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Thanutchaporn Kumrungsee et al.
Biochimica et biophysica acta, 1840(10), 3073-3078 (2014-08-06)
Tryptophan-histidine (Trp-His) was found to suppress the activity of the Ca²⁺/calmodulin (CaM)-dependent protein kinases II (CaMKII), which requires the Ca²⁺-CaM complex for an initial activation. In this study, we attempted to clarify whether Trp-His inhibits Ca²⁺-CaM complex formation, a CaMKII
Jiafeng Geng et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), 9639-9644 (2013-05-31)
The diheme enzyme MauG catalyzes posttranslational modifications of a methylamine dehydrogenase precursor protein to generate a tryptophan tryptophylquinone cofactor. The MauG-catalyzed reaction proceeds via a bis-Fe(IV) intermediate in which one heme is present as Fe(IV)=O and the other as Fe(IV)
A L Casey et al.
The Journal of antimicrobial chemotherapy, 70(8), 2255-2260 (2015-04-24)
The antimicrobial efficacy of an iodine-impregnated incise drape against MRSA was evaluated in a skin model. The permeation of iodine from this drape into the skin was also assessed. The antimicrobial efficacy was evaluated in ex vivo studies following application
Leslie E Gentry et al.
Biochemistry, 52(35), 6085-6096 (2013-08-06)
Human frataxin has a vital role in the biosynthesis of iron-sulfur (Fe-S) clusters in mitochondria, and its deficiency causes the neurodegenerative disease Friedreich's ataxia. Proposed functions for frataxin in the Fe-S pathway include iron donation to the Fe-S cluster machinery
Susanne Klumpp et al.
Science signaling, 2(61), pe13-pe13 (2009-03-13)
Signaling by kinases and phosphatases that act on serine, threonine, and tyrosine residues of proteins is among the most extensively studied regulatory mechanisms in mammalian cells, and research focused in this area is ongoing. We are just beginning to appreciate
Maarja-Liisa Oldekop et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 147-155 (2014-08-12)
For liquid chromatographic analysis of amino acids involving derivatization and mass-spectrometric detection, it becomes more important to evaluate the presence of matrix effects in complex samples. This is somewhat complicated for amino acid analysis where analyte free sample matrix is
Smriti Kala et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(16), 6022-6027 (2014-04-09)
The genome packaging reactions of tailed bacteriophages and herpes viruses require the activity of a terminase enzyme, which is comprised of large and small subunits. Phage genomes are replicated as linear concatemers composed of multiple copies of the genome joined
Anas Al-Hussein et al.
Pharmaceutical development and technology, 20(1), 50-59 (2013-11-30)
The objective of this study was to investigate both the cryoprotective and lyoprotective effects of the polymer hydroxyethyl cellulose (HEC) on the model protein lactate dehydrogenase (LDH) during freeze thawing and freeze drying cycles. The effect of annealing on both
Seppo Parkkila et al.
Bioorganic & medicinal chemistry letters, 16(15), 3955-3959 (2006-05-30)
The first activation study of isoform XIII of carbonic anhydrase (CA, EC 4.2.1.1) is reported. A series of amino acids and amines incorporating protonatable moieties of the primary/heterocyclic amine type were included in the study. As for CA I and
Christian Bamann et al.
Biochimica et biophysica acta, 1837(5), 614-625 (2013-09-26)
Proteorhodopsins are the most abundant retinal based photoreceptors and their phototrophic function might be relevant in marine ecosystems. Here, we describe their remarkable molecular properties with a special focus on the green absorbing variant. Its distinct features include a high
Junlei Sun et al.
Biochimica et biophysica acta, 1837(8), 1362-1375 (2014-04-22)
The axial ligands of the acceptor chlorophylls, A(0A) and A(0B), in Photosystem I are the Met sulfur atoms of M688(PsaA) and M668(PsaB). To determine the role of the Met, His variants were generated in Synechocystis sp. PCC 6803. Molecular dynamics
Ingrid Richter et al.
Toxicon : official journal of the International Society on Toxinology, 95, 13-22 (2015-01-01)
Marine microalgae can produce biotoxins that cause widespread poisoning in marine ecosystems and may also affect human health. While established microalgal biotoxins are detectable using chemical methods, a need remains for robust, inexpensive bioassays. Ligand-binding domains (LBDs) from a tunicate
Doreen Braun et al.
Endocrinology, 154(7), 2553-2561 (2013-04-18)
Mutations in monocarboxylate transporter 8 (MCT8; SLC16A2) cause the Allan-Herndon-Dudley syndrome, a severe X-linked psychomotor retardation syndrome. MCT8 belongs to the major facilitator superfamily of 12 transmembrane-spanning proteins and transports thyroid hormones across the blood-brain barrier and into neurons. How
Stefan Harjes et al.
Journal of virology, 87(12), 7008-7014 (2013-04-19)
APOBEC3G has an important role in human defense against retroviral pathogens, including HIV-1. Its single-stranded DNA cytosine deaminase activity, located in its C-terminal domain (A3Gctd), can mutate viral cDNA and restrict infectivity. We used time-resolved nuclear magnetic resonance (NMR) spectroscopy
Junjie Zhao et al.
