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Tatyana Isayeva et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(5), 631-653 (2014-12-20)
A large body of evidence shows that p16(INK4a) overexpression predicts improved survival and increased radiosensitivity in HPV-mediated oropharyngeal squamous cell carcinomas.(OPSCC). Here we demonstrate that the presence of transcriptionally active HPV16 in oral cavity squamous cell carcinomas does not correlate
Lucas Moreno et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(2), 267-273 (2014-11-06)
A phase I trial of AT9283 (a multitargeted inhibitor of Aurora kinases A and B) was conducted in children and adolescents with solid tumors, to identify maximum-tolerated dose (MTD), safety, efficacy, pharmacokinetics, and pharmacodynamic (PD) activity. AT9283 was administered as
Paul R Gielen et al.
Journal of neuropathology and experimental neurology, 74(5), 390-400 (2015-04-09)
Myeloid-derived suppressor cells (MDSCs), defined as CD33-positive major histocompatibility complex class II-negative cells, are increased in a variety of human tumors and are associated with immunosuppression. Myeloid-derived suppressor cells can be further subdivided into CD14-positive monocytic MDSC and CD15-positive granulocytic
Maryse Lemaire et al.
PloS one, 10(9), e0136592-e0136592 (2015-09-04)
Epidemiological studies have shown that arsenic exposure increases atherosclerosis, but the mechanisms underlying this relationship are unknown. Monocytes, macrophages and platelets play an important role in the initiation of atherosclerosis. Circulating monocytes and macrophages bind to the activated vascular endothelium
Xianlei Wang et al.
Journal of biosciences, 39(5), 849-858 (2014-11-29)
During the development of B and T lymphocytes, Ig and TCR variable region genes are assembled from germline V, D, and J gene segments by a site-specific recombination reaction known as V(D)J recombination. The process of somatic V(D)J recombination, mediated
Young-Sam Cho et al.
Molecular medicine reports, 12(2), 1796-1802 (2015-04-22)
Ulinastatin is a urinary trypsin inhibitor, originally extracted and purified from human urine. Ulinastatin has cytoprotective effects against ischemic injury in several organs. In the present study, the neuroprotective effects of ulinastatin following ischemic cerebral injury in the hippocampus of
Martijn L L Chatrou et al.
PloS one, 10(11), e0142335-e0142335 (2015-11-12)
Vascular calcification is associated with poor cardiovascular outcome. Histochemical analysis of calcification and the expression of proteins involved in mineralization are usually based on whole section analysis, thereby often ignoring regional differences in atherosclerotic lesions. At present, limited information is
Ha Na Oh et al.
Cornea, 34(9), 1130-1136 (2015-07-24)
To evaluate the effect of treatment with quercetin in a mouse model of dry eye. 0.5% quercetin eye drops were prepared and an experimental dry eye model was induced in NOD.B10.H2(b) mice through desiccation stress. The mice were divided into
Mariola Śliwińska-Mossoń et al.
Applied immunohistochemistry & molecular morphology : AIMM, 23(4), 288-296 (2014-09-10)
The aim of this study is to prove the influence of tobacco smoking on the endothelin-1 (ET-1) level in the plasma and on the immunohistochemical localization in the pancreatic tissues. The blood was collected from 50 healthy individuals and 63
Sang Woo Lee et al.
Biochemical and biophysical research communications, 464(4), 1178-1184 (2015-07-26)
Activin A, which is a signaling molecule similar to Nodal, rapidly promotes endoderm induction of both embryonic stem (ES) cells and MSCs. Protocols for hepatic induction exhibit differences in efficiency and reproducibility depending on the specific methods or sources of
Xavier Deschênes-Simard et al.
Aging cell, 18(2), e12889-e12889 (2019-01-08)
Most cancers arise in old individuals, which also accumulate senescent cells. Cellular senescence can be experimentally induced by expression of oncogenes or telomere shortening during serial passage in culture. In vivo, precursor lesions of several cancer types accumulate senescent cells
Yan Huang et al.
Journal of biomedical science, 16, 87-87 (2009-09-24)
Stem cell therapy has emerged as a potential therapeutic option for tissue engineering and regenerative medicine, but many issues remain to be resolved, such as the amount of seed cells, committed differentiation and the efficiency. Several previous studies have focused
Monica Boita et al.
Innate immunity, 21(2), 167-174 (2014-03-04)
The aims of this study were to investigate OX40 ligand expression in sinus tissue from patients with nasal polyposis compared with patients with chronic rhinosinusitis without nasal polyps (NPs), and to determine if OX40 ligand expression is related to eosinophilic
Kun Huang et al.
Molecular medicine reports, 11(3), 1685-1692 (2014-11-21)
Pulmonary fibrosis is an irreversible chronic progressive fibroproliferative lung disease, which usually has a poor prognosis. Previous studies have confirmed that the transplantation of bone marrow mesenchymal stem cells (MSCs) significantly reduces lung damage in a number of animal models.
Luigi Strizzi et al.
