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Jihua Wu et al.
Journal of agricultural and food chemistry, 67(25), 7087-7097 (2019-06-15)
Limonene, a cyclic monoterpene, is widely used in food and cosmetics industries as well as in agriculture. In the work described herein, employing a systematic optimization strategy, we constructed an efficient platform for producing limonene via the heterologous mevalonate pathway
Wenshuang Xie et al.
Phytochemistry, 69(14), 2539-2545 (2008-09-19)
Natural rubber, cis-1,4-polyisoprene, is a vital industrial material synthesized by plants via a side branch of the isoprenoid pathway by the enzyme rubber transferase. While the specific structure of this enzyme is not yet defined, based on activity it is
Ayelign M Adal et al.
Plant molecular biology, 102(4-5), 517-535 (2020-01-14)
We reported the functional characterization of cDNAs encoding short-chain isoprenyl diphosphate synthases that control the partitioning of precursors for lavender terpenoids. Lavender essential oil is composed of regular and irregular monoterpenes, which are derived from linear precursors geranyl diphosphate (GPP)
Yoshihisa Hirota et al.
PloS one, 10(4), e0125737-e0125737 (2015-04-16)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis. We investigated the enzymological properties of UBIAD1 using microsomal fractions from Sf9 cells expressing UBIAD1 by analysing MK-4 biosynthetic activity. With regard to UBIAD1 enzyme
Fabrication of polymer monoliths within the confines of non-transparent 3D-printed polymer housings.
Noor Abdulhussain et al.
Journal of chromatography. A, 1623, 461159-461159 (2020-06-09)
In the last decade, 3D-printing has emerged as a promising enabling technology in the field of analytical chemistry. Fused-deposition modelling (FDM) is a popular, low-cost and widely accessible technique. In this study, RPLC separations are achieved by in-situ fabrication of
Rui Ma et al.
Frontiers in bioengineering and biotechnology, 9, 631863-631863 (2021-03-02)
(+)-Borneol is a desirable monoterpenoid with effective anti-inflammatory and analgesic effects that is known as soft gold. (+)-bornyl diphosphate synthase is the key enzyme in the (+)-borneol biosynthesis pathway. Despite several reported (+)-bornyl diphosphate synthase genes, relatively low (+)-borneol production
Xu Yue et al.
Global change biology, 22(11), 3750-3759 (2016-10-21)
Ozone (O
Mohammad N Mhaissen et al.
Journal of the Pediatric Infectious Diseases Society, 6(3), 275-280 (2016-09-01)
Diarrhea is common in children with cancer, but this has not been systematically studied to date. Remnant stool samples collected between January 2010 and June 2011 from pediatric oncology patients with diarrhea were tested for bacterial, viral, and parasitic enteropathogens
Camille Williams et al.
BMC infectious diseases, 20(1), 741-741 (2020-10-11)
Cholera remains a major global health challenge. Uvira, in the Democratic Republic of the Congo (DRC), has had endemic cholera since the 1970's and has been implicated as a possible point of origin for national outbreaks. A previous study among
Kathryn L Kavanagh et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(20), 7829-7834 (2006-05-11)
Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting >50% of the female population over the age of 50. Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of
[A new development in isoprenoid biochemistry brought by the discovery of prenylated proteins].
H Sagami et al.
Seikagaku. The Journal of Japanese Biochemical Society, 66(12), 1488-1501 (1994-12-01)
Juliana Sobczyk et al.
Open forum infectious diseases, 7(1), ofz547-ofz547 (2020-01-25)
Gastrointestinal pathogen panels (GPPs) are increasingly used to identify stool pathogens, but their impact in people with HIV (PWH) is unknown. We performed a retrospective cohort study comparing GPP and conventional stool evaluation in PWH. We included all PWH who
A Smit et al.
Genome research, 10(10), 1468-1484 (2000-10-24)
Isoprenoid compounds are ubiquitous in living species and diverse in biological function. Isoprenoid side chains of the membrane lipids are biochemical markers distinguishing archaea from the rest of living forms. The mevalonate pathway of isoprenoid biosynthesis has been defined completely
Trevor F Keenan et al.
Nature communications, 7, 13428-13428 (2016-11-09)
Terrestrial ecosystems play a significant role in the global carbon cycle and offset a large fraction of anthropogenic CO
Sven Reichardt et al.
Horticulture research, 7(1), 190-190 (2020-12-18)
In plants, low molecular weight terpenes produced by terpene synthases (TPS) contribute to multiple ecologically and economically important traits. The present study investigates a carrot terpene synthase gene cluster on chromosome 4 associated with volatile monoterpene production. Two carrot mutants
X Gan et al.
