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J-C Makenga Bof et al.
Tropical medicine & international health : TM & IH, 20(1), 48-62 (2014-10-11)
To evaluate onchocerciasis control activities in the Democratic Republic of Congo (DRC) in the first 12 years of community-directed treatment with ivermectin (CDTI). Data from the National Programme for Onchocerciasis (NPO) provided by the National Onchocerciasis Task Force (NOTF) through the
Md Musfiqur Rahman et al.
Environmental monitoring and assessment, 185(11), 9461-9469 (2013-06-05)
The pre-harvest residue limit (PHRL) of abamectin (abamectin B1a and B1b) in Perilla frutescens leaves grown under greenhouse conditions were investigated using high-performance liquid chromatography with a fluorescence detector. Samples were extracted with acetonitrile. The extract was purified through a
Wolfram Gottfried Metzger et al.
The Lancet. Infectious diseases, 14(4), 353-357 (2013-12-18)
More than 10 million people in western and central Africa are estimated to be infected with Loa loa filarial nematodes. Like most other infectious diseases, L loa filariasis (loiasis) covers a wide range of symptoms. Severe complications have been reported;
Meeting of the International Task Force for Disease Eradication, January 2014.
Releve epidemiologique hebdomadaire, 89(15), 153-160 (2014-04-23)
S Omura
International journal of antimicrobial agents, 31(2), 91-98 (2007-11-27)
Ivermectin is a drug that many people will never have heard of. Yet thousands of villagers of all ages in communities scattered throughout the remotest parts of Africa and Latin America know its name, and some experts regard it as
G Molinari et al.
Cytogenetic and genome research, 128(1-3), 37-45 (2010-04-15)
Abamectin and Ivermectin are 2 closely related members of the Avermectin family of 16-membered macrocyclic lactones derived from the actinomycete Streptomyces avermectinius which exhibit extraordinary anthelmintic activity. They are used worldwide in veterinary and human medicine as well as in
Mario A Rodríguez-Pérez et al.
PLoS neglected tropical diseases, 7(3), e2133-e2133 (2013-04-05)
The Southern Chiapas focus of onchocerciasis in Southern Mexico represents one of the major onchocerciasis foci in Latin America. All 559 endemic communities of this focus have undergone semi-annual mass treatment with ivermectin since 1998. In 50 communities of this
Ivermectin for scabies and headlice: veterinary use only.
Mark N Lowenthal
The Israel Medical Association journal : IMAJ, 15(5), 262-262 (2013-07-12)
Aránzazu González-Canga et al.
Current drug metabolism, 10(4), 359-368 (2009-06-13)
The antiparasitic activity of ivermectin depends on the presence of an active drug concentration at the site of parasites location for an adapted length of time. Ivermectin interactions with another concurrently administered drug can occur. Concomitant administration of some drugs
Liang Luo et al.
Chemico-biological interactions, 203(2), 430-439 (2013-03-26)
Avermectin (AVM) is a macrocyclic lactone agent widely used as a nematicide, acaricide and insecticide in veterinary medicine and plant protection. P-glycoprotein (P-gp) is an ATP-dependent drug efflux pump for xenobiotic compounds, and is involved in multidrug resistance. To understand
Thorsten Althoff et al.
Nature, 512(7514), 333-337 (2014-08-22)
Cys-loop receptors are neurotransmitter-gated ion channels that are essential mediators of fast chemical neurotransmission and are associated with a large number of neurological diseases and disorders, as well as parasitic infections. Members of this ion channel superfamily mediate excitatory or
Cytokine responses to egg protein in previously allergic children who developed tolerance naturally.
Anna B Fishbein et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 113(6), 667-670 (2014-10-06)
Valerie Kvaternick et al.
Veterinary parasitology, 202(1-2), 2-9 (2014-04-08)
Four studies were conducted to determine the pharmacokinetic characteristics and in vitro metabolism of eprinomectin, a semi-synthetic avermectin, in cats. Pharmacokinetic parameters including bioavailability of eprinomectin were determined in a parallel study design comprised of one group of eight cats
Aránzazu González Canga et al.
The AAPS journal, 10(1), 42-46 (2008-05-01)
Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. Since 1987, this compound has a widespread use in veterinary medicine and it use has been extended in humans.
Jemma Cripps et al.
Journal of wildlife diseases, 49(3), 535-544 (2013-06-20)
Effective anthelmintics are valuable tools for biologists conducting manipulative field experiments to examine effects of parasites on wildlife. However, before such experiments are carried out the efficacy of these drugs must be determined. We conducted three field experiments (May 2010-September
Sarah Murri et al.
