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Periostin expression is upregulated and associated with myocardial fibrosis in human failing hearts.
Sheng Zhao et al.
Journal of cardiology, 63(5), 373-378 (2013-11-14)
Periostin, a matricellular protein, plays an important role in cardiac development and remodeling. Its expression profile and the association with myocardial fibrosis have not been investigated in human failing hearts. This work aimed to explore the behavior and pathologic significance
Mario Heindl et al.
PloS one, 10(5), e0125556-e0125556 (2015-05-12)
Beta-site alpha-amyloid protein cleaving enzyme1 (BACE1) plays a key role in the pathogenesis of Alzheimer's disease. Additional to its moderate expression in the brain, high levels of BACE1 mRNA were found in the pancreas. Murine Bace1 has been immunohistochemicaly detected
Neel M Fofaria et al.
Oncotarget, 5(16), 7051-7064 (2014-09-13)
Anoikis is an anchorage-independent cell death. Resistance to anoikis is one of the key features of metastatic cells. Here, we analyzed the role of STAT3 in anoikis resistance in melanoma cells leading to metastasis. When grown under anchorage-independent conditions, significant
Rita-Eva Varga et al.
PLoS genetics, 11(8), e1005454-e1005454 (2015-08-19)
Hereditary spastic paraplegia (HSP) is characterized by a dying back degeneration of corticospinal axons which leads to progressive weakness and spasticity of the legs. SPG11 is the most common autosomal-recessive form of HSPs and is caused by mutations in SPG11.
Stephen P McAdoo et al.
Kidney international, 88(1), 52-60 (2015-02-26)
Spleen tyrosine kinase (SYK) is an important component of the intracellular signaling pathway for various immunoreceptors. Inhibition of SYK has shown promise in preclinical models of autoimmune and glomerular disease. However, the description of SYK expression in human renal tissue
Si Hui Tan et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), E5262-E5271 (2014-11-26)
Wnt signaling is a critical regulator of bone development, but the identity and role of the Wnt-producing cells are still unclear. We addressed these questions through in situ hybridization, lineage tracing, and genetic experiments. First, we surveyed the expression of
Y Chen et al.
Transplantation proceedings, 46(5), 1649-1657 (2014-06-18)
The efficacy of any bioartificial liver device requires both rapid production and proper bioactivity of the cells for the bioreactor. The goal of this study was to observe the effect of spinner speed and cell density on the proliferation of
Chia-Hui Chuang et al.
Acta biomaterialia, 19, 85-99 (2015-03-10)
To manufacture tissue engineering-based functional tissues, scaffold materials that can be sufficiently vascularized to mimic the functionality and complexity of native tissues are needed. Currently, vascular network bioengineering is largely carried out using natural hydrogels as embedding scaffolds, but most
Darcy R Denner et al.
Annals of the American Thoracic Society, 12(9), 1302-1309 (2015-08-01)
Bronchial thermoplasty is an alternative treatment for patients with severe, uncontrolled asthma in which the airway smooth muscle is eliminated using radioablation. Although this emerging therapy shows promising outcomes, little is known about its effects on airway inflammation. We examined
Mohammad A Assaggaf et al.
The American journal of pathology, 185(6), 1588-1599 (2015-04-07)
Drug-induced gingival overgrowth is caused by the antiseizure medication phenytoin, calcium channel blockers, and ciclosporin. Characteristics of these drug-induced gingival overgrowth lesions differ. We evaluate the ability of a mouse model to mimic human phenytoin-induced gingival overgrowth and assess the
Chia-Yu Chang et al.
BioMed research international, 2015, 159015-159015 (2015-06-27)
Accumulating evidence implicates that subchronic arsenic exposure causes cerebral neurodegeneration leading to behavioral disturbances relevant to psychiatric disorders. However, there is still little information regarding the influence of subchronic exposure to arsenic-contaminated drinking water on mood disorders and its underlying
Min-Je Kim et al.
Journal of microbiology and biotechnology, 25(5), 648-657 (2015-02-03)
H9, a novel herbal extract, demonstrated cytotoxicity in A549 non-small cell lung cancer (NSCLC) cell lines. In this study, we investigated whether H9, and/or co-treatment with an anticancer drug, pemetrexed (PEM), inhibited tumor growth in BALB/c nude mice models bearing
T M Work et al.
Veterinary pathology, 52(6), 1195-1201 (2014-12-03)
Cancers in humans and animals can be caused by viruses, but virus-induced tumors are considered to be poor sites for replication of intact virions (lytic replication). Fibropapillomatosis (FP) is a neoplastic disease associated with a herpesvirus, chelonid herpesvirus 5 (ChHV5)
Hye Ryoun Jang et al.
American journal of physiology. Renal physiology, 307(10), F1149-F1161 (2014-08-22)
Human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) have been studied in several models of immune-mediated disease because of their unique immunomodulatory properties. We hypothesized that HUCB-MSCs could suppress the inflammatory response in postischemic kidneys and attenuate early renal injury.
Fabio R Faucz et al.
Endocrine-related cancer, 22(1), 47-54 (2014-12-21)
IGSF1 is a membrane glycoprotein highly expressed in the anterior pituitary. Pathogenic mutations in the IGSF1 gene (on Xq26.2) are associated with X-linked central hypothyroidism and testicular enlargement in males. In this study, we tested the hypothesis that IGSF1 is
Ruile Shen et al.
