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Matthias Kappler et al.
Clinical oral investigations, 21(1), 211-224 (2016-03-10)
The stabilization of the transcription factor and prognostic tumor marker hypoxia-inducible factor 1α (HIF1α) is considered to be crucial for cellular metabolic adaptations to hypoxia. However, HIF1α has also been shown to accumulate under normoxic conditions, although this phenomenon is
Andrew M Borman et al.
Journal of clinical microbiology, 46(3), 933-938 (2008-01-18)
In 2005, Candida nivariensis, a yeast species genetically related to Candida glabrata, was described following its isolation from three patients in a single Spanish hospital. Between 2005 and 2006, 16 fungal isolates with phenotypic similarities to C. nivariensis were submitted
Feng-Jin Shao et al.
Journal of proteome research, 17(10), 3445-3453 (2018-09-05)
Pulmonary arterial hypertension (PAH) is the major cause of death in fast growing meat-type chickens (broiler chickens). At present, the underlying mechanisms that give rise to PAH are not fully understood. To identify the metabonomics profiles characterizing the process, we
Li-Zhi Mi et al.
Biochemistry, 47(39), 10314-10323 (2008-09-06)
Cellular signaling mediated by the epidermal growth factor receptor (EGFR or ErbB) family of receptor tyrosine kinases plays an important role in regulating normal and oncogenic cellular physiology. While structures of isolated EGFR extracellular domains and intracellular protein tyrosine kinase
Wei Wang et al.
Journal of agricultural and food chemistry, 67(1), 19-31 (2018-12-12)
Organophosphorus insecticide diazinon (DZN) is diffusely used in agriculture, home gardening, and crop peats. Much work so far has focused on the link between DZN exposure and the occurrence of neurological diseases, while little is known on the reproductive toxicological
Shahid Mahmood Chohan et al.
Folia microbiologica, 64(3), 313-320 (2018-10-27)
The genome sequence of Pyrobaculum calidifontis contains two open reading frames, Pcal_0144 and Pcal_0970, exhibiting homology with L-asparaginases. In search of a thermostable L-asparaginase with no glutaminase activity, we have cloned and expressed the gene encoding Pcal_0970 in Escherichia coli.
Xiaowei Shi et al.
Experimental cell research, 383(2), 111511-111511 (2019-07-31)
Clinical trials testing mesenchymal stem cell (MSC) as a cellular remedy for acute liver injury (ALI) are underway, but its underlying mechanism has not been thoroughly scrutinized. We highlight that the metabolomic profile of the liver-resident immune cells is significantly
Jinhong Meng et al.
PloS one, 6(3), e17454-e17454 (2011-03-17)
Stem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche in the majority of the patient's
Rosa Guerrero et al.
PloS one, 6(6), e21294-e21294 (2011-07-09)
Lafora disease is an autosomal recessive form of progressive myoclonus epilepsy with no effective therapy. Although the outcome is always unfavorable, onset of symptoms and progression of the disease may vary. We aimed to identify modifier genes that may contribute
Martin F Engelke et al.
Viruses, 3(3), 233-253 (2011-10-14)
Unlike transport vesicles or organelles, human adenovirus (HAdV) directly binds to the microtubule minus end-directed motor dynein for transport to the nucleus. The dynein cofactor dynactin enhances nuclear transport of HAdV and boosts infection. To determine if dynactin has a
Qiong Wu et al.
Microbial cell factories, 17(1), 155-155 (2018-10-05)
Bacillus spp. are a genus of biocontrol bacteria widely used for antibiosis, while Trichoderma spp. are biocontrol fungi that are abundantly explored. In this study, a liquid co-cultivation of these two organisms was tried firstly. Through liquid chromatography-mass spectrometry/mass spectrometry
Jia Song et al.
Experimental gerontology, 134, 110843-110843 (2020-02-12)
Scutellaria baicalensis Georgi flowers is rich in flavonoids resources but not effectively exploited. This study aimed to investigate the anti-aging effects and potential mechanism of Scutellaria baicalensis Georgi flowers extract (SFE). The chemical components of the SFE were analyzed by
Vanessa M Ferreira et al.
PloS one, 4(3), e4845-e4845 (2009-03-17)
Normal pregnancy is associated with systemic and intrarenal vasodilatation resulting in an increased glomerular filtration rate. This adaptive response occurs in spite of elevated circulating levels of angiotensin II (Ang II). In the present study, we evaluated the potential mechanisms
Xiangmin Lin et al.
Journal of proteome research, 14(3), 1515-1525 (2015-01-27)
To date, above ten thousand tons of antibiotics are used in aquaculture each year that lead to the deterioration of natural resources. However, knowledge is limited on the molecular biological behavior of common aquatic pathogens against antibiotics stress. In this
Youpei Wang et al.
Iranian journal of basic medical sciences, 20(8), 944-950 (2017-11-01)
High-glucose (HG) stress, a mimic of diabetes mellitus (DM) in culture cells, alters expression of a large number of genes including Wnt and NF-κB signaling-related genes; however, the role of Wnt signaling during HG-mediated fibroblast damage and the relationship between
Young-Mi Kim et al.
