CN
Search Within
M-108
应用筛选条件
关键词:'M-108'
显示 31-60 共 244 条结果 关于 "M-108" 范围 论文
Hiroshi Oneda et al.
Journal of biochemistry, 134(5), 683-690 (2003-12-23)
Bovine erythrocyte Cu,Zn-superoxide dismutase (BESOD) is a dimeric enzyme composed of identical subunits associated through unusually strong non-covalent interactions. The state of the unique tyrosyl residue (Tyr 108) of BESOD was examined, and the kinetics of subunit exchange was studied
Carsten Boltze et al.
Oncology reports, 10(6), 1783-1787 (2003-10-10)
The serine protease inhibitor maspin has been reported to inhibit invasiveness and motility of tumor cells. Additionally, a p53-dependent regulatory pathway of maspin in human cancer has been indicated. In a pre-study we were able to detect maspin protein in
Xiaofeng Shi et al.
Journal of the American Chemical Society, 129(15), 4542-4550 (2007-03-27)
Ketyl radicals produced by photolysis of ketones or di-tert-butyl peroxide (DTBP) in alcohol solvents react rapidly with tirapazamine (TPZ). The acetone ketyl radical (ACOH) reacts with TPZ with an absolute second-order rate constant of (9.7 +/- 0.4) x 108 M-1
Fredrick Fidelis Umaru et al.
Insects, 11(5) (2020-05-07)
Elasmolomus pallens is a post-harvest insect pest of groundnuts which causes severe yield loss to farmers, particularly in Africa and Asia. Resistance to synthetic chemicals has been on the rise among insects and is a constraint on insecticides regulations. In
A Kashishian et al.
The Journal of biological chemistry, 273(42), 27412-27419 (1998-10-09)
Targeting of protein kinases and phosphatases provides additional specificity to substrate selectivity in cellular signaling. In the case of the Ca2+/calmodulin-dependent protein phosphatase calcineurin, AKAP79 has been shown to bind calcineurin and inhibit its activity in vitro (Coghlan, V., Perrino
Kyle J Moor et al.
Environmental science & technology, 53(14), 8078-8086 (2019-07-04)
Sorbic acid (2,4-hexadienoic acid; HDA) is commonly used as a probe and quencher for triplet-excited chromophoric dissolved organic matter (3CDOM*), an important transient species in natural waters, yet much remains unknown about its reactivity with 3CDOM* and its triplet energy.
J T Hoskins et al.
Biochemical and biophysical research communications, 375(4), 506-511 (2008-08-30)
A site-directed mutagenesis approach was taken to disrupt each of 3 disulfide bonds within human HB-EGF by substituting serine for both cysteine residues that contribute to disulfide bonding. Each HB-EGF disulfide analogue (HB-EGF-Cys/Ser(108/121), HB-EGF-Cys/Ser(116/132), and HB-EGF-Cys/Ser(134/143)) was cloned under the
Tobias Winkler et al.
Journal of cachexia, sarcopenia and muscle, 9(5), 880-897 (2018-09-20)
No regenerative approach has thus far been shown to be effective in skeletal muscle injuries, despite their high frequency and associated functional deficits. We sought to address surgical trauma-related muscle injuries using local intraoperative application of allogeneic placenta-derived, mesenchymal-like adherent
Steven S Yu et al.
Clinical genitourinary cancer, 15(6), 742-749 (2017-07-03)
AEZS-108 (zoptarelin doxorubicin) is a cytotoxic hybrid molecule consisting of doxorubicin covalently coupled with a luteinizing hormone-releasing hormone (LHRH) analogue, which selectively targets doxorubicin to tumor cells expressing LHRH receptors. We report the clinical efficacy of AEZS-108 in a phase
M R Barbaro et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, e13388-e13388 (2018-06-30)
Intestinal permeability is altered in a subgroup of irritable bowel syndrome (IBS) patients and may contribute to symptom development. The aim of this study was to evaluate the in vitro effect of the probiotic Escherichia coli Nissle 1917 (EcN) on
Karen Rutherford et al.
Biochemistry, 45(7), 2178-2188 (2006-02-16)
The human gene for catechol O-methyltransferase (COMT) contains a common polymorphism that results in substitution of methionine (M) for valine (V) at residue 108 of the soluble form of the protein. While the two proteins have similar kinetic properties, 108M
J F Clémence et al.
Bioconjugate chemistry, 6(4), 411-417 (1995-07-01)
To attain light-dependent functionalization of biocompatible materials, a photolabel-derivatized, bioactive laminin fragment has been synthesized, chemically characterized, and photoimmobilized. Covalent high-resolution patterning of the laminin fragment CDPGYIGSR to hydroxylated fluorinated ethylene propylene (FEP-OH), poly(vinyl alcohol), and glycophase glass has been
S Frutiger et al.
Biochemistry, 31(50), 12643-12647 (1992-12-22)
The assignment of disulfide bonds in human J chain and its covalent pairing with immunoglobulin M was determined under conditions which minimize disulfide bond interchange. We show that in J chain the three intradisulfide bridges are formed between Cys 12
Dean J Mastropietro et al.
Physical review letters, 108(10), 106101-106101 (2012-04-03)
Much research has focused on the discovery and description of long-ranged forces between hydrophobic solids immersed in water. Here we show that the force between high contact-angle solids in concentrated salt solution (1 M KCl) agrees very well with van der Waals forces
Akiko Mizuno-Yasuhira et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 885-886, 8-14 (2012-01-10)
A highly selective, sensitive, and robust liquid chromatography-tandem mass spectrometric method for the determination of 5-thio-d-glucose concentrations in rat and human plasma was developed and validated. The sample preparation procedure involved protein precipitation and solid phase extraction, which efficiently removed
Tao Yang et al.
