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Stephan W Reinhold et al.
Lipids, 48(2), 167-175 (2013-01-01)
Acute transplant rejection is the leading cause of graft loss in the first months after kidney transplantation. Lipoxygenase products mediate pro- and anti-inflammatory actions and thus we aimed to correlate the histological reports of renal transplant biopsies with urinary lipoxygenase
Christine Tayeh et al.
Phytopathology, 104(3), 293-305 (2013-10-01)
Powdery mildew would be one of the most damaging wheat diseases without the extensive use of conventional fungicides. Some of the alternative control strategies currently emerging are based on the use of resistance inducers. The disacharride trehalose (TR) is classically
David S Cafiso
Biophysical journal, 103(10), 2047-2048 (2012-12-04)
An article by Gaffney et al. in this issue establishes a method using pulse electron paramagnetic resonance spectroscopy to determine the location of protein substrates or binding partners with high precision.
Somnath Mandal et al.
Indian journal of biochemistry & biophysics, 50(1), 54-63 (2013-04-27)
The consumption of soybean is limited worldwide, despite being highly nutritious and having versatile uses due to the presence of grassy, beany and rancid off-flavour. The lipoxygenase-2 (LOX-2) is the key enzyme responsible for the production of volatiles released from
Ruo-Bing Guo et al.
PloS one, 7(11), e49701-e49701 (2012-11-21)
Paeoniflorin (PF), the principal component of Paeoniae Radix prescribed in traditional Chinese medicine, has been reported to exhibit many pharmacological effects including protection against ischemic injury. However, the mechanisms underlying the protective effects of PF on cerebral ischemia are still
Amina Kunovac et al.
Nanotoxicology, 15(6), 812-831 (2021-05-11)
Maternal engineered nanomaterial (ENM) exposure during gestation has been associated with negative long-term effects on cardiovascular health in progeny. Here, we evaluate an epitranscriptomic mechanism that contributes to these chronic ramifications and whether overexpression of mitochondrial phospholipid hydroperoxide glutathione peroxidase
Chang-ke Chen et al.
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 31(9), 641-648 (2013-09-26)
The oxidation of benzo (a) pyrene mediated by 5-lipoxygenase (5-LOX) were investigated in HBE cells in order to provide further proof that lipoxygenase is the alternative pathway for the oxidation of xenobiotics. Enzymic experiment: Soybean lipoxygenase (SLO), substrate (benzo[a] pyrene)
Astrid Bachmann et al.
Biological chemistry, 383(10), 1645-1657 (2002-11-28)
In addition to a previously characterized 13-lipoxygenase of 100 kDa encoded by LOX2:Hv:1 [Vörös et al., Eur. J. Biochem. 251 (1998), 36-44], two full-length cDNAs (LOX2:Hv:2, LOX2:Hv:3) were isolated from barley leaves (Hordeum vulgare cv. Salome) and characterized. Both of
Yuji Tasaki et al.
Bioscience, biotechnology, and biochemistry, 77(1), 38-45 (2013-01-08)
The full-length cDNA of the gene PoLOX1 encoding a lipoxygenase (LOX) and its corresponding genomic DNA were isolated from the basidiomycete mushroom Pleurotus ostreatus strain H1. The deduced amino acid sequence of PoLOX1 showed similarity to a valencene dioxygenase of
Betty J Gaffney et al.
Biophysical journal, 103(10), 2134-2144 (2012-12-04)
Lipoxygenase enzymes initiate diverse signaling pathways by specifically directing oxygen to different carbons of arachidonate and other polyunsaturated acyl chains, but structural origins of this specificity have remained unclear. We therefore determined the nature of the lipoxygenase interaction with the
Almerinda Di Venere et al.
Biochimica et biophysica acta, 1841(1), 1-10 (2013-09-10)
Lipoxygenases (LOXs) are lipid-peroxidizing enzymes that are involved in the metabolism of polyunsaturated fatty acids. Their biological activity includes a membrane binding process whose molecular details are not completely understood. The mechanism of enzyme-membrane interactions is thought to involve conformational
Netsanet Shiferaw Terefe et al.
Critical reviews in food science and nutrition, 54(1), 24-63 (2013-11-06)
The activity of endogenous deteriorative enzymes together with microbial growth (with associated enzymatic activity) and/or other non-enzymatic (usually oxidative) reactions considerably shorten the shelf life of fruits and vegetable products. Thermal processing is commonly used by the food industry for
Rajan Katoch
Journal of food science, 78(1), C8-16 (2013-01-03)
Rice bean, a less known and underutilized legume, has emerged as a potential legume because of its nutritional potential. The nutritional quality of rice bean is higher as compared to many other legumes of Vigna family. In the present study
Isolation of an isozyme of soybean lipoxygenase.
J Christopher et al.
Biochimica et biophysica acta, 198(1), 12-19 (1970-01-14)
Thanasak Sae-Leaw et al.
