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Hong Lv et al.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 32(2), 283-288 (2012-08-11)
Ningdong granule is a traditional Chinese medicine preparation for the treatment of Tourette's syndrome. Sixty-four rats were randomly assigned to a control group and three experimental groups, respectively. Rat models of Tourette's syndrome were established via intraperitoneal injection of apomorphine
P Sambo et al.
Arthritis and rheumatism, 44(11), 2653-2664 (2001-11-17)
To explore the role of reactive oxygen species (ROS) in the in vitro activation of skin fibroblasts from patients with systemic sclerosis (SSc). Fibroblasts were obtained from involved skin of patients with limited or diffuse SSc. Oxidative activity imaging in
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the
Ingvar J Rognum et al.
Journal of neuropathology and experimental neurology, 73(2), 115-122 (2014-01-16)
Forensic biomarkers are needed in sudden infant death syndrome (SIDS) to help identify this group among other sudden unexpected deaths in infancy. Previously, we reported multiple serotonergic (5-HT) abnormalities in nuclei of the medulla oblongata that help mediate protective responses
Donna Crabtree et al.
Neuroscience letters, 538, 3-8 (2013-02-09)
Cathepsin D (CD) is a lysosomal aspartyl protease which plays an important role in α-synuclein degradation, and neuronal survival. CD knockout mice die by post-natal day 25±1 due to intestinal necrosis. We analyzed the young adult male heterozygous mice, and
Le Qu et al.
Neuropharmacology, 144, 291-300 (2018-10-22)
Rosmarinic acid (RA) is a naturally occurring polyphenolic compound. In this study, we demonstrated that RA could protect against the degeneration of the nigrostriatal dopaminergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease (PD). In addition, RA could inhibit
Ken H Darzy et al.
The Journal of clinical endocrinology and metabolism, 91(3), 987-994 (2005-12-31)
In patients with severe radiation-induced GH deficiency, we previously demonstrated that pulsatile GH secretion and diurnal rhythm are maintained in the fed state, albeit with great attenuation of the pulse amplitude. However, it remained unclear whether stressing the hypothalamic-pituitary axis
D Pickar et al.
Annals of the New York Academy of Sciences, 537, 339-346 (1988-01-01)
Despite the limitations of the dopamine hypothesis, compelling evidence remains that implicates dysfunction of CNS dopamine systems in the pathophysiology of schizophrenia. The longitudinal measurement of levels of plasma HVA has proved a useful tool in studying neuroleptic effects and
Imola Plangár et al.
Ideggyogyaszati szemle, 66(11-12), 407-414 (2014-02-22)
The available scientific data indicate that the pathomechanism of Parkinson's disease (PD) involves the accumulation of endogenous and exogenous toxic substances. The disruption of the proper functioning of certain transporters in the blood-brain barrier and in the blood-cerebrospinal fluid barrier
Takashi Ichinose et al.
Bioscience, biotechnology, and biochemistry, 79(9), 1542-1547 (2015-05-23)
In this study, we examined the effect of orally administrated dipeptides containing Tyr (Y) on the metabolism of catecholamines in mouse brains. We found that among eight synthetic dipeptides whose sequences are present frequently in soy proteins, Ser-Tyr (SY), Ile-Tyr
M I Botez et al.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 28(2), 134-140 (2001-06-01)
The aims of the present study were: i) to measure levels of the dopamine metabolite homovanillic acid (HVA), the serotonin metabolite 5-hydroxindoleacetic acid (5HIAA) and precursor tryptophan, as well as the noradrenaline metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and thiamine in the
Simona Codruţa Cobzac et al.
Journal of chromatographic science, 52(9), 1095-1103 (2013-10-29)
The retention behavior for a series of amine neurotransmitters, their precursors, metabolites and structurally related drugs has been investigated in reversed-phase thin-layer chromatography using RP-18, RP-8, RP-2, CN and Diol stationary phases and mixtures of phosphate buffer and methanol as
Wojciech Ostrowski et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 21-27 (2014-07-27)
Liquid chromatography coupled to mass spectrometry (MS) with electrospray ionization (ESI) is one of analytical techniques to obtain accurate results of low molecular weight aromatic compounds in biological samples of different origin. The interpretations of mass spectra of these aromatic
Xinguang Zhou et al.
Journal of chromatography. A, 1409, 125-131 (2015-07-25)
Concentration of blood catecholamines (CAs) is linked to a host of cardiovascular diseases, including hypertension and stenocardia. The matrix interferences and low concentration require tedious sample pretreatment methods before quantitative analysis by the gold standard method of high-performance liquid chromatography-electrochemical
K V Anil Kumar et al.
