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A Gostner et al.
The British journal of nutrition, 95(1), 40-50 (2006-01-31)
Due to its low digestibility in the small intestine, a major fraction of the polyol isomalt reaches the colon. However, little is known about effects on the intestinal microflora. During two 4-week periods in a double-blind, placebo-controlled, cross-over design, nineteen
Oliver Luhn et al.
Journal of pharmaceutical sciences, 101(8), 2675-2680 (2012-05-11)
There is a growing interest towards the application of inert cores as starting materials for pharmaceutical pellet manufacturing. They serve as alternatives to develop and adapt a relatively simple manufacturing technology compared with an extrusion/spheronisation process. The major objective of
Tongzhi Wu et al.
The American journal of clinical nutrition, 95(1), 78-83 (2011-12-14)
Macronutrient "preloads" can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both. We determined
Jitka Muzíková et al.
Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 60(1), 11-16 (2011-06-09)
The paper compares the compressibility of two directly compressible isomalts, galenIQ 720 and galenIQ721, using the energy evaluation of the compaction process by means of the force--displacement profiles. It evaluates the energies for friction, energies accumulated by the tablet, energy
F Ndindayino et al.
International journal of pharmaceutics, 235(1-2), 159-168 (2002-03-07)
Isomalt, a disaccharide alcohol was co-extruded with paracetamol or hydrochlorothiazide (HCT) in order to improve its tabletting properties. After extrusion, isomalt was transformed into an amorphous form, while paracetamol remained crystalline. Hot stage microscopy showed that HCT was amorphous in
David M Storey et al.
The British journal of nutrition, 87(4), 291-297 (2002-06-18)
Sugar-free confectionery products containing the low-energy, non-cariogenic sweetener isomalt are widely available in the market place and increasingly aimed at children. However, over-consumption of such products may lead to gastrointestinal symptoms and/or osmotic diarrhoea. Little is known about the gastrointestinal
A Lee et al.
European journal of clinical nutrition, 56(8), 755-764 (2002-07-18)
To determine the gastrointestinal responses of children and adults following consumption of sucrose, isomalt and lycasin HBC and to compare these at two different dose levels in adults. Both studies were randomised, double-blind, cross-over designs. Fifty-one children aged 6-9 y
Gerad K Bolhuis et al.
Drug development and industrial pharmacy, 35(6), 671-677 (2009-03-11)
Although polyols are frequently used as tablet excipients in lozenges, chewing tablets, and orodisperse tablets, special directly compressible (DC) forms are recommended as filler-binder in common disintegrating tablets. In this article, DC types of isomalt, lactitol, mannitol, sorbitol and xylitol
U Isik et al.
Journal of dairy science, 94(4), 1647-1656 (2011-03-24)
The objective of this study was to produce a frozen yogurt containing low fat and no added sugar. Samples containing 5% polydextrose, 0.065% aspartame and acesulfame-K mixture, and different levels of inulin and isomalt (5.0, 6.5, and 8.0%) were produced
F Ndindayino et al.
International journal of pharmaceutics, 235(1-2), 149-157 (2002-03-07)
Isomalt, a sugar alcohol, was melt-extruded prior to compression in order to improve its tabletting properties. After fusion, crystalline isomalt was transformed into an amorphous form as shown by X-ray diffraction and differential scanning calorimetry (DSC). The tabletting properties of
Ilija Ilić et al.
International journal of pharmaceutics, 446(1-2), 6-15 (2013-02-14)
This study investigated deformation mechanisms of some commonly used pharmaceutical fillers, such as microcrystalline cellulose, lactose, dicalcium phosphate, isomalt and cornstarch, using a combination of the in-die and out-die method with the Heckel and Walker models. The tableting mixtures contained
A D'Alessandro et al.
La Clinica terapeutica, 150(1), 29-32 (1999-06-15)
This study investigates the bowel function in outdoor runners drinking sweetened solutions both by determination of H2 in exhaled air and asking about intestinal discomfort. Twenty-two athletes with a mean age of 22 +/- 3 yrs, received 100 ml of
F Ndindayino et al.
