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Yu-bin Su et al.
Journal of proteome research, 14(3), 1612-1620 (2015-02-13)
Edwardsiella tarda, the causative agent of Edwardsiellosis, imposes medical challenges in both the clinic and aquaculture. The emergence of multidrug resistant strains makes antibiotic treatment impractical. The identification of molecules that facilitate or promote antibiotic efficacy is in high demand.
Miles Trupp et al.
Journal of Parkinson's disease, 4(3), 549-560 (2014-06-15)
Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective disease modifying treatment. A critical requirement for designing successful clinical trials is the development of robust and reproducible biomarkers identifying PD in preclinical stages. To
Sandeep Deshmukh et al.
Journal of chromatography. A, 1388, 1-8 (2015-03-01)
Accurate quantitation of compounds in samples of biological origin is often hampered by matrix interferences one of which occurs in GC-MS analysis from the presence of highly abundant phosphate. Consequently, high concentrations of phosphate need to be removed before sample
B H Chen et al.
Journal of analytical toxicology, 14(1), 12-17 (1990-01-01)
Pentafluoropropionic anhydride (PFPA) and heptafluorobutyric anhydride (HFBA) derivatives of morphine and codeine demonstrated poor spectra due to low abundances of secondary and tertiary ions. Trifluoroacetamide (MBTFA) has been a widely used derivative; however, the internal standard, nalorphine, displayed very poor
Silke Matysik et al.
Steroids, 99(Pt B), 151-154 (2015-02-07)
A fast and sensitive GC-MS/MS method is proposed to determine pregnenolone, dehydroepiandrosterone (DHEA), testosterone and dihydrotestosterone from human plasma. Steroids were extracted by liquid/liquid extraction, and derivatized with N-methyl-N-trimethylsilyl-trifluoracetamide. Electron ionization at 30eV was applied to generate high abundant precursor
Dong Ho Suh et al.
Journal of agricultural and food chemistry, 62(34), 8764-8771 (2014-08-08)
Metabolite profiling of red and white pitayas (Hylocereus polyrhizus and Hylocereus undatus) was performed using gas chromatography-time-of-flight-mass spectrometry and ultraperformance liquid chromatography-quadrupole-time-of-flight-mass spectrometry with multivariate analysis. Different species and parts of pitayas (red peel, RP; white peel, WP; red flesh
Min Kyung Kong et al.
Journal of biotechnology, 214, 95-102 (2015-09-24)
The ent-kaurene is a dedicated precursor pool and is responsible for synthesizing natural sweeteners such as steviol glycosides. In this study, to produce ent-kaurene in Escherichia coli, we modularly constructed and expressed two ent-kaurene genes encoding ent-copalyl diphosphate synthase (CPPS)
J.E.Sullivan and L.R.Schewe
Journal of Chromatographic Science, 15, 196-196 (1977)
Sanja Milkovska-Stamenova et al.
Journal of agricultural and food chemistry, 63(25), 5911-5919 (2015-06-06)
Glycation is a ubiquitous nonenzymatic reaction of carbonyl compounds with amino groups of peptides and proteins, resulting in the formation of advanced glycation end-products (AGEs) and thereby affecting the properties and quality of thermally processed foods. In this context, mechanisms
Joon-Young Jung et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 974, 101-108 (2014-12-03)
Determination of fluxes by (13)C tracer experiments depends on monitoring the (13)C labeling pattern of metabolites during isotope experiments. In metabolome-based (13)C metabolic flux analysis, liquid chromatography combined with mass spectrometry or tandem mass spectrometry (LC/MS or LC/MS/MS, respectively) has
Thomas B Kakule et al.
Journal of the American Chemical Society, 136(51), 17882-17890 (2014-12-02)
The programming of the fungal polyketide synthase (PKS) is quite complex, with a simple domain architecture leading to elaborate products. An additional level of complexity has been found within PKS-based pathways where the PKS is fused to a single module
Bin Huang et al.
Environmental science and pollution research international, 21(22), 12898-12908 (2014-07-01)
The occurrence and behavior of endocrine disrupting chemicals (EDCs) in sewage treatment plants (STPs), especially estrogens and phenols, have been closely concerned in previous studies. However, the systematical researches about progestogens and androgens were scarce in STPs adopting different treatment
Hye-Ran Yoon et al.
Archives of pharmacal research, 33(2), 317-323 (2010-03-03)
If early diagnosis is not made, patients with peroxisomal disorders rapidly progress to sudden death, physical defect or mental retardation resulted in storage of the toxic material into the brain. Therefore, it is necessary to develop the analytical method for
J Hadrévi et al.
Scientific reports, 5, 15925-15925 (2015-11-03)
Chronic musculoskeletal pain exists either as localised to a single region or as widespread to multiple sites in several quadrants of the body. Prospective studies indicate that widespread pain could act as a far end of a continuum of musculoskeletal
Josep Marcos et al.
The Journal of steroid biochemistry and molecular biology, 152, 53-61 (2015-04-29)
The presence of two cysteinyl progestogens, 16-cysteinyl-progesterone (16-Cys-Prog) and 16-cysteinyl-pregnenolone (16-Cys-Preg), in human urine is described for the first time. Their occurrence was unequivocally confirmed by comparison with synthesized material by using mass spectrometric detectors. Several experiments were performed in
Margit Drapal et al.
