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Christine Lin Chin et al.
BMC biotechnology, 15, 44-44 (2015-06-03)
Expression vector engineering technology is one of the most convenient and timely method for cell line development to meet the rising demand of novel production cell line with high productivity. Destabilization of dihydrofolate reductase (dhfr) selection marker by addition of
Hlengiwe Pretty Madlala et al.
PloS one, 10(6), e0128192-e0128192 (2015-06-06)
The triterpene oleanolic acid (OA) is known to possess antihypertensive actions. In the present study we to compared the effects of the triterpene on mean arterial blood pressure (MAP) and kidney function following acute administration in normotensive animals with those
Tara R deBoer et al.
Journal of inorganic biochemistry, 138, 24-30 (2014-05-27)
Peroxynitrite has been shown to play a critical role in inflammation and affords 3-nitrotyrosine as the hallmark product. The reported methods of generating this reactive nitrogen species in situ often fails to provide a high and steady flux of peroxynitrite
Mei-Ying Liao et al.
International journal of oncology, 46(4), 1788-1800 (2015-02-06)
We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chromatography, LC-MS/MS analysis, co-immunoprecipitation, and RNA interference studies, the target
Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production.
O D Saugstad
Pediatric research, 23(2), 143-150 (1988-02-01)
Alba Gigante et al.
European journal of medicinal chemistry, 82, 459-465 (2014-06-16)
8-Arylinosines have been scarcely studied for therapeutic purposes, probably due to difficulties in their synthesis. The recently described direct arylation reaction at position 8 of purine nucleosides has been employed to synthesize a series of 8-aryl and 8-pyridylinosines. These compounds
Aoli Xiong et al.
STAR protocols, 2(3), 100797-100797 (2021-09-17)
Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based on the same
Beata Wielgus-Kutrowska et al.
Bioorganic & medicinal chemistry, 20(22), 6758-6769 (2012-10-09)
Transition-state analogue inhibitors, immucillins, were reported to bind to trimeric purine nucleoside phosphorylase (PNP) with the stoichiometry of one molecule per enzyme trimer [Miles, R. W.; Tyler, P. C.; Furneaux, R. H.; Bagdassarian, C. K.; Schramm, V. L. Biochem. 1998
Juozas Nainys et al.
BMC biotechnology, 14, 100-100 (2014-12-10)
Porcine circovirus type 2 (PCV2) is considered to be an important emerging pathogen associated with a number of different syndromes and diseases in pigs known as PCV2-associated diseases. It has been responsible for significant mortality among pigs and remains a
Emilia Krypotou et al.
The Journal of biological chemistry, 287(44), 36792-36803 (2012-09-13)
The recent elucidation of crystal structures of a bacterial member of the NCS1 family, the Mhp1 benzyl-hydantoin permease from Microbacterium liquefaciens, allowed us to construct and validate a three-dimensional model of the Aspergillus nidulans purine-cytosine/H(+) FcyB symporter. The model consists
Chang-Fang Wang et al.
Acta biomaterialia, 16, 206-214 (2015-02-01)
Dual-drug delivery of antiangiogenic and chemotherapeutic drugs can enhance the therapeutic effect for cancer therapy. Conjugation of methotrexate (MTX) to porous silicon (PSi) nanoparticles (MTX-PSi) with positively charged surface can improve the cellular uptake of MTX and inhibit the proliferation
Galen P Miley et al.
Antimicrobial agents and chemotherapy, 59(9), 5555-5560 (2015-07-01)
ELQ-300 is a preclinical candidate that targets the liver and blood stages of Plasmodium falciparum, as well as the forms that are crucial to transmission of disease: gametocytes, zygotes, and ookinetes. A significant obstacle to the clinical development of ELQ-300
Phanida Phanthong et al.
Natural product communications, 10(8), 1387-1390 (2015-10-06)
Dolichandrone serrulata (DC.) Seem flowers are widely used as vegetables in northern and eastern Thailand. Biological studies of the methanolic extract of these flowers have shown promising antioxidant activity. Biological-guided separation of D. serrulata flowers yielded six compounds, identified as
Lucia Natarelli et al.
PloS one, 10(11), e0142421-e0142421 (2015-11-07)
Epidemiological studies suggest that moderate and prolonged consumption of coffee is associated with a reduced risk of developing type 2 diabetes but the molecular mechanisms underlying this effect are not known. In this study, we report the effects of physiological
Michael Horckmans et al.
Journal of immunology (Baltimore, Md. : 1950), 194(4), 1874-1881 (2015-01-18)
Nucleotides are released in the heart under pathological conditions, but little is known about their contribution to cardiac inflammation. The present study defines the P2Y4 nucleotide receptor, expressed on cardiac microvascular endothelial cells and involved in postnatal heart development, as
Harmanjit S Hira et al.