The Journal of biological chemistry, 276(52), 48702-48708 (2001-10-20)
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor
G F Barnard et al.
Biochimica et biophysica acta, 661(1), 87-99 (1981-09-15)
Prenyltransferase (dimethylallydiphosphate: isopentenyldiphosphate dimethylallytransferase, EC 2.5.1.1) has been purified to homogeneity from human liver obtained at autopsy. The enzyme is a dimer with a native molecular weight of 74 000 +/- 1 400. The amino acid composition is reported. the
Koh-Ichi Emi et al.
Biochemical and biophysical research communications, 520(2), 291-296 (2019-10-09)
Cis-prenyltransferases are enzymes responsible for the biosynthesis of glycosyl carrier lipids, natural rubber, and some secondary metabolites. Certain organisms, including some archaeal species, possess multiple genes encoding cis-prenyltransferase homologs, and the physiological roles of these seemingly-redundant genes are often obscure.
Sarah A Holstein et al.
Lipids, 39(4), 293-309 (2004-09-11)
The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In
P Jiang et al.
British journal of cancer, 111(8), 1562-1571 (2014-08-06)
The increasing usage of statins (the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors) has revealed a number of unexpected beneficial effects, including a reduction in cancer risk. We investigated the direct anticancer effects of different statins approved for clinical use on human breast
Y Zboromyrska et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(10), O753-O759 (2014-03-14)
Traveller's diarrhoea (TD) is the most common illness reported in international travellers. TD is caused by a wide range of pathogens, including bacteria, viruses and parasites. Multiplex PCR assays can be especially useful for studying the aetiology of TD. The
Hang Fan et al.
BMC plant biology, 19(1), 82-82 (2019-02-21)
There exist differences in morphological traits and phytochemical compositions between field- and mountain-cultivated Panax ginseng (FCG and MCG), which might be attributed to variations of terpenoids metabolism adapting to different growth conditions. The present work aims to uncover these variations.
Xu Lian et al.
Nature communications, 12(1), 983-983 (2021-02-14)
The state of ecosystems is influenced strongly by their past, and describing this carryover effect is important to accurately forecast their future behaviors. However, the strength and persistence of this carryover effect on ecosystem dynamics in comparison to that of
Wei Zhang et al.
Genes & development, 34(7-8), 580-597 (2020-03-03)
Dysregulation of early neurodevelopment is implicated in macrocephaly/autism disorders. However, the mechanism underlying this dysregulation, particularly in human cells, remains poorly understood. Mutations in the small GTPase gene RAB39b are associated with X-linked macrocephaly, autism spectrum disorder (ASD), and intellectual
Victor Marco Emmanuel N Ferriols et al.
Scientific reports, 5, 10246-10246 (2015-05-23)
The diatom Rhizosolenia setigera Brightwell produces highly branched isoprenoid (HBI) hydrocarbons that are ubiquitously present in marine environments. The hydrocarbon composition of R. setigera varies between C25 and C30 HBIs depending on the life cycle stage with regard to auxosporulation.
Zhifei Zhan et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 99, 414-420 (2020-08-18)
To compare the performance of two syndromic panels: Luminex xTAG Gastrointestinal Pathogen Panel (GPP) and FilmArray Gastrointestinal (GI) panel. A total of 243 diarrhea specimens were detected by two panels in parallel, and the inconsistent results were analyzed by real-time
Jonathan E Henninger et al.
Cell, 184(1), 207-225 (2020-12-18)
Regulation of biological processes typically incorporates mechanisms that initiate and terminate the process and, where understood, these mechanisms often involve feedback control. Regulation of transcription is a fundamental cellular process where the mechanisms involved in initiation have been studied extensively
Dandan Xu et al.
Molecular carcinogenesis, 58(11), 2052-2064 (2019-08-10)
Recent studies have indicated that using statins to inhibit the mevalonate pathway induces mutant p53 degradation by impairing the interaction of mutant p53 with DnaJ subfamily A member 1 (DNAJA1). However, the role of the C-terminus of DNAJA1 with a
Mathieu Gand et al.
Food microbiology, 87, 103394-103394 (2020-01-18)
Salmonella is a major pathogen having a public health and economic impact in both humans and animals. Six serotypes of the Salmonella genus are mentioned in the Belgian and European regulation as to be rapidly excluded from the food chain
Birgit Piechulla et al.
Plant physiology, 172(4), 2120-2131 (2016-10-13)
Flowers of Nicotiana species emit a characteristic blend including the cineole cassette monoterpenes. This set of terpenes is synthesized by multiproduct enzymes, with either 1,8-cineole or α-terpineol contributing most to the volatile spectrum, thus referring to cineole or terpineol synthase
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