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I2018
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显示 1-30 #N/A 174 条结果 关于 "I2018" 范围 论文
Irene Andrés-Blasco et al.
The Journal of endocrinology, 227(3), 179-191 (2015-10-02)
Metabolic syndrome and type 2 diabetes mellitus constitute a major problem to global health, and their incidence is increasing at an alarming rate. Non-alcoholic fatty liver disease, which affects up to 90% of obese people and nearly 70% of the
Kentaro Nakamura et al.
Transplant international : official journal of the European Society for Organ Transplantation, 29(9), 1039-1050 (2016-06-17)
Cell death cluster in transplanted cells remains a critical obstacle for regeneration strategies. This study describes a novel platform for cell transplantation (CellSaic) consisting of human mesenchymal stem cells (hMSCs) and petaloid pieces of recombinant peptide (RCP), which can prevent
Charting a high-resolution roadmap for regeneration of pancreatic I? cells by in vivo transdifferentiation from adult acinar cells.
Liu, et al.
Science Advances, 9, eadg2183-eadg2183 (2023)
Wan J Gan et al.
Journal of cell science, 130(1), 143-151 (2016-02-28)
The structural organisation of pancreatic β-cells in the islets of Langerhans is relatively unknown. Here, using three-dimensional (3D) two-photon, 3D confocal and 3D block-face serial electron microscopy, we demonstrate a consistent in situ polarisation of β-cells and define three distinct
Jin-Yong Chung et al.
iScience, 26(4), 106439-106439 (2023-04-07)
Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To understand transcriptional changes driving these adaptations in β-cells and other islet cell types, we performed single-cell RNA
Himadri Singh et al.
Islets, 6(5-6), e998099-e998099 (2015-04-04)
WNIN/GR-Ob mutant rat is a novel animal model to study metabolic syndrome (obesity, insulin resistance, hyperinsulinemia, impaired glucose tolerance and cardiovascular diseases). We have investigated the islet characteristics of obese mutants at different age groups (1, 6 and 12 months)
Elisabeth Kemter et al.
Proceedings of the National Academy of Sciences of the United States of America, 118(37) (2021-09-12)
β cells produce, store, and secrete insulin upon elevated blood glucose levels. Insulin secretion is a highly regulated process. The probability for insulin secretory granules to undergo fusion with the plasma membrane or being degraded is correlated with their age.
Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.
Ruiz-Otero, et al.
Frontiers in Endocrinology, 14, 1161085-1161085 (2023)
Gozde Uzunalli et al.
Acta biomaterialia, 22, 8-18 (2015-05-02)
Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However, viability and functionality of the islets after transplantation are limited due to loss of integrity and destruction of blood vessel networks. Thus, it is important to provide a
Yan Yang et al.
Metabolism: clinical and experimental, 123, 154863-154863 (2021-08-11)
Reduced β-cell mass and impaired β-cell function are primary causes of all types of diabetes. However, the intrinsic molecular mechanism that regulates β-cell growth and function remains elusive. Here, we demonstrate that the small GTPase Rheb1 is a critical regulator
Satoshi Ninagawa et al.
eLife, 9 (2020-11-18)
Second-generation antipsychotics are widely used to medicate patients with schizophrenia, but may cause metabolic side effects such as diabetes, which has been considered to result from obesity-associated insulin resistance. Olanzapine is particularly well known for this effect. However, clinical studies
Seiga Ohmine et al.
Aging, 4(1), 60-73 (2012-02-07)
Nuclear reprogramming enables patient-specific derivation of induced pluripotent stem (iPS) cells from adult tissue. Yet, iPS generation from patients with type 2 diabetes (T2D) has not been demonstrated. Here, we report reproducible iPS derivation of epidermal keratinocytes (HK) from elderly
Habiba Alaa et al.
Scientific reports, 13(1), 10617-10617 (2023-07-01)
Nanotechnology is used to overcome fundamental flaws in today's marketed pharmaceuticals that obstruct therapy, like restricted solubility and quick release of drugs into the bloodstream. In both human and animal researches, melatonin was demonstrated to regulate glucose levels. Despite the
Metabolic endotoxemia initiates obesity and insulin resistance.
Cani P D, et al.
Diabetes, 56(7), 1761-1772 (2007)
T Thatava et al.
Gene therapy, 18(3), 283-293 (2010-11-05)
Nuclear reprogramming of somatic tissue enables derivation of induced pluripotent stem (iPS) cells from an autologous, non-embryonic origin. The purpose of this study was to establish efficient protocols for lineage specification of human iPS cells into functional glucose-responsive, insulin-producing progeny.
