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H9627
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关键词:'H9627'
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Eun Ji Joo et al.
Chemico-biological interactions, 233, 25-34 (2015-04-01)
Ginsenoside Rg3 (Rg3), a pharmacologically active compound from red ginseng, has been reported to induce cell death in various cancer cell lines, although the specific mechanisms have not been well established. In the present study, Rg3 treatment to A549 human
Konstantinos Kyriakidis et al.
Inflammation, 38(3), 949-958 (2014-11-02)
Growing evidence associates histamine with arthritis, but its implication in shaping vascular function in chronic inflammation remains largely elusive. This study explored the involvement of vascular histamine in the extra-articular responses in peripheral large blood vessels using a rat model
Nathan M Long et al.
PloS one, 10(4), e0122152-e0122152 (2015-04-16)
Maternal obesity in women is increasing worldwide. The objective of this study was to evaluate differences in adipose tissue metabolism and function in adult male offspring from obese and control fed mothers subjected to an ad libitum feeding challenge. We
Marina Jerebtsova et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1314-H1325 (2015-08-16)
Critically ill children can develop bleeding complications when treated with heparin-like drugs. These events are usually attributed to the anticoagulant activity of these drugs. However, previous studies showed that fibroblast growth factor-2 (FGF-2), a heparin-binding growth factor released in the
Yangxiao Wu et al.
Tissue engineering. Part A, 21(13-14), 2001-2012 (2015-03-27)
Small-diameter tissue-engineered blood vessels (TEBVs) have been associated with low, long-term patency rates primarily because of acute thrombosis in early stages and an inability to achieve early endothelialization. Platelets and endothelial progenitor cells (EPCs) play a key role in these
Teng Jiang et al.
Neuropharmacology, 85, 121-130 (2014-06-01)
In a variety of neurodegenerative tauopathies including Alzheimer's disease, frontotemporal dementia and some types of Parkinson's disease, tau protein is abnormally hyperphosphorylated by several kinases and eventually aggregates to form neurofibrillary tangles, a neurotoxic pathological characteristic that closely correlates with
Diptadip Dattaroy et al.
American journal of physiology. Gastrointestinal and liver physiology, 308(4), G298-G312 (2014-12-17)
Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) is the common pathophysiological process resulting from chronic liver inflammation and oxidative stress. Although significant research has been carried out on the role of leptin-induced NADPH oxidase in fibrogenesis, the molecular mechanisms that connect
Ligia Almeida Paiva et al.
Parasites & vectors, 8, 577-577 (2015-11-11)
Hepatic myofibroblasts are relevant for pathogenesis of S. mansoni infection. In normal liver, these perisinusoidal cells are quiescent, express the lipocyte phenotype, and are located in the Disse's space, being the major site of vitamin A storage. When activated, they
Rita-Eva Varga et al.
PLoS genetics, 11(8), e1005454-e1005454 (2015-08-19)
Hereditary spastic paraplegia (HSP) is characterized by a dying back degeneration of corticospinal axons which leads to progressive weakness and spasticity of the legs. SPG11 is the most common autosomal-recessive form of HSPs and is caused by mutations in SPG11.
Stephen P McAdoo et al.
Kidney international, 88(1), 52-60 (2015-02-26)
Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue
Vladislava Paharkova et al.
Molecular and cellular endocrinology, 413, 96-100 (2015-06-28)
Evidence for the putative mitochondrial origin of the Humanin (HN) peptide has been lacking, although its cytoprotective activity has been demonstrated in a variety of organismal and cellular systems. We sought to establish proof-of-principle for a mitochondria-derived peptide (MDP) in
Melissa F Jackson et al.
Endocrinology, 155(5), 1771-1785 (2014-02-13)
Attenuating myostatin enhances striated muscle growth, reduces adiposity, and improves cardiac contractility. To determine whether myostatin influences tissue potency in a manner that could control such pleiotropic actions, we generated label-retaining mice with wild-type and mstn(-/-) (Jekyll) backgrounds in which
M Askmyr et al.
Blood cancer journal, 4, e269-e269 (2014-12-17)
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitutively active tyrosine kinase, is thought to be sufficient
Carlos F Santos et al.
PloS one, 10(8), e0134601-e0134601 (2015-08-06)
The initiation or progression of periodontitis might involve a local renin-angiotensin system (RAS) in periodontal tissue. The aim of this study was to further characterize the local RAS in human and rat periodontal tissues between healthy and periodontally-affected tissue. Components
Abel Torres-Espín et al.
