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显示 31-60 共 221 条结果 关于 "G6772" 范围 论文
Sohee Lee et al.
Cells, 9(2) (2020-02-28)
Protein import across the endoplasmic reticulum membrane is physiologically regulated in a substrate-selective manner to ensure the protection of stressed ER from the overload of misfolded proteins. However, it is poorly understood how different types of substrates are accurately distinguished
Francisco J Meza et al.
Scientific reports, 8(1), 8570-8570 (2018-06-07)
Biosphere-atmosphere water and carbon fluxes depend on ecosystem structure, and their magnitudes and seasonal behavior are driven by environmental and biological factors. We studied the seasonal behavior of net ecosystem CO2 exchange (NEE), Gross Primary Productivity (GPP), Ecosystem Respiration (RE)
Hui Jin et al.
Journal of chromatography. A, 1598, 30-38 (2019-04-02)
Isoprenoid diphosphates are important precursors actively participating in many downstream metabolisms; they are often in modified forms, e.g., protein-coupled or esterified form. Therefore, in vivo level of free isoprenoid diphosphates is quite low, ˜0.07 nmol/g fresh weight in plants. In order
Ravi S Singh et al.
BMC molecular biology, 11, 88-88 (2010-11-26)
Geranyl pyrophosphate (GPP) and p-hydroxybenzoate (PHB) are the basic precursors involved in shikonins biosynthesis. GPP is derived from mevalonate (MVA) and/or 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway(s), depending upon the metabolite and the plant system under consideration. PHB, however, is synthesized by
Shambhuprasad K Togarsimalemath et al.
Pediatric research, 84(1), 118-124 (2018-05-26)
Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement
David Berendes et al.
Epidemiology and infection, 148, e39-e39 (2020-02-28)
Nutritional factors and infectious agents may contribute to paediatric growth deficits in low- and middle-income countries; however, the contribution of enteric pathogens is only beginning to be understood. We analysed the stool from children <5 years old from an open
Manisha Agarwal et al.
American journal of respiratory cell and molecular biology, 63(5), 613-622 (2020-07-22)
Fibrosis is characterized by fibroblast activation, leading to matrix remodeling culminating in a stiff, type I collagen-rich fibrotic matrix. Alveolar epithelial cell (AEC) apoptosis is also a major feature of fibrogenesis, and AEC apoptosis is sufficient to initiate a robust
K C Chang et al.
The Journal of experimental zoology, 290(6), 642-651 (2001-12-19)
BALB/3T3 cells were transformed by transfection with DNA encoding the mutated ras(Q(61)K) from shrimp Penaeus japonicus (Huang et al., 2000). The GTPase-activating protein (GAP) in the cytosol fraction was significantly expressed and degraded, compared to untransformed cells on the western
Leslie C Morey
Psychological assessment, 29(10), 1302-1308 (2017-02-28)
The DSM-5 presents an Alternative Model for Personality Disorder (AMPD) recommending the assessment of impairments in core personality functions as well as clinically relevant personality traits. Although a self-report assessment instrument has been provided corresponding to the trait model proposed
Koh-Ichi Emi et al.
Biochemical and biophysical research communications, 520(2), 291-296 (2019-10-09)
Cis-prenyltransferases are enzymes responsible for the biosynthesis of glycosyl carrier lipids, natural rubber, and some secondary metabolites. Certain organisms, including some archaeal species, possess multiple genes encoding cis-prenyltransferase homologs, and the physiological roles of these seemingly-redundant genes are often obscure.
G F Barnard et al.
Biochimica et biophysica acta, 661(1), 87-99 (1981-09-15)
Prenyltransferase (dimethylallydiphosphate: isopentenyldiphosphate dimethylallytransferase, EC 2.5.1.1) has been purified to homogeneity from human liver obtained at autopsy. The enzyme is a dimer with a native molecular weight of 74 000 +/- 1 400. The amino acid composition is reported. the
Yoshihisa Hirota et al.
PloS one, 10(4), e0125737-e0125737 (2015-04-16)
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) plays a significant role in vitamin K2 (MK-4) synthesis. We investigated the enzymological properties of UBIAD1 using microsomal fractions from Sf9 cells expressing UBIAD1 by analysing MK-4 biosynthetic activity. With regard to UBIAD1 enzyme
Congqiang Zhang et al.
Communications biology, 4(1), 223-223 (2021-02-19)
Enzymes empower chemical industries and are the keystone for metabolic engineering. For example, linalool synthases are indispensable for the biosynthesis of linalool, an important fragrance used in 60-80% cosmetic and personal care products. However, plant linalool synthases have low activities
Sean R Johnson et al.
The New phytologist, 223(1), 323-335 (2019-03-08)
The mint family (Lamiaceae) is well documented as a rich source of terpene natural products. More than 200 diterpene skeletons have been reported from mints, but biosynthetic pathways are known for just a few of these. We crossreferenced chemotaxonomic data
Ibne Karim M Ali
Clinics in laboratory medicine, 35(2), 393-422 (2015-05-26)
Among the Entamoeba species that infect humans, Entamoeba histolytica causes diseases, Entamoeba dispar is a harmless commensal, Entamoeba moshkovskii seems to be a pathogen, and the pathogenicity of Entamoeba bangladeshi remains to be investigated. Species-specific detection needed for treatment decisions
Yaoqi Li et al.
