GF61155378

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Asymptomatic malaria infection affects the interpretation of biomarkers of iron and vitamin A status, even after adjusting for systemic inflammation, but does not affect plasma zinc concentrations among young children in Burkina Faso.

K Ryan Wessells et al.

The Journal of nutrition, 144(12), 2050-2058 (2014-11-21)

Biomarkers of iron [plasma ferritin (pF)], vitamin A [retinol binding protein (RBP)], and zinc status [plasma zinc (pZn)] are affected by the acute phase response, independent of micronutrient status. The objective of these analyses was to assess how asymptomatic malaria

Zinc and human disease.

Wolfgang Maret

Metal ions in life sciences, 13, 389-414 (2014-01-29)

The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases.

Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase.

Georges Chreifi et al.

Biochemistry, 53(25), 4216-4223 (2014-05-14)

The nitric oxide synthase (NOS) dimer is stabilized by a Zn(2+) ion coordinated to four symmetry-related Cys residues exactly along the dimer 2-fold axis. Each of the two essential tetrahydrobiopterin (H4B) molecules in the dimer interacts directly with the heme

Determination of traces of copper and zinc in honeys by the solid phase extraction pre-concentration followed by the flame atomic absorption spectrometry detection.

Helena Stecka et al.

Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)

A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage

Synthesis and photophysical studies of self-assembled multicomponent supramolecular coordination prisms bearing porphyrin faces.

Yanhui Shi et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9390-9395 (2014-07-01)

Multicomponent self-assembly, wherein two unique donor precursors are combined with a single metal acceptor instead of the more common two-component assembly, can be achieved by selecting Lewis-basic sites and metal nodes that select for heteroligated coordination spheres. Platinum(II) ions show

Histatins: salivary peptides with copper(II)- and zinc(II)-binding motifs: perspectives for biomedical applications.

Sonia Melino et al.

The FEBS journal, 281(3), 657-672 (2013-11-14)

Natural antimicrobial peptides represent a primordial mechanism of immunity in both vertebrate and nonvertebrate organisms. Among them, histatins belong to a family of human salivary metal-binding peptides displaying potent antibacterial, antifungal and wound-healing activities. These properties, along with the ability

Measurement of microelectric potentials in a bioelectrically-active wound care device in the presence of bacteria.

S S Park et al.

Journal of wound care, 24(1), 23-33 (2014-12-30)

Wound healing is enhanced in the presence of an external electrical field. The purpose of this study was first to investigate whether microelectric potentials (EPs) can be generated when the innovative design of a silver (Ag)- and zinc (Zn)-printed wound

Short peptides self-assemble to produce catalytic amyloids.

Caroline M Rufo et al.

Nature chemistry, 6(4), 303-309 (2014-03-22)

Enzymes fold into unique three-dimensional structures, which underlie their remarkable catalytic properties. The requirement to adopt a stable, folded conformation is likely to contribute to their relatively large size (>10,000 Da). However, much shorter peptides can achieve well-defined conformations through

Responses of Beta vulgaris exposed to cadmium and zinc through soil drenching.

R K Sharma et al.

Journal of environmental biology, 35(4), 727-732 (2014-07-10)

The present study investigates the responses of Indian palak (Beta vulgaris L. cv. All Green H1) exposed to cadmium (Cd) and zinc (Zn) at growth, biochemical and physiological levels. The results revealed that Cd and Zn accumulation was higher in

Complementary feeding recommendations based on locally available foods in Indonesia.

Umi Fahmida et al.

Food and nutrition bulletin, 35(4 Suppl), S174-S179 (2015-02-03)

Affordable, locally contextual complementary feeding recommendations (CFRs) that take into account cultural diversity and differences in food availability will be more likely to result in long-term improvements in complementary feeding practices than general recommendations. More objective approaches, such as linear

Additivity and synergy between an antimicrobial peptide and inhibitory ions.

William F Walkenhorst et al.

Biochimica et biophysica acta, 1838(9), 2234-2242 (2014-05-21)

Recently we described the pH dependence of activity for a family of cationic antimicrobial peptides (CAMPs) selected from a combinatorial library. In the current work we report on the effects of toxic ions (Cu(2+), Zn(2+), and F(-)) and the chelator

Tetrameric ZBRK1 DNA binding domain has affinity towards cognate DNA in absence of zinc ions.

