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Zhonghua Liu et al.
Electrophoresis, 36(17), 2002-2016 (2015-06-04)
Fuzhuan brick tea has received increasing attention in recent years owing to its benefits for nonalcoholic fatty liver disease (NAFLD) and associated metabolic syndrome. For exploring the ameliorative mechanism, the liver proteomes from three groups of rats fed either a
Basavaraju G Sanganahalli et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 33(7), 1115-1126 (2013-04-18)
Local calcium (Ca(2+)) changes regulate central nervous system metabolism and communication integrated by subcellular processes including mitochondrial Ca(2+) uptake. Mitochondria take up Ca(2+) through the calcium uniporter (mCU) aided by cytoplasmic microdomains of high Ca(2+). Known only in vitro, the
Wioleta Jesionek et al.
Journal of AOAC International, 98(4), 1013-1020 (2015-08-14)
Fast high-throughput TLC-direct bioautography (DB) is an effect-directed analysis method that enables searching for biologically active (e.g., antimicrobial) substances in complex mixtures like plant extracts. The principle of the method is that separation and detection of biological properties of given
Germán Günther et al.
PloS one, 10(6), e0129749-e0129749 (2015-06-23)
In this work, the relationship between the molecular structure of three flavonoids (kaempferol, quercetin and morin), their relative location in microheterogeneous media (liposomes and erythrocyte membranes) and their reactivity against singlet oxygen was studied. The changes observed in membrane fluidity
P Basabe et al.
European journal of medicinal chemistry, 45(9), 4258-4269 (2010-07-14)
Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8
Naiani Ferreira Marques et al.
Neurochemical research, 40(6), 1197-1210 (2015-04-24)
Oxidative stress has been implicated in several pathologies including neurological disorders. Centella asiatica is a popular medicinal plant which has long been used to treat neurological disturbances in Ayurvedic medicine. In the present study, we quantified of compounds by high
Khalid S Al-Numair et al.
Redox report : communications in free radical research, 20(5), 198-209 (2014-12-17)
The aim of the present study was to evaluate the protective effect of kaempferol against oxidative stress in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male, adult albino rats of the Wistar strain, by intraperitoneal administration of STZ (40
Susana Ferreyra et al.
Food chemistry, 348, 129063-129063 (2021-01-26)
Grapevine woody by-products contain bioactive substances, mainly phenolic compounds (PCs), whose beneficial health effects initially depends on their levels of intake and bioavailability. Therefore, in-vitro simulated gastrointestinal digestion (GID; oral, gastric and intestinal phases) was performed to evaluate the bioaccessibility
Radka Václavíková et al.
Bioorganic & medicinal chemistry, 16(4), 2034-2042 (2007-11-21)
This study investigated the effect of naturally occurring flavonoids and synthetic aurone derivatives on the formation of cardiotoxic doxorubicinol and transport of doxorubicin in breast cancer cells. Quercetin significantly inhibited the formation of doxorubicinol. Quercetin and aurones did not significantly
Paula Aranaz et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-20)
Phenolic compounds might modulate adiposity. Here, we report our observation that polyphenols and phenolic acids inhibit adipogenesis in 3T3-L1 with different intensity depending on the family and the stage of differentiation. While quercetin and resveratrol inhibited lipid accumulation along the
L M Berger et al.
Journal of dairy science, 98(8), 5688-5698 (2015-06-22)
The aim of the present study was to investigate the ruminal degradation of the flavonol quercetin and to determine its potential antimicrobial effects on ruminal fermentation in cows. Ruminal degradation of quercetin (0 or 100μmol/L, respectively) as well as its
Sheldon Holder et al.
Bioorganic & medicinal chemistry, 15(19), 6463-6473 (2007-07-20)
The PIM-1 protein, the product of the pim-1 oncogene, is a serine/threonine kinase. Dysregulation of the PIM-1 kinase has been implicated in the development of human malignancies including lymphomas, leukemias, and prostate cancer. Comparative molecular field analysis (CoMFA) is a
Nurcan Değirmencioğlu et al.
Food chemistry, 194, 587-594 (2015-10-17)
In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total
Ayokunle O Ademosun et al.
Journal of basic and clinical physiology and pharmacology, 26(5), 471-477 (2015-06-02)
Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus
Hisashi Matsuda et al.
Bioorganic & medicinal chemistry, 17(16), 6048-6053 (2009-07-21)
The 80% aqueous acetone extract from the rhizomes of Alpinia officinarum, a Chinese medicinal herb, were found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, four diarylheptanoids [5-hydroxy-1,7-diphenyl-3-heptanone, 7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenylhept-4-en-3-one, 5-hydroxy-7-(4('')-hydroxy-3('')-methoxyphenyl)-1-phenyl-3-heptanone, and 3,5-dihydroxy-1,7-diphenylheptane] and two
Markus Trunzer et al.
