M-919

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关键词:'M-919'

显示 31-46 共 46 条结果关于 "M-919" 范围论文

Depression treatment after myocardial infarction and long-term risk of subsequent cardiovascular events and mortality: a randomized controlled trial.

Marij Zuidersma et al.

Journal of psychosomatic research, 74(1), 25-30 (2013-01-01)

Evaluating the effects of implementing an antidepressant treatment strategy in depressed myocardial infarction (MI)-patients on long-term cardiovascular outcomes and all-cause mortality. MI-patients were evaluated for the presence of a diagnosis of post-MI depression at 3, 6, 9 and 12months after

Effects of sedative antidepressants on prefrontal cortex activity during verbal fluency task in healthy subjects: a near-infrared spectroscopy study.

Kunihiro Kohmura et al.

Psychopharmacology, 226(1), 75-81 (2012-10-12)

Japanese researchers have recently conducted studies using near-infrared spectroscopy (NIRS) to help diagnose psychiatric disorders based on changes in brain activity. However, the influence of psychotropic drugs on NIRS measurements has not been clarified. To assess the effects of sedative

Antidepressant use in underweight older adults.

Carmela Avena-Woods et al.

The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 27(12), 868-870 (2012-12-12)

Mirtazapine is an antidepressant approved for the treatment of major depressive disorder. It has been reported to also stimulate appetite and/or increase body weight, which may be beneficial in certain patient populations such as the elderly. To evaluate the use

Leptin plasma concentrations increase during antidepressant treatment with amitriptyline and mirtazapine, but not paroxetine and venlafaxine: leptin resistance mediated by antihistaminergic activity?

Claudia Schilling et al.

Journal of clinical psychopharmacology, 33(1), 99-103 (2013-01-02)

Treatment with several psychopharmacological agents has been associated with increased leptin plasma concentrations. We measured leptin plasma concentrations in 76 adult depressed patients after a 6-day washout phase and again after 35 days of treatment with amitriptyline or paroxetine, as

Effects of cytochrome P450 2D6 and 3A5 genotypes and possible coadministered medicines on the metabolic clearance of antidepressant mirtazapine in Japanese patients.

Maho Okubo et al.

Biochemical pharmacology, 93(1), 104-109 (2014-12-06)

A personalized treatment approach should be considered with the second-generation psychiatric drug mirtazapine because of high frequencies of side effects, including characteristic drowsiness. Plasma concentrations of mirtazapine in patients are influenced by many factors, including polymorphic cytochrome P450 enzymes contributing

Cost-effectiveness analyses for mirtazapine and sertraline in dementia: randomised controlled trial.

Renee Romeo et al.

The British journal of psychiatry : the journal of mental science, 202, 121-128 (2012-12-22)

Depression is a common and costly comorbidity in dementia. There are very few data on the cost-effectiveness of antidepressants for depression in dementia and their effects on carer outcomes. To evaluate the cost-effectiveness of sertraline and mirtazapine compared with placebo

Mass spectrometric characterization of the human androgen receptor ligand-binding domain expressed in Escherichia coli.

Z Zhu et al.

Biochemistry, 40(36), 10756-10763 (2001-09-06)

The ligand-binding domain (LBD) of the human androgen receptor (hAR LBD), encompassing amino acids (AAs) 647-919, was expressed in Escherichia coli with an N-terminal polyhistidine tag (His(10)-hAR LBD) from a pET-16b vector. The overexpressed protein was initially insoluble in inclusion

Molecular and genetic mapping of the mouse mdx locus.

J S Cavanna et al.

Genomics, 3(4), 337-341 (1988-11-01)

mdx is an X-linked muscular dystrophy mutant of the mouse and a putative homolog of the human X-linked muscular dystrophy locus--Duchenne muscular dystrophy (DMD). Utilizing a C57BL/10/Mus Spretus interspecific cross in which the mdx mutation was segregating, we have constructed

Endothelial nitric oxide synthase plays an essential role in regulation of renal oxygen consumption by NO.

