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Manuela Mellone et al.
Journal of neurochemistry, 132(2), 159-168 (2014-10-17)
Zinc (Zn(2+) ) is believed to play a relevant role in the physiology and pathophysiology of the brain. Hence, Zn(2+) homeostasis is critical and involves different classes of molecules, including Zn(2+) transporters. The ubiquitous Zn(2+) transporter-1 (ZNT-1) is a transmembrane
Nicola M Lowe et al.
Critical reviews in food science and nutrition, 53(10), 1110-1123 (2013-08-21)
Zinc was selected as a priority micronutrient for EURRECA, because there is significant heterogeneity in the Dietary Reference Values (DRVs) across Europe. In addition, the prevalence of inadequate zinc intakes was thought to be high among all population groups worldwide
S S Park et al.
Journal of wound care, 24(1), 23-33 (2014-12-30)
Wound healing is enhanced in the presence of an external electrical field. The purpose of this study was first to investigate whether microelectric potentials (EPs) can be generated when the innovative design of a silver (Ag)- and zinc (Zn)-printed wound
K Ryan Wessells et al.
The Journal of nutrition, 144(12), 2050-2058 (2014-11-21)
Biomarkers of iron [plasma ferritin (pF)], vitamin A [retinol binding protein (RBP)], and zinc status [plasma zinc (pZn)] are affected by the acute phase response, independent of micronutrient status. The objective of these analyses was to assess how asymptomatic malaria
Ida Beathe Overjordet et al.
The Science of the total environment, 502, 548-556 (2014-10-10)
Seasonal fluctuations in mercury (Hg), cadmium (Cd), zinc (Zn), copper (Cu) and selenium (Se) concentrations were studied in black-legged kittiwakes (Rissa tridactyla) from Kongsfjorden, Svalbard (79°57'N, 12°12'E). Element concentrations were determined in muscle and liver tissue in kittiwakes collected in
Priscilla K Walker et al.
Health physics, 106(4), 523-527 (2014-02-25)
Beam shaping in scattered and uniform scanned proton beam therapy (PBT) is made commonly by brass apertures. Due to proton interactions, these devices become radioactive and could pose safety issues and radiation hazards. Nearly 2,000 patient-specific devices per year are
Yongmei Zhao et al.
Stroke, 45(4), 1139-1147 (2014-03-20)
Zinc has been reported to possess both neurotoxic and neuroprotective capabilities. The effects of elevated intracellular zinc accumulation following transient focal cerebral ischemia remain to be fully elucidated. Here, we investigated whether removing zinc with the membrane-permeable zinc chelator, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Xiang Sheng et al.
Biochemistry, 53(27), 4455-4466 (2014-06-26)
Pyruvate carboxylase (PC) catalyzes the carboxylation of pyruvate to produce oxaloacetate. Its activity is directly related to insulin release and thus PC has recently attracted great interest as a potential target for diabetes treatment. In this article, the catalytic mechanism
Beatriz Garrido-Rodriguez et al.
Chemosphere, 107, 379-385 (2014-01-29)
Batch type and column experiments were used to study competitive adsorption-desorption and transport for Cd, Cu, Ni and Zn in a mine soil, both un-amended and amended with mussel shell. Batch type experiments showed that adsorption was affected by the
Marcella C Galvão et al.
Life sciences, 120, 54-60 (2014-12-03)
Previous investigations by our group have shown that prenatal treatment with lipopolysaccharide (LPS; 100 μg/kg, intraperitoneally) on gestation day (GD) 9.5 in rats, which mimics infections by Gram-negative bacteria, induces short- and long-term behavioral and neuroimmune changes in the offspring.
Kohei Takeshita et al.
Nature structural & molecular biology, 21(4), 352-357 (2014-03-04)
The voltage-gated proton channel Hv1 (or VSOP) has a voltage-sensor domain (VSD) with dual roles of voltage sensing and proton permeation. Its gating is sensitive to pH and Zn(2+). Here we present a crystal structure of mouse Hv1 in the
Johan Hattne et al.
Nature methods, 11(5), 545-548 (2014-03-19)
X-ray free-electron laser (XFEL) sources enable the use of crystallography to solve three-dimensional macromolecular structures under native conditions and without radiation damage. Results to date, however, have been limited by the challenge of deriving accurate Bragg intensities from a heterogeneous
Xuan-Yu Min et al.
International journal of radiation biology, 90(10), 909-913 (2014-05-16)
To develop a new biological dosimeter based on serum zinc concentration. Male mice (8 weeks old) were exposed to different doses (0, 1.0, 2.0, 4.0, or 8.0 Gy) of gamma rays from a (60)Co source. Blood was then collected from
Wolfgang Maret
Metal ions in life sciences, 13, 389-414 (2014-01-29)
The vast knowledge of the physiologic functions of zinc in at least 3000 proteins and the recent recognition of fundamental regulatory functions of zinc(II) ions released from cells or within cells links this nutritionally essential metal ion to numerous diseases.
Helena Stecka et al.
