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Hai-Jeon Yoon et al.
European journal of nuclear medicine and molecular imaging, 41(8), 1534-1543 (2014-03-22)
Imaging biomarkers from functional imaging modalities were assessed as potential surrogate markers of disease status. Specifically, in this prospective study, we investigated the relationships between functional imaging parameters and histological prognostic factors and breast cancer subtypes. In total, 43 patients
Fei Zhang et al.
Tissue engineering. Part A, 21(17-18), 2404-2416 (2015-07-02)
Cytotoxic T lymphocyte-associated antigen 4-Ig (CTLA4-Ig)-modified bone marrow-derived mesenchymal stem cells (MSCs-CTLA4) have excellent osteogenic function in xenografts, but their mechanism of action remains to be elucidated. As bidirectional signaling between erythropoietin-producing hepatocyte receptors B4 (EphB4) and ephrinB2 is vital
Ying Wang et al.
The American journal of pathology, 172(6), 1491-1499 (2008-05-10)
Macrophages are important mediators of injury in most types of human kidney diseases; however, the pathogenic importance of both macrophage number and activation status is unknown. To examine this question, severe-combined immunodeficient mice with adriamycin nephrosis, an experimental model of
Li Zhang et al.
Journal of translational medicine, 12, 236-236 (2014-08-28)
Salvia-Nelumbinis naturalis (SNN), initially called Jiangzhi Granula as a formulae of Chinese medicinal decoction, has been used clinically to treat non-alcoholic fatty liver disease (NAFLD) and related syndromes. The mechanism of SNN action is unknown. HepG2 cells were cultured in
Konrad Gabrusiewicz et al.
Oncotarget, 5(8), 2208-2220 (2014-05-09)
The addition of anti-angiogenic therapy to the few treatments available to patients with malignant gliomas was based on the fact that these tumors are highly vascularized and on encouraging results from preclinical and clinical studies. However, tumors that initially respond
Prudence A Russell et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27(12), 1621-1631 (2014-04-26)
The aim of this study was to investigate the prevalence of fibroblast growth factor receptor 1 (FGFR1) amplification by fluorescence in situ hybridization (FISH) in a lung cancer patient cohort and to correlate results with morphology, silver in situ hybridization
Tian-Zhu Zhang et al.
Chinese journal of natural medicines, 13(5), 368-374 (2015-05-20)
The aim of the study was to investigate the anti-asthmatic effects of oxymatrine (OXY) and the possible underlying mechanisms. The mouse asthma model was established by ovalbumin (OVA) intraperitoneal injection. A total of fifty mice were randomly assigned to five
Sonja Aits et al.
Autophagy, 11(8), 1408-1424 (2015-06-27)
Lysosomal membrane permeabilization (LMP) contributes to tissue involution, degenerative diseases, and cancer therapy. Its investigation has, however, been hindered by the lack of sensitive methods. Here, we characterize and validate the detection of galectin puncta at leaky lysosomes as a
Lanlan Zhang et al.
International journal of clinical and experimental medicine, 7(12), 5403-5411 (2015-02-11)
To explore the significance of assessing persistent airway obstruction (PAO) in asthma patients by airway wall remodeling with bronchoscopy, high-resolution computed tomography (HRCT), and biological markers in the induced sputum and serum, exhaled nitric oxide (FENO), and lung function. The
Yan Sun et al.
Oncology letters, 9(6), 2750-2756 (2015-07-03)
Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in
Jun Yan et al.
Molecular medicine reports, 12(1), 498-502 (2015-03-12)
Osteosarcoma (OS) is the most common type of malignant bone tumor. Despite aggressive multimodal treatments, including surgical resection, chemotherapy and adjunctive immunotherapies, patients with OS with high-grade malignancy have a poor five-year survival rate that has remained unchanged over the
Hiroshi Kameyama et al.
Legal medicine (Tokyo, Japan), 17(4), 255-260 (2015-03-22)
Wound healing evaluation is important in forensic pathology, in which angiogenesis plays an important role. We have already shown that vascular endothelial growth factor A (VEGF) is produced in the rat skin incision wounds by neutrophils, endothelial cells, and fibroblasts.
Xiaoyong Zhong et al.
Molecular medicine reports, 12(2), 1699-1708 (2015-04-01)
Previous studies by our group showed that Qianliening capsules (QC), a clinically proven effective traditional Chinese formulation that has long been used in the treatment of benign prostatic hyperplasia (BPH), is capable of inhibiting BPH in vivo and in vitro
Lei Lv et al.
Cancer letters, 357(1), 105-113 (2014-12-03)
Chemoresistance prevents the curative cancer chemotherapy and presents a formidable challenge for both cancer researchers and clinicians. We have previously shown that miR-193a-3p promotes the multi-chemoresistance of bladder cancer cells via repressing its three target genes: SRSF2, PLAU and HIC2.
Catherine Rhéaume et al.
