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Saeed Samarghandian et al.
BioMed research international, 2014, 920857-920857 (2014-08-13)
Diabetic encephalopathy is one of the severe complications in patients with diabetes mellitus. Findings indicate that saffron extract has antioxidant properties but its underlying beneficial effects on diabetic encephalopathy were unclear. In the present study, the protective activities of saffron
Fred K Tabung et al.
Annals of epidemiology, 25(6), 398-405 (2015-04-23)
Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a
Sarah Afshordel et al.
Pharmacological research, 91, 69-77 (2014-12-17)
Alterations in small GTPase mediated signal transduction pathways have emerged as a central step in the molecular pathogenesis of glioblastoma (GBM), the most common malignant brain tumor in adults. Farnesylpyrophosphate (FPP) and geranylgeranylpyrophosphate (GGPP) are derived from mevalonate, whose production
Chihiro Okuma et al.
Journal of pharmacological sciences, 128(3), 150-157 (2015-07-29)
Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and
Tsubasa Miyoshi et al.
Biochimica et biophysica acta, 1838(12), 3069-3077 (2014-08-26)
We examined the volumetric behavior of the dipalmitoylphosphatidylcholine (DPPC)/cholesterol binary bilayer system with high accuracy and more cholesterol concentrations to reveal the detailed molecular states in the liquid-disordered (Ld) phase, the liquid-ordered (Lo) phase and the gel phase. We measured
José M A Wijnands et al.
Journal of hypertension, 33(8), 1642-1650 (2015-07-03)
Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose
Nitin Shivappa et al.
Cancer causes & control : CCC, 26(10), 1439-1447 (2015-07-26)
Diet and inflammation have been suggested to be important risk factors for esophageal squamous cell cancer (ESCC). In this study, we examined the association between the dietary inflammatory index (DII) and ESCC in a case-control study conducted between 1992 and
P Lestaevel et al.
Journal of molecular neuroscience : MN, 53(3), 469-479 (2013-06-12)
Alzheimer's disease is associated with genetic risk factors, of which the apolipoprotein E (ApoE) is the most prevalent, and is affected by environmental factors that include education early in life and exposure to metals. The industrial and military use of
Erdem Cokluk et al.
Redox report : communications in free radical research, 20(5), 210-214 (2015-01-15)
Warts are abnormal skin growths caused by human papilloma virus (HPV) infections within the skin of patients. Genital warts usually appear in the perianal and perigenital regions. Asymptomatic warts may be activated after years and may damage natural immunity. The
T G Cotter et al.
Diabetes research and clinical practice, 106(3), e56-e59 (2014-12-03)
We sought to determine the attainment of targets for glycaemic control and vascular risk reduction in an Irish cohort of T1DM adults. Of 797 patients (53% male, mean age 40.3 ± 14.8 years, HbA1c 8.5 ± 1.6% (69.6 ± 17.8
José A Luchsinger et al.
Psychosomatic medicine, 77(6), 653-663 (2015-07-15)
To examine the association of glycemia and diabetes status with cognition among 600 Hispanics aged 55 to 64 years from Northern Manhattan. Diabetes was ascertained by history or hemoglobin A1c. Normal glucose tolerance and prediabetes were ascertained with hemoglobin A1c.
Zhiping Hu et al.
Physical chemistry chemical physics : PCCP, 17(35), 22711-22720 (2015-08-11)
The aggregation and fibril formation of amyloid β(Aβ) peptides onto a ganglioside-GM1-containing lipid membrane is a cause of neurodegenerative diseases. The mechanism of the initial binding and the conformational changes of Aβ on the membrane should be clarified. Fluorescence microscopy
Gabriel F Ballester-Lozano et al.
The British journal of nutrition, 114(5), 713-726 (2015-07-30)
Seven isoproteic and isolipidic semi-purified diets were formulated to assess specific nutrient deficiencies in sulphur amino acids (SAA), n-3 long-chain PUFA (n-3 LC-PUFA), phospholipids (PL), P, minerals (Min) and vitamins (Vit). The control diet (CTRL) contained these essential nutrients in
N P Mikaelyan et al.
Bulletin of experimental biology and medicine, 159(2), 197-200 (2015-06-23)
Considerable changes in serum lipids and lipoprotein profiles associated with hypertriglyceridemia, hypercholesterolemia, increased VLDL and LDL concentrations, and reduced HDL level occur at the early stages of streptozotocin-induced diabetes (day 7) in rats. The level of saturated palmitic fatty acid
T Pina et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(10), 1995-2001 (2015-04-01)
Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases. To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients
Soichiro Murata et al.
