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Lindsey Mayes-Hopfinger et al.
Nature communications, 12(1), 4546-4546 (2021-07-29)
The NLRP3 inflammasome mediates the production of proinflammatory cytokines and initiates inflammatory cell death. Although NLRP3 is essential for innate immunity, aberrant NLRP3 inflammasome activation contributes to a wide variety of inflammatory diseases. Understanding the pathways that control NLRP3 activation
Toshihiko Morichika et al.
The Journal of pharmacology and experimental therapeutics, 304(2), 624-633 (2003-01-23)
Lipopolysaccharide (LPS) is recognized as a key molecule in the pathogenesis of Gram negative sepsis and septic shock. In the present study, we demonstrate that LPS (1-1000 pg/ml) concentration dependently up-regulated the expression of intercellular adhesion molecule (ICAM)-1, B7.1, and
Krishnendu Chakraborty et al.
Nature communications, 8, 13944-13944 (2017-01-12)
Bacterial pneumonia is a significant healthcare burden worldwide. Failure to resolve inflammation after infection precipitates lung injury and an increase in morbidity and mortality. Gram-negative bacteria are common in pneumonia and increased levels of the mito-damage-associated molecular pattern (DAMP) cardiolipin
Toru Fukushima et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(15), 6371-6376 (2007-04-04)
Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity. Gene ablation was used to study the function of
Julia E Sepulveda-Diaz et al.
Glia, 64(11), 1912-1924 (2016-07-28)
Purified microglial cells in culture are frequently used to model brain inflammatory responses but obtaining large yields of these cells on a routine basis can be quite challenging. Here, we demonstrate that it is possible to achieve high-yield isolation of
Murat Dabak et al.
Endocrine, metabolic & immune disorders drug targets, 20(9), 1523-1530 (2020-05-31)
Extrarenal 1α,25-dihydroxyvitamin D3 (1,25-D) locally produced by immune cells plays crucial roles in the regulation of the immune system. However, in vivo status of extrarenal 1,25-D and 25-hydroxyvitamin D (25-D) in acute inflammatory conditions are unknown. The aim of this
Maurício Dos Santos Pereira et al.
Frontiers in pharmacology, 11, 617085-617085 (2021-01-30)
Our present objective was to better characterize the mechanisms that regulate striatal neuroinflammation in mice developing L-DOPA-induced dyskinesia (LID). For that, we used 6-hydroxydopamine (6-OHDA)-lesioned mice rendered dyskinetic by repeated intraperitoneal injections of 3,4-dihydroxyphenyl-L-alanine (L-DOPA) and quantified ensuing neuroinflammatory changes
João G N Moraes et al.
Journal of dairy science, 100(6), 4784-4796 (2017-04-25)
The objectives of the current experiment were to investigate the effects of intrauterine treatment of cows with purulent vaginal discharge (PVD) using lipopolysaccharide (LPS) from Escherichia coli on uterine mRNA expression of genes related to inflammatory responses, peripheral polymorphonuclear leukocyte
Lei Li et al.
PloS one, 8(6), e65278-e65278 (2013-06-12)
First reported as a vasoactive peptide in the cardiovascular system, intermedin (IMD), also known as adrenomedullin 2 (ADM2), is a hormone with multiple potent roles, including its antioxidant action on the pulmonary, central nervous, cardiovascular and renal systems. Though IMD
Anthony P Thomas et al.
The Journal of nutrition, 141(6), 1172-1180 (2011-04-22)
In severe obesity, white adipose tissue (WAT) inflammation and macrophage infiltration are thought to contribute to WAT and whole-body insulin resistance. Specific players involved in triggering and maintaining inflammation (i.e. those regulating adipokine release and WAT macrophage recruitment, retention, or
Francisco Azuaje et al.
Theoretical biology & medical modelling, 8, 7-7 (2011-04-12)
We investigated an algorithmic approach to modelling angiogenesis controlled by vascular endothelial growth factor (VEGF), the anti-angiogenic soluble VEGF receptor 1 (sVEGFR-1) and adenosine (Ado). We explored its feasibility to test angiogenesis-relevant hypotheses. We illustrated its potential to investigate the
Ryota Sakai et al.
Clinical & translational immunology, 9(11), e1203-e1203 (2020-11-10)
Tocilizumab (TCZ) is a humanised anti-interleukin (IL)-6 receptor (IL-6R) monoclonal antibody that is a promising agent to treat various autoimmune diseases. However, the mechanism of TCZ efficacy is unclear. This study aims to elucidate the relationship between Tregs and IL-6R
Feng-Ming Ho et al.
British journal of pharmacology, 141(6), 1037-1047 (2004-02-26)
1. The present study was undertaken to investigate the anti-inflammatory effects of a synthetic compound, LCY-2-CHO, on the expression of inducible nitric oxide synthase (iNOS), COX-2, and TNF-alpha in murine RAW264.7 macrophages. 2. Within 1-30 microm, LCY-2-CHO concentration-dependently inhibited lipopolysaccharide
Nilson Carlos Ferreira Junior et al.
Cells, 10(8) (2021-08-28)
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS) or α-synuclein amyloid aggregates (αSa) to study the anti-inflammatory effects of COL-3, a tetracycline derivative without antimicrobial activity. Under LPS or αSa stimulation, COL-3 (10, 20 µM) efficiently repressed
Yi-Chin Lin et al.
The Journal of pharmacology and experimental therapeutics, 323(3), 877-887 (2007-09-15)
Glyceryl nonivamide (GLNVA), a vanilloid receptor (VR) agonist, has been reported to have calcitonin gene-related peptide-associated vasodilatation and to prevent subarachnoid hemorrhage-induced cerebral vasospasm. In this study, we investigated the neuroprotective effects of GLNVA on activated microglia-like cell mediated- and
J J Gross et al.
