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Carmen Ferrero et al.
Journal of controlled release : official journal of the Controlled Release Society, 170(2), 175-182 (2013-06-04)
The two main purposes of this work were: (i) to critically consider the use of thermodynamic parameters of activation for elucidating the drug release mechanism from hydroxypropyl methylcellulose (HPMC) matrices, and (ii) to examine the effect of neutral (pH 6)
Francis W Hunter et al.
Biochemical pharmacology, 89(2), 224-235 (2014-03-19)
The nitro-chloromethylbenzindoline prodrug SN29428 has been rationally designed to target tumour hypoxia. SN29428 is metabolised to a DNA minor groove alkylator via oxygen-sensitive reductive activation initiated by unknown one-electron reductases. The present study sought to identify reductases capable of activating
May S Freag et al.
International journal of pharmaceutics, 454(1), 462-471 (2013-07-09)
Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanoprecipitation technique has been employed for nanosuspension
Javier Esteban et al.
Toxicology letters, 229(1), 41-51 (2014-06-03)
Polychlorinated biphenyls (PCBs) induce a broad spectrum of biochemical and toxic effects in mammals including alterations of the vital retinoid (vitamin A) system. The aim of this study was to characterize alterations of tissue retinoid levels in rat offspring and
Pirom Chenprakhon et al.
Biochemistry, 53(25), 4084-4086 (2014-06-01)
The protonation status of the peroxide moiety in C4a-(hydro)peroxyflavin of p-hydroxyphenylacetate-3-hydroxylase can be directly monitored using transient kinetics. The pKa for the wild-type (WT) enzyme is 9.8 ± 0.2, while the values for the H396N, H396V, and H396A variants are
Takuya Ogawa et al.
The FEBS journal, 281(14), 3165-3176 (2014-05-23)
Saturation of a prenyl group to various levels is a frequently observed modification of isoprenoids. The members of the geranylgeranyl reductase family, however, are the only known enzymes responsible for such reductive modifications in archaea. A methanogenic archaeon, Methanosarcina acetivorans
Malwenn Lassudrie et al.
Aquatic toxicology (Amsterdam, Netherlands), 154, 27-38 (2014-05-27)
Manila clam stock from Arcachon Bay, France, is declining, as is commercial harvest. To understand the role of environmental biotic interactions in this decrease, effects of a toxic dinoflagellate, Alexandrium ostenfeldii, which blooms regularly in Arcachon bay, and the interaction
Lu Xiao et al.
Drug development and industrial pharmacy, 39(9), 1284-1290 (2012-09-27)
A new self-microemulsifying mouth dissolving film (SMMDF) for poorly water-soluble drugs such as indomethacin was developed by incorporating self-microemulsifying components with solid carriers mainly containing microcrystalline cellulose, low-substituted hydroxypropyl cellulose and hypromellose. The uniformity of dosage units of the preparation
Gaetano Lamberti et al.
Carbohydrate polymers, 92(1), 765-768 (2012-12-12)
In this work, a fast and accurate method to evaluate the water content in a cellulose derivative-based matrix subjected to controlled hydration was proposed and tuned. The method is based on the evaluation of the work of penetration required in
True L Rogers et al.
Drug development and industrial pharmacy, 37(11), 1259-1271 (2011-05-28)
This three-part review has been developed following the evaluation of literature where ethylcellulose, methylcellulose or hypromellose was used to make microcapsules. Parts 1 and 3 of the review are published as separate papers. Part 1 covers the various materials used
Gülgez Gökçe Yıldız et al.
Journal of bacteriology, 196(10), 1825-1832 (2014-02-25)
The heme-copper superfamily of proton-pumping respiratory oxygen reductases are classified into three families (A, B, and C families) based on structural and phylogenetic analyses. Most studies have focused on the A family, which includes the eukaryotic mitochondrial cytochrome c oxidase
A Akbarian et al.
Poultry science, 93(8), 1930-1941 (2014-06-17)
Heat stress in poultry is a serious problem in many countries and has been associated with oxidative stress. Hence, nutritional interventions with antioxidants might be beneficial. Therefore, the effects of dietary Curcuma xanthorrhiza (CX) and Origanum compactum (OC) essential oils
Junsung Park et al.
International journal of pharmaceutics, 441(1-2), 50-55 (2012-12-25)
Telmisartan is a biopharmaceutical classification system (BCS) class II drug that has extremely low water solubility but is freely soluble in highly alkalized solutions. Few organic solvents can dissolve telmisartan. This solubility problem is the main obstacle achieving the desired
Dan Xu et al.
Journal of nanoscience and nanotechnology, 14(6), 4692-4699 (2014-04-18)
The V-based complex oxides were found to exhibit good catalytic reactivity for the selective oxidation of benzene to phenol. In order to understand the effect of the catalyst on the reaction, a series of Ag/VO(x)-TiO2 catalysts with different Ag loadings
Sajid Bashir et al.