Journal of the renin-angiotensin-aldosterone system : JRAAS, 14(1), 34-40 (2012-10-30)
The renin-angiotensin system is distributed centrally as well as peripherally, which works in association with SNS and HPA in stress. Angiotensin is considered one of the principal hormones for bringing out stress-related changes. To find the influence of enalapril on
Hyun Jin Park et al.
Neurochemistry international, 83-84, 19-27 (2015-03-10)
The present study investigated the effects of (-)-sesamin on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity using PC12 cells and dopaminergic neuronal cells of 6-OHDA-lesioned rat model of Parkinson's disease (PD). In PC12 cells, treatment with (-)-sesamin (25 µM) reduced 6-OHDA (100 µM)-induced cell death and
S J Kish et al.
Journal of neurochemistry, 58(2), 642-648 (1992-02-01)
To examine the possible causal contribution of normal or accelerated aging to the neurodegenerative process of Parkinson's disease, we measured the influence of aging on subregional striatal dopamine and homovanillic acid levels in postmortem brain of 23 neurologically and psychiatrically
A D Kay et al.
Annals of neurology, 21(4), 408-411 (1987-04-01)
Under conditions of rest and a low monoamine diet, brain monoamine activity was examined in young (less than 35 years) and old (greater than 35 years) adults with Down's syndrome and in control subjects by measuring the cerebrospinal fluid (CSF)
Lilian R F Faro et al.
Toxicology, 311(3), 154-161 (2013-07-03)
The purpose of the present work was to assess the possible role of glutamatergic receptors and nitric oxide (NO) production on effects of glufosinate ammonium (GLA), an organophosphate pesticide structurally related to glutamate, on in vivo striatal dopamine release in
Ferdinand A van Dorsten et al.
Molecular nutrition & food research, 54(7), 897-908 (2009-12-17)
The metabolic impact of polyphenol-rich red wine and grape juice consumption in humans was studied using a metabolomics approach. Fifty-eight men and women participated in a placebo-controlled, double-crossover study in which they consumed during a period of 4 wk, either
Tashjian AH and Armstrong EJ
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2011)
C Fernández-Ávila et al.
Biomedical chromatography : BMC, 29(7), 1035-1041 (2014-11-27)
In recent years it has been confirmed that the consumption of olive oil prevents the oxidation of biomolecules owing to its monounsaturated fatty acids (MUFA) and phenolic content. The main objective of the study was to develop an ultra-high-performance liquid
Asuka Katsuki et al.
CNS spectrums, 17(3), 155-163 (2012-08-14)
We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). We also examined mirtazapine's effects on the serum BDNF and plasma levels of
[Homovanillic acid (HVA)].
S Shigetomi et al.
Nihon rinsho. Japanese journal of clinical medicine, 53 Su Pt 2, 520-523 (1995-03-01)
Mattia Gasperotti et al.
Talanta, 128, 221-230 (2014-07-26)
An increasing number of studies have concerned the profiling of polyphenol microbial metabolites, especially in urine or plasma, but only a few have regarded their accurate quantification. This study reports on a new ultra-performance liquid chromatography tandem mass spectrometry method
C Härnryd et al.
Psychopharmacology, 64(2), 131-134 (1979-08-08)
The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.
J Jaeken et al.
Lancet (London, England), 2(8411), 1058-1061 (1984-11-10)
Succinyladenosine and succinylaminoimidazole carboxamide riboside were found in body fluids from 3 children, including a brother and sister, with severe psychomotor delay and autism. Both succinylpurines were identified by acid hydrolysis, anion-exchange chromatography, and ultraviolet spectrophotometry. Concentrations of both compounds
Shamim Akhtar et al.
Pakistan journal of pharmaceutical sciences, 25(4), 705-713 (2012-09-27)
Study of natural products led to the development of new molecules of potential biological activity. Piperidine nucleus constitutes one of the components of various alkaloids and drugs. During the course of our project regarding the synthesis of derivatives of piperidine
Takashi Abe et al.
Neuroscience letters, 336(2), 105-108 (2002-12-25)
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with
Shuzhen Wang et al.
Bioscience trends, 6(4), 212-218 (2012-09-26)
Many studies have indicated that a variety of neurotransmitters are implicated in the pathophysiology of Tourette syndrome (TS), including dopamine (DA), serotonin (5-TH), homovanillic acid (HVA), and gamma-amino butyric acid (GABA). Our previous studies found that Ningdong granule (NDG) is
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