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显示 1-30 #N/A 173 条结果 关于 "I2018" 范围 论文
Lucie Yammine et al.
Molecular metabolism, 78, 101831-101831 (2023-11-05)
Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand
Gillian I Bell et al.
Current protocols in stem cell biology, 26, 2B-2B (2014-02-11)
This unit describes our current knowledge regarding the isolation human bone marrow-derived progenitor cells for the paracrine stimulation of islet regeneration after transplantation into immunodeficient mouse models of diabetes. By using high aldehyde dehydrogenase (ALDH(hi) ) activity, a conserved function
Divya P Kumar et al.
The Journal of biological chemistry, 291(13), 6626-6640 (2016-01-14)
The physiological role of the TGR5 receptor in the pancreas is not fully understood. We previously showed that activation of TGR5 in pancreatic β cells by bile acids induces insulin secretion. Glucagon released from pancreatic α cells and glucagon-like peptide
Manal M Elbandrawy et al.
Saudi journal of biological sciences, 29(5), 3871-3880 (2022-07-19)
Type 2 diabetes (T2DM) is a chronic metabolic disorder. Although therapeutic pharmaceutical agents continue to advance, herbal medicines are potential complementary treatments for the promotion of glucose homeostasis, with minimal adverse effects. Conventionally, ellagic acid (EA) has been utilized for
Laura Ariza et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 247(7), 924-933 (2018-05-01)
The Wilms tumor suppressor gene (Wt1) encodes a transcription factor involved in the development of a number of organs, but the role played by Wt1 in pancreatic development is unknown. The pancreas contains a population of pancreatic stellate cells (PSC)
Décio L Eizirik et al.
PLoS genetics, 8(3), e1002552-e1002552 (2012-03-14)
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or
Alyaa Farid et al.
Saudi journal of biological sciences, 29(7), 103313-103313 (2022-06-17)
Melatonin, a pleiotropic hormone, has many regulatory effects on the circadian and seasonal rhythms, sleep and body immune system. It is used in the treatment of blind circadian rhythm sleep disorders, delayed sleep phase and insomnia. It is a potent
Ishant Khurana et al.
NPJ Regenerative medicine, 6(1), 7-7 (2021-02-14)
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in
Heja Aga et al.
Frontiers in genetics, 11, 567191-567191 (2020-11-03)
Type 2 diabetes (T2D) is a complex metabolic disease regulated by an interaction of genetic predisposition and environmental factors. To understand the genetic contribution in the development of diabetes, mice varying in their disease susceptibility were crossed with the obese
Ioannis Giannios et al.
Stem cells (Dayton, Ohio), 37(5), 640-651 (2019-01-27)
Understanding the mechanisms that promote the specification of pancreas progenitors and regulate their self-renewal and differentiation will help to maintain and expand pancreas progenitor cells derived from human pluripotent stem (hPS) cells. This will improve the efficiency of current differentiation
Daisong Wang et al.
Cell, 180(6), 1198-1211 (2020-03-24)
It has generally proven challenging to produce functional β cells in vitro. Here, we describe a previously unidentified protein C receptor positive (Procr+) cell population in adult mouse pancreas through single-cell RNA sequencing (scRNA-seq). The cells reside in islets, do not
Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice.
Samantha M Solon-Biet et al.
Cell reports, 11(10), 1529-1534 (2015-06-02)
Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose, and blood lipids. Severe CR, however, is unsustainable for most people; therefore, it is important to determine whether manipulating macronutrient
Chloé Amouyal et al.
EBioMedicine, 58, 102895-102895 (2020-08-03)
Bariatric surgery is an effective treatment for type 2 diabetes. Early post-surgical enhancement of insulin secretion is key for diabetes remission. The full complement of mechanisms responsible for improved pancreatic beta cell functionality after bariatric surgery is still unclear. Our
Ayumi Horikawa et al.
PloS one, 16(7), e0254373-e0254373 (2021-07-13)
Human induced pluripotent stem cells (hiPSCs) are considered a promising source of pancreatic β-cells for the treatment of diabetes. However, this approach is limited by issues such as low efficiency and high cost. Here, we have developed a new protocol
Theodora Yung et al.
Nature communications, 10(1), 4647-4647 (2019-10-13)
Human embryonic stem cell-derived beta cells offer a promising cell-based therapy for diabetes. However, efficient stem cell to beta cell differentiation has proven difficult, possibly due to the lack of cross-talk with the appropriate mesenchymal niche. To define organ-specific niche
Lin Wang et al.
