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Su Mei Wu et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 187, 202-213 (2015-05-31)
The present study seeks to detect oxidative damage and to compare anti-oxidative responses among liver, gills and brain of adult zebrafish that were cooled from 28 °C (control) to 12 °C (treatment) for 0-24 h. The lipid peroxidation of liver
Zhou Luan et al.
Molecular medicine reports, 11(1), 203-211 (2014-10-22)
The enhancement of apoptosis is a therapeutic strategy used in the treatment of cancer. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent. However, hepatocellular carcinoma (HCC) cells exhibit marked resistance to the induction of cell death by
Carlota Recio et al.
Basic research in cardiology, 110(2), 8-8 (2015-01-22)
Chronic activation of Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway contributes to vascular inflammation and atherosclerosis by inducing expression of genes involved in cell proliferation, differentiation and migration. We aimed to investigate whether enforced expression of negative regulators
Hemanth Akkiraju et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(2), 208-215 (2014-10-22)
Bone Morphogenetic Protein 2 (BMP2) regulates bone integrity by driving both osteogenesis and osteoclastogenesis. However, BMP2 as a therapeutic has significant drawbacks. We have designed a novel peptide CK2.3 that blocks the interaction of Casein Kinase 2 (CK2) with Bone
Wonhwa Lee et al.
Canadian journal of physiology and pharmacology, 93(8), 709-720 (2015-08-06)
Cyclopia subternata is a medicinal plant commonly used in traditional medicine to relieve pain. In this study, we investigated the antiseptic effects and underlying mechanisms of vicenin-2 and scolymoside, which are 2 active compounds from C. subternata that act against
Halide Nur Urer et al.
TheScientificWorldJournal, 2012, 657316-657316 (2012-10-03)
Diffuse alveolar damage (DAD) is a morphological prototype of acute interstitial pneumonia. Hospital autopsies or open-lung biopsies are used to monitor common alveolar damage and hyaline membrane (HM) development histopathologically. The aim of this study was to detect histopathological profiles
Solange Le Blanc et al.
Experimental cell research, 338(2), 136-148 (2015-09-20)
Multipotent human bone marrow stromal cells (hBMSCs) are the common progenitors of osteoblasts and adipocytes. A shift in hBMSC differentiation in favor of adipogenesis may contribute to the bone loss and marrow fat accumulation observed in aging and osteoporosis. Hence
Jia Shen et al.
Medical oncology (Northwood, London, England), 32(8), 210-210 (2015-07-01)
Perivascular epithelioid cell tumors (PEComas) are an uncommon family of soft tissue tumors with dual myoid-melanocytic differentiation. Although PEComa family tumors commonly demonstrate a perivascular growth pattern, pericyte antigen expression has not yet been examined among this unique tumor group.
Mei-Yin C Polley et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28(6), 778-786 (2015-02-24)
Although an important biomarker in breast cancer, Ki67 lacks scoring standardization, which has limited its clinical use. Our previous study found variability when laboratories used their own scoring methods on centrally stained tissue microarray slides. In this current study, 16
Summer L Gibbs et al.
Molecular imaging, 14 (2015-03-31)
Hematoxylin-eosin (H&E) staining of tissue has been the mainstay of pathology for more than a century. However, the learning curve for H&E tissue interpretation is long, whereas intra- and interobserver variability remain high. Computer-assisted image analysis of H&E sections holds
Aránzazu Mediero et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 30(5), 837-854 (2014-12-09)
Bone metabolism is a vital process that involves resorption by osteoclasts and formation by osteoblasts, which is closely regulated by immune cells. The neuronal guidance protein Netrin-1 regulates immune cell migration and inflammatory reactions, but its role in bone metabolism
B Dorweiler et al.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 48(3), 248-257 (2014-07-26)
To analyze expression of keystone markers of apoptosis and the proapoptotic signaling pathway "unfolded protein response" (UPR) in rupture-prone plaques of the human carotid artery. Plaque specimens were obtained during endarterectomy for high-grade carotid stenosis, and were formalin-fixed. Ten specimens
Pengfei Xu et al.
Molecular and cellular endocrinology, 406, 87-101 (2015-03-01)
White adipose tissue has now been recognized as an important endocrine organ secreting bioactive molecules termed adipocytokines. In obesity, anti-inflammatory adipocytokines like adiponectin are decreased while pro-inflammatory factors are over-produced. These changes contribute to the development of insulin resistance and
Guojian Yin et al.
International journal of clinical and experimental pathology, 8(5), 4457-4468 (2015-07-21)
Mesenchymal stem cells (MSCs) have shown an obvious protective effect on systemic inflammation. The purpose of this study is to assess the effect and possible mechanism of bone marrow MSCs (bmMSCs) on acute pancreatitis (AP). BmMSCs of SD rats were
Ashling Holland et al.
Molecules (Basel, Switzerland), 20(6), 11317-11344 (2015-06-24)
The primary deficiency in the membrane cytoskeletal protein dystrophin results in complex changes in dystrophic muscles. In order to compare the degree of secondary alterations in differently affected subtypes of skeletal muscles, we have conducted a global analysis of proteome-wide
Carolin Kurz et al.