Annals of Saudi medicine, 34(4), 308-313 (2015-03-27)
Tissue hypoxia due to repeated apneas among patients of obstructive sleep apnea syndrome (OSAS) leads to cumulative oxidative stress. It is established that an increased plasma level of hypoxanthine/xanthine may serve as a criterion of tissue hypoxia. We presumed that
Maylis Raphaël et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(37), E3870-E3879 (2014-08-31)
Transient receptor potential vanilloid subfamily member 6 (TRPV6) is a highly selective calcium channel that has been considered as a part of store-operated calcium entry (SOCE). Despite its first discovery in the early 2000s, the role of this channel in
Jacek Zieliński et al.
European journal of applied physiology, 113(3), 763-773 (2012-09-12)
Changes in purine derivatives may be considered as signs of training-induced metabolic adaptations. The purpose of this study was to assess the effect of a 1-year training cycle on the response of hypoxanthine (Hx) concentration and Hx-guanine phosphoribosyltransferase (HGPRT) activity.
Abdulazeez T Lawal et al.
Talanta, 100, 217-228 (2012-11-13)
This review provides an update on the research conducted on the fabrication and utilization of hypoxanthine (Hx) biosensors published over the past four decades. In particular, the review focuses on progress made in the development and use of Hx biosensors
Talita P C Chierrito et al.
Malaria journal, 13, 142-142 (2014-04-16)
Several species of Aspidosperma (Apocynaceae) are used as treatments for human diseases in the tropics. Aspidosperma olivaceum, which is used to treat fevers in some regions of Brazil, contains the monoterpenoid indole alkaloids (MIAs) aspidoscarpine, uleine, apparicine, and N-methyl-tetrahydrolivacine. Using
Noa Hasky et al.
Human reproduction (Oxford, England), 30(5), 1089-1101 (2015-03-23)
Can gonadotrophin-releasing hormone agonists (GnRH-a) preserve long-term fertility when administered prior to and concomitantly with chemotherapy? GnRH-a display a differential protective effect on fertility, depending upon the specific chemotherapy-induced mechanism of ovarian injury. The role of GnRH-a in fertility preservation
Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx
Hempel C, et al.
Malaria Journal, 16(1), 1-11 (2017)
Paolo Alberton et al.
Stem cells and development, 24(5), 597-609 (2014-10-30)
Tenomodulin (Tnmd) is a well-known gene marker for the tendon and ligament lineage, but its exact functions in these tissues still remain elusive. In this study, we investigated Tnmd loss of function in mouse tendon stem/progenitor cells (mTSPC) by implicating
Qiong Li et al.
Molecular microbiology, 97(5), 1006-1020 (2015-06-06)
The causative agent of human African trypanosomiasis, Trypanosoma brucei, lacks de novo purine biosynthesis and depends on purine salvage from the host. The purine salvage pathway is redundant and contains two routes to guanosine-5'-monophosphate (GMP) formation: conversion from xanthosine-5'-monophosphate (XMP)
Xiyuan Liu et al.
Journal of laboratory automation, 20(4), 506-510 (2015-03-04)
Paper-based electrochemical biosensors are a promising technology that enables rapid, quantitative measurements on an inexpensive platform. However, the control of liquids in paper networks is generally limited to a single sample delivery step. Here, we propose a simple method to
D Mirmohammadi et al.
Journal of animal science, 93(8), 3843-3853 (2015-10-07)
During a 125-d experimental period, 24 Afshari × Kurdish male lambs initially weighing 25.2 ± 1.2 kg were grouped by BW and randomly assigned to treatments under a completely randomized design with a 2 × 2 factorial arrangement of treatments
Alvaro Mongui et al.
Malaria journal, 14, 233-233 (2015-06-05)
The chemical treatment of Plasmodium falciparum for human infections is losing efficacy each year due to the rise of resistance. One possible strategy to find novel anti-malarial drugs is to access the largest reservoir of genomic biodiversity source on earth
Ian A Lewis et al.
PLoS genetics, 10(1), e1004085-e1004085 (2014-01-07)
Drug resistant strains of the malaria parasite, Plasmodium falciparum, have rendered chloroquine ineffective throughout much of the world. In parts of Africa and Asia, the coordinated shift from chloroquine to other drugs has resulted in the near disappearance of chloroquine-resistant
Christian D Laourdakis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 127-133 (2014-08-05)
Targeted metabolite profiling has aided in the understanding of a variety of biological processes in the malaria parasite as well as in drug discovery. A fast and sensitive analytical method, based on ion-pairing reversed phase ultra-high performance liquid chromatography tandem
Li-Ting Liao et al.
Clinica chimica acta; international journal of clinical chemistry, 436, 72-77 (2014-05-13)
Uric acid measurement has become increasingly important, and electrochemically modified detection method based portable devices hold a dominant position in the market for point of care and self-monitoring of uric acid blood levels. However, there has been a lack of
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