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关键词:'L4509'
显示 1-30 共 6445 条结果 关于 "L4509" 范围 论文
Guanhua Yang et al.
Biopolymers, 104(1), 11-20 (2014-12-05)
Caveolin-1 is a main structural component of caveolae and essential for the invagination of caveolae by forming a hairpin-shaped structure in the membrane-inserting domain (residues, 102-122). In this article, we determined the tertiary structures of the peptides comprising residues 93-126
Jason M Dwyer et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(19), 6188-6193 (2015-04-29)
Current treatments for major depressive disorder (MDD) have a time lag and are ineffective for a large number of patients. Development of novel pharmacological therapies requires a comprehensive understanding of the molecular events that contribute to MDD pathophysiology. Recent evidence
Jiaojiao Su et al.
PloS one, 9(12), e114420-e114420 (2014-12-05)
Insulin-like growth factor 1 receptor (IGF1R) is a transmembrane receptor that is activated by insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors and plays an important
Francisco J Rios et al.
The Journal of pharmacology and experimental therapeutics, 353(1), 27-34 (2015-01-27)
Hyperaldosteronism and hypertension were unexpected side effects observed in trials of torcetrapib, a cholesteryl ester-transfer protein (CETP) inhibitor that increases high-density lipoprotein. Given that CETP inhibitors are lipid soluble, accumulate in adipose tissue, and have binding sites for proteins involved
Ji-Feng Xu et al.
Molecular diagnosis & therapy, 19(5), 299-308 (2015-08-04)
The aim of this study was to investigate the microRNA (miRNA) expression pattern in synovial fluid from patients with knee osteoarthritis (OA) after treatment with intra-articular injection of hyaluronan (HA). Twelve OA patients were enrolled in accordance with the Kellgren-Lawrence
Simon Kaja et al.
Experimental eye research, 138, 159-166 (2015-06-07)
Optic nerve head astrocytes (ONHAs) are the major glia cell type in the non-myelinated optic nerve head where they contribute critically to extracellular matrix synthesis during development and throughout life. In glaucoma, and in related disorders affecting the optic nerve
Hui-Mei Wu et al.
Human pathology, 45(9), 1936-1943 (2014-08-02)
Gene associated with retinoid and interferon-induced mortality 1 (GRIM-1) acts as a tumor growth suppressor via apoptosis induction. However, GRIM-1 expression in human non-small cell lung cancer (NSCLC) and its potential interaction with another apoptosis-associated protein-glucose-regulated protein 78 (GRP78)-are as
Xin Zhou et al.
PloS one, 9(12), e115148-e115148 (2014-12-17)
We sought develop and characterize a diet-induced model of metabolic syndrome and its related diseases. The experimental animals (Spague-Dawley rats) were randomly divided into two groups, and each group was fed a different feed for 48 weeks as follows: 1)
Rong Xu et al.
Methods (San Diego, Calif.), 87, 11-25 (2015-04-19)
Secretion and exchange of extracellular vesicles (EVs) by most cell types is emerging as a fundamental biological process. Although much is known about EVs, there is still a lack of definition as to how many naturally occurring EV subtypes there
Kyu-Min Han et al.
Stem cells (Dayton, Ohio), 33(5), 1447-1455 (2015-02-03)
Cardio-facio-cutaneous (CFC) syndrome is a developmental disorder caused by constitutively active ERK signaling manifesting mainly from BRAF mutations. Little is known about the role of elevated ERK signaling in CFC syndrome during early development. Here, we show that both SMAD1
Ewa Augustin et al.
Acta pharmacologica Sinica, 36(3), 385-399 (2015-02-03)
FMS-like receptor tyrosine kinase (FLT3) is expressed in some normal hematopoietic cell types and plays an important role in the pathogenesis of acute myeloid leukemia (AML). In this study, we examined the effects of triazoloacridinone C-1305, an antitumor compound, on
Ioanna Tiniakou et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4676-4687 (2015-04-15)
Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with autoimmune inflammatory diseases. Whether HDL affects the development of an autoimmune response remains elusive. In this study, we used apolipoprotein
Aya Muramatsu et al.
Biochemical and biophysical research communications, 463(4), 999-1005 (2015-06-15)
Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression. We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular zone (SVZ) and the
Lawrence W Castellani et al.
Journal of lipid research, 45(12), 2377-2387 (2004-10-07)
We previously demonstrated that transgenic mice overexpressing mouse apolipoprotein A-II (apoA-II) exhibit several traits associated with the insulin resistance (IR) syndrome, including increased atherosclerosis, hypertriglyceridemia, obesity, and IR. The skeletal muscle appeared to be the insulin-resistant tissue in the apoA-II
Sorina Morar-Mitrica et al.
mAbs, 7(4), 792-803 (2015-06-16)
The physical and chemical integrity of a biopharmaceutical must be maintained not only during long-term storage but also during administration. Specifically for the intravenous (i.v.) delivery of a protein drug, loss of stability can occur when the protein formulation is
Yoon Jin Lee et al.