Molecular medicine (Cambridge, Mass.), 21, 479-486 (2015-06-13)
Somatic DNA alterations are known to occur in atherosclerotic carotid artery lesions; however, their significance is unknown. The accumulation of microsatellite mutations in coding DNA regions may reflect a deficiency of the DNA mismatch repair (MMR) system. Alternatively, accumulation of
Rajaletchumy Veloo Kutty et al.
Biomaterials, 63, 58-69 (2015-06-18)
In this study we examined the efficacy of our micellar system in xenograft models of triple negative breast cancers and explored the effect of the micelles on post-treatment tumours in order to elucidate the mechanism underlying the nanomedicine treatment in
Marie Plante et al.
Gynecologic oncology, 137(3), 443-447 (2015-03-17)
Indocyanine green (ICG) with near-infrared (NIR) fluorescence imaging is a new tracer modality used for lymphatic mapping. We report our initial experience with ICG for SLN mapping in cervical and endometrial cancer using a new endoscopic fluorescence imaging system. We
Peggy Richard-Fiardo et al.
Biomaterials, 45, 10-17 (2015-02-11)
In the present study, we evaluated, in mice, the efficacy of the tetrafunctional block copolymer 704 as a nonviral gene delivery vector to the lungs. SPECT/CT molecular imaging of gene expression, biochemical assays, and immunohistochemistry were used. Our dataset shows
C Hue-Beauvais et al.
Journal of animal science, 93(4), 1641-1655 (2015-05-29)
Alterations to the metabolic endocrine environment during early life are crucial to mammary gland development. Among these environmental parameters, the initial nutritional event after birth is the consumption of milk, which represents the first maternal support provided to mammalian newborns.
Nhu Thuy Can et al.
Fetal and pediatric pathology, 34(2), 80-90 (2014-10-30)
Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV) related disease in both children and adults, characterized by recurrent benign squamous papillomas of the respiratory mucosa. Malignant transformation is rare. The present report concerns the natural history of RRP in
Teresa Wierzba-Bobrowicz et al.
Folia neuropathologica, 52(4), 457-466 (2015-01-13)
Frontotemporal lobar degeneration (FTLD) with mutations in the MAPT (microtubule-associated protein tau) gene (FTLD with MAPT mutation) is a neurodegenerative disease with various clinical phenotypes. We present an Italian- Polish family with a IVS10+3G>A mutation in the MAPT gene, linked
Liu Junhui et al.
Microscopy research and technique, 78(9), 754-760 (2015-07-17)
To describe the microarchitecture of the annulus-endplate region with reference to disc herniation. Twenty-five motion segments (L1-2 to L5-S1) were harvested from five cadaveric spines (four males, one female). Superior and inferior annulus-endplate junctions were divided into anterior, lateral and
Young-Sun Nam et al.
World journal of gastroenterology, 21(7), 2030-2039 (2015-02-27)
To investigate the effects of mesenchymal stem cells (MSCs) on dextran sulfate sodium-induced inflammatory bowel disease (IBD). C57BL/6 mice were fed 3.5% (g/L) dextran sulfate sodium. On day seven, the mice received intraperitoneal injections of 1×10(6) MSCs. The survival rate
Hui Wang et al.
Arthritis research & therapy, 17, 4-4 (2015-01-13)
Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder that has pain and loss of joint function as major pathological features. In the present study, we explored the mechanisms of possible involvement and regulation of substance P (SP)
Chellappagounder Thangavel et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(21), 5468-5482 (2014-08-29)
Perturbations in the retinoblastoma pathway are over-represented in advanced prostate cancer; retinoblastoma loss promotes bypass of first-line hormone therapy. Conversely, preliminary studies suggested that retinoblastoma-deficient tumors may become sensitized to a subset of DNA-damaging agents. Here, the molecular and in
Jialin Liu et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 2305017-2305017 (2020-04-25)
Xiaoyukang Jiaonang (XYK) is a Chinese patent medicine approved by the National Medical Product Administration which is used to treat intracranial hematoma in China. In this study, we observed the molecular mechanism of XYK in hypoxia-inducible factor 1α (HIF-1α), inflammation
Alexander Nyström et al.
EMBO molecular medicine, 7(9), 1211-1228 (2015-07-22)
Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB)-a severe skin fragility disorder associated with lifelong blistering and disabling progressive soft tissue fibrosis. Causative therapies for this complex disorder face major hurdles, and clinical implementation remains elusive. Here
Ha Young Shin et al.
Neuromuscular disorders : NMD, 25(6), 502-510 (2015-04-15)
Dysferlinopathy comprises a group of autosomal recessive muscular dystrophies caused by mutations in the DYSF gene. Due to the large size of the gene and its lack of mutational hot spots, analysis of the DYSF gene is time-consuming and laborious
E A Kogan et al.
Bulletin of experimental biology and medicine, 157(5), 683-688 (2014-09-27)
We propose a new surgical approach to the treatment of familial colorectal adenomatous polyposis implying preservation of a portion of the rectum with removed mucosa. For reconstruction of the rectum, allotransplantation of the mixed culture of fetal allogenic somatic cells
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