International journal of pharmaceutics, 246(1-2), 199-202 (2002-09-25)
The bioavailability of hydrochlorothiazide (HCT) from moulded isomalt-based tablets was evaluated after oral administration of 50 mg HCT to healthy volunteers as an oral moulded tablet and as a lozenge, in comparison with a conventional tablet formulation (Dichlotride 50 mg).
What clients need to know about sugar replacers.
K McNutt
Journal of the American Dietetic Association, 100(4), 466-469 (2000-04-18)
G D Walker et al.
Caries research, 44(1), 33-40 (2010-01-22)
Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has been demonstrated to exhibit anticariogenic activity in randomized, controlled clinical trials of sugar-free gum and a tooth cream. Two randomized, double-blind, crossover studies were conducted to investigate the potential of CPP-ACP added to hard
István Antal et al.
Journal of pharmaceutical and biomedical analysis, 84, 124-128 (2013-07-06)
The major objective of this study was to disclose the relationships between the physical quality attributes and supramolecular structure of novel composite pellet cores containing microcrystalline cellulose (MCC) and isomalt in different ratios. The novel composite pellet cores were manufactured
F Ndindayino et al.
International journal of pharmaceutics, 189(1), 113-124 (1999-10-16)
Isomalt is a sugar substitute with a wide range of potential pharmaceutical applications as a result of its physicochemical properties. Four grades of this material were evaluated for their physical characteristics. Only Palatinit(R) C and F exhibited potential characteristics for
Gerad K Bolhuis et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 72(3), 621-625 (2009-03-31)
Although other polyols have been described extensively as filler-binders in direct compaction of tablets, the polyol isomalt is rather unknown as pharmaceutical excipient, in spite of its description in all the main pharmacopoeias. In this paper the compaction properties of
I Holub et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 41(12), 886-892 (2009-08-25)
The polyol isomalt (Palatinit) is a very low glycaemic sugar replacer. The effect of food supplemented with isomalt instead of higher glycaemic ingredients like sucrose and/or starch hydrolysates on metabolic control in patients with type 2 diabetes was examined in
J Kashimura et al.
Biological trace element research, 54(3), 239-250 (1996-09-01)
We carried out a balance study to examine the effects of isomaltulose, lactose, isomalt, and isomaltulose-based oligomers (IBOs) on mineral (calcium, magnesium, phosphorus, and iron) absorption and retention. Four-week-old male Wistar rats were divided into five groups of six rats
A Gostner et al.
The British journal of nutrition, 94(4), 575-581 (2005-10-04)
The polyol isomalt (Palatinit) is a well established sugar replacer. The impact of regular isomalt consumption on metabolism and parameters of gut function in nineteen healthy volunteers was examined in a randomised, double-blind, cross-over trial with two 4-week test periods.
Tsutomu Takatsuka et al.
Clinical oral investigations, 12(2), 173-177 (2007-12-25)
Isomalt is a non-cariogenic sweetener, which is widely used in sugar-free candy and chewing gum. Little is known about the effects of Isomalt on de- and remineralization. Binding between calcium and Isomalt has been reported, which could affect the mineral
Nikolett Kállai et al.
AAPS PharmSciTech, 11(1), 383-391 (2010-03-20)
The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of
Mohamed Hassan G Dehghan et al.
AAPS PharmSciTech, 14(1), 53-59 (2012-12-12)
Lactulose is used as a triggering substance in a unique colon-specific delivery technology called CODESTM. Colonic microflora degrades lactulose and forms short-chain fatty acids to activate the CODESTM system. However, lactulose has been reported to cause a Maillard-type reaction with
Susanne Bredenberg et al.
Pharmaceutical development and technology, 18(6), 1366-1371 (2012-09-25)
This study investigated a sieve classification method for evaluating carrier materials and particle size fractions, which could be a valuable tool in the early development of pharmaceutical dosage forms containing low-dose interactive mixtures. When developing new products based on interactive
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