Veterinary parasitology, 203(1-2), 114-119 (2014-03-26)
Eprinomectin (EPN) is a member of the avermectin class of compounds and the only anthelmintic registered for goats in Switzerland with a zero milk withdrawal period. The aim of the present study was to identify the actual efficacy of EPN
Eric Tielemans et al.
Veterinary parasitology, 202(1-2), 26-29 (2014-04-08)
Although foxes are the main reservoir of Echinococcus multilocularis, it is recognized that dogs and cats also may become infected. In cats the infection and egg production rates are usually low. Nevertheless, cats are a potential source of transmission of
E Tielemans et al.
Veterinary parasitology, 202(1-2), 59-63 (2014-04-08)
Five controlled, blinded and randomized studies were conducted to examine the efficacy of a single topical application of a combination of fipronil, (S)-methoprene, eprinomectin, and praziquantel (BROADLINE(®), Merial) against induced infestations with Ixodes ticks on cats. Three studies investigated the
M Escribano et al.
Current pharmaceutical biotechnology, 13(6), 987-998 (2011-11-02)
From a human safety perspective, the administration of ivermectin to food producing animal species entails potential risks related to the presence of drug residues in edible tissues, milk, and other derived products. The European Medicines Agency has established the maximum
Christine F Baker et al.
Veterinary parasitology, 202(1-2), 49-53 (2014-04-08)
Cats may be infected by heartworm, Dirofilaria immitis, through mosquito bites. They can develop severe heartworm disease when infective D. immitis larvae migrate and develop into adults in the pulmonary vasculature or other tissues. As there is no curative treatment
Leanne M Fox
Current opinion in infectious diseases, 19(6), 588-593 (2006-11-01)
Ivermectin was first discovered and used in veterinary medicine over 20 years ago. This review highlights some of the recent published research from 2005 through June 2006 on the use of ivermectin in both helminth and arthropod infection. In recent
Loa loa: neglected neurology and nematodes.
David Holmes
The Lancet. Neurology, 12(7), 631-632 (2013-06-19)
Iu V Lopatina et al.
Meditsinskaia parazitologiia i parazitarnye bolezni, (1)(1), 20-27 (2013-06-29)
The activity of insecticides (CK50, CK95 ) from different chemical classes against permethrin-resistant body and head lice was investigated. Having developed resistance to pyrethroids (permethrin, d-phenothrin, cypermethrin, and deltamethrin), the lice remain susceptible to organophosphorus compounds, phenylpyrazoles, neonicotinoids, and avermectins.
Martin Knaus et al.
Veterinary parasitology, 202(1-2), 18-25 (2014-04-08)
The efficacy of a novel topical combination formulation of fipronil, (S)-methoprene, eprinomectin and praziquantel against naturally acquired intestinal nematode and cestode infections in cats was evaluated in seven negative control, blinded studies. Cats were selected based on a pre-treatment faecal
Comparative trial of oral ivermectin versus sulfur 8% ointment for the treatment of scabies.
Mohamad Goldust et al.
Journal of cutaneous medicine and surgery, 17(5), 299-300 (2013-09-27)
[Larva migrans].
Thomas Larsen Reilev et al.
Ugeskrift for laeger, 175(14), 969-969 (2013-04-16)
Guilherme Herzog-Neto et al.
The American journal of tropical medicine and hygiene, 90(1), 96-98 (2013-12-04)
To determine the influence of onchocercal eye disease on the intraocular pressure of the Yanomami Tribe Aratha-ú of Roraima State, Brazil, considered endemic for onchocerciasis, a total of 86 patients were submitted to an ophthalmologic exam that included external examination
V Vijayasree et al.
Environmental monitoring and assessment, 186(7), 4499-4506 (2014-04-01)
Dissipation and decontamination of the semisynthetic macrolide emamectin benzoate and the natural insecticide spinosad on cowpea pods were studied following field application at single and double doses of 11.0 and 22 and 73 and 146 g ai ha(-1), respectively. Residues of these naturalytes
River blindness elimination in Columbia.
Talha Burki
The Lancet. Infectious diseases, 13(11), 922-923 (2013-12-10)
Hannah C Slater et al.
The Journal of infectious diseases, 210(12), 1972-1980 (2014-06-22)
Ivermectin (IVM), used alongside mass treatment strategies with an artemisinin combination therapy, has been suggested as a possible tool for reducing malaria transmission. Mosquitoes ingesting a bloodmeal containing IVM have increased mortality, reducing the probability that the parasite completes sporogony.
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