Food chemistry, 141(3), 2466-2472 (2013-07-23)
Changes in lipids, lipoxygenase activity and fishy odour development in the skin of Nile tilapia (Oreochromis niloticus) during iced storage of 18 days were monitored. Triacylglycerol content of skin decreased with coincidental increases in free fatty acid, monoacylglycerol, diacylglycerol and
Zhuo Shao et al.
Arteriosclerosis, thrombosis, and vascular biology, 34(3), 581-586 (2014-01-25)
Regulation of angiogenesis is critical for many diseases. Specifically, pathological retinal neovascularization, a major cause of blindness, is suppressed with dietary ω3-long-chain polyunsaturated fatty acids (ω3LCPUFAs) through antiangiogenic metabolites of cyclooxygenase and lipoxygenase. Cytochrome P450 epoxygenases (CYP2C8) also metabolize LCPUFAs
Tae Joung Ha et al.
Archives of pharmacal research, 35(10), 1811-1816 (2012-11-10)
Luteolin, isolated from the seeds of Perilla frutescens (perilla seeds), inhibited the peroxidation of linoleic acid catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) with an IC(50) of 5.0 M (1.43 μg/mL) noncompetitively. The progress curves for an enzyme reaction
Peng Zhang et al.
Archives of pharmacal research, 36(1), 109-115 (2013-01-18)
Inflammation is an immune response against a variety of noxious stimuli, such as infection, chemicals, and physical injury. Eugenol, a natural phenolic extract, has drawn much attention for its various desirable pharmacological functions and is, therefore, broadly used in our
Specificity of flaxseed lipoxidase.
D C Zimmerman et al.
Lipids, 5(4), 392-397 (1970-04-01)
Alessandra Lanubile et al.
Plant science : an international journal of experimental plant biology, 210, 183-192 (2013-07-16)
Fusarium verticillioides infects maize producing ear rot, yield loss and the accumulation of fumonisins. In the present study, a transcriptomic approach was employed to investigate the molecular aspects of the interaction of susceptible/resistant maize genotypes with fumonisin-producing/nonproducing strains of F.
Suman Kundu et al.
Journal of lipid research, 54(2), 436-447 (2012-11-20)
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic phospholipase A(2) (cPLA(2)). Here we investigated the involvement of AA
Agnieszka Zienkiewicz et al.
Journal of experimental botany, 64(1), 293-302 (2012-11-08)
In some plants, pollen grains accumulate storage lipids that serve as energy supply during germination. Here, three enzymes involved in early steps of oil body mobilization in the male gametophyte were functionally characterized for the first time. The effect of
Agustí Muñoz-Garcia et al.
Biochimica et biophysica acta, 1841(3), 401-408 (2013-09-12)
This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning. In the outer epidermis, their consecutive actions oxidize linoleic acid esterified in
Xinyao Lu et al.
Applied microbiology and biotechnology, 97(21), 9419-9427 (2013-03-16)
Self-assembling amphipathic peptides (SAPs) are a category of peptides that have unique sequences with alternating hydrophobic and hydrophilic residues that can spontaneously assemble into ordered nanostructures. In this study, we investigated the potential of fusion technique with SAPs to improve
Martin Mariutto et al.
Plant molecular biology, 84(4-5), 455-467 (2013-10-23)
The rhizobacterium Pseudomonas putida BTP1 stimulates induced systemic resistance (ISR) in tomato. A previous work showed that the resistance is associated in leaves with the induction of the first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a
J Royo et al.
The Journal of biological chemistry, 271(35), 21012-21019 (1996-08-30)
Lipoxygenases are ubiquitous enzymes in eukaryotes. In plants, lipoxygenases are involved in the synthesis of the hormone jasmonic acid that regulates plant responses to wounding and, in addition, is an inducer of tuberization in potato. We have isolated potato lipoxygenase
Edward B Dosz et al.
Journal of food science, 78(9), H1459-H1463 (2013-08-07)
Frozen broccoli can provide a cheaper product, with a longer shelf life and less preparation time than fresh broccoli. We previously showed that several commercially available frozen broccoli products do not retain the ability to generate the cancer-preventative agent sulforaphane.
Irina A Potapova et al.
PloS one, 8(9), e73929-e73929 (2013-09-27)
Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in endothelial
Tamara Vellosillo et al.
Plant physiology, 161(2), 617-627 (2013-02-02)
9-Lipoxygenases (9-LOXs) initiate fatty acid oxygenation, resulting in the formation of oxylipins activating plant defense against hemibiotrophic pathogenic bacteria. Previous studies using nonresponding to oxylipins (noxy), a series of Arabidopsis (Arabidopsis thaliana) mutants insensitive to the 9-LOX product 9-hydroxy-10,12,15-octadecatrienoic acid
Juan Du et al.
Molecular biology reports, 40(2), 957-967 (2012-12-12)
The most significant threat to potato production worldwide is the late blight disease, which is caused by the oomycete pathogen Phytophthora infestans. Based on previous cDNA microarrays and cDNA-amplified fragment length polymorphism analysis, 63 candidate genes that are expected to
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