Toxins, 7(7), 2354-2370 (2015-06-27)
Botulinum neurotoxin type-A (BoNT/A), as onabotulinumtoxinA, is approved globally for 11 major therapeutic and cosmetic indications. While the mechanism of action for BoNT/A at the presynaptic nerve terminal has been established, questions remain regarding intracellular trafficking patterns and overall fate
Bryan J Holtz et al.
American journal of physiology. Gastrointestinal and liver physiology, 307(7), G700-G710 (2014-08-12)
High levels of cholecystokinin (CCK) can stimulate pancreatic adaptive growth in which mature acinar cells divide, leading to enhanced pancreatic mass with parallel increases in protein, DNA, RNA, and digestive enzyme content. Prolonged release of CCK can be induced by
Shuai Wang et al.
Oncology letters, 10(5), 2705-2712 (2016-01-02)
Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated.
Zhigang Yang et al.
Stem cells (Dayton, Ohio), 33(9), 2798-2810 (2015-05-28)
The advent of mesenchymal stem cell (MSC)-based therapies has been an exciting innovation for the treatment of degenerative and inflammatory diseases. However, the surface markers that accurately reflect the self-renewal and differentiation potential of MSCs and their sensitivity to environmental
Hui Yu et al.
Experimental and therapeutic medicine, 9(5), 1631-1638 (2015-07-03)
The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular
J-F An et al.
Cellular and molecular biology (Noisy-le-Grand, France), 60(4), 8-12 (2014-11-17)
Germacrone is one of the main bioactive components in the traditional Chinese medicine Rhizoma curcuma and has been shown to possess an anti-inflammatory activity. Our present study aimed to investigate the protective effects of germacrone on lipopolysaccharide (LPS)-induced acute lung
Amy Winship et al.
Scientific reports, 5, 13237-13237 (2015-08-15)
The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Specialized trophoblast cells derived from the embryonic trophectoderm play a pivotal role in the establishment of the placenta. Leukemia
Catherine A Mayer et al.
Pediatric research, 78(2), 145-151 (2015-05-08)
Continuous positive airway pressure (CPAP) is a primary form of respiratory support used in the intensive care of preterm infants, but its long-term effects on airway (AW) function are unknown. We developed a neonatal mouse model of CPAP treatment to
Brett Schrand et al.
Cancer immunology research, 2(9), 867-877 (2014-06-19)
Despite the recent successes of using immune modulatory Abs in patients with cancer, autoimmune pathologies resulting from the activation of self-reactive T cells preclude the dose escalations necessary to fully exploit their therapeutic potential. To reduce the observed and expected
Ivanesa Pardo et al.
Breast cancer research : BCR, 16(2), R26-R26 (2014-03-19)
Our efforts to prevent and treat breast cancer are significantly impeded by a lack of knowledge of the biology and developmental genetics of the normal mammary gland. In order to provide the specimens that will facilitate such an understanding, The
Bo Sun Joo et al.
Reproductive biology and endocrinology : RB&E, 12, 113-113 (2014-11-26)
Many studies have proposed that putative ovarian stem cells (OSCs) derived from the ovarian surface epithelium (OSE) layer of adult mammalian ovaries can produce oocytes. Few studies have reported that ovaries of aged mammalian females including mice and women possess
Rosario Caltabiano et al.
Histology and histopathology, 29(10), 1325-1334 (2014-04-26)
Melanoma arising from melanocytes within the choroid is the most frequent primary intraocular neoplasm in adults. It is biologically distinct from cutaneous melanoma by a very strong propensity to metastasize the liver. Raf kinase inhibitor protein is a member of
Hideki Maejima et al.
PloS one, 9(7), e101773-e101773 (2014-07-11)
To identify diagnostic markers for psoriasis vulgaris and psoriatic arthritis, autoantibodies in sera from psoriasis vulgaris and psoriatic arthritis patients were screened by two-dimensional immunoblotting (2D-IB). Based on 2D-IB and MADLI TOF/TOF-MS analyses, eleven proteins each in psoriasis vulgaris and
Sylvain Chauvet et al.
American journal of physiology. Lung cellular and molecular physiology, 309(3), L314-L322 (2015-06-07)
Enhanced lung angiogenesis has been reported in cystic fibrosis (CF). Recently, two highly homologous ligands, endocrine gland vascular endothelial growth factor (EG-VEGF) and mammalian Bv8, have been described as new angiogenic factors. Both ligands bind and activate two closely related
Angèle Nalbandian et al.
Clinical and translational science, 8(1), 8-16 (2014-11-13)
Dominant mutations in the valosin-containing protein (VCP) gene cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia, which is characterized by progressive muscle weakness, dysfunction in bone remodeling, and frontotemporal dementia. More recently, VCP has been
Patricia S Nielsen et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(3), 404-413 (2012-11-24)
Cellular proliferation is correlated with the progression of melanoma. Accordingly, the proliferation index of H&E-stained thin melanomas was recently included in the staging system of the American Joint Committee on Cancer. Yet, the immunohistochemical markers of proliferation phosphohistone H3 and
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