The Science of the total environment, 760, 144304-144304 (2020-12-21)
Benzothiazole (BZA) and benzotriazole (BTZ) as emerging contaminants were found persistent in aquatic environments and toxic to aquatic organisms. The degradation of BZA and BTZ by UV/chlorine was systematically investigated in this study, and the results showed that BZA and
Monrudee Sukma et al.
Journal of ethnopharmacology, 135(2), 450-454 (2011-03-29)
γ-Mangostin is a xanthone found in the fruit hulls of Garcinia mangostana L., which have long been used in Southeast Asia as a traditional medicine for the treatment of abdominal pain, dysentery, wound infections, fever and convulsions. Recent studies have
Juan Qin et al.
Biomedical chromatography : BMC, 29(2), 261-267 (2014-06-14)
A simple, specific and sensitive LC-MS/MS method was developed and validated for the determination of mesalazine in beagle dog plasma. The plasma samples were prepared by protein precipitation, then the separation of the analyte was achieved on a Waters Spherisorb
Yukiko Nakamura et al.
PLoS neglected tropical diseases, 13(7), e0007568-e0007568 (2019-07-26)
The tsetse fly, Glossina morsitans morsitans, is a significant problem in Zambia and Malawi. It is the vector for the human infective parasite Trypanosoma brucei rhodesiense, which causes human African trypanosomiasis, and various Trypanosoma species, which cause African animal trypanosomiasis.
P B Eisenhauer et al.
Infection and immunity, 60(9), 3556-3565 (1992-09-01)
Paneth cells are specialized small intestine epithelial cells that contain lysozyme, possess phagocytic properties, and secrete cytoplasmic granules into the intestinal crypt lumen after the entry of bacteria. Recent studies by Ouellette and associates (A. J. Ouellette, R. M. Greco
Inho Kim et al.
American journal of hematology, 88(1), 10-15 (2012-10-19)
We performed a phase II trial to evaluate the efficacy and safety of the modified fludarabine, cytarabine, and attenuated-dose idarubicin (m-FLAI) regimen in elderly acute myeloid leukemia (AML) patients. Elderly (≥60 years) AML patients who had not previously received chemotherapy
K Takahashi et al.
The Journal of biological chemistry, 266(20), 13284-13288 (1991-07-15)
cDNA clones encoding two isoforms of chicken gizzard calponin, a recently identified actin- and tropomyosin-binding protein, have been isolated and sequenced. The deduced polypeptides, 292 (Mr 32,333) and 252 (Mr 28,127) amino acids, contain sequences homologous to: a smooth muscle
T K Rosiere et al.
Developmental biology, 154(2), 309-317 (1992-12-01)
The ability of mouse zona pellucida glycoprotein ZP3 (mZP3) to function as a sperm receptor is attributable to certain of its oligosaccharides, not to its polypeptide (P. M. Wassarman, 1990. Development 108, 1-17). Here, purified, radioiodinated mZP3 was digested by
Xiaoxiang Peng et al.
Molecular and cellular biochemistry, 449(1-2), 207-218 (2018-04-22)
Association studies suggest that TRβ1 functions as a tumor suppressor. Thyroid hormone receptors (TRs) mediate transcriptional responses through a highly conserved DNA-binding domain (DBD). We previously constructed an artificially modified human TRβ1 (m-TRβ1) via the introduction of a 108-bp exon
Michael West et al.
Journal of the American Society of Nephrology : JASN, 20(5), 1132-1139 (2009-04-10)
In male patients with Fabry disease, an X-linked disorder of glycosphingolipid metabolism caused by deficient activity of the lysosomal enzyme alpha-galactosidase A, kidney dysfunction becomes apparent by the third decade of life and invariably progresses to ESRD without treatment. Here
Naoyuki Miyashita et al.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 21(3), 153-160 (2014-12-24)
Serum interleukin (IL)-18 level was thought to be a useful as a predictor of refractory or severe Mycoplasma pneumoniae pneumonia, and steroid administration is reported to be effective in this situation. The serum levels of IL-18 correlated significantly with those
C Gao et al.
Zhonghua yi xue za zhi, 81(23), 1436-1438 (2002-04-05)
To investigate the relationship between the polymorphism of apolipoprotein CII (apoCII) microsatellite DNA (TG) n (AG) m and coronary heart disease (CHD). The apoCII microsatellite DNA (TG) n(AG)m genotypes of 108 patients with CHD and 231 healthy persons were detected
A J Fenton et al.
Endocrinology, 129(4), 1762-1768 (1991-10-01)
PTH-related protein (PTHrP) interacts, via its amino-terminal 34 residues, with PTH receptors on osteoblasts to stimulate osteoclastic bone resorption indirectly. We now report that mature hPTHrP-(1-141) (EC50, approximately 10(-11) M) and a carboxyl-terminal fragment, PTHrP-(107-139) (EC50, approximately 10(-15) M), are
A Haese et al.
Journal of molecular biology, 243(1), 116-122 (1994-10-14)
Enniatin synthetase catalyzes the biosynthesis of N-methylated cyclohexadepsipeptides. The 347 kDa enzyme is encoded by the esyn1 gene of Fusarium scirpi and contains two domains (EA and EB) homologous to each other and to regions of other microbial peptide synthetases.
Jerry R Mendell et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(1), 192-201 (2014-10-18)
Becker muscular dystrophy (BMD) is a variant of dystrophin deficiency resulting from DMD gene mutations. Phenotype is variable with loss of ambulation in late teenage or late mid-life years. There is currently no treatment for this condition. In this BMD
2/9