Pakistan journal of pharmaceutical sciences, 26(6), 1229-1235 (2013-11-06)
This study involves the design and characterization of Nateglinide (NAT) microspheres to enhance patient compliance. Ionic gelation technique was used to prepare Nateglinide Microspheres by using rate controlling polymers Carbopol-940 and Hydroxypropylmethyl cellulose (HPMC). Shape and surface were evaluated with
Zbynek Sklenár et al.
Acta poloniae pharmaceutica, 70(4), 759-762 (2013-08-08)
Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers
T Tinny et al.
Drug development and industrial pharmacy, 39(9), 1357-1363 (2012-08-31)
Chronotherapeutic drug delivery offers a new approach in the pharmacologic interventions design for the effective treatment in the diseases which follows circadian rhythm. In the present study chronotherapeutic tablets of indometacin was designed to match the timing of rheumatoid arthritis
Eyal Zur
International journal of pharmaceutical compounding, 17(1), 10-22 (2013-05-01)
Compounding pharmacists throughout the world are compounding a special type of capsule called "slow-release." This type of capsule is a compounding pharmacy application of the commercial hydrophilic matrix tablets. It is a relatively simple system that allows formulating a robust
Gati Krushna Panigrahi et al.
Toxicology letters, 229(1), 273-283 (2014-06-29)
The present study was undertaken to investigate the effect of Cassia occidentalis (CO) seeds on the transcriptional expression patterns of mRNAs in rat liver by microarray analysis. The results indicated that exposure of CO (0.5%) seeds in diet to rats
Muhammad K Shahzad et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(2), 177-183 (2013-05-28)
The aim of the present work was to formulate flurbiprofen (FLB) loaded microspheres of hydroxypropylmethycellulose and ethylcellulose polymers to study the effect of different proportions of the polymer mixture on the release behavior of the drug. A series of microspheres
Kawthar Bouchemal et al.
International journal of pharmaceutics, 454(2), 649-652 (2013-03-19)
The miniCD4 M48U1 was formulated into thermosensitive and mucoadhesive pluronic(®) hydrogels as anti-HIV-1 microbicide. The release kinetics of M48U1 from F127/HPMC (20/1 wt%) and F127/F68/HPMC (22.5/2.5/1 wt%) studied during 24h by using Franz diffusion cells showed that HEC hydrogel (1.5
Lindsay A Wegiel et al.
Pharmaceutical development and technology, 19(8), 976-986 (2013-11-07)
We have investigated the physical stability of amorphous curcumin dispersions and the role of curcumin-polymer intermolecular interactions in delaying crystallization. Curcumin is an interesting model compound as it forms both intra and intermolecular hydrogen bonds in the crystal. A structurally
Akio Suzuki et al.
PloS one, 14(6), e0217944-e0217944 (2019-06-07)
Anti-prion protein (PrP) monoclonal antibody 132, which recognizes mouse PrP amino acids 119-127, enables us to reliably detect abnormal isoform prion protein (PrPSc) in cells or frozen tissue sections by immunofluorescence assay, although treatment with guanidinium salts is a prerequisite.
Rozina Kousar et al.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(1), 41-45 (2013-03-08)
The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coacervation technique. Based on the physico-chemical characteristics of three formulations (FMC1, FMC2 and FMC3), FMC2 having
A H Maitland-van der Zee et al.
Clinical pharmacology and therapeutics, 96(1), 15-17 (2014-06-20)
Observational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin anticoagulants needed to maintain a therapeutic international normalized ratio (INR).(1) Until recently, however, few randomized clinical trials had been
Daniele Ouellet et al.
Journal of pharmaceutical sciences, 102(9), 3100-3109 (2013-04-24)
Dabrafenib is a small-molecule inhibitor of BRAF kinase activity that is currently being developed for the treatment of BRAF V600 mutation-positive melanoma. This clinical, open-label, two-cohort (n = 14 per cohort), randomized study was designed to evaluate the effect of
Liangmei Chen et al.
Die Pharmazie, 68(10), 796-799 (2013-11-28)
The objective of this research was to develop and evaluate sustained-release matrix tablets of BKP-01-041 (tilorone derivative) based on Hypromellose (hydroxypropyl methylcellulose, HPMC) as the matrix forming polymer. The sustained-release tablets were prepared by the wet granulation method. The influence
Iqrar Ahmad Khan et al.
Colloids and surfaces. B, Biointerfaces, 103, 496-501 (2012-12-25)
In this paper we report the effect of two cationic (imipramine hydrochloride (IMP) and promazine hydrochloride (PMZ)) and one anionic (sodium salt of ibuprofen (IBF)) drugs on the clouding behavior of a nonionic polymer hydroxypropyl methyl cellulose (HPMC). Though all
Navnit Shah et al.
Journal of pharmaceutical sciences, 102(3), 967-981 (2013-01-03)
The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hypromellose acetate succinate (HPMCAS), an enteric polymer, is termed
Armagan Kaya et al.
Ecotoxicology and environmental safety, 106, 232-238 (2014-05-27)
In this study, we comparatively evaluated the effects of the flurochloridone as well as flurochloridone and exogenously applied salicylic acid (SA) on Helianthus annuus L. to find out herbicide-induced toxicity reducing influence of SA. We examined and compared the physiological
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