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显示 1-30 共 46 条结果 关于 "M-919" 范围 论文
Mehmet Bilici et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4897-4900 (2012-12-19)
In this study, anticancer effects of mirtazapine on rats were investigated in an adenocarcinoma model induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and compared with those of cisplatin. For this purpose, 10 mg/kg doses of mirtazapine were administered orally to one group of
Xiaoyu Liu et al.
Neurochemical research, 38(9), 1973-1979 (2013-07-10)
Chemotherapic drugs may elicit acute or chronic peripheral neuropathies. Mirtazapine, as an antidepressant, is also used for the treatment of neuropathic pain. The current study aimed to investigate the effect of mirtazapine on the oxaliplatin-induced neuropathy in rats as well
Steven M Graves et al.
Pharmacology & therapeutics, 136(3), 343-353 (2012-09-11)
Understanding substance use disorders (SUDs) and the problems associated with abstinence has grown in recent years. Nonetheless, highly efficacious treatment targeting relapse prevention has remained elusive, and there remains no FDA-approved pharmacotherapy for psychostimulant dependence. Preclinical and clinical investigations assessing
[Posttraumatic stress disorder].
Ruth V Reed et al.
Praxis, 102(1), 45-48 (2013-02-07)
Zofia Rogóż
Pharmacological reports : PR, 64(6), 1567-1572 (2013-02-15)
Several clinical reports have suggested that the mirtazapine-induced augmentation of risperidone activity may effectively improve the positive, negative and some cognitive symptoms of schizophrenia. The present study was aimed at examining the effect of mirtazapine and risperidone, given separately or
Mary F Grubb et al.
Bioanalysis, 4(14), 1747-1761 (2012-08-11)
An integrated method that provides rates of both parent disappearance and metabolite formation was developed. Buspirone, mirtazapine and verapamil were used as model compounds in developing the method. Incubations were carried out on a robotic platform. Qualitative analysis of metabolites
S Banerjee et al.
Health technology assessment (Winchester, England), 17(7), 1-166 (2013-02-27)
Depression is common in dementia, causing considerable distress and other negative impacts. Treating it is a clinical priority, but the evidence base is sparse and equivocal. This trial aimed to determine clinical effectiveness of sertraline and mirtazapine in reducing depression
Jieyun Yin et al.
American journal of physiology. Gastrointestinal and liver physiology, 306(9), G796-G801 (2014-03-15)
Mirtazapine is a noradrenergic and specific serotonergic antidepressant. The aim of this study was to investigate the effects of mirtazapine on gastrointestinal motility in dogs, including solid gastric emptying, antral and small intestinal contractions, and small intestinal and colonic transit.
Letícia Lenz Sfair et al.
Chemical & pharmaceutical bulletin, 60(11), 1387-1394 (2012-11-06)
A simple, stability-indicating micellar electrokinetic chromatography (MEKC) method was developed and validated for the analysis of mianserin hydrochloride in coated tablets. The method employed (hydroxymethyl)aminomethane (TRIS) 50 mM to which sodium dodecyl sulfate (SDS) 50 mM was added at pH 10.6 as
Mustafa Gulec et al.
Psychiatry and clinical neurosciences, 67(1), 50-58 (2013-01-03)
Cisplatin chemotherapy is associated with neurotoxicity, and oxidative stress might play an important role in the pathogenesis. Mirtazapine may be a preventative agent via its less-known antioxidant properties. The aim of this study was to examine the potential chemoprotective effects
Jens Knud Larsen
Ugeskrift for laeger, 174(46), 2864-2866 (2012-11-17)
A Cochrane analysis compared efficacy and side effects of mirtazapine with other antidepressants. After six weeks of treatment no reliable difference of efficacy between mirtazapine, selective serotonin reuptake inhibitors (SSRI), noradrenaline reuptake inhibitors or tricyclic antidepressants was found. The side
Seda G Sagdinc et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 104, 222-234 (2012-12-26)
Mirtazapine (±)-1,2,3,4,10,14b-hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine is a compound with antidepressant therapeutic effects. It is the 6-aza derivative of the tetracyclic antidepressant mianserin (±)-2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine. The FT-IR and FT-Raman spectra of mirtazapine have been recorded in 4000-400 cm(-1) and 3500-10 cm(-1), respectively. The optimized geometry
Naveen Rajpurohit et al.
South Dakota medicine : the journal of the South Dakota State Medical Association, 67(4), 137-139 (2014-05-06)
We describe a rare case of severe drug-drug interaction between propafenone and mirtazapine leading to propafenone toxicity. A 69-year-old Caucasian male taking propafenone for atrial fibrillation was prescribed mirtazapine for insomnia. Subsequent to the first dose of mirtazapine the patient
Munehiro Masuzawa et al.
