K2389

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关键词:'K2389'

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Altered expression of genes regulating inflammation and synaptogenesis during regrowth of afferent neurons to cochlear hair cells.

Chen-Chi Wu et al.

PloS one, 15(10), e0238578-e0238578 (2020-10-02)

The spiral ganglion neurons constitute the primary connection between auditory hair cells and the brain. The spiral ganglion afferent fibers and their synapse with hair cells do not regenerate to any significant degree in adult mammalian ears after damage. We

Basic Neurochemistry: Molecular, Cellular and Medical Aspects. (2005)

Medical Physiology, 342-342 (2016)

Poly-arginine-18 (R18) Confers Neuroprotection through Glutamate Receptor Modulation, Intracellular Calcium Reduction, and Preservation of Mitochondrial Function.

Gabriella MacDougall et al.

Molecules (Basel, Switzerland), 25(13) (2020-07-03)

Recent studies have highlighted that a novel class of neuroprotective peptide, known as cationic arginine-rich peptides (CARPs), have intrinsic neuroprotective properties and are particularly effective anti-excitotoxic agents. As such, the present study investigated the mechanisms underlying the anti-excitotoxic properties of

Neuroglobin deficiency increases seizure susceptibility but does not affect basal behavior in mice.

Casper R Gøtzsche et al.

Journal of neuroscience research, 100(10), 1921-1932 (2022-07-14)

Neuroglobin (Ngb) is found in the neurones of several different brain areas and is known to bind oxygen and other gaseous molecules and reactive oxygen species (ROS) in vitro, but it does not seem to act as a respiratory molecule

Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice.

Heidi Elbrønd-Bek et al.

Synapse (New York, N.Y.), 68(10), 427-436 (2014-07-06)

Kainate-induced seizures constitute a model of temporal lobe epilepsy where prominent changes are observed in the hippocampal neuropeptide Y (NPY) system. However, little is known about the functional state and signal transduction of the NPY receptor population resulting from kainate

Long-term exposure to low-intensity environmental noise aggravates age-related hearing loss via disruption of cochlear ribbon synapses.

Shuai Feng et al.

American journal of translational research, 12(7), 3674-3687 (2020-08-11)

Noise pollution is a major public hazard. Previous studies have shown that environmental noise affects the reorganization of the auditory cortex and leads to behavioral abnormality; however, the effects of long-term environmental noise exposure on the inner ear and hearing

Functional role of neurotrophin-3 in synapse regeneration by spiral ganglion neurons on inner hair cells after excitotoxic trauma in vitro

Wang Q and Green SH

The Journal of Neuroscience, 31(21), 7938-7949 (2011)

Distinct patterns of dentate gyrus cell activation distinguish physiologic from aberrant stimuli.

Jason C You et al.

PloS one, 15(5), e0232241-e0232241 (2020-05-15)

Under physiologic conditions, the dentate gyrus (DG) exhibits exceptionally low levels of activity compared to other brain regions. A sparse activation pattern is observed even when the DG is engaged to process new information; for example, only ~1-3% of neurons

Histopathological modeling of status epilepticus-induced brain damage based on in vivo diffusion tensor imaging in rats.

Isabel San Martín Molina et al.

Frontiers in neuroscience, 16, 944432-944432 (2022-08-16)

Non-invasive magnetic resonance imaging (MRI) methods have proved useful in the diagnosis and prognosis of neurodegenerative diseases. However, the interpretation of imaging outcomes in terms of tissue pathology is still challenging. This study goes beyond the current interpretation of in

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Gotzsche CR, et al.

Neurobiology of Disease, 45(1), 288-296 (2012)

Simultaneous BOLD fMRI and local field potential measurements during kainic acid-induced seizures.

Antti M Airaksinen et al.

Epilepsia, 53(7), 1245-1253 (2012-06-14)

To investigate how kainic acid-induced epileptiform activity is related to hemodynamic changes probed by blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI). Epileptiform activity was induced with kainic acid (KA) (10 mg/kg, i.p.), and simultaneous fMRI at 7 Tesla

Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures

Woldbye David PD, et al.

Brain, 133(9), 2778-2788 (2010)

Insulin-like growth factor 1 promotes cochlear synapse regeneration after excitotoxic trauma in vitro.

Kohei Yamahara et al.

Hearing research, 374, 5-12 (2019-01-27)

In the context of acquired sensorineural hearing loss (SNHL), cochlear hair cells have long been thought to be among the most vulnerable elements in mammalian cochleae. However, recent studies have indicated that the synaptic connection between inner hair cells (IHC)

MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells.

Marijn Schouten et al.

Scientific reports, 5, 12448-12448 (2015-07-25)

Adult neurogenesis continuously contributes new neurons to hippocampal circuits and the programmed death of a subset of immature cells provides a primary mechanism controlling this contribution. Epileptic seizures induce strong structural changes in the hippocampus, including the induction of adult

Diffusion tensor MRI of axonal plasticity in the rat hippocampus

Laitinen T, et al.

Neuroimage, 51(2), 521-530 (2010)

Urokinase-type plasminogen activator deficiency has little effect on seizure susceptibility and acquired epilepsy phenotype but reduces spontaneous exploration in mice

Rantala J, et al.

Epilepsy & Behavior : E&B, 42, 117-128 (2015)

Adeno-associated viral vector-induced overexpression of neuropeptide Y Y2 receptors in the hippocampus suppresses seizures.

David P D Woldbye et al.

Brain : a journal of neurology, 133(9), 2778-2788 (2010-08-07)

Gene therapy using recombinant adeno-associated viral vectors overexpressing neuropeptide Y in the hippocampus exerts seizure-suppressant effects in rodent epilepsy models and is currently considered for clinical application in patients with intractable mesial temporal lobe epilepsy. Seizure suppression by neuropeptide Y

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