Lumbini R Yadav et al.

Biochemical and biophysical research communications, 450(1), 283-288 (2014-06-14)

Zinc finger transcription regulatory proteins play crucial roles in cell-cycle regulation, DNA damage response and tumor genesis. Human ZBRK1 is a zinc-finger transcription repressor protein, which recognizes double helical DNA containing consensus sequences of 5'GGGXXXCAGXXXTTT3'. In the present study, we

Sewage sludge and fly ash mixture as an alternative for decontaminating lead and zinc ore regions.

M Pogrzeba et al.

Environmental monitoring and assessment, 187(1), 4120-4120 (2014-11-10)

Many years of heavy industrial processes in the Upper Silesian Industrial Region in Poland (ore flotation, metal smelting and battery scrap processing) have resulted in lead, zinc and cadmium pollution of the air and soil. The most significant issues stem

Effects of sub-chronic aluminum chloride on spermatogenesis and testicular enzymatic activity in male rats.

Y Z Zhu et al.

Life sciences, 102(1), 36-40 (2014-03-13)

The aim of this study was to determine the effects of sub-chronic aluminum chloride (AlCl3) on spermatogenesis and testicular enzymatic activity in male rats. Forty Wistar male rats were randomly divided into four groups: control group (CG, 0), low-dose group

The molecular mechanisms of zinc neurotoxicity and the pathogenesis of vascular type senile dementia.

Dai Mizuno et al.

International journal of molecular sciences, 14(11), 22067-22081 (2013-11-12)

Zinc (Zn) is an essential trace element that is abundantly present in the brain. Despite its importance in normal brain functions, excess Zn is neurotoxic and causes neurodegeneration following transient global ischemia and plays a crucial role in the pathogenesis

Comparison of trace element concentrations in grey heron and black-crowned night heron chicks.

Jungsoo Kim et al.

Environmental monitoring and assessment, 187(1), 4124-4124 (2014-11-21)

Cadmium (Cd), lead (Pb), manganese (Mn), zinc (Zn), and iron (Fe) concentrations were measured in the prey and liver of grey heron (Ardea cinerea) and black-crowned night heron (Nycticorax nycticorax) chicks (24-26 days after hatching) at the Pyeongtaek colony, Korea

Zinc status in South Asian populations--an update.

Saeed Akhtar

Journal of health, population, and nutrition, 31(2), 139-149 (2013-08-13)

This article attempts to highlight the prevalence of zinc deficiency and its health and economic consequences in South Asian developing countries and to shed light on possible approaches to combating zinc deficiency. A computer-based search was performed on PubMed, Google

High-nutrition biscuits to increase animal protein in diets of HIV-infected Kenyan women and their children: a study in progress.

Judith Ernst et al.

Food and nutrition bulletin, 35(4 Suppl), S198-S204 (2015-02-03)

Preliminary evidence suggests that improved nutrition early in HIV infection may delay progression to AIDS and delay the initiation or improve the effectiveness of antiretroviral drug therapy. There are few studies that evaluate food-based interventions in drug-naïve, HIV-infected women and

Preparation of superhydrophobic coatings on zinc, silicon, and steel by a solution-immersion technique.

Hongqin Liu et al.

ACS applied materials & interfaces, 1(9), 2086-2091 (2010-04-02)

Zinc, silicon, and steel superhydrophobic surfaces were prepared by a simple solution-immersion technique. In the case of zinc, the method consists of dipping of the substrate in a prehydrolyzed methanol solution of 1H,1H,2H,2H-(perfluorooctyl)trichlorosilane [CF(3)(CF(2))(5)(CH(2))(2)SiCl(3), PFTS] for 24 h at 50

Organic-inorganic hybrids of imidazole complexes of zinc (II) for catalysts in the glycerolysis of urea.

Dong-Woo Kim et al.