International immunopharmacology, 24(2), 224-231 (2014-12-22)
Multiple sclerosis (MS) is an autoimmune disease that is characterized by recurrent episodes of T cell-mediated immune attack on central nervous system (CNS) myelin, leading to axon damage and progressive disability. Icariin, a natural flavonoid glucoside isolated from plants in
Alexia Le Breton et al.
Surgical and radiologic anatomy : SRA, 37(7), 815-823 (2015-05-02)
Knowledge of cochlear trauma resulting from the implantation of electrodes is important for the development of atraumatic surgical techniques. The purpose of this study was to demonstrate the advantages of micro-CT scanning, back-scattered electron microscopy (BSEM) and optical microscopy (OM)
Ji-Won Park et al.
Infection and immunity, 83(12), 4791-4799 (2015-10-07)
Pseudomonas aeruginosa infections persist in patients with cystic fibrosis (CF) and drive lung disease progression. P. aeruginosa potently activates the innate immune system mostly through the recognition of pathogen-associated molecular patterns, such as flagellin. Matrix metalloproteinases 12 and 13 (MMP-12
Chan-Jung Liang et al.
Cell transplantation, 24(7), 1363-1377 (2014-05-14)
Ischemia-reperfusion (I/R) injury to the kidney, a major cause of acute renal failure in humans, is associated with a high mortality, and the development of a new therapeutic strategy is therefore highly desirable. In this study, we examined the therapeutic
Eunjeong Kim et al.
Scientific reports, 5, 8272-8272 (2015-02-06)
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L(-/-)) mice have impaired bile acid (BA)
Jelena Lazovic et al.
Neuro-oncology, 17(1), 53-62 (2014-07-31)
Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and in vivo using glioma cell lines and a genetically engineered PTEN/KRAS mouse glioma model. The effect
Syed Imran Bukhari et al.
Phytotherapy research : PTR, 29(4), 617-627 (2015-03-11)
The present study involves evaluation of antioxidant potential of Crocus sativus and its main constituents, safranal (SFN) and crocin (CRO), in bronchial epithelial cells, followed antiinflammatory potential of the active constituent safranal, in a murine model of asthma. To investigate
Chunhui Yang et al.
Scientific reports, 5, 12941-12941 (2015-08-08)
Transgenic expression of I-E molecules prevents diabetes in NOD mice. So far, the precise role of these non-classical MHC II molecules remains elusive. Here, we showed that transgenic expression of I-E(k) alpha 16 molecule in NOD mice selectively reduced Th17
Cynthia L Forsman et al.
Developmental biology, 373(1), 95-106 (2012-10-30)
Bone morphogenetic proteins (BMPs) are involved in embryonic mammary gland (MG) development and can be dysregulated in breast cancer. However, the role BMPs play in the postnatal MG remains virtually unknown. BMPs are potent morphogens that are involved in cell
Eva Nozik-Grayck et al.
American journal of physiology. Lung cellular and molecular physiology, 307(11), L868-L876 (2014-10-19)
Excess superoxide has been implicated in pulmonary hypertension (PH). We previously found lung overexpression of the antioxidant extracellular superoxide dismutase (EC-SOD) attenuates PH and pulmonary artery (PA) remodeling. Although comprising a small fraction of total SOD activity in most tissues
Maria G Crespo-Leiro et al.
Transplantation, 94(11), 1172-1177 (2012-12-12)
There has been no large evaluation of the ISHLT 2004 acute cellular rejection grading scheme for heart graft endomyocardial biopsy specimens (EMBs). We evaluated agreement within the CARGO II pathology panel and between the panel (acting by majority) and the
Christian Erbel et al.
International journal of cardiology, 186, 219-225 (2015-04-02)
The platelet chemokine CXCL4 induces monocyte differentiation resulting in a macrophage phenotype called "M4", which co-expresses CD68, MMP7, and S100A8. We hypothesized that M4 macrophages are associated with plaque destabilization. Atherosclerotic arteries were obtained from explanted hearts of patients with
Zhiquan Huang et al.
Molecular carcinogenesis, 53(10), 777-786 (2013-05-11)
Resistance to cisplatin-based chemotherapy is responsible for the majority of deaths from head and neck squamous cell carcinoma (HNSCC). In this study, using genome-wide gene expression analysis to investigate potential molecular mediators of HNSCC chemoresistance, we identified SERPINB2, a known
Tomohiro Onodera et al.
Foot & ankle international, 36(7), 774-779 (2015-03-05)
Ultrasonography is among the valid methods to assess articular cartilage in the foot. This study aimed to evaluate the validity of ultrasonographic grading to assess metatarsal head articular cartilage for rheumatoid forefoot deformity in vivo and to compare the findings
Su Jin Lee et al.
PloS one, 10(4), e0120577-e0120577 (2015-04-08)
The mechanisms underlying the progression of simple steatosis to steatohepatitis are yet to be elucidated. To identify the proteins involved in the development of liver tissue inflammation, we performed comparative proteomic analysis of non-alcoholic steatohepatitis (NASH). Mice fed a methionine
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