Biochemistry, 53(15), 2474-2482 (2014-03-29)
Dehaloperoxidase hemoglobin A (DHP A) is a multifunctional hemoglobin that appears to have evolved oxidative pathways for the degradation of xenobiotics as a protective function that complements the oxygen transport function. DHP A possesses at least two internal binding sites
Chang-Hoon Choi et al.
The Journal of cell biology, 202(6), 849-859 (2013-09-18)
Intracellular pH (pHi) dynamics regulates diverse cellular processes, including remodeling of focal adhesions. We now report that focal adhesion kinase (FAK), a key regulator of focal adhesion remodeling, is a pH sensor responding to physiological changes in pH. The initial
P Rosenfelder et al.
Journal of animal science, 93(3), 1133-1144 (2015-05-29)
A study with growing pigs was conducted to determine the chemical composition and standardized ileal digestibility (SID) of CP and AA of 8 wheat genotypes that have recently been added to the German Descriptive Variety List. These genotypes included Tabasco
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 17(5), 1336-1340 (2006-12-19)
The mitochondrial isozymes of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VA and hCA VB, were investigated for activation with a series of amino acids and amines. D-His, L-DOPA, histamine, dopamine, and 4-(2-aminoethyl)morpholine were excellent hCA VA activators, with KAs
Ivan Anastassov et al.
Journal of neurochemistry, 129(2), 249-255 (2013-11-30)
Our recent studies have shown that endogenous zinc, co-released with glutamate from the synaptic terminals of vertebrate retinal photoreceptors, provides a feedback mechanism that reduces calcium entry and the concomitant vesicular release of glutamate. We hypothesized that zinc feedback may
Hong Zhang et al.
Chemical research in toxicology, 28(6), 1196-1204 (2015-05-06)
The present study investigated the human constitutive androstane receptor (CAR) binding activities of 23 phthalate esters and 10 phthalate monoesters using a fast and sensitive human CAR yeast two-hybrid assay. Of 23 phthalate esters, 16 were evaluated as positive, and
Urszula Kosinska Eriksson et al.
Science (New York, N.Y.), 340(6138), 1346-1349 (2013-06-15)
Aquaporins are membrane channels that facilitate the flow of water across biological membranes. Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). Here, we present the
Maryam Rezazadeh et al.
Analytica chimica acta, 773, 52-59 (2013-04-09)
In the present work, pulsed electromembrane extraction (PEME) was performed for the first time, as a new concept of electrically enhanced microextraction method, for extraction and quantification of histidine, phenylalanine and tryptophan in different matrices. PEME offers an alternative to
Cyprian E Oshoma et al.
PloS one, 10(8), e0135626-e0135626 (2015-08-19)
Formic acid is one of the major inhibitory compounds present in hydrolysates derived from lignocellulosic materials, the presence of which can significantly hamper the efficiency of converting available sugars into bioethanol. This study investigated the potential for screening formic acid
Xavier Brazzolotto et al.
The Biochemical journal, 460(1), 79-89 (2014-03-15)
Iron is an essential element for almost all organisms. In eukaryotes, it is mainly used in mitochondria for the biosynthesis of iron-sulfur clusters and haem group maturation. Iron is delivered into the mitochondrion by mitoferrins, members of the MCF (mitochondrial
Florian P Seebeck
Chimia, 67(5), 333-336 (2013-07-19)
Ergothioneine and ovothiol A are sulfur-containing histidine derivatives produced by microorganisms including Mycobacterium tuberculosis, Trypanosoma cruzi or Erwinia amylovora and may also play important roles in human physiology. Based on our recent identification of thiohistidine biosynthetic enzymes from Mycobacterium smegmatis
Sunanda Margrett Williams et al.
The Journal of biological chemistry, 289(16), 11042-11058 (2014-02-28)
Dps (DNA-binding protein from starved cells) are dodecameric assemblies belonging to the ferritin family that can bind DNA, carry out ferroxidation, and store iron in their shells. The ferritin-like trimeric pore harbors the channel for the entry and exit of
Robert A Bender
Microbiology and molecular biology reviews : MMBR, 76(3), 565-584 (2012-08-31)
The ability to degrade the amino acid histidine to ammonia, glutamate, and a one-carbon compound (formate or formamide) is a property that is widely distributed among bacteria. The four or five enzymatic steps of the pathway are highly conserved, and
Lauren Ramm et al.
American journal of infection control, 43(7), 724-728 (2015-05-23)
The rise in health care-associated infections has placed a greater emphasis on cleaning and disinfection practices. The majority of policies advocate using detergent-based products for routine cleaning, with detergent wipes increasingly being used; however, there is no information about their
Opening the black box: revealing the molecular basis of thyroid hormone transport.
Alexandro J Martagón et al.
Endocrinology, 154(7), 2266-2269 (2013-06-26)
Jiancheng Hu et al.
Molecular and cellular biology, 35(1), 264-276 (2014-10-29)
A new model of kinase regulation based on the assembly of hydrophobic spines has been proposed. Changes in their positions can explain the mechanism of kinase activation. Here, we examined mutations in human cancer for clues about the regulation of
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