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Zongchang Song et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36(7), 5591-5596 (2015-02-25)
Recent researches have suggested that autophagy may play critical roles in tumorigenesis. Immunity-related GTPase family M (IRGM) is a human protein highlighted for its contribution to autophagy upon inflammation and infections. Studies have shown that IRGM is involved in the
Rebecca J Linger et al.
PloS one, 10(10), e0141544-e0141544 (2015-10-28)
In most animals that have X and Y sex chromosomes, chromosome-wide mechanisms are used to balance X-linked gene expression in males and females. In the fly Drosophila melanogaster, the dosage compensation mechanism also generally extends to X-linked transgenes. Over 70
Md Saydur Rahman et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 185, 91-106 (2015-04-07)
Neuronal nitric oxide synthase (nNOS) catalyzes production of nitric oxide in vertebrate brains. Recent findings indicate that endothelial NOS and reactive oxygen species (ROS) are significantly increased during hypoxic stress and are modulated by antioxidants. However, the influence of antioxidants
Teresa Sposito et al.
Human molecular genetics, 24(18), 5260-5269 (2015-07-03)
The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult human central nervous system (CNS). Tau splicing is developmentally regulated and dysregulated in disease. Mutations in MAPT that alter tau splicing cause frontotemporal dementia (FTD)
Courtney M Karner et al.
The Journal of clinical investigation, 125(2), 551-562 (2015-01-07)
WNT signaling stimulates bone formation by increasing both the number of osteoblasts and their protein-synthesis activity. It is not clear how WNT augments the capacity of osteoblast progenitors to meet the increased energetic and synthetic needs associated with mature osteoblasts.
Víctor M López-Álvarez et al.
Pain, 156(9), 1812-1825 (2015-06-20)
Activity treatments, such as treadmill exercise, are used to improve functional recovery after nerve injury, parallel to an increase in neurotrophin levels. However, despite their role in neuronal survival and regeneration, neurotrophins may cause neuronal hyperexcitability that triggers neuropathic pain.
Janet K Horton et al.
Radiation research, 184(5), 456-469 (2015-10-22)
Although a standardized approach to radiotherapy has been used to treat breast cancer, regardless of subtype (e.g., luminal, basal), recent clinical data suggest that radiation response may vary significantly among subtypes. We hypothesized that this clinical variability may be due
Young Ah Lee et al.
Experimental parasitology, 149, 7-15 (2014-12-17)
Entamoeba histolytica is an enteric tissue-invading protozoan parasite that causes amoebic colitis and occasionally liver abscess in humans. During tissue invasion, amoebic adhesion to host components is an important event for host cell death leading to successful invasion and infection.
Reeja S Maskey et al.
Nature communications, 5, 5744-5744 (2014-12-17)
Spartan (also known as DVC1 and C1orf124) is a PCNA-interacting protein implicated in translesion synthesis, a DNA damage tolerance process that allows the DNA replication machinery to replicate past nucleotide lesions. However, the physiological relevance of Spartan has not been
Hubert Tseng et al.
Scientific reports, 5, 13987-13987 (2015-09-15)
An ongoing challenge in biomedical research is the search for simple, yet robust assays using 3D cell cultures for toxicity screening. This study addresses that challenge with a novel spheroid assay, wherein spheroids, formed by magnetic 3D bioprinting, contract immediately
Martin Akerman et al.
Genome biology, 16, 119-119 (2015-06-07)
During spliceosome assembly, protein-protein interactions (PPI) are sequentially formed and disrupted to accommodate the spatial requirements of pre-mRNA substrate recognition and catalysis. Splicing activators and repressors, such as SR proteins and hnRNPs, modulate spliceosome assembly and regulate alternative splicing. However
Jennifer Hirst et al.
Human molecular genetics, 24(17), 4984-4996 (2015-06-19)
Adaptor proteins (AP 1-5) are heterotetrameric complexes that facilitate specialized cargo sorting in vesicular-mediated trafficking. Mutations in AP5Z1, encoding a subunit of the AP-5 complex, have been reported to cause hereditary spastic paraplegia (HSP), although their impact at the cellular
Jelena Cvetkovic et al.
Comparative immunology, microbiology and infectious diseases, 37(5-6), 355-367 (2014-12-04)
Trichinella spiralis muscle larvae excretory-secretory antigens (ES L1) are most likely responsible for the induction of immune response during infection by this parasitic. The antigens bear carbohydrate structures that may contribute to immune system activation resulting in a Th2/anti-inflammatory immune
Takakuni Maki et al.
Stem cell research, 15(1), 68-74 (2015-05-24)
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs). However, the differentiation from OPCs to oligodendrocytes is disturbed under stressed conditions. Therefore, drugs that can improve oligodendrocyte regeneration
N O Mchedlov-Petrossyan et al.
Physical chemistry chemical physics : PCCP, 17(24), 16186-16203 (2015-06-03)
This study was aimed to reveal the principal colloidal properties of the aqueous dispersion of extremely small primary single-crystalline diamond particles in water. Together with the non-diamond layer, the size of the colloidal species is 2.8 ± 0.6 nm as
Hiroshi Itoh et al.