Journal of translational medicine, 16(1), 297-297 (2018-10-26)
Neurogenin3 (Ngn3) and neurogenic differentiation 1 (NeuroD1), two crucial transcriptional factors involved in human diabetes (OMIM: 601724) and islet development, have been previously found to directly target to the E-boxes of the insulinoma-associated 2 (Insm2) gene promoter, thereby activating the
Xiao-Yi Zeng et al.
PloS one, 7(7), e42115-e42115 (2012-08-04)
The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J mice were fed a high-fat diet followed by low doses of streptozotocin to generate a
Adam Wang et al.
International journal of physiology, pathophysiology and pharmacology, 11(4), 115-125 (2019-09-17)
The growth of neurites underlies the axonal pathfinding and synaptic formation during neuronal development and regeneration. Neurite growth is regulated by specific interactions between growth cone receptors and their ligands that function as molecular cues existing in microenvironments. Neurexins (NRXNs)
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Wang F, et al.
Diabetes, 50(11), 2514-2520 (2001)
Pascale de Lonlay et al.
The Journal of clinical endocrinology and metabolism, 91(3), 933-940 (2006-01-13)
Congenital hyperinsulinism (HI) is characterized by hypoglycemia related to inappropriate insulin secretion. Focal and diffuse forms of hyperinsulinism share a similar clinical presentation, but their treatment is dramatically different. Preoperative differential diagnosis was based on pancreatic venous sampling, a technically
Sara McEwan et al.
Molecular metabolism, 53, 101260-101260 (2021-05-24)
The regulation of glucose-stimulated insulin secretion and glucose excursion has a sensory component that operates in a sex-dependent manner. Here, we aim to dissect the basis of the sexually dimorphic interaction between sensory neurons and pancreatic β cells and its
Cheng-Chieh Hsu et al.
Protein science : a publication of the Protein Society, 33(2), e4854-e4854 (2023-12-08)
Type 2 diabetes (T2D) results from insulin secretory dysfunction arising in part from the loss of pancreatic islet β-cells. Several factors contribute to β-cell loss, including islet amyloid formation, which is observed in over 90% of individuals with T2D. The
Melis Karaca et al.
Cell reports, 13(2), 365-375 (2015-10-07)
Glucose, the main energy substrate used in the CNS, is continuously supplied by the periphery. Glutamate, the major excitatory neurotransmitter, is foreseen as a complementary energy contributor in the brain. In particular, astrocytes actively take up glutamate and may use
Thomas A Legøy et al.
Acta physiologica (Oxford, England), 228(4), e13433-e13433 (2019-12-25)
The loss of insulin-secreting β-cells, ultimately characterizing most diabetes forms, demands the development of cell replacement therapies. The common endpoint for all ex vivo strategies is transplantation into diabetic patients. However, the effects of hyperglycaemia environment on the transplanted cells
Sapna Puri et al.
Nature communications, 15(1), 588-588 (2024-01-19)
Despite significant research, mechanisms underlying the failure of islet beta cells that result in type 2 diabetes (T2D) are still under investigation. Here, we report that Sox9, a transcriptional regulator of pancreas development, also functions in mature beta cells. Our
Heidrun Vethe et al.
Frontiers in endocrinology, 10, 293-293 (2019-05-30)
Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of
Juan de Toro-Martín et al.
Scientific reports, 10(1), 17651-17651 (2020-10-21)
Maternal malnutrition plays a critical role in the developmental programming of later metabolic diseases susceptibility in the offspring, such as obesity and type 2 diabetes. Because the liver is the major organ that produces and supplies blood glucose, we aimed
Shigeru Murakami et al.
Metabolites, 12(6) (2022-06-24)
Taurine is a sulfated amino acid derivative that plays an important role in maintaining the cell function of the living body. Although taurine has been shown to ameliorate diabetes, its mechanism of action has not yet been fully elucidated. The
Ryosuke Inoue et al.
FEBS open bio, 8(3), 449-460 (2018-03-08)
The development of therapeutic options to promote hepatic regeneration following severe liver injury is essential. While humoral factors have been reported as mechanisms of liver regeneration, the contributions of interorgan communication to liver regeneration have not been reported. In this
Roger Lehmann et al.
Diabetes, 56(3), 594-603 (2007-03-01)
Many factors influence the outcome of islet transplantation. As islets in the early posttransplant setting are supplied with oxygen by diffusion only and are in a hypoxic state in the portal system, we tested whether small human islets are superior
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