Masui. The Japanese journal of anesthesiology, 61(9), 1003-1005 (2012-09-28)
This case report describes a successful outcome of mirtazapine treatment in a patient with difficult post-thoracotomy pain. A 63-year-old man received thoracotomy for the resection of esophageal tumor. The pain continued 2 years after the operation. Allodynia was present in
Sunitha Rangaraju et al.
eLife, 4, e08833-e08833 (2015-12-02)
Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we
E L Theunissen et al.
Clinical pharmacology and therapeutics, 93(6), 493-501 (2013-04-17)
The aim of this study was to assess the effects of a novel antidepressant, vortioxetine 10 mg, on driving, cognitive, and psychomotor performance in 24 healthy subjects in a double-blind, placebo-controlled, three-way crossover design. Mirtazapine 30 mg was included as an active
Maho Okubo et al.
Biochemical pharmacology, 93(1), 104-109 (2014-12-06)
A personalized treatment approach should be considered with the second-generation psychiatric drug mirtazapine because of high frequencies of side effects, including characteristic drowsiness. Plasma concentrations of mirtazapine in patients are influenced by many factors, including polymorphic cytochrome P450 enzymes contributing
A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest.
Daniel Kiblboeck et al.
BMJ case reports, 2012, doi:10-doi:10 (2012-08-29)
Kunihiro Kohmura et al.
Psychopharmacology, 226(1), 75-81 (2012-10-12)
Japanese researchers have recently conducted studies using near-infrared spectroscopy (NIRS) to help diagnose psychiatric disorders based on changes in brain activity. However, the influence of psychotropic drugs on NIRS measurements has not been clarified. To assess the effects of sedative
Asuka Katsuki et al.
CNS spectrums, 17(3), 155-163 (2012-08-14)
We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). We also examined mirtazapine's effects on the serum BDNF and plasma levels of
Deborah S Kreiss et al.
Pharmacology, biochemistry, and behavior, 104, 119-124 (2013-01-22)
Obsessive Compulsive Disorder (OCD) is characterized by recurrent, anxiety-producing thoughts accompanied by unwanted, overwhelming urges to perform ritualistic behaviors. Pharmacological treatments for this disorder (serotonin uptake inhibitors) are problematic because there is a 6-8 week delayed onset and half of
Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial.
Renee Romeo et al.
The British journal of psychiatry : the journal of mental science, 202, 121-128 (2012-12-22)
Depression is a common and costly comorbidity in dementia. There are very few data on the cost-effectiveness of antidepressants for depression in dementia and their effects on carer outcomes. To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo
Claudia Schilling et al.
Journal of clinical psychopharmacology, 33(1), 99-103 (2013-01-02)
Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with amitriptyline or paroxetine, as
Carmela Avena-Woods et al.
The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 27(12), 868-870 (2012-12-12)
Mirtazapine is an antidepressant approved for the treatment of major depressive disorder. It has been reported to also stimulate appetite and/or increase body weight, which may be beneficial in certain patient populations such as the elderly. To evaluate the use
Zsófia Bognár et al.
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 15(3), 177-180 (2013-10-11)
Hyponatremia is a potential side-effect of antidepressants that was observed most frequently in connection with compounds acting on the serotonin system. Risk of hyponatremia was found to be higher in the elderly. Authors report a case of a 65-year old
Marij Zuidersma et al.
Journal of psychosomatic research, 74(1), 25-30 (2013-01-01)
Evaluating the effects of implementing an antidepressant treatment strategy in depressed myocardial infarction (MI)-patients on long-term cardiovascular outcomes and all-cause mortality. MI-patients were evaluated for the presence of a diagnosis of post-MI depression at 3, 6, 9 and 12months after
Neeradi Dinesh et al.
Experimental parasitology, 144, 84-90 (2014-06-21)
In the present study, we have investigated the antileishmanial potential of mianserin, an antidepressant. Mianserin was found to inhibit both the promastigote and amastigote forms of the parasite in a dose dependant manner. The IC50 values for promastigotes and amastigotes
I Berling et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 20-24 (2013-11-16)
There is limited information on mirtazapine overdose, but cases of severe effects (seizures, serotonin toxicity and coma) have been reported. We aimed to investigate the clinical effects and complications of mirtazapine overdose. This was an observational case series of mirtazapine
Jonathon Holland et al.
Psychiatria Danubina, 25 Suppl 2, S286-S290 (2013-10-23)
Depression within the geriatric patient population is an important issue as it is associated with increased mortality. Such depression may have a different aetiology to that in younger patients and be associated with comorbid chronic physical health problems or cognitive
Clinical practice. Chronic pruritus.
Gil Yosipovitch et al.
The New England journal of medicine, 368(17), 1625-1634 (2013-04-26)
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