Divya P Kumar et al.
The Journal of biological chemistry, 291(13), 6626-6640 (2016-01-14)
The physiological role of the TGR5 receptor in the pancreas is not fully understood. We previously showed that activation of TGR5 in pancreatic β cells by bile acids induces insulin secretion. Glucagon released from pancreatic α cells and glucagon-like peptide
Ishant Khurana et al.
NPJ Regenerative medicine, 6(1), 7-7 (2021-02-14)
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findings emphasise DNA methylation is a barrier in
Cheng-Chieh Hsu et al.
Protein science : a publication of the Protein Society, 33(2), e4854-e4854 (2023-12-08)
Type 2 diabetes (T2D) results from insulin secretory dysfunction arising in part from the loss of pancreatic islet β-cells. Several factors contribute to β-cell loss, including islet amyloid formation, which is observed in over 90% of individuals with T2D. The
Lucie Yammine et al.
Molecular metabolism, 78, 101831-101831 (2023-11-05)
Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand
Décio L Eizirik et al.
PLoS genetics, 8(3), e1002552-e1002552 (2012-03-14)
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic beta cells are killed by infiltrating immune cells and by cytokines released by these cells. Signaling events occurring in the pancreatic beta cells are decisive for their survival or
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Joy G Ghosh et al.
Biochemistry, 46(21), 6308-6317 (2007-05-10)
Protein pin arrays assessed interactions between alphaB crystallin and 12 regulatory proteins, including EGF, FGF-2, IGF-1, NGF-beta, TGF-beta, VEGF, insulin, beta-catenin, caspase-3, caspase-8, Bcl-2, and Bcl-xL, which are important in cellular differentiation, proliferation, signaling, cytoskeletal assembly, and apoptosis. FGF-2, NGF-beta
Luiza Ghila et al.
Biomedicines, 8(7) (2020-07-02)
Mutations in the hepatocyte nuclear factor 4α (HNF4α) gene affect prenatal and postnatal pancreas development, being characterized by insulin-producing β-cell dysfunction. Little is known about the cellular and molecular mechanisms leading to β-cell failure as result of HNF4α mutation. In
Alonso Camacho-Ramírez et al.
Tissue & cell, 57, 78-83 (2019-04-06)
The aim of this study is to describe in depth how different bariatric surgeries affect to the cellularity of β-cells in the pancreatic islet. There are much data regarding the possible physiological mechanisms involved in resolution of type 2 diabetes
Christopher Gribben et al.
Cell stem cell, 28(11), 2000-2008 (2021-09-04)
Ductal cells have been proposed as a source of adult β cell neogenesis, but this has remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA sequencing (scRNA-seq) approaches, we show that ductal cells contribute to the β cell
Sergey N Zolov et al.
The Journal of biological chemistry, 296, 100712-100712 (2021-04-30)
The retinal insulin receptor (IR) exhibits basal kinase activity equivalent to that of the liver of fed animals, but unlike the liver, does not fluctuate with feeding and fasting; it also declines rapidly after the onset of insulin-deficient diabetes. The
Andreas Blutke et al.
Molecular metabolism, 6(8), 931-940 (2017-07-29)
The prevalence of diabetes mellitus and associated complications is steadily increasing. As a resource for studying systemic consequences of chronic insulin insufficiency and hyperglycemia, we established a comprehensive biobank of long-term diabetic INSC94Y transgenic pigs, a model of mutant INS
Sohei Tsukita et al.
EBioMedicine, 15, 163-172 (2016-12-16)
Major symptoms of diabetes mellitus manifest, once pancreatic β-cell numbers have become inadequate. Although natural regeneration of β-cells after injury is very limited, bone marrow (BM) transplantation (BMT) promotes their regeneration through undetermined mechanism(s) involving inter-cellular (BM cell-to-β-cell) crosstalk. We
Irini Topalidou et al.
Molecular biology of the cell, 31(1), 59-79 (2019-11-14)
Dense-core vesicles (DCVs) are secretory vesicles found in neurons and endocrine cells. DCVs package and release cargoes including neuropeptides, biogenic amines, and peptide hormones. We recently identified the endosome-associated recycling protein (EARP) complex and the EARP-interacting-protein EIPR-1 as proteins important
Weixiang Liu et al.
Nutrition & metabolism, 16, 34-34 (2019-05-30)
Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to determine how blueberry affects glucose metabolism and pancreatic β-cell proliferation in
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