搜索范围
H50004
应用筛选条件
关键词:'H50004'
显示 31-60 #N/A 90 条结果 关于 "H50004" 范围 论文
Wolfram Gronwald et al.
Kidney international, 79(11), 1244-1253 (2011-03-11)
Autosomal dominant polycystic kidney disease (ADPKD) is a frequent cause of kidney failure; however, urinary biomarkers for the disease are lacking. In a step towards identifying such markers, we used multidimensional-multinuclear nuclear magnetic resonance (NMR) spectroscopy with support vector machine-based
Umeo Takahama et al.
European journal of oral sciences, 117(5), 555-562 (2009-09-18)
4-Hydroxyphenylacetic acid (HPA) and nitrite are present in human mixed whole saliva, and HPA can be nitrated by peroxidase/hydrogen peroxide (H(2)O(2))/nitrite systems in the oral cavity. Thus, the objectives of the present study were to estimate the concentrations of HPA
Ferdinand A van Dorsten et al.
Molecular nutrition & food research, 54(7), 897-908 (2009-12-17)
The metabolic impact of polyphenol-rich red wine and grape juice consumption in humans was studied using a metabolomics approach. Fifty-eight men and women participated in a placebo-controlled, double-crossover study in which they consumed during a period of 4 wk, either
Nantidaporn Ruangchan et al.
The Journal of biological chemistry, 286(1), 223-233 (2010-10-30)
p-Hydroxyphenylacetate (HPA) 3-hydroxylase (HPAH) catalyzes the hydroxylation of HPA at the ortho-position to yield 3,4-dihydroxyphenylacetate. The enzyme is a flavin-dependent two-component monooxygenase that consists of a reductase component and an oxygenase component (C(2)). C(2) catalyzes the hydroxylation of HPA using
C Härnryd et al.
Psychopharmacology, 64(2), 131-134 (1979-08-08)
The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.
Sébastien Brier et al.
Biochemistry, 51(34), 6738-6752 (2012-07-28)
Neisserial adhesin A (NadA) is a surface exposed trimeric protein present in most hypervirulent meningococcal strains and involved in epithelial cell adhesion and colonization. The expression of nadA is controlled by Neisserial adhesin regulator (NadR), a member of the MarR
Luca Fagnocchi et al.
Journal of bacteriology, 194(2), 460-474 (2011-11-15)
The Neisseria meningitidis regulator NadR was shown to repress expression of the NadA adhesin and play a major role in NadA phase-variable expression. In this study, we identified through microarray analysis over 30 genes coregulated with nadA in the NadR
F Guneral et al.
Clinical chemistry, 40(6), 862-866 (1994-06-01)
Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days to 16 years, subdivided into five age groups. We quantified 69
Feelly Ruether et al.
Journal of pharmaceutical sciences, 98(11), 4205-4215 (2009-03-14)
The knowledge of the solubility of pharmaceuticals in pure solvents and solvent mixtures is crucial for designing the crystallization process of drug substances. The first step in finding optimal crystallization conditions is usually a solvent screening. Since experiments are very
Lihui Fu et al.
Analytical biochemistry, 421(1), 198-202 (2011-11-15)
G-quadruplex ligands can interfere with the telomere structure, telomere elongation/replication, and proliferation of cancer cells. A key element in the development of potent G-quadruplex ligands is the screening of large chemical libraries of potential candidates. Here, we describe a simple
Shu-yan Niu et al.
Biosensors & bioelectronics, 24(9), 2943-2946 (2009-03-25)
A novel DNA biosensor based on enzyme-enhanced fluorescence detection on etched optical fibers was developed. The hybridization complex of DNA probe and biotinylated target was formed on the etched optical fiber, and was then bound with streptavidin labeled horseradish peroxidase
Umeo Takahama et al.
FEBS letters, 518(1-3), 116-118 (2002-05-09)
Human saliva contained 4-hydroxyphenylacetic acid (HPA) (2-10 microM) and nitrite (60-300 microM). HPA was nitrated to 4-hydroxy-3-nitrophenylacetic acid (NO2HPA) when HPA and sodium nitrite were mixed at pH 1.0. NO2HPA was also formed when saliva was incubated under acidic conditions.
Korean J. Med. Chem., 1, 2-2 (1991)
David S Wishart et al.
Nucleic acids research, 37(Database issue), D603-D610 (2008-10-28)
The Human Metabolome Database (HMDB, http://www.hmdb.ca) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first release in 2007, the
Ali A Akhiani et al.
Cancer immunology research, 8(12), 1532-1541 (2020-09-25)
The phosphatidylinositol-4,5-bisphosphate-3 kinase-δ (PI3Kδ) inhibitor idelalisib, used alone or in combination with anti-CD20, is clinically efficacious in B-cell lymphoma and chronic lymphocytic leukemia (CLL) by promoting apoptosis of malignant B cells. PI3K regulates the formation of reactive oxygen species (ROS)
Sachiko Hirota et al.
