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immunoglobulin kappa variable 1/OR-1 (pseudogene)
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关键词:'immunoglobulin kappa variable 1/OR-1 (pseudogene)'
显示 1-30 共 42 条结果 关于 "immunoglobulin kappa variable 1/OR-1 (pseudogene)" 范围 论文
E Lötscher et al.
Nature, 320(6061), 456-458 (1986-04-03)
The gene segments encoding the constant and variable regions of human immunoglobulin light chains of the kappa type (C kappa, V kappa) have been localized to chromosome 2. The distance between the C kappa and V kappa genes and the
R S Liou et al.
Journal of immunology (Baltimore, Md. : 1950), 143(12), 3967-3975 (1989-12-15)
Murine mAb BAT123, which was made against the envelope glycoprotein gp120 of HTLV-IIIB strain of HIV type 1 (HIV-1), is capable of neutralizing HTLV-IIIB in vitro. It also inhibits the fusion between uninfected CD4+ cells and HIV-1-infected cells to form
L Briant et al.
The Journal of biological chemistry, 272(31), 19441-19450 (1997-08-01)
The role of CD4 during the human immunodeficiency virus type 1 (HIV-1) life cycle in T cells is not restricted to binding functions. HIV-1 binding to CD4 also triggers signals that lead to nuclear translocation of NF-kappaB and are important
J M Pléau et al.
Molecular immunology, 30(14), 1257-1264 (1993-10-01)
The nonobese diabetic (NOD) mouse is a model of human type I diabetes. This diabetes is due to massive infiltration of the pancreatic beta cell of islets by autoreactive T cells (insulitis) followed by the destruction of insulin-producing cells. Circulating
Richard J N Allcock et al.
European journal of immunology, 33(2), 567-577 (2003-03-21)
We have characterized a cluster of single immunoglobulin variable (IgV) domain receptors centromeric of the major histocompatibility complex (MHC) on human chromosome 6. In addition to triggering receptor expressed on myeloid cells (TREM)-1 and TREM2, the cluster contains NKp44, a
M H Parseghian et al.
Journal of cellular biochemistry, 83(4), 643-659 (2001-12-18)
For nearly twenty years researchers have observed changes in the histone H1 subtype content of tissues as an organism develops into an adult. To better understand the consequences of such changes, immunofractionation of chromatin using previously characterized antibodies specific for
M Pech et al.
Nucleic acids research, 12(24), 9229-9236 (1984-12-21)
The variable regions of immunoglobulins are encoded by multigene families which are rearranged during B-cell differentiation. These families were classified in groups and subgroups based on their amino acid sequences. Genes belonging to a distinct subgroup are believed to occur
T J Henderson et al.
Immunogenetics, 37(6), 426-436 (1993-01-01)
To examine genetic variation at immunoglobulin (Ig) multigene loci over short spans of evolutionary time, we have compared members of an Ig kappa chain variable (V kappa) region family from several mouse species. In this study, seven unique Igk-V24 family
F Matsuda et al.
The Journal of experimental medicine, 188(11), 2151-2162 (1998-12-08)
The complete nucleotide sequence of the 957-kb DNA of the human immunoglobulin heavy chain variable (VH) region locus was determined and 43 novel VH segments were identified. The region contains 123 VH segments classifiable into seven different families, of which
C A Reynaud et al.
Cell, 40(2), 283-291 (1985-02-01)
The chicken immunoglobulin lambda locus contains a single C lambda gene with a unique J lambda element, 1.9 kb upstream. The same V lambda gene (V lambda 1) is rearranged in most cells of the Bursa of Fabricius. This V
S Xiao et al.
Zhonghua wai ke za zhi [Chinese journal of surgery], 34(1), 13-15 (1996-01-01)
We have designed two sets of oligonucleotide primers to amplify the immunoglobulin heavy- and light-chain variable region genes from genomic DNA by the polymerase chain reaction, PCR. The genomic DNA was extracted from hybridoma BDI-1 cell, which secrets a monoclonal
B H Nilson et al.
The Journal of biological chemistry, 267(4), 2234-2239 (1992-02-05)
Protein L is an immunoglobulin light chain-binding protein expressed by some strains of the anaerobic bacterial species Peptostreptococcus magnus. The major variable region subgroups of human kappa and lambda light chains were tested for protein L binding; V kappa I
M Weigert et al.
Nature, 276(5690), 785-790 (1978-12-21)
The nearly complete amino-acid sequences of 22 closely related immunoglobulin kappa variable (Vkappa) regions from the inbred NZB mouse are presented. This group of Vkappa regions is encoded by at least six germline Vkappa genes. These data also suggest that
M Kawaichi et al.
The Journal of biological chemistry, 267(6), 4016-4022 (1992-02-25)
We have isolated a cDNA clone (RBP-2) for the protein (RBP-J kappa) which binds to immunoglobulin recombination signals with 23-base pair spacers (Matsunami, N., Hamaguchi, Y., Yamamoto, Y., Kuze, K., Kangawa, K., Matsuo, H., Kawaichi, M., and Honjo, T. (1989)
S Eccles et al.
