H8384

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Influence of tamarind seed gum derivatives on the in vitro performance of gastro-retentive tablets based on hydroxypropylmethylcellulose.

M Rajab et al.

Die Pharmazie, 67(11), 956-957 (2012-12-06)

An ethA-ethR-deficient Mycobacterium bovis BCG mutant displays increased adherence to mammalian cells and greater persistence in vivo, which correlate with altered mycolic acid composition.

Michelle Lay Teng Ang et al.

Infection and immunity, 82(5), 1850-1859 (2014-02-26)

Tuberculosis remains a major worldwide epidemic because of its sole etiological agent, Mycobacterium tuberculosis. Ethionamide (ETH) is one of the major antitubercular drugs used to treat infections with multidrug-resistant M. tuberculosis strains. ETH is a prodrug that requires activation within

Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis.

Yan Zhang et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(17), E1695-E1704 (2014-04-16)

Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe(III)2-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, inactivation, and reactivation are poorly

Effects of spray-drying and choice of solid carriers on concentrations of Labrasol® and Transcutol® in solid self-microemulsifying drug delivery systems (SMEDDS).

Liang Li et al.

Molecules (Basel, Switzerland), 18(1), 545-560 (2013-01-04)

Solid self-microemulsifying drug delivery systems (SMEDDS) have been used increasingly for improving the bioavailability of hydrophobic drugs. Labrasol® and Transcutol® are used widely as surfactant and solubilizer in the formulation of solid SMEDDS. We investigated the effects of spray-drying and

Efficacy of ophthalmic viscosurgical devices in maintaining corneal epithelial hydration and clarity: in vitro assessment.

Ana Prinz et al.

Journal of cataract and refractive surgery, 38(12), 2154-2159 (2012-12-01)

To determine the efficacy of hydroxypropyl methylcellulose (HPMC) and hyaluronic acid (HA) in maintaining corneal hydration and optical clarity. Department of Ophthalmology, Medical University of Vienna, Vienna, Austria. Experimental study. In porcine autopsy eyes, the effect of 13 ophthalmic viscosurgical

Effects of a dietary antioxidant blend and vitamin E on growth performance, oxidative status, and meat quality in broiler chickens fed a diet high in oxidants.

T Lu et al.

Poultry science, 93(7), 1649-1657 (2014-05-28)

The aim of the study was to determine the effects of a dietary antioxidant blend (AB) and vitamin E on performance, oxidative status, and meat quality. Cobb 500 male broilers (n = 1,200, d 0) were randomly distributed into 6

Superior limbic keratoconjunctivitis causing chronic ocular irritation in a child.

Amit Gupta et al.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, 16(6), 579-581 (2012-11-20)

Superior limbic keratoconjunctivitis (SLK) is an uncommon, painful inflammation of the ocular surface localized to the superior sectors of the cornea, limbus, and conjunctiva. The clinical course tends to be chronic, with alternating periods of remission and exacerbation. Many patients

Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled coprecipitation process.

Navnit Shah et al.

Journal of pharmaceutical sciences, 102(3), 967-981 (2013-01-03)

The present work deals with improving the solubility of vemurafenib, a practically insoluble drug, by converting it into an amorphous-solid dispersion using a solvent-controlled precipitation process. The dispersion containing vemurafenib and hypromellose acetate succinate (HPMCAS), an enteric polymer, is termed

NIR imaging spectroscopy for quantification of constituents in polymers thin films loaded with paracetamol.

Guilherme L Alexandrino et al.

Analytica chimica acta, 765, 37-44 (2013-02-16)

Thin films loaded with the drug paracetamol were produced from polymer blends formed by hydroxypropylmethylcellulose (HPMC), polyvinylpyrrolidone (PVP) and polyethyleneglycol (PEG), at various mass ratios of polymers and drug defined by a D-optimal experimental design. NIR hyperspectral images were obtained

The physiological and biochemical effects of salicylic acid on sunflowers (Helianthus annuus) exposed to flurochloridone.

Armagan Kaya et al.

Ecotoxicology and environmental safety, 106, 232-238 (2014-05-27)

In this study, we comparatively evaluated the effects of the flurochloridone as well as flurochloridone and exogenously applied salicylic acid (SA) on Helianthus annuus L. to find out herbicide-induced toxicity reducing influence of SA. We examined and compared the physiological

Curcumin Enhanced Busulfan-Induced Apoptosis through Downregulating the Expression of Survivin in Leukemia Stem-Like KG1a Cells.