Journal of leukocyte biology, 98(1), 107-117 (2015-04-25)
Autophagy occurs in human neutrophils after the phagocytosis of multidrug-resistant bacteria and drug-sensitive strains, including Escherichia coli and Pseudomonas aeruginosa. The present study detected autophagy by immunoblot analysis of LC3B conversion, by confocal scanning microscopic examination of LC3B aggregate formation
Huifang Cheng et al.
Kidney international, 88(1), 85-94 (2015-03-12)
The aged population suffers increased morbidity and higher mortality in response to episodes of acute kidney injury (AKI). Aging is associated with telomere shortening, and both telomerase reverse transcriptase (TerT) and RNA (TerC) are essential to maintain telomere length. To
Cornelis J J Huijsmans et al.
Diagnostic pathology, 10, 56-56 (2015-05-30)
Breast cancer is a heterogeneous disease with various histological features and molecular markers. These are utilized for the prediction of clinical outcome and therapeutic decision making. In addition to well established markers such as HER2 overexpression and estrogen and progesterone
Biao Hu et al.
The American journal of pathology, 185(11), 3066-3075 (2015-09-12)
Notch signaling pathway is involved in the regulation of cell fate, differentiation, proliferation, and apoptosis in development and disease. Previous studies suggest the importance of Notch1 in myofibroblast differentiation in lung alveogenesis and fibrosis. However, direct in vivo evidence of Notch1-mediated
Sven Staufenbiel et al.
International journal of pharmaceutics, 485(1-2), 87-96 (2015-03-10)
The surface properties of intravenously injected nanoparticles determine the acquired blood protein adsorption pattern and subsequently the organ distribution and cellular recognition. A series of poly[acrylonitrile-co-(N-vinyl pyrrolidone)] (PANcoNVP) model nanoparticles (133-181 nm) was synthesized, in which the surface properties were
Zhiqiang Zhao et al.
Cancer prevention research (Philadelphia, Pa.), 7(9), 927-938 (2014-06-05)
Numerous patients with osteosarcoma either are not sensitive to chemotherapy or develop drug resistance to current chemotherapy regimens. Therefore, it is necessary to develop several potentially useful therapeutic agents. Dihydromyricetin is the major flavonoid component derived from Ampelopsis grossedentata, which
Prathima Arvind et al.
Journal of cardiology, 64(5), 339-346 (2014-03-29)
Genetic regulation of plasma lipids has been shown to influence the risk of coronary artery disease (CAD). We analyzed the relationship between rs599839 and rs646776 single nucleotide polymorphisms (SNPs) present in the CELSR2-PSRC1-SORT1 gene cluster, candidate gene expression, and their
W J M Landman et al.
Avian pathology : journal of the W.V.P.A, 43(4), 345-356 (2014-06-20)
Escherichia coli colonies isolated from the bone marrow of fresh dead hens of laying flocks with the E. coli peritonitis syndrome (EPS) were genotyped using pulsed-field gel electrophoresis (PFGE). Typing is important from an epidemiological point of view and also
Ayten Hijazi et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4968-4977 (2015-08-19)
Developmental exposure to bisphenol A (BPA) is associated with lung dysfunction and diseases. However, it is unknown if this association has a fetal origin. The present study addressed this important question by examining the effects of BPA on fetal lung
Shefeeq M Theparambil et al.
Glia, 63(9), 1581-1594 (2015-03-31)
Cytosolic H(+) buffering plays a major role for shaping intracellular H(+) shifts and hence for the availability of H(+) for biochemical reactions and acid/base-coupled transport processes. H(+) buffering is one of the prime means to protect the cell from large
Michaela Stolz et al.
Pflugers Archiv : European journal of physiology, 467(10), 2121-2140 (2015-01-17)
The P2X7 receptor (P2X7R) is a ligand-gated ion channel that conducts Na(+), K(+), and Ca(2+) when activated by extracellular ATP. In various cell types, such as secretory epithelia, the P2X7R is co-expressed with Ca(2+)-dependent Cl(-) channels of the TMEM16/anoctamin family.
Justyna Borawska et al.
Food chemistry, 194, 770-779 (2015-10-17)
The presence of specific peptides with antioxidant properties released during carp protein ex vivo and in vitro hydrolysis by human/porcine digestive enzymes, respectively, was examined. Based on the results of the in silico data analysis, antioxidant peptides were selected for
Bumsup Kwon et al.
Biochimie, 118, 141-150 (2015-09-08)
Excessive saturated free fatty acids (SFFAs; e.g. palmitate) in blood are a pathogenic factor in diabetes, obesity, cardiovascular disease and liver failure. In contrast, monounsaturated free fatty acids (e.g. oleate) prevent the toxic effect of SFFAs in various types of
Yu Zhao et al.
The Plant cell, 27(9), 2469-2483 (2015-08-27)
Crown roots are the main components of the fibrous root system in rice (Oryza sativa). WOX11, a WUSCHEL-related homeobox gene specifically expressed in the emerging crown root meristem, is a key regulator in crown root development. However, the nature of
A Rak-Mardyła et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(7), 493-498 (2014-03-15)
In a previous study, we showed that resistin expression increased during ovarian follicle development in prepubertal pigs and had direct effects on steroidogenesis, suggesting an important role for resistin in the ovary during puberty. To determine its potential regulatory role
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