The New biologist, 2(9), 801-811 (1990-09-01)
In contrast to the mouse immunoglobulin heavy chain and kappa light chain genes, very little is known about the regulation of expression of the immunoglobulin lambda light chain locus. To identify elements responsible for lambda gene regulation we mapped DNaseI
T J Vasicek et al.
The Journal of experimental medicine, 172(2), 609-620 (1990-08-01)
We determined the DNA sequence of two large regions of chromosome 22: 33.7 kb containing the C lambda complex; and 5.2 kb 5' of the functionally rearranged lambda gene from the human myeloma, U266. Analysis of these sequences reveals the
Fei Xiao et al.
Brain research, 1255, 180-189 (2008-12-27)
Proteomic analysis of cerebrospinal fluid (CSF) from patients with temporal lobe epilepsy (TLE) and controls was carried out using two-dimensional gel electrophoresis followed by liquid chromatography electrospray ionization tandem mass spectrometry. Five protein spots showed significant differential expression (p<0.05): vitamin
Muriel Viau et al.
Infection and immunity, 72(6), 3515-3523 (2004-05-25)
Some pathogens have evolved to produce proteins, called B-cell superantigens, that can interact with human immunoglobulin variable regions, independently of the combining site, and activate B lymphocytes that express the target immunoglobulins. However, the in vivo consequences of these interactions
L Reininger et al.
Journal of immunology (Baltimore, Md. : 1950), 138(1), 316-323 (1987-01-01)
The variable (V) region sequences of six immunoglobulin M (IgM, kappa) monoclonal autoantibodies that recognize bromelinized isologous red blood cells, obtained by fusions of peritoneal cells from NZB or CBA/J nonimmunized mice with BALB/c myeloma cells, were determined by direct
Stephen Malin et al.
Nature immunology, 11(2), 171-179 (2009-12-01)
STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus. Using conditional mutagenesis to delete the gene
W Altenburger et al.
Nucleic acids research, 9(4), 971-981 (1981-02-25)
The constant (C; ref. 3) gene segment of the immunoglobulin kappa light chain and about 1 kb upstream as well as downstream of the segment have been sequenced. The sequences of the C gene segment itself and parts of the
R Kofler et al.
Immunogenetics, 29(2), 65-74 (1989-01-01)
To define the polymorphism and extent of the mouse immunoglobulin kappa (Igk) gene complex, we have analyzed restriction-enzyme digested genomic DNA from 33 inbred strains of mice with labeled DNA probes corresponding to 16 Vk protein groups (1 of them
R T Boyd et al.
Proceedings of the National Academy of Sciences of the United States of America, 83(23), 9134-9138 (1986-12-01)
Two phenotypic markers of mouse immunoglobulin kappa light chains, the IB-peptide marker and the Ef1a isoelectric focusing marker, are expressed by the C58/J, AKR/J, RF/J, and PL/J strains (called expressor strains) but not by BALB/c and most inbred strains. Expression
T J Kipps et al.
The Journal of experimental medicine, 167(3), 840-852 (1988-03-01)
Recently the minor B cell subpopulation that expresses the CD5 (Leu-1) antigen has been implicated as a source of IgM autoantibodies. Chronic lymphocytic leukemia (CLL), the most common leukemia in humans, represents a malignancy of small B lymphocytes that also
Luis Requena et al.
Archives of dermatology, 139(4), 475-486 (2003-04-23)
Specific cutaneous involvement in patients with multiple myeloma (MM) is very uncommon. It usually occurs in late stages of MM as a reflection of increased tumor cell burden. We studied 8 patients with cutaneous involvement of MM without underlying bony
P H Sayre et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(9), 2941-2945 (1987-05-01)
The T11 (CD2) sheep-erythrocyte-binding protein is a T-cell surface molecule involved in activation of T lymphocytes and thymocytes, including those lacking the T3-Ti antigen-receptor complex. The primary structure of T11 was deduced from protein microsequencing and cDNA cloning. The mature
T J Henderson et al.
Immunogenetics, 37(6), 415-425 (1993-01-01)
We have examined the same kappa chain variable (V kappa) region family in several mouse species in order to observe short-term, incremental change at immunoglobulin (Ig) multigene loci. In the present study, the Igk-V24 family has been characterized in a
P Sanchez et al.
Proceedings of the National Academy of Sciences of the United States of America, 84(24), 9185-9188 (1987-12-01)
Recently, we reported evidence for the existence of an immunoglobulin lambda light chain (lambda x) whose variable region differs from those encoded by the known V lambda gene segments V lambda 1 and V lambda 2. Expression of lambda x
Katherine Rego et al.
Developmental and comparative immunology, 104, 103566-103566 (2019-12-15)
This study characterizes immunoglobulin light chain (IgL) expression and variable family usage in rainbow trout. IgL transcripts were generated by 5' RACE from both immune and TNP-KLH immunized fish. Phylogenetic analysis revealed that the IgL variable regions clustered into seven
K P Lam et al.
The Journal of experimental medicine, 190(4), 471-477 (1999-08-17)
Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V(H)12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other V(H) region transgenes (V(H)B1-8 and V(H)glD42) leads to the almost
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