Guangyang Weng et al.

BioMed research international, 2015, 630397-630397 (2015-11-12)

Leukemia relapse and nonrecurrence mortality (NRM) due to leukemia stem cells (LSCs) represent major problems following hematopoietic stem cell transplantation (HSCT). To eliminate LSCs, the sensitivity of LSCs to chemotherapeutic agents used in conditioning regimens should be enhanced. Curcumin (CUR)

Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.

Qiuna Zhou et al.

International journal of pharmaceutics, 454(1), 125-134 (2013-07-16)

The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba and hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was first developed to increase the stability

Structural insights into the cofactor-assisted substrate recognition of yeast methylglyoxal/isovaleraldehyde reductase Gre2.

Peng-Chao Guo et al.

Biochimica et biophysica acta, 1844(9), 1486-1492 (2014-06-01)

Saccharomyces cerevisiae Gre2 (EC1.1.1.283) serves as a versatile enzyme that catalyzes the stereoselective reduction of a broad range of substrates including aliphatic and aromatic ketones, diketones, as well as aldehydes, using NADPH as the cofactor. Here we present the crystal

Development, evaluation and pharmacokinetics of time-dependent ketorolac tromethamine tablets.

Sateesh Kumar Vemula et al.

Expert opinion on drug delivery, 10(1), 33-45 (2012-12-04)

The present study was intended to develop a time-dependent colon-targeted compression-coated tablets of ketorolac tromethamine (KTM) using hydroxypropyl methylcellulose (HPMC) that release the drug slowly but completely in the colonic region by retarding the drug releases in stomach and small

Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.

Samuel A Jensen et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(15), 5682-5687 (2014-04-08)

Therapy resistance is a major limitation to the successful treatment of cancer. Here, we identify Bcl2-like 13 (Bcl2L13), an atypical member of the Bcl-2 family, as a therapy susceptibility gene with elevated expression in solid and blood cancers, including glioblastoma

ROI-scavenging enzyme activities as toxicity biomarkers in three species of marine microalgae exposed to model contaminants (copper, Irgarol and atrazine).

Pablo Lozano et al.

Ecotoxicology and environmental safety, 104, 294-301 (2014-04-15)

There is a need to develop efficient tools to prevent damage to marine ecosystems due to pollution. Since microalgae play a key role in marine ecosystems, they are considered potentially useful for quick and sensitive toxicity bioassays. In this study

[TET-OGT interaction potentiates transcription by regulating histone H3 methylation].

Benjamin Delatte

Medecine sciences : M/S, 30(6-7), 619-621 (2014-07-12)

β-carotene-producing bacteria residing in the intestine provide vitamin A to mouse tissues in vivo.

Lesley Wassef et al.

The Journal of nutrition, 144(5), 608-613 (2014-03-07)

Vitamin A deficiency (VAD) is an overwhelming public health problem that affects hundreds of millions of people worldwide. A definitive solution to VAD has yet to be identified. Because it is an essential nutrient, vitamin A or its carotenoid precursor

Influence of Carbopol 71G-NF on the release of dextromethorphan hydrobromide from extended-release matrix tablets.

Mohamed H Fayed et al.

Pharmaceutical development and technology, 18(5), 971-981 (2011-06-07)

The objective of this study was to evaluate the potential of Carbopol(®) 71G-NF on the release of dextromethorphan hydrobromide (DM) from matrix tablets in comparison with hydroxypropyl methylcellulose (HPMC(®) K15M) and Eudragit(®) L100-55 polymers. Controlled release DM matrix tablets were

Compounding slow-release capsules: a comprehensive review and an Excel spreadsheet for faster calculations of excipients.

Eyal Zur

International journal of pharmaceutical compounding, 17(1), 10-22 (2013-05-01)

Compounding pharmacists throughout the world are compounding a special type of capsule called "slow-release." This type of capsule is a compounding pharmacy application of the commercial hydrophilic matrix tablets. It is a relatively simple system that allows formulating a robust

Note on the formulation of thermosensitive and mucoadhesive vaginal hydrogels containing the miniCD4 M48U1 as anti-HIV-1 microbicide.

Kawthar Bouchemal et al.