Journal of agricultural and food chemistry, 53(9), 3265-3272 (2005-04-28)
Local pH in the oral cavity can decrease to below 7 at the site where acid-producing bacteria are proliferating. Effects of pH on nitration of 4-hydroxyphenylacetic acid were studied using dialyzed human saliva. Dialyzed saliva nitrated 4-hydroxyphenylacetic acid to 4-hydroxy-3-nitrophenylacetic
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A
M V Spanaki et al.
Neurology, 53(7), 1518-1522 (1999-10-26)
To investigate the effect of vigabatrin (VGB; gamma-vinyl gamma-aminobutyric acid [GABA]), a selective irreversible GABA-transaminase inhibitor, on cerebral metabolic rate for glucose (CMRGlc) and cerebral blood flow (CBF) measured with 18F-fluorodeoxyglucose (FDG) PET and 15O water PET. Antiepileptic drugs (AEDs)
K Kobayashi et al.
Clinica chimica acta; international journal of clinical chemistry, 123(1-2), 161-168 (1982-08-04)
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on a Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid, the oxidatively deaminated metabolite of p-tyramine. The metabolite was measured in cerebrospinal
S R Perosa et al.
Epilepsia, 43 Suppl 5, 159-161 (2002-07-18)
This work studied the profile of glycosaminoglycans (GAGs) in the hippocampus, cortex, and cerebrospinal fluid of patients with temporal lobe epilepsy (TLE). The GAGs were analyzed by agarose gel electrophoresis, enzymatic degradation, and enzyme-linked immunosorbent assay (ELISA). The hippocampus of
A A Roĭ et al.
Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993), 74(5), 74-80 (2012-11-06)
It has been shown that bacteria of the genus Bacillus inhibited the development of infection caused by Clavibacter michiganensis subsp. michiganensis, in tomatoes. Pre-sowing seed treatment with suspensions of Bacillus subtilis IMV B-7023 and Bacillus pumilus 3 enhanced resistance of
Kai Zhang et al.
Journal of agricultural and food chemistry, 52(2), 222-227 (2004-01-22)
A GC-MS method was developed for the determination of various flavonoids and phenolic and benzoic acids in human plasma. The procedure involved the extraction of flavonoids and phenolic and benzoic acids with ethyl acetate, followed by the derivatization of the
Elaine F Walker et al.
Neuropsychiatry, neuropsychology, and behavioral neurology, 15(1), 10-17 (2002-03-06)
To examine plasma cortisol, adrencorticotropin hormone, and indicators of catecholamine activity in monozygotic twins discordant for schizophrenia or major affective disorders. Previous research has suggested that catecholamines play a role in the etiology of major mental illness. Several findings have
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
E B Cady et al.
Magnetic resonance in medicine, 32(6), 764-767 (1994-12-01)
Cerebral in vivo proton magnetic resonance spectroscopy of 13 newborn infants displaying seizures and receiving phenobarbitone, in one case supplemented by phenytoin, showed signals from propan-1,2-diol (the injection vehicle for both these anticonvulsants). Subsequent in vitro spectroscopy of cerebro spinal
K Q Do et al.
Journal of neurochemistry, 65(6), 2652-2662 (1995-12-01)
HPLC and gas chromatography-mass spectrometry analyses of 18 amino acids, N-acetylaspartate, N-acetylaspartylglutamate, and 5-hydroxyindoleacetic acid, derived from serotonin, and homovanillic acid, derived from dopamine, were performed in CSF collected from a group of patients with schizophrenia who either had been
K Kobayashi et al.
No to shinkei = Brain and nerve, 34(8), 769-774 (1982-08-01)
Using reversed-phase high-performance liquid chromatography and electrochemical detection with a rapid one-step purification on Sephadex G-10 column, we have developed a sensitive technique to measure p-hydroxyphenylacetic acid (PHPA), the oxidatively deaminated metabolite of p-tyramine, in cerebrospinal fluid (CSF). The method
Uriel Heresco-Levy et al.
Schizophrenia research, 91(1-3), 14-21 (2007-02-06)
Prepulse inhibition (PPI) of the startle reflex, a measure of sensorimotor gating, is decreased in schizophrenia. The validity of a glutamatergic, N-methyl-d-aspartate receptor (NMDAR)-mediated model of PPI disruption is presently equivocal. The NMDAR antagonist ketamine disrupts PPI in rodents, but
Sinéad Currivan et al.
Journal of chromatography. A, 1402, 82-93 (2015-05-30)
Zwitterionic methacrylate based polymeric monolithic columns were prepared in two-step polymerizations, with reduced polymerization times. Characteristic properties such as hydrodynamic permeability, porosity, retention factors, and pore size distribution charts were used for column evaluation. A scaffold column was fabricated by
Lan Luan et al.
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 33(2), 220-221 (2010-06-26)
To study the chemical constituents of the extract with water from Forsythia suspensa. The compounds were isolated and repeatedly purified on TLC, silica gel column chromatograph, gel column chromatography, and preparative HPLC, and the structures were elucidated by physico-chemical properties
2/3