Journal of neurotrauma, 32(6), 367-380 (2014-09-10)
Cell therapy for spinal cord injury (SCI) is a promising strategy for clinical application. Mesenchymal stem cells (MSC) have demonstrated beneficial effects following transplantation in animal models of SCI. However, despite the immunoprivilege properties of the MSC, their survival in
M C Buss et al.
Oncogene, 34(9), 1126-1140 (2014-03-19)
Recent studies suggest that medulloblastoma, the most common malignant brain tumor of childhood, is comprised of four disease variants. The WIP1 oncogene is overexpressed in Group 3 and 4 tumors, which contain medulloblastomas with the most aggressive clinical behavior. Our
Neel M Fofaria et al.
Oncotarget, 5(16), 7051-7064 (2014-09-13)
Anoikis is an anchorage-independent cell death. Resistance to anoikis is one of the key features of metastatic cells. Here, we analyzed the role of STAT3 in anoikis resistance in melanoma cells leading to metastasis. When grown under anchorage-independent conditions, significant
Zeng-Jie Yang et al.
Cancer cell, 14(2), 135-145 (2008-08-12)
Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of
Kyung-Soo Nam et al.
Oncology letters, 9(1), 483-487 (2014-12-02)
Colorectal adenocarcinoma is the most common type of gastrointestinal cancer. Colon adenocarcinoma is a major health problem worldwide due to the high prevalence and mortality rates associated with the disease. The majority of colorectal carcinomas are adenocarcinomas, which originate from
Hwan D Kim et al.
Tissue engineering. Part A, 21(3-4), 757-766 (2014-10-01)
Articular cartilage damage is a persistent and increasing problem with the aging population. Strategies to achieve complete repair or functional restoration remain a challenge. Photopolymerizing-based hydrogels have long received an attention in the cartilage tissue engineering, due to their unique
Darcy R Denner et al.
Annals of the American Thoracic Society, 12(9), 1302-1309 (2015-08-01)
Bronchial thermoplasty is an alternative treatment for patients with severe, uncontrolled asthma in which the airway smooth muscle is eliminated using radioablation. Although this emerging therapy shows promising outcomes, little is known about its effects on airway inflammation. We examined
Imir G Metushi et al.
Molecular and cellular biochemistry, 393(1-2), 229-235 (2014-04-29)
The mechanism of idiosyncratic drug reactions (IDRs) remains poorly understood. D-penicillamine treatment is associated with a wide range of autoimmune reactions including liver injury. An animal model which utilizes brown Norway (BN) rats has been used to investigate the mechanism
Laure Thibaudeau et al.
Disease models & mechanisms, 7(2), 299-309 (2014-04-10)
The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only
Svenja Nölting et al.
Endocrinology, 155(7), 2377-2390 (2014-04-26)
Currently, there are no reliably effective therapeutic options for metastatic pheochromocytoma (PCC) and paraganglioma. Moreover, there are no therapies that may prevent the onset or progression of tumors in patients with succinate dehydrogenase type B mutations, which are associated with
Mohammad A Assaggaf et al.
The American journal of pathology, 185(6), 1588-1599 (2015-04-07)
Drug-induced gingival overgrowth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin. Characteristics of these drug-induced gingival overgrowth lesions differ. We evaluate the ability of a mouse model to mimic human phenytoin-induced gingival overgrowth and assess the
Chia-Yu Chang et al.
BioMed research international, 2015, 159015-159015 (2015-06-27)
Accumulating evidence implicates that subchronic arsenic exposure causes cerebral neurodegeneration leading to behavioral disturbances relevant to psychiatric disorders. However, there is still little information regarding the influence of subchronic exposure to arsenic-contaminated drinking water on mood disorders and its underlying
Si Hui Tan et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5262-E5271 (2014-11-26)
Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of
Y Chen et al.
Transplantation proceedings, 46(5), 1649-1657 (2014-06-18)
The efficacy of any bioartificial liver device requires both rapid production and proper bioactivity of the cells for the bioreactor. The goal of this study was to observe the effect of spinner speed and cell density on the proliferation of
Alexandra Wittmann et al.
Inflammatory bowel diseases, 21(3), 507-519 (2015-02-04)
Toll-like receptor (TLR) expression in patients with inflammatory bowel disease is increased when compared with healthy controls. However, the impact of TLR signaling during inflammatory bowel disease is not fully understood. In this study, we used a murine model of
Yasir Alhamdi et al.
PLoS pathogens, 11(5), e1004836-e1004836 (2015-05-15)
Streptococcus pneumoniae accounts for more deaths worldwide than any other single pathogen through diverse disease manifestations including pneumonia, sepsis and meningitis. Life-threatening acute cardiac complications are more common in pneumococcal infection compared to other bacterial infections. Distinctively, these arise despite
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