S Adler et al.

American journal of physiology. Renal physiology, 280(5), F838-F843 (2001-04-09)

Nitric oxide (NO) regulates renal O2 consumption, but the source of NO mediating this effect is unclear. We explored the effects of renal NO production on O2 consumption using renal cortex from mice deficient (-/-) in endothelial (e) nitric oxide

Detailed analysis of the repeat domain of dystrophin reveals four potential hinge segments that may confer flexibility.

M Koenig et al.

The Journal of biological chemistry, 265(8), 4560-4566 (1990-03-15)

Most of dystrophin, the protein product of the Duchenne muscular dystrophy locus, is composed of spectrin-like repeats, suggesting that dystrophin is an elongated cytoskeletal molecule (Davison, M. D., and Critchley, D. R. (1988) Cell 52, 159-160; Koenig, M., Monaco, A.

A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells.

Aimee W Kao et al.

Proceedings of the National Academy of Sciences of the United States of America, 108(11), 4441-4446 (2011-03-04)

Frontotemporal lobar degeneration is a progressive neurodegenerative syndrome that is the second most common cause of early-onset dementia. Mutations in the progranulin gene are a major cause of familial frontotemporal lobar degeneration [Baker M, et al. (2006) Nature 442:916-919 and

Gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) in toxicological analysis. Studies on the detection of clobenzorex and its metabolites within a systematic toxicological analysis procedure by GC-MS and by immunoassay and studies on the detection of alpha- and beta-amanitin in urine by atmospheric pressure ionization electrospray LC-MS.

H H Maurer et al.

Journal of chromatography. B, Biomedical sciences and applications, 689(1), 81-89 (1997-02-07)

GC-MS is the method of choice for toxicological analysis of toxicants volatile in GC while non-volatile and/or thermally labile toxicants need LC-MS for their determination. Studies are presented on the toxicological detection of the amphetamine-like anorectic clobenzorex in urine by

Vibrations of the p-chlorofluorobenzene cation.

David J Kemp et al.

Physical chemistry chemical physics : PCCP, 20(18), 12503-12516 (2018-05-01)

The vibrations of the ground state cation (X[combining tilde]2B1) of para-chlorofluorobenzene (pClFB) have been investigated using zero-electron-kinetic-energy (ZEKE) spectroscopy. ZEKE spectra were recorded using different vibrational levels of the S1 state as intermediate levels, for which assignments were put forward

Peptides derived from the C2 domain of protein kinase C epsilon (epsilon PKC) modulate epsilon PKC activity and identify potential protein-protein interaction surfaces.

Relly Brandman et al.

The Journal of biological chemistry, 282(6), 4113-4123 (2006-12-05)

Peptides derived from protein kinase C (PKC) modulate its activity by interfering with critical protein-protein interactions within PKC and between PKC and PKC-binding proteins (Souroujon, M. C., and Mochly-Rosen, D. (1998) Nat. Biotechnol. 16, 919-924). We previously demonstrated that the

Modified Glanulopexy Technique for Supersonic Transporter Deformity and Glanular Hypermobility in Men With Penile Prostheses.

Matthew J Ziegelmann et al.

The journal of sexual medicine, 15(6), 914-919 (2018-05-08)

Glanular hypermobility (GH) or supersonic transporter (SST) deformity are occasionally encountered during penile prosthesis (PP) implantation, yet management strategies are underreported with minimal data available on surgical outcomes. To describe a modified technique for glanulopexy to correct GH/SST in men

Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trial.

Bradley J Monk et al.

The Lancet. Oncology, 15(8), 799-808 (2014-06-22)

Angiogenesis is a valid target in the treatment of epithelial ovarian cancer. Trebananib inhibits the binding of angiopoietins 1 and 2 to the Tie2 receptor, and thereby inhibits angiogenesis. We aimed to assess whether the addition of trebananib to single-agent

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