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T Kiss et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 40(4), 376-380 (2010-05-04)
Several beta-cyclodextrin (beta-CD) derivatives have been synthesized recently to improve the physicochemical properties and inclusion capacities of the parent molecule, however, there is limited information available about their cytotoxic effects. In this study we investigated the cytotoxic and hemolytic properties
Z Aigner et al.
Journal of pharmaceutical and biomedical analysis, 57, 62-67 (2011-09-17)
The steps of formation of an inclusion complex produced by the co-grinding of gemfibrozil and dimethyl-β-cyclodextrin were investigated by differential scanning calorimetry (DSC), X-ray powder diffractometry (XRPD) and Fourier transform infrared (FTIR) spectroscopy with curve-fitting analysis. The endothermic peak at
Fernanda Pérez-Cruz et al.
Bioorganic & medicinal chemistry, 17(13), 4604-4611 (2009-05-26)
Four different 5-nitroindazole derivatives (1-4) and its inclusion with Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DMbetaCD) were investigated. The stoichiometric ratios and stability constants describing the extent of formation of the complexes were determined by phase-solubility measurements obtaining in all cases a type-A(L) diagram. Also
F Hirayama et al.
Journal of pharmaceutical sciences, 88(10), 970-975 (1999-10-09)
Acetyl groups were introduced to the hydroxyl groups of heptakis(2, 6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD), and the resulting heptakis(2,6-di-O-methyl-3-O-acetyl)-beta-CyD (DMA-beta-CyD) was evaluated for the inclusion property and hemolytic activity. It was confirmed by means of NMR and mass spectroscopies that in the DMA-beta-CyD
Shaimaa M Badr-Eldin et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 70(3), 819-827 (2008-07-29)
The aim of this work was to investigate the inclusion complexation between tadalafil, a practically insoluble selective phosphodiesterase-5 inhibitor (PDE5), and two chemically modified beta-cyclodextrins: hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and heptakis-[2,6-di-O-methyl]-beta-cyclodextrin (DM-beta-CD), in comparison with the natural beta-cyclodextrin (beta-CD) in order to
Kanokthip Boonyarattanakalin et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(4), 752-758 (2012-08-28)
The inclusion complexes of highly potent anti-HIV agent, UC781, with β-cyclodextrin (βCD), 2,6-dimethyl-β-cyclodextrin (MβCD), and 2-hydroxypropyl-β-cyclodextrin (HPβCD) in aqueous solution were investigated by molecular dynamics simulations. Simulations show that the phenyl ring of UC781 is trapped inside CD cavities, while
X-ray diffraction analysis of butyl-and isobornyl acrylate/heptakis (2, 6-di-O-methyl)-beta-cyclodextrin complexes and correlation to 1H NMR-spectra
Glockner P, et al.
Designed Monomers and Polymers, 5(2-3), 163-172 (2002)
Michelle Amoako-Tuffour et al.
Acta pharmaceutica (Zagreb, Croatia), 59(4), 395-405 (2009-11-19)
The potential for nasal delivery of losartan, a drug with poor oral bioavailability, was investigated using Calu-3 cells. Epithelial permeation of the drug with or without dimethyl-beta-cyclodextrin (DM-beta-CD) and glycocholate was investigated. Possible transport mechanism of the compound and epithelial
Paola Franchi et al.
Journal of the American Chemical Society, 126(13), 4343-4354 (2004-04-01)
EPR spectroscopy has been employed to investigate the formation of complexes between heptakis-(2,6-O-dimethyl)-beta-cyclodextrin (DM-beta-CD) and different enantiomeric pairs of chiral nitroxides of general structure PhCH2NO.CH(R)R'. Accurate equilibrium measurements of the concentrations of free and included radicals afforded the binding constant
Serena Orlandini et al.
Electrophoresis, 31(19), 3296-3304 (2010-10-01)
A dual system of CDs was used for the first time in MEEKC with the aim of determining clemastine and its three main related impurities in both drug substances and tablets. The addition of methyl-β-cyclodextrin and heptakis(2,6-di-O-methyl)-β-cyclodextrin to the microemulsion
Thitirat Mantim et al.
Electrophoresis, 33(2), 388-394 (2011-12-16)
CE methods with capacitively coupled contactless conductivity detection (C(4)D) were developed for the enantiomeric separation of the following stimulants: amphetamine (AP), methamphetamine (MA), ephedrine (EP), pseudoephedrine (PE), norephedrine (NE) and norpseudoephedrine (NPE). Acetic acid (pH 2.5 and 2.8) was found
Enantiomeric separation of amphetamine related drugs by capillary zone electrophoresis using native and derivatized beta-cyclodextrin as chiral additives
Cladrowa-Runge S, et al.
Journal of Chromatography A, 710(2), 339-345 (1995)
Madhurima Jana et al.
Langmuir : the ACS journal of surfaces and colloids, 26(17), 14097-14102 (2010-08-14)
Atomistic molecular dynamics (MD) simulations have been carried out to study the low-frequency intermolecular vibrational spectrum of water present in the surrounding hydration layers and inside the cavities of beta-cyclodextrin (BCD) and its di- and trimethyl substituted derivatives, namely, heptakis(2,6-di-O-methyl)-beta-cyclodextrin
R Nageswara Rao et al.