Oncotarget, 6(33), 34071-34086 (2015-10-16)
Nodal is highly expressed in various human malignancies, thus supporting the rationale for exploring Nodal as a therapeutic target. Here, we describe the effects of a novel monoclonal antibody (mAb), 3D1, raised against human Nodal. In vitro treatment of C8161
Diana L Castillo-Carranza et al.
Journal of Alzheimer's disease : JAD, 40 Suppl 1, S97-S111 (2014-03-08)
Neurodegenerative disease is one of the greatest health crises in the world and as life expectancy rises, the number of people affected will continue to increase. The most common neurodegenerative disease, Alzheimer's disease, is a tauopathy, characterized by the presence
Satoshi Saida et al.
Pediatrics international : official journal of the Japan Pediatric Society, 57(4), 558-566 (2015-02-17)
Hepatoblastoma is a rare childhood malignant tumor that originates from immature hepatic cells. Aminopeptidase-N(CD13), an ectopeptidase that promotes tumor invasion and metastasis, is expressed in fetal stage hepatic progenitor cells, although its role in hepatoblastoma remains unclear. The expression pattern
Aparecida D Malvezi et al.
Antimicrobial agents and chemotherapy, 58(10), 6157-6164 (2014-08-06)
The intracellular protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, a serious disorder that affects millions of people in Latin America. Cell invasion by T. cruzi and its intracellular replication are essential to the parasite's life cycle
Zhongliang Hu et al.
Cancer, 121(2), 214-225 (2014-09-12)
To understand the mechanism of frequent and early lymph node metastasis in high-risk human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC), this study investigated whether β-catenin is regulated by the HPV oncoprotein and contributes to OPSCC metastasis. Expression levels of
Yong Joo Lee et al.
PloS one, 10(7), e0131863-e0131863 (2015-07-07)
Various types of histone methylation have been associated with cancer progression. Depending on the methylation site in histone proteins, its effects on transcription are different. DPY30 is a common member of SET1/MLL histone H3K4 methyltransferase complexes. However, its expression and
Jun Li et al.
Brain research, 1356, 11-23 (2010-08-17)
Transient cerebral ischemia may result in neuronal apoptosis. During this process, several apoptosis-regulatory genes are induced in apoptotic cells. Among these genes, cysteinyl aspartate-specific protease-3 (caspase-3) and B-cell leukemia-2 (Bcl-2) are the most effective apoptotic regulators because they play a
Stefanie A Sydlik et al.
ACS nano, 9(4), 3866-3874 (2015-04-08)
Graphene oxide (GO) is suggested to have great potential as a component of biomedical devices. Although this nanomaterial has been demonstrated to be cytocompatible in vitro, its compatibility in vivo in tissue sites relevant for biomedical device application is yet
Martin W Huellner et al.
EJNMMI research, 4(1), 6-6 (2014-01-24)
The purpose of this study was to assess the relationship of CT-perfusion (CTP), 18F-FDG-PET/CT and histological parameters, and the possible added value of CTP to FDG-PET/CT in the initial staging of lung cancer. Fifty-four consecutive patients (median age 65 years
Jianglong Yu et al.
International journal of clinical and experimental medicine, 8(8), 13377-13382 (2015-11-10)
The present study is to investigate the pathological changes in rabbits with traumatic optic neuropathy (TON), as well as the effect of fasudil on the lesions. A total of 144 New Zealand rabbits were successfully established as TON models. Twelve
Alexander Nyström et al.
EMBO molecular medicine, 7(9), 1211-1228 (2015-07-22)
Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)-a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here
Ha Young Shin et al.
Neuromuscular disorders : NMD, 25(6), 502-510 (2015-04-15)
Dysferlinopathy comprises a group of autosomal recessive muscular dystrophies caused by mutations in the DYSF gene. Due to the large size of the gene and its lack of mutational hot spots, analysis of the DYSF gene is time-consuming and laborious
E A Kogan et al.
Bulletin of experimental biology and medicine, 157(5), 683-688 (2014-09-27)
We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells
Lorena Rocha Ayres et al.
The journal of venomous animals and toxins including tropical diseases, 21, 29-29 (2015-08-15)
Activation of the complement system plays an important role in the regulation of immune and inflammatory reactions, and contributes to inflammatory responses triggered by envenomation provoked by Bothrops snakes. The present study aimed to assess whether Bothrops jararacussu and Bothrops
Hueliton Wilian Kido et al.
Aging clinical and experimental research, 26(5), 473-481 (2014-02-18)
The aim of this study was to evaluate the influence of postmenopausal bone loss (induced by ovariectomy) in the process of bone healing in a tibial bone defect model in rats by means of histological evaluation of bone defects and
Maria Chang et al.
Pediatric research, 64(3), 240-245 (2008-06-07)
In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with age, approaching zero as the animal approaches adult body size. To investigate the underlying changes in cell-cycle kinetics, [methyl-H]thymidine and 5'-bromo-2'deoxyuridine were used
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