International journal of molecular sciences, 16(6), 12051-12063 (2015-05-30)
Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of
Jamie L Betker et al.
Molecular pharmaceutics, 12(1), 264-273 (2014-11-25)
Cationic reagents are commonly used to facilitate DNA delivery, and transfection experiments are typically initiated in cell culture where the optimal charge ratio is determined. While transfection rates are often enhanced at higher +/- charge ratios, the cellular toxicity associated
Yuting Zhao et al.
Biosensors & bioelectronics, 72, 348-354 (2015-05-26)
A new technology was developed to quantitatively detect a broad range of disease biomarkers and proven to be portable, economical, and conveniently accessible. Measurements were performed based on releasing encapsulated glucose from antibody-tagged liposomes and subsequently detecting the released glucose
Jing Tong et al.
International journal of clinical and experimental medicine, 8(4), 6397-6405 (2015-07-02)
Colorectal cancer primarily arises from the polyps of the colon. Early identification of the recurrence of colorectal polyps represents the best opportunity to prevent the occurrence of colorectal cancer. Thus, the high risk of recurrence is the primary problem. The
Vasanti S Malik et al.
Circulation, 132(4), 260-268 (2015-06-07)
Circulating very-long-chain saturated fatty acids (VLCSFAs) may play an active role in the origin of cardiometabolic diseases. We measured 3 VLCSFAs (C20:0, C22:0, and C24:0) in plasma and erythrocytes using gas-liquid chromatography among 794 incident coronary heart disease (CHD) cases
Gabriele Bonanno et al.
Scientific reports, 5, 11980-11980 (2015-07-15)
The goal of this study was to investigate the performance of 3D synchrotron differential phase contrast (DPC) imaging for the visualization of both macroscopic and microscopic aspects of atherosclerosis in the mouse vasculature ex vivo. The hearts and aortas of
Kenichi Komukai et al.
Journal of the American College of Cardiology, 64(21), 2207-2217 (2014-12-03)
The detailed mechanism of plaque stabilization by statin therapy is not fully understood. The aim of this study was to assess the effect of lipid-lowering therapy with 20 mg/day of atorvastatin versus 5 mg/day of atorvastatin on fibrous cap thickness
Marwan Abdelbaset et al.
Canadian journal of physiology and pharmacology, 92(6), 481-489 (2014-06-05)
Statins are the first line treatment for the management of hyperlipidemia. However, the primary adverse effect limiting their use is myopathy. This study examines the efficacy and safety of red yeast rice (RYR), a source of natural statins, as compared
Lihua Jin et al.
Scientific reports, 5, 17288-17288 (2015-12-02)
Non-alcoholic fatty liver disease (NAFLD) has become a predictive factor of death from many diseases. Farnesoid X receptor (FXR) is an ideal target for NAFLD drug development due to its crucial roles in lipid metabolism. The aim of this work
Rajiv Chowdhury et al.
European journal of epidemiology, 30(7), 577-587 (2015-05-02)
During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, is a major cause of death in the country. However, there is limited
Valerija Vezočnik et al.
Journal of chromatography. A, 1418, 185-191 (2015-09-28)
Asymmetric-flow field-flow fractionation technique coupled to a multi-angle light-scattering detector (AF4-MALS) was used together with dynamic light-scattering (DLS) in batch mode and transmission electron microscopy (TEM) to study the size characteristics of the trioleoylglycerol lipid droplets covered by a monolayer
Yanbo Yang et al.
Biochemical and biophysical research communications, 451(4), 632-636 (2014-08-19)
Lipoprotein lipase (LPL) is an extracellular lipase that primarily hydrolyzes triglycerides within circulating lipoproteins. Macrophage LPL contributes to atherogenesis, but the mechanisms behind it are poorly understood. We hypothesized that the products of lipoprotein hydrolysis generated by LPL promote atherogenesis
Emina Vorkapic et al.
Atherosclerosis, 241(2), 561-568 (2015-06-24)
Abdominal aortic aneurysm (AAA) is characterized by inflammation, loss of smooth muscle cells (SMCs), and degradation of the extracellular matrix in the vessel wall. Innate immune receptors such as Toll-like receptors (TLRs) were recently shown to regulate immunological processes leading
Eriks Smagris et al.
Hepatology (Baltimore, Md.), 61(1), 108-118 (2014-06-12)
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3 affects liver
Marilia C O Sprandel et al.
Cardiovascular diabetology, 14, 107-107 (2015-08-14)
We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diabetic patients with coronary artery disease (CAD). The aim was to investigate whether, in patients
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