Journal of pharmaceutical and biomedical analysis, 50(3), 281-286 (2009-06-09)
A reversed-phase high-performance liquid chromatographic (HPLC) method was developed and validated for evaluating the chiral discrimination ability of CYCLOBOND I 2000 DM chiral stationary phase (CSP) towards sertraline and its related enantiomers. The effect of pH, buffer concentration as well
Andreia Ascenso et al.
AAPS PharmSciTech, 12(2), 553-563 (2011-05-03)
The aim of this work is to prepare tretinoin/dimethyl-beta-cyclodextrin complexes and fully characterize them through various analytical techniques. According to the phase solubility studies performed, the equilibrium for maximum complexation is reached in about 8 days presenting an A(L)-type diagram
S R Jim et al.
Journal of chromatography. A, 1218(40), 7203-7210 (2011-09-09)
Ultrathin-layer chromatography (UTLC) provides the high sensitivities and rapid separations over short distances desirable in many analytical applications. The dependence of these performance benefits on UTLC layer microstructure motivates continued stationary phase engineering efforts. A new method of modifying the
Fernanda Pérez-Cruz et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 226-234 (2012-12-12)
A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and (2-hydroxypropyl)-β-cyclodextrin. In order to assess the inclusion degree reached by nitrooxoisoaporphine in cyclodextris
Fei Liu et al.
Chemical & pharmaceutical bulletin, 60(12), 1479-1486 (2012-12-05)
Thienorphine hydrochloride (ThH) is a highly insoluble and readily metabolized partial-opioid agonist. It is used for the treatment of pain and heroin addiction. This study aimed to formulate and evaluate sublingual delivery systems containing ThH. Dimethyl-β-cyclodextrin (DM-β-CD) can enhance the
Anita Zamboni et al.
BMC genomics, 10, 363-363 (2009-08-08)
In response to pathogen attack, grapevine synthesizes phytoalexins belonging to the family of stilbenes. Grapevine cell cultures represent a good model system for studying the basic mechanisms of plant response to biotic and abiotic elicitors. Among these, modified beta-cyclodextrins seem
Virginia Pérez-Fernández et al.
Electrophoresis, 31(9), 1533-1539 (2010-04-28)
The first CE method enabling the enantiomeric separation of the synthetic pyrethroid cis-bifenthrin (BF) was developed in this work. CD-MEKC was the CE mode employed for this purpose. The influence of several experimental parameters such as temperature, voltage, type and
F Karamustafa et al.
Die Pharmazie, 64(2), 98-103 (2009-03-27)
The transport of alendronate through Caco-2 monolayers in the absence and presence of absorption enhancers (sodium taurocholate-STC and dimethyl-beta-cyclodextrin-DM-beta-CD) was studied. The viability of Caco-2 cells was determined by MTT assay. The effects of the experiment period and serum existence
Fabrizio Melani et al.
Electrophoresis, 32(21), 3062-3069 (2011-10-18)
Electrokinetic chromatography (EKC) allows the separation of closely related substances by the detection of fine effects in analyte-separation system interactions. With the goal of understanding the fine effects involved in separation using a dual cyclodextrin-microemulsion EKC system, an integrated study
Zhan Yu et al.
Journal of mass spectrometry : JMS, 45(4), 444-450 (2010-03-23)
Oleanolic acid (OA) and ursolic acid (UA) are isomeric triterpenoid compounds with similar pharmaceutical properties. Usually, modern chromatographic and electrophoretic methods are widely utilized to differentiate these two compounds. Compared with mass spectrometric (MS) methods, these modern separation methods are
Jana Svobodová et al.
Journal of chromatography. A, 1218(40), 7211-7218 (2011-08-30)
Two novel methods for determination of binding constants in the systems with borate and cyclodextrin complexation were developed. The methods enable to determine all binding parameters in these systems and even the binding constants of interaction of a neutral analyte
Hoa Thi Le et al.
Journal of pharmaceutical sciences, 103(10), 3183-3189 (2014-08-22)
To explore the possibility of cyclodextrin click clusters (CCCs) as a new cyclodextrin-based excipient, we prepared three different CCCs; heptakis{6-(4-hydroxymethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (HT-β-CD), heptakis{6-(4-hydroxymethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}{2,3-di-O-methyl}-β-cyclodextrin (HT-β-CD(OMe)2 ), and heptakis{6-(4-sulfonylmethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (ST-β-CD). The CCCs were prepared using copper(I)-catalyzed azide-alkyne cycloaddition from 6-azido-6-deoxy-β-CD and their water
Z Degim et al.
Die Pharmazie, 65(1), 32-40 (2010-03-02)
Transportations of rivastigmine containing liposomes across Caco-2 cells were studied and in vitro test results were compared with in vivo results. MTT test was used for cell viability studies. Series of formulations were prepared containing rivastigmine which is used for
Samir G Patel et al.
AAPS PharmSciTech, 10(2), 660-669 (2009-05-22)
The study was designed to investigate the effect of cyclodextrins (CDs) on the solubility, dissolution rate, and bioavailability of cilostazol by forming inclusion complexes. Natural CDs like beta-CD, gamma-CD, and the hydrophilic beta-CD derivatives, DM-beta-CD and HP-beta-CD, were used to
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