widely used in the pharmaceutical, food, and cosmetics industries. The conventional limonene biosynthetic (CLB) pathway in engineered Saccharomyces cerevisiae consists of heterologous limonene synthase (LS) using endogenous substrate geranyl diphosphate (GPP) and suffers
Jianling Xie et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 131, 104565-104565 (2020-08-19)
To determine if the clinical characteristics of children with gastroenteritis and influenza identified in their stool differ from those whose stool was influenza-negative. Children <18-years with gastroenteritis whose stool tested negative for enteropathogen were tested for influenza in stool. The
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