Domestic animal endocrinology, 74, 106554-106554 (2020-09-14)
Glucocorticoids, particularly cortisol and corticosterone, are key homeostatic regulators during metabolic and endocrine adaptations including inflammatory responses. Besides the established response of total cortisol (TC) concentrations during inflammatory processes in dairy cows, we investigated changes of corticosterone, free cortisol (FC)
Krista G Haanstra et al.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8(5), 1251-1264 (2013-07-04)
The experimental autoimmune encephalitis (EAE) model is used for preclinical research into the pathogenesis of multiple sclerosis (MS), mostly in inbred, specific pathogen free (SPF)-raised laboratory mice. However, the naive state of the laboratory mouse immune system is considered a
Yi-Ching Lo et al.
Toxicology and applied pharmacology, 228(2), 247-255 (2008-01-15)
Many herbal medicines and dietary supplements sold as aids to improve memory or treat neurodegenerative diseases or have other favorable effects on the CNS contain a catechol or similar 1,2-dihydroxy aromatic moiety in their structure. As an approach to isolate
Richard T Waldron et al.
The Journal of physiology, 597(12), 3085-3105 (2019-05-06)
This work confirms previous reports that CM4620, a small molecule inhibitor of Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by stromal interaction molecule 1 (STIM1)/Orai complexes, attenuates acinar cell pathology and acute pancreatitis in mouse experimental models.
João G N Moraes et al.
Journal of dairy science, 100(6), 4772-4783 (2017-04-25)
The objectives of the current experiment were to evaluate the effects of intrauterine infusion of Escherichia coli lipopolysaccharide (LPS) in cows diagnosed with purulent vaginal discharge (PVD) on intrauterine cell population, resolution of PVD, uterine health, and reproductive performance. Jersey
Masih-ul Alam et al.
Journal of immunology (Baltimore, Md. : 1950), 183(9), 5728-5737 (2009-10-09)
Inflammation following tissue damage promotes lymphocyte recruitment, tissue remodeling, and wound healing while maintaining self tolerance. Endogenous signals associated with tissue damage and cell death have been proposed to initiate and instruct immune responses following injury. In this study, we
Bernhard Schaaf et al.
Diagnostic pathology, 4, 12-12 (2009-04-18)
Pattern recognition receptors are a key component of the first line host defense against infection, recognizing specific microbial products. We hypothesize that monocyte hyporesponsiveness in human sepsis is associated with a downregulation of the pattern recognition receptors Toll-like receptor (TLR)-2
Eutteum Jeong et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12894-12906 (2020-08-03)
Osteoclast-mediated inflammatory bone resorption is a major cause of many inflammatory bone disorders, including rheumatoid arthritis and periodontitis. However, the mechanisms regulating osteoclast differentiation in inflammatory settings are not well understood. We demonstrate here that early estrogen-induced gene 1 (EEIG1)-deficient
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Janna Schneppenheim et al.
Molecular and cellular biology, 34(8), 1398-1411 (2014-02-05)
We reported recently that the presenilin homologue signal peptide peptidase-like 2a (SPPL2a) is essential for B cell development by cleaving the N-terminal fragment (NTF) of the invariant chain (li, CD74). Based on this, we suggested that pharmacological modulation of SPPL2a
Chun-Yu Wei et al.
Molecular pharmacology, 69(3), 960-967 (2005-12-01)
An optimal level of NO has protective effects in atherosclerosis, whereas large amounts contribute to septic shock. To study how statins, the potent inhibitors of cholesterol synthesis, regulate NO in the vascular wall, we determined their effects on interleukin-1beta (IL-1beta)-
Yannick Moret et al.
Proceedings. Biological sciences, 270(1532), 2475-2480 (2003-12-12)
A primary infection by a parasite may indicate a higher risk of being reinfected in the near future (since infection may indicate that enemies are becoming more abundant). Acquired immunity does not exist in invertebrates despite the fact that they
J J Gross et al.
Journal of animal science, 93(7), 3395-3401 (2015-10-07)
Cortisol in dairy cows is released in an episodic manner underlying a circadian rhythm. The involvement of cortisol in numerous adaptive processes to cope with adverse conditions such as pain and inflammation is well characterized. Recent studies described contradictory effects
Dipti Tripathi et al.
Arteriosclerosis, thrombosis, and vascular biology, 39(6), 1100-1112 (2019-05-10)
Objective- This study investigates the functional significance of mitochondria present in endothelial microparticles (EMP) and how MK2 (MAPKAPK2 [MAPK-activated protein kinase 2]) governs EMP production and its physiological effect on cardiac hypertrophy. Approach and Results- Flow cytometric analysis, confocal imaging
Yoshikuni Nagayama et al.
American journal of physiology. Renal physiology, 307(3), F346-F355 (2014-06-06)
Renal inflammation, in particular glomerular, is often characterized by increased IL-6 levels. The in vivo relevance of IL-6 signaling in glomerular podocytes, which play central roles in most glomerular diseases, is unknown. Here, we show that in normal mice, podocytes
Mauricio Dos-Santos-Pereira et al.
Glia, 68(3), 561-573 (2019-10-28)
We used mouse microglial cells in culture activated by lipopolysaccharide (LPS, 10 ng/ml) to study the anti-inflammatory potential of cannabidiol (CBD), the major nonpsychoactive component of cannabis. Under LPS stimulation, CBD (1-10 μM) potently inhibited the release of prototypical proinflammatory
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