Journal of microbiological methods, 106, 23-32 (2014-08-12)
In order to decipher the complex biological networks underlying biochemical and physiological processes, cellular regulation at all levels must be studied. The metabolites determined by metabolomics represent the end-point of cellular regulation and thus vital components of any integrative network.
Kai Lun Chang et al.
PloS one, 9(8), e104621-e104621 (2014-08-08)
Findings from epidemiology, preclinical and clinical studies indicate that consumption of coffee could have beneficial effects against dementia and Alzheimer's disease (AD). The benefits appear to come from caffeinated coffee, but not decaffeinated coffee or pure caffeine itself. Therefore, the
Qiao Zhao et al.
Phytochemistry, 112, 170-178 (2014-08-12)
Pinoresinol reductase (PrR) catalyzes the conversion of the lignan (-)-pinoresinol to (-)-lariciresinol in Arabidopsis thaliana, where it is encoded by two genes, PrR1 and PrR2, that appear to act redundantly. PrR1 is highly expressed in lignified inflorescence stem tissue, whereas
Xianqin Wang et al.
Biological & pharmaceutical bulletin, 38(3), 470-475 (2015-03-12)
Numerous people die of paraquat (PQ) poisoning every year in the world. Although several studies regarding paraquat (PQ) poisoning have been conducted, the metabolic changes in plasma remain unknown. In this study, the metabolomics of 15 PQ poisoned patients with
P Kiousi et al.
Journal of mass spectrometry : JMS, 50(12), 1409-1419 (2015-12-05)
This manuscript describes the direct detection of mesteroloe sulfo-conjugated metabolites by liquid chromatography/quadrupole/time of flight mass spectrometry (LC/Q/TOFMS) with special focus on evaluation of their retrospective detectability and their structure elucidation. A comparison of their long-term detectability, with the mesterolone
Meiling Zhang et al.
Chemical & pharmaceutical bulletin, 62(6), 505-507 (2014-06-03)
Hydrogen sulfide (H2S) is the second leading cause of toxin-related deaths in the operational site. Its main target organs of toxic effects are the central nervous system and respiratory system. In this study, we developed a serum metabonomic method, based
Yang Bai et al.
Molecular genetics and genomics : MGG, 290(4), 1247-1263 (2015-01-13)
Apple fruit acidity, which affects the fruit's overall taste and flavor to a large extent, is primarily determined by the concentration of malic acid. Previous studies demonstrated that the major QTL malic acid (Ma) on chromosome 16 is largely responsible
Bilal Yilmaz et al.
Journal of AOAC International, 97(4), 1061-1066 (2014-08-26)
This paper describes a GCIMS method for the determination of flurbiprofen in human plasma. Flurbiprofen and internal standard ibuprofen were extracted from plasma by using a liquid-liquid extraction method. Derivatization was carried out using N-Methyl-N-(trimethylsilyl)trifluoroacetamide. The calibration curve was linear
Devin H Currie et al.
BMC systems biology, 9, 30-30 (2015-06-27)
Thermoanaerobacterium saccharolyticum is a hemicellulose-degrading thermophilic anaerobe that was previously engineered to produce ethanol at high yield. A major project was undertaken to develop this organism into an industrial biocatalyst, but the lack of genome information and resources were recognized
Keyvan Dastmalchi et al.
Journal of agricultural and food chemistry, 63(30), 6810-6822 (2015-07-15)
The cultivation, storage, and distribution of potato tubers are compromised by mechanical damage and suboptimal healing. To investigate wound-healing progress in cultivars with contrasting russeting patterns, metabolite profiles reported previously for polar tissue extracts were complemented by GC/MS measurements for
Syed Ghulam Musharraf et al.
Scientific reports, 5, 8607-8607 (2015-02-26)
Lung cancer has been the most common death causing cancer in the world for several decades. This study is focused on the metabolite profiling of plasma from lung cancer (LC) patients with three control groups including healthy non-smoker (NS), smokers
Suganthagunthalam Dhakshinamoorthy et al.
Molecular bioSystems, 11(9), 2406-2416 (2015-07-16)
Altered metabolism is increasingly acknowledged as an important aspect of cancer, and thus serves as a potentially fertile area for the identification of therapeutic targets or leads. Our recent work using transcriptional data to predict metabolite levels in cancer cells
M A Andrews
Carbohydrate research, 194, 1-19 (1989-12-01)
Two new procedures for the gas-chromatographic analysis of monosaccharides are reported. One involves derivatization of the sugars by reaction with O-benzylhydroxylamine followed by trifluoroacetylation with N-methylbis(trifluoroacetamide) and chromatography on a DB-1701 capillary column. This technique probably provides the best resolution
Andreas Üllen et al.
Biochemical pharmacology, 93(4), 470-481 (2015-01-13)
Hypochlorous acid added as reagent or generated by the myeloperoxidase (MPO)-H2O2-Cl(-) system oxidatively modifies brain ether-phospholipids (plasmalogens). This reaction generates a sn2-acyl-lysophospholipid and chlorinated fatty aldehydes. 2-Chlorohexadecanal (2-ClHDA), a prototypic member of chlorinated long-chain fatty aldehydes, has potent neurotoxic potential
David P Enot et al.
Cell cycle (Georgetown, Tex.), 14(15), 2399-2407 (2015-06-23)
Recently, we reported that saturated and unsaturated fatty acids trigger autophagy through distinct signal transduction pathways. Saturated fatty acids like palmitate (PA) induce autophagic responses that rely on phosphatidylinositol 3-kinase, catalytic subunit type 3 (PIK3C3, best known as VPS34) and
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