Annals of dermatology, 27(5), 507-516 (2015-10-30)
Reactive oxygen species (ROS) play an important role in the induction of apoptosis under pathological conditions. Recently, a significant increase in ROS production and disrupted apoptosis mechanisms in keloids have been reported. Nuclear factor erythroid 2-related factor 2 (Nrf2) represents
Keita Fukushima et al.
Cancer science, 106(8), 1000-1007 (2015-05-29)
Patients with inflammatory bowel disease (IBD) have an increased risk of developing colitis-associated colorectal cancer (CAC). CAC cells often develop chemoresistance, resulting in a poorer prognosis than that of sporadic colorectal cancer (CRC). The mechanism by which CAC enhances malignant
Shouping Dai et al.
Biochemical and biophysical research communications, 467(2), 204-210 (2015-10-10)
MicroRNA-139-5p was identified to be significantly down-regulated in glioblastoma multiform (GBM) by miRNA array. In this report we aimed to clarify its biological function, molecular mechanisms and direct target gene in GBM. Twelve patients with GBM were analyzed for the
Seemana Bhattacharya et al.
Cellular oncology (Dordrecht), 38(4), 265-277 (2015-05-01)
The de-ubiquitinase HAUSP has been reported to exhibit various biological roles implicated in the development of cancer and other pathologies. The dual nature of HAUSP (i.e., oncogenic and tumor suppressive) makes the protein even more versatile. The major aims of
Edy Kornelius et al.
CNS neuroscience & therapeutics, 21(7), 549-557 (2015-05-27)
It is now clear that insulin signaling has important roles in regulation of neuronal functions in the brain. Dysregulation of brain insulin signaling has been linked to neurodegenerative disease, particularly Alzheimer's disease (AD). In this regard, there is evidence that
Katja Witschas et al.
Biochimica et biophysica acta, 1848(5), 1147-1156 (2015-02-18)
The transient receptor potential ankyrin 1 channel (TRPA1) belongs to the TRP cation channel superfamily that responds to a panoply of stimuli such as changes in temperature, calcium levels, reactive oxygen and nitrogen species and lipid mediators among others. The
Shahram Teimourian et al.
Molecular immunology, 66(2), 319-324 (2015-04-29)
NETosis has been associated with a particular mode of cell death although it is still controversial as to what extent autophagy is involved in NETosis. Class I/AKT/mTOR pathway is a key regulator of autophagy. PTEN tumor suppressor gene encodes a
Melissa Rosso et al.
Oncotarget, 6(33), 34573-34591 (2015-09-30)
A single nucleotide polymorphism (T to G) in the mdm2 P2 promoter, mdm2 SNP309, leads to MDM2 overexpression promoting chemotherapy resistant cancers. Two mdm2 G/G SNP309 cancer cell lines, MANCA and A875, have compromised wild-type p53 that co-localizes with MDM2
Domenica Scumaci et al.
PloS one, 10(6), e0129762-e0129762 (2015-06-11)
Breast cancer (BC) is a leading cause of death among women. Among the major risk factors, an important role is played by familial history of BC. Germ-line mutations in BRCA1/2 genes account for most of the hereditary breast and/or ovarian
Yan Li et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(8), 1349-1357 (2015-06-09)
Osteoporosis, caused by a relative increase of bone resorption over bone formation, is characterized by decreased bone mass and bone strength, resulting in an increased incidence of bone fractures, which often leads to further disability and early mortality in the
Knut H Lauritzen et al.
American journal of physiology. Heart and circulatory physiology, 309(3), H434-H449 (2015-06-10)
Cardiac mitochondrial dysfunction has been implicated in heart failure of diverse etiologies. Generalized mitochondrial disease also leads to cardiomyopathy with various clinical manifestations. Impaired mitochondrial homeostasis may over time, such as in the aging heart, lead to cardiac dysfunction. Mitochondrial
Matthew R Panasevich et al.
The Journal of nutrition, 145(12), 2781-2788 (2015-10-23)
Dietary fiber intake leading to short-chain fatty acid (SCFA) production could be a strategy to combat intermittent bouts of inflammation during ulcerative colitis. Our objective was to evaluate dietary potato fiber (PF) in attenuating inflammation using a dextran sodium sulfate
Uwe Richter et al.
The Journal of cell biology, 211(2), 373-389 (2015-10-28)
Mitochondrial ribosomes synthesize a subset of hydrophobic proteins required for assembly of the oxidative phosphorylation complexes. This process requires temporal and spatial coordination and regulation, so quality control of mitochondrial protein synthesis is paramount to maintain proteostasis. We show how
Pan Ma et al.
PloS one, 9(11), e112243-e112243 (2014-11-13)
Our previous studies demonstrated that glimepiride enhanced the proliferation and differentiation of osteoblasts and led to activation of the PI3K/Akt pathway. Recent genetic evidence shows that endothelial nitric oxide synthase (eNOS) plays an important role in bone homeostasis. In this
Su Yao et al.
The Journal of pathology, 236(1), 65-77 (2014-12-19)
The epidermal growth factor receptor (EGFR) is implicated in many types of cancer, including colorectal cancer (CRC), and has become one of the most common candidates for targeted therapy. Here, we found that Erbin, a member of the leucine-rich repeat
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