Journal of nanoscience and nanotechnology, 14(6), 4632-4638 (2014-04-18)

Bis(alkylimidazole) complexes of zinc, (RIm)2ZnX2, were prepared by a metal insertion reaction. The synthesized (RIm)2ZnX2 exhibited good catalytic performance during synthesis of glycerol carbonate (GC) from glycerol and urea. (HEIm)2ZnCl2 with a hydroxyl group exhibited the highest GC yield during

Zinc in traumatic brain injury: from neuroprotection to neurotoxicity.

Deborah R Morris et al.

Current opinion in clinical nutrition and metabolic care, 16(6), 708-711 (2013-08-16)

In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury. Data

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.

Simard M, Hill LA, Underhill CM, et al.

Endocrinology, 155(8), 2900-2908 (2014)

Zinc and myocardial ischemia/reperfusion injury.

Zhelong Xu et al.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 26(6), 863-878 (2013-08-29)

As an important trace element, zinc is required for the normal cellular structure and function, and impairment of zinc homeostasis is associated with a variety of health problems including cardiovascular disease. Zinc homeostasis is regulated through zinc transporters, zinc binding

Hydrothermally Grown ZnO Micro/Nanotube Arrays and Their Properties.

Huibo Chen et al.

Nanoscale research letters, 5(3), 570-575 (2009-01-01)

We reported the optical and wettability properties of aligned zinc oxide micro/nanotube arrays, which were synthesized on zinc foil via a simple hydrothermal method. As-synthesized ZnO micro/nanotubes have uniform growth directions along the [0001] orientations with diameters in the range

Adhesin competence repressor (AdcR) from Streptococcus pyogenes controls adaptive responses to zinc limitation and contributes to virulence.

Misu Sanson et al.

Nucleic acids research, 43(1), 418-432 (2014-12-17)

Altering zinc bioavailability to bacterial pathogens is a key component of host innate immunity. Thus, the ability to sense and adapt to the alterations in zinc concentrations is critical for bacterial survival and pathogenesis. To understand the adaptive responses of

Zinc-induced structural changes of the disordered tppp/p25 inhibits its degradation by the proteasome.

Attila Lehotzky et al.

Biochimica et biophysica acta, 1852(1), 83-91 (2014-12-03)

Tubulin Polymerization Promoting Protein/p25 (TPPP/p25), a neomorphic moonlighting protein displaying both physiological and pathological functions, plays a crucial role in the differentiation of the zinc-rich oligodendrocytes, the major constituent of myelin sheath; and it is enriched and co-localizes with α-synuclein

Zinc transferred through breast milk does not differ between appropriate- and small-for-gestational-age, predominantly breast-fed Bangladeshi infants.

M Munirul Islam et al.

The Journal of nutrition, 144(5), 771-776 (2014-03-07)

Information is needed on breast milk zinc concentration and amount of zinc transferred to the infant in relation to the time since birth for both appropriate-for-gestational-age (AGA) and small-for-gestational-age (SGA) infants. Breast milk zinc concentration and total milk volume were

Curcumin alters the salt bridge-containing turn region in amyloid β(1-42) aggregates.

Venus Singh Mithu et al.

The Journal of biological chemistry, 289(16), 11122-11131 (2014-03-07)

Amyloid β (Aβ) fibrillar deposits in the brain are a hallmark of Alzheimer disease (AD). Curcumin, a common ingredient of Asian spices, is known to disrupt Aβ fibril formation and to reduce AD pathology in mouse models. Understanding the structural

Zinc and copper changes in serum and urine after aerobic endurance and muscular strength exercise.

J Granell

The Journal of sports medicine and physical fitness, 54(2), 232-237 (2014-02-11)

The role of zinc and copper has been shown essential in the scope of physical exercise. The outcomes of the studies about changes in the concentrations of these elements in blood, in physical effort situations, are sometimes discordant and seem

De novo design of a transmembrane Zn²⁺-transporting four-helix bundle.

Nathan H Joh et al.

Science (New York, N.Y.), 346(6216), 1520-1524 (2014-12-20)

The design of functional membrane proteins from first principles represents a grand challenge in chemistry and structural biology. Here, we report the design of a membrane-spanning, four-helical bundle that transports first-row transition metal ions Zn(2+) and Co(2+), but not Ca(2+)

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