International journal of pharmaceutics, 454(2), 649-652 (2013-03-19)

The miniCD4 M48U1 was formulated into thermosensitive and mucoadhesive pluronic(®) hydrogels as anti-HIV-1 microbicide. The release kinetics of M48U1 from F127/HPMC (20/1 wt%) and F127/F68/HPMC (22.5/2.5/1 wt%) studied during 24h by using Franz diffusion cells showed that HEC hydrogel (1.5

Solubilization of the poorly water soluble drug, telmisartan, using supercritical anti-solvent (SAS) process.

Junsung Park et al.

International journal of pharmaceutics, 441(1-2), 50-55 (2012-12-25)

Telmisartan is a biopharmaceutical classification system (BCS) class II drug that has extremely low water solubility but is freely soluble in highly alkalized solutions. Few organic solvents can dissolve telmisartan. This solubility problem is the main obstacle achieving the desired

Pharmacokinetic study of hydroxypropylmethylcellulose microparticles loaded with cimetidine.

Rozina Kousar et al.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(1), 41-45 (2013-03-08)

The objective of this study was to assess the pharmacokinetic behavior of floating hydroxypropylmethylcellulose microparticles loaded with cimetidine (FMC) prepared using the non-solvent addition coacervation technique. Based on the physico-chemical characteristics of three formulations (FMC1, FMC2 and FMC3), FMC2 having

Mechanisms of reduced flavin transfer in the two-component flavin-dependent monooxygenases.

Jeerus Sucharitakul et al.

Archives of biochemistry and biophysics, 555-556, 33-46 (2014-05-27)

Two-component flavin-dependent enzymes are abundant in nature and are involved in a wide variety of biological reactions. These enzymes consist of a reductase which generates a reduced flavin and a monooxygenase that utilizes the reduced flavin as a substrate for

Evaluating food additives as antifungal agents against Monilinia fructicola in vitro and in hydroxypropyl methylcellulose-lipid composite edible coatings for plums.

Hakan Karaca et al.

International journal of food microbiology, 179, 72-79 (2014-04-20)

Common food preservative agents were evaluated in in vitro tests for their antifungal activity against Monilinia fructicola, the most economically important pathogen causing postharvest disease of stone fruits. Radial mycelial growth was measured in Petri dishes of PDA amended with

Structural basis for high substrate-binding affinity and enantioselectivity of 3-quinuclidinone reductase AtQR.

Feng Hou et al.

Biochemical and biophysical research communications, 446(4), 911-915 (2014-03-20)

(R)-3-Quinuclidinol, a useful compound for the synthesis of various pharmaceuticals, can be enantioselectively produced from 3-quinuclidinone by 3-quinuclidinone reductase. Recently, a novel NADH-dependent 3-quinuclidionone reductase (AtQR) was isolated from Agrobacterium tumefaciens, and showed much higher substrate-binding affinity (>100 fold) than

The influence of process variables of preparation of oxycellulose beads on their dissolution profile.

Martina Bajerová et al.

Acta poloniae pharmaceutica, 70(2), 271-281 (2013-04-26)

Particles preparation from biodegradable polymers as carriers for the controlled release of drugs has been the focus of many investigations and the subject of a growing field of research in recent years. The aim of this study was to develop

Sublethal toxicity of carbofuran on the African catfish Clarias gariepinus: Hormonal, enzymatic and antioxidant responses.

Ahmed Th A Ibrahim et al.

Ecotoxicology and environmental safety, 106, 33-39 (2014-05-20)

The present study examined the impacts of carbofuran on endocrinology of the catfish, Clarias gariepinus, for the first time and evaluated cortisol (CRT), triiodothyronine (T3), thyroxin (T4), 17β-estradiol (E2) and testosterone (TST) and the oxidative stress markers including SOD, CAT

Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring.

Javier Esteban et al.

Toxicology letters, 229(1), 41-51 (2014-06-03)

Polychlorinated biphenyls (PCBs) induce a broad spectrum of biochemical and toxic effects in mammals including alterations of the vital retinoid (vitamin A) system. The aim of this study was to characterize alterations of tissue retinoid levels in rat offspring and

Development of novel polymer-stabilized diosmin nanosuspensions: in vitro appraisal and ex vivo permeation.

May S Freag et al.

International journal of pharmaceutics, 454(1), 462-471 (2013-07-09)

Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanoprecipitation technique has been employed for nanosuspension

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