Journal of medicinal chemistry, 52(2), 329-335 (2008-12-26)
Metabolic stability is a key property to enable drugs to reach therapeutic concentrations. Microsomal clearance assays are used to dial out labile compounds in early discovery phases. However, because they do not provide any information on soft spots, the rational
Antioxidant, anti-inflammatory and neuroprotective effect of kaempferol on rotenone-induced Parkinson?s disease model of rats and SH-S5Y5 cells by preventing loss of tyrosine hydroxylase
Pan X, et al.,
Journal of functional foods, 74, 104140-104140 (2020)
Milan S Geybels et al.
American journal of epidemiology, 177(12), 1388-1398 (2013-06-01)
Flavonoids are natural antioxidants found in various foods, and a major source is black tea. Some experimental evidence indicates that flavonoids could prevent prostate cancer. We investigated the associations between flavonoid intake, black tea consumption, and prostate cancer risk in
Nam Hee Yoo et al.
Journal of natural products, 71(4), 713-715 (2008-02-27)
A novel 2,3-dioxygenated flavanone, erigeroflavanone ( 1), as well as eight known flavonoids and two known gamma-pyranone derivatives, were isolated from an ethyl acetate-soluble extract of the flowers of Erigeron annuus. The structure of compound 1 was elucidated by interpretation
Sadaf Naeem et al.
Bioorganic & medicinal chemistry, 20(3), 1251-1258 (2012-01-21)
Data on phytochemical constituents of plants commonly used in traditional Indonesian medicine have been compiled as a computer database. This database (the Indonesian Herbal constituents database, IHD) currently contains details on ∼1,000 compounds found in 33 different plants. For each
Brian J Song et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(1), 195-202 (2012-12-15)
The present study reports the presence of several carotenoids and flavonoids in human milk samples. Samples were collected from 17 women who delivered healthy term babies (≥ 37 wk of gestation) at 1-, 4-, and 13-wk postpartum intervals. Epicatechin (63.7-828.5
Lea Bredsdorff et al.
The American journal of clinical nutrition, 98(1), 209-216 (2013-05-24)
Epidemiologic studies have suggested that a higher intake of flavonoids may be associated with lower risk of ischemic heart disease. However, the traditional estimation of flavonoid intake by using dietary assessment methods is affected by subjective measures. We examined whether
Alaina M Forbes et al.
International journal of oncology, 45(2), 831-842 (2014-05-27)
Flavonoids have been studied intensely for their ability to act as anti-carcinogenic, anti-inflammatory, anti-viral and anti-aging agents and are often marketed as supplements related to their anti-inflammatory activity. Previous studies have primarily focused on the effects of polar natural flavonoids.
Muhammad Jahangir Hossen et al.
Journal of ethnopharmacology, 168, 217-228 (2015-04-04)
Phyllanthus acidus (L.) Skeels (Phyllanthaceae) has traditionally been used to treat gastric trouble, rheumatism, bronchitis, asthma, respiratory disorders, and hepatitis. Despite this widespread use, the pharmacological activities of this plant and their molecular mechanisms are poorly understood. Therefore, we evaluated
Elisabeta Baiceanu et al.
Molecules (Basel, Switzerland), 20(6), 11063-11075 (2015-06-18)
Artemisia abrotanum L. ("southernwood") belongs to the Artemisia genus and it is used in traditional medicine for the treatment of a variety of illnesses. Scarce data is available on the chemical composition of this medicinal plant, most research being focused
Veljko Veljkovic et al.
Bioorganic & medicinal chemistry letters, 17(5), 1226-1232 (2006-12-27)
Flavonoid compounds represent an important natural source of antiretrovirals for AIDS therapy due to their significant anti-HIV-1 activity and low toxicity. Here we propose a simple theoretical criterion to discriminate active from inactive flavonoids that is suitable for rapid in
Haitao Luo et al.
Nutrition and cancer, 61(4), 554-563 (2009-10-20)
Ovarian cancer is 1 of the most significant malignancies in the Western world, and the antiangiogenesis strategy has been postulated for prevention and treatment of ovarian cancers. Kaempferol is a natural flavonoid present in many fruits and vegetables. The antiangiogenesis
Ayuta Funaki et al.
Plant & cell physiology, 56(8), 1512-1520 (2015-05-29)
Isoflavone conjugates [7-O-β-D-glucosides and 7-O-(6″-malonyl-β-D-glucosides) of daidzein and genistein] accumulate in soybean roots and serve as the stored precursors of isoflavones (aglycons), which play very important roles in the rhizobia-mediated nodulation of this plant. Thus far, the isoflavone 7-O-glucosyltransferase (GmIF7GT
Marta Moskot et al.
Metabolic brain disease, 30(5), 1257-1267 (2015-07-26)
Natural flavonoids such as genistein, kaempferol and daidzein were previously found to be able to reduce efficiency of glycosaminoglycan synthesis in cells of patients suffering from mucopolysaccharidoses, inherited metabolic diseases with often brain disease symptoms. This feature was employed to
Muhammad N Safdar et al.
Journal of food and drug analysis, 25(3), 488-500 (2017-09-16)
An investigation was carried out to extract polyphenols from the peel of kinnow (Citrus reticulate L.) by maceration and ultrasound-assisted extraction (UAE) techniques. The antioxidant potential of these polyphenols was evaluated using ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and
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