Ecology letters, 23(6), 1003-1013 (2020-04-07)
A key challenge in ecology is to understand the relationships between organismal traits and ecosystem processes. Here, with a novel dataset of leaf length and width for 10 480 woody dicots in China and 2374 in North America, we show that
Matthew Edwards et al.
PloS one, 15(3), e0226173-e0226173 (2020-03-05)
Trophic interactions can result in changes to the abundance and distribution of habitat-forming species that dramatically reduce ecosystem functioning. In the coastal zone of the Aleutian Archipelago, overgrazing by herbivorous sea urchins that began in the 1990s resulted in widespread
Ayelign M Adal et al.
Plant molecular biology, 102(4-5), 517-535 (2020-01-14)
We reported the functional characterization of cDNAs encoding short-chain isoprenyl diphosphate synthases that control the partitioning of precursors for lavender terpenoids. Lavender essential oil is composed of regular and irregular monoterpenes, which are derived from linear precursors geranyl diphosphate (GPP)
Orapin Ariyawutthiphan et al.
Acta crystallographica. Section D, Biological crystallography, 68(Pt 11), 1558-1569 (2012-10-24)
In the typical isoprenoid-biosynthesis pathway, condensation of the universal C(5)-unit precursors isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) occurs via the common intermediates prenyl pyrophosphates (C(10)-C(20)). The diversity of isoprenoids reflects differences in chain length, cyclization and further additional modification
Birgit Piechulla et al.
Plant physiology, 172(4), 2120-2131 (2016-10-13)
Flowers of Nicotiana species emit a characteristic blend including the cineole cassette monoterpenes. This set of terpenes is synthesized by multiproduct enzymes, with either 1,8-cineole or α-terpineol contributing most to the volatile spectrum, thus referring to cineole or terpineol synthase
Xu Yue et al.
Global change biology, 22(11), 3750-3759 (2016-10-21)
Ozone (O
Mohammad N Mhaissen et al.
Journal of the Pediatric Infectious Diseases Society, 6(3), 275-280 (2016-09-01)
Diarrhea is common in children with cancer, but this has not been systematically studied to date. Remnant stool samples collected between January 2010 and June 2011 from pediatric oncology patients with diarrhea were tested for bacterial, viral, and parasitic enteropathogens
Fabrication of polymer monoliths within the confines of non-transparent 3D-printed polymer housings.
Noor Abdulhussain et al.
Journal of chromatography. A, 1623, 461159-461159 (2020-06-09)
In the last decade, 3D-printing has emerged as a promising enabling technology in the field of analytical chemistry. Fused-deposition modelling (FDM) is a popular, low-cost and widely accessible technique. In this study, RPLC separations are achieved by in-situ fabrication of
Kathryn L Kavanagh et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(20), 7829-7834 (2006-05-11)
Osteoporosis and low bone mass are currently estimated to be a major public health risk affecting >50% of the female population over the age of 50. Because of their bone-selective pharmacokinetics, nitrogen-containing bisphosphonates (N-BPs), currently used as clinical inhibitors of
Sven Reichardt et al.
Horticulture research, 7(1), 190-190 (2020-12-18)
In plants, low molecular weight terpenes produced by terpene synthases (TPS) contribute to multiple ecologically and economically important traits. The present study investigates a carrot terpene synthase gene cluster on chromosome 4 associated with volatile monoterpene production. Two carrot mutants
Sarah A Holstein et al.
Lipids, 39(4), 293-309 (2004-09-11)
The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In
Rui Ma et al.
Frontiers in bioengineering and biotechnology, 9, 631863-631863 (2021-03-02)
(+)-Borneol is a desirable monoterpenoid with effective anti-inflammatory and analgesic effects that is known as soft gold. (+)-bornyl diphosphate synthase is the key enzyme in the (+)-borneol biosynthesis pathway. Despite several reported (+)-bornyl diphosphate synthase genes, relatively low (+)-borneol production
X Gan et al.
The Journal of biological chemistry, 276(52), 48702-48708 (2001-10-20)
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor
A Montalvetti et al.
The Journal of biological chemistry, 276(36), 33930-33937 (2001-07-04)
We report the cloning and sequencing of a gene encoding the farnesyl pyrophosphate synthase of Trypanosoma cruzi. The protein (T. cruzi farnesyl pyrophosphate synthase, TcFPPS) is an attractive target for drug development, since the growth of T. cruzi is inhibited
Yong Yang et al.
PloS one, 9(6), e99537-e99537 (2014-06-12)
Xiamenmycin (1) is a prenylated benzopyran derivative with anti-fibrotic activity. To investigate the genetic basis of xiamenmycin biosynthesis, we performed genome mining in the xiamenmycin-producing Streptomyces xiamenensis wild-type strain 318 to identify a candidate gene cluster. The complete gene cluster
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