Environmental monitoring and assessment, 186(10), 6145-6155 (2014-05-30)
A simple and fast solid phase extraction procedure was developed to pre-concentrate traces of Cu and Zn prior to their determination in honey samples by flame atomic absorption spectrometry. The sample preparation included dissolution of honey samples and the passage
Yanhui Shi et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(26), 9390-9395 (2014-07-01)
Multicomponent self-assembly, wherein two unique donor precursors are combined with a single metal acceptor instead of the more common two-component assembly, can be achieved by selecting Lewis-basic sites and metal nodes that select for heteroligated coordination spheres. Platinum(II) ions show
Laura M Lamberti et al.
Nutrients, 5(11), 4715-4740 (2013-11-29)
Evidence supporting the impact of therapeutic zinc supplementation on the duration and severity of diarrhea among children under five is largely derived from studies conducted in South Asia. China experiences a substantial portion of the global burden of diarrhea, but
Rebecca G Mitchell et al.
Environmental pollution (Barking, Essex : 1987), 187, 162-169 (2014-02-08)
Urban gardens provide affordable fresh produce to communities with limited access to healthy food but may also increase exposure to lead (Pb) and other soil contaminants. Metals analysis of 564 soil samples from 54 New York City (NYC) community gardens
Caroline M Rufo et al.
Nature chemistry, 6(4), 303-309 (2014-03-22)
Enzymes fold into unique three-dimensional structures, which underlie their remarkable catalytic properties. The requirement to adopt a stable, folded conformation is likely to contribute to their relatively large size (>10,000 Da). However, much shorter peptides can achieve well-defined conformations through
Brittany L Mortensen et al.
Journal of bacteriology, 196(14), 2616-2626 (2014-05-13)
Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia in intensive care units, and the increasing rates of antibiotic resistance make treating these infections challenging. Consequently, there is an urgent need to develop new antimicrobials to treat A. baumannii infections.
Yang Liu et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 13(23), 6667-6673 (2007-05-31)
Well-aligned zinc oxide microrod and microtube arrays with high aspect ratios were fabricated on zinc foil by a simple solution-phase approach in an aqueous solution of ethylenediamine (en). The shape of the ZnO microstructures can be easily modulated from rods
Zinc and copper toxicity in host defense against pathogens: Mycobacterium tuberculosis as a model example of an emerging paradigm.
Olivier Neyrolles et al.
Frontiers in cellular and infection microbiology, 3, 89-89 (2013-12-19)
Jun-Hui Choi et al.
Journal of bioscience and bioengineering, 118(4), 372-377 (2014-04-22)
A thrombolytic protease named kitamase possessing anticoagulant property was purified from edible and medicinal plant Aster yomena (Kitam.) Honda. Kitamase showed a molecular weight of 50 kDa by SDS-PAGE and displayed a strong fibrin zymogram lysis band corresponding to the similar
A Di Veroli et al.
Chemosphere, 112, 9-17 (2014-07-23)
Mouthpart deformities of Chironomus riparius larvae (Diptera) have been investigated to evaluate the toxic effects of contamination by heavy metals in the Genna Stream (Central Italy), situated in an area subjected to intensive swine farms (40000 heads). The livestock farming
Charley C Staats et al.
Frontiers in cellular and infection microbiology, 3, 65-65 (2013-10-18)
Zinc is a ubiquitous metal in all life forms, as it is a structural component of the almost 10% of eukaryotic proteins, which are called zinc-binding proteins. In zinc-limiting conditions such as those found during infection, pathogenic fungi activate the
Nir Sterer et al.
Journal of medical microbiology, 63(Pt 8), 1071-1075 (2014-06-11)
Oral malodour is thought to be caused mainly by the production of volatile sulfide compounds (VSCs) by anaerobic Gram-negative oral bacteria. Previous studies have shown that these bacteria are susceptible to blue light (400-500 nm wavelength). In the present study
Dong Cao et al.
Bulletin of environmental contamination and toxicology, 93(2), 171-176 (2014-05-03)
Accumulation and distribution of Zn and Cd in the hyperaccumulator plant Sedum plumbizincicola were investigated in a hydroponic experiment. Mean Cd and Zn concentrations in shoots (7,010 and 18,400 mg kg(-1)) were about sevenfold and fivefold higher than those in
Jianye Song et al.
Journal of nanoscience and nanotechnology, 14(6), 4649-4654 (2014-04-18)
A single-source ZnTi-layered double hydroxide precursor was used to prepare single phase Zn2TiO4. This approach involves two steps: the calcination of a ZnTi-layered double hydroxide precursor and selective leaching zinc oxide from the resultant calcined products. The materials were characterized
Bin Zhu et al.
Ecotoxicology and environmental safety, 104, 269-277 (2014-04-15)
Using rare minnow (Gobiocypris rarus) embryos as experimental model, the developmental toxicity of Cu, Zn and Cd were investigated following exposure to 0.001-1.000mg/L for 72h, and the toxicity effects were evaluated by larval malformation rate, heart rate, pericardial area, spontaneous
J Granell
The Journal of sports medicine and physical fitness, 54(2), 232-237 (2014-02-11)
The role of zinc and copper has been shown essential in the scope of physical exercise. The outcomes of the studies about changes in the concentrations of these elements in blood, in physical effort situations, are sometimes discordant and seem
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