Experimental & molecular medicine, 41(12), 896-911 (2009-09-12)
4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is a major costimulatory receptor that is rapidly expressed on the surface of CD4(+) and CD8(+) T cells after antigen- or mitogen-induced activation. The interaction of 4-1BB with 4-1BBL
Mark Bishay et al.
JPEN. Journal of parenteral and enteral nutrition, 44(1), 80-91 (2019-09-11)
To determine whether parenteral plus enteral glutamine supplementation influences microbial invasion in surgical infants who require parenteral nutrition (PN). An prospective double-blind randomized controlled trial studying surgical infants receiving PN for at least 5 days for congenital or acquired intestinal anomalies
Raluca-Ioana Stefan-van Staden et al.
Analytical and bioanalytical chemistry, 412(13), 3199-3207 (2020-03-19)
Gastric cancer is the second leading cause of death in the world. Early detection will facilitate early treatment and full recovery of the patients. Metabolomics facilitated the detection of few amino acids able to be used as biomarkers. It was
María Luisa Castrejón-Godínez et al.
PeerJ, 7, e6822-e6822 (2019-05-16)
Burkholderia zhejiangensis CEIB S4-3 has the ability to degrade methyl parathion (MP) and its main hydrolysis byproduct p-nitrophenol (PNP). According to genomic data, several genes related with metabolism of MP and PNP were identified in this strain. However, the metabolic
Lynette Steele et al.
Molecular cancer, 10, 20-20 (2011-02-23)
As well as inducing direct oncolysis, reovirus treatment of melanoma is associated with activation of innate and adaptive anti-tumour immune responses. Here we characterise the effects of conditioned media from reovirus-infected, dying human melanoma cells (reoTCM), in the absence of
Magali Saint-Geniez et al.
PloS one, 3(11), e3554-e3554 (2008-11-04)
Vascular endothelial growth factor (VEGF) is well known for its role in normal and pathologic neovascularization. However, a growing body of evidence indicates that VEGF also acts on non-vascular cells, both developmentally as well as in the adult. In light
Steven N Steinway et al.
PLoS computational biology, 11(5), e1004338-e1004338 (2015-06-24)
We present a novel methodology to construct a Boolean dynamic model from time series metagenomic information and integrate this modeling with genome-scale metabolic network reconstructions to identify metabolic underpinnings for microbial interactions. We apply this in the context of a
Zane W Taylor et al.
Biochemistry, 57(37), 5447-5455 (2018-08-25)
Campylobacter jejuni, a leading cause of gastroenteritis worldwide, has a unique O-methyl phosphoramidate (MeOPN) moiety attached to its capsular polysaccharide. Investigations into the biological role of MeOPN have revealed that it contributes to the pathogenicity of C. jejuni, and this
Tai-Na Wu et al.
Scientific reports, 9(1), 5298-5298 (2019-03-30)
Lithium has been used for maintenance treatment of bipolar disorder, but drug response varies among patients. Single-nucleotide polymorphisms in glutamate decarboxylase-like protein 1 (GADL1) are found to be associated with lithium response in Han Chinese bipolar patients. In this study
Chengxiang Wu et al.
Journal of virological methods, 153(2), 120-128 (2008-08-30)
Generation of adenovirus-based vectors through homologous recombination within Escherichia coli cells is one of the most efficient strategies. A common challenge associated with this method is the formation of colonies containing self-ligated shuttle plasmid. To improve homologous recombination, a new
Yupeng Liao et al.
Journal of agricultural and food chemistry, 66(26), 6926-6935 (2018-06-16)
This study was to determine differences in the global metabolic profiles of serum and urine of Xuanhan yellow cattle, Simmental crossbred cattle (Simmental × Xuanhan yellow cattle), and cattle-yaks (Jersey × Maiwa yak) under heat stress (temperature-humidity index remained above
Yuyan Li et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 8524132-8524132 (2020-10-27)
Our previous studies have demonstrated that Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese herbal decoction, has a renoprotective effect in 5/6 nephrectomy-induced chronic kidney injury. However, the role and potential mechanisms of JPYSF in the treatment of acute kidney injury (AKI)
Ivan Fernandez-Bueno et al.
Molecular vision, 14, 2148-2156 (2008-12-05)
To analyze the in vitro Müller cell modifications in an organotypic culture of porcine neuroretina in response to the addition of a blood-derived mononuclear fraction (MNF; monocytes and lymphocytes) as a source of macrophages. Control and MNF-stimulated neuroretinal explants were
Siqing Yue et al.
Environment international, 129, 59-67 (2019-05-24)
Bisphenol analogues including bisphenol A (BPA), bisphenol AF (BPAF), bisphenol F (BPF), and bisphenol S (BPS) share similar chemical structures and endocrine disrupting effects. Their effects on metabolisms, however, are so far only marginally understood. In this study, NMR-based metabonomic
M Lichtenberg et al.
Cell death & disease, 2, e196-e196 (2011-08-26)
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common known cause of Parkinson's disease (PD). The clinical features of LRRK2 PD are indistinguishable from idiopathic PD, with accumulation of α-synuclein and/or tau and/or ubiquitin in intraneuronal aggregates. This suggests
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