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M1902
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[Left-sided hemiparesis in a diabetic patient: chronic granulomatous encephalitis due to Acanthamoeba].
M J Blanco-Vidal et al.
Revista de neurologia, 56(3), 187-188 (2013-01-30)
Weverton M Luchi et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(3), R215-R222 (2015-06-05)
Vitamin D deficiency (VDD) is widespread in the general population. Iodinated (IC) or gadolinium-based contrast media (Gd) may decrease renal function in high-risk patients. This study tested the hypothesis that VDD is a predisposing factor for IC- or Gd-induced nephrotoxicity.
Anna Avantaggiato et al.
Rejuvenation research, 18(3), 270-276 (2015-02-03)
Bio-revitalization is a commonly used technique in aesthetic medicine for improving skin quality and appearance by intra-dermal injection of hyaluronic acid (HA)-containing compounds. The present study compares different HA-containing injectables regarding their effects on cultured skin fibroblasts over time (24
Katherine P Morgan et al.
The Annals of pharmacotherapy, 46(2), 276-281 (2012-02-03)
To review the efficacy and safety of concomitant mannitol administration with cisplatin therapy to reduce the incidence of nephrotoxicity. A literature search was performed via MEDLINE, PubMed, and the Cochrane Library (1945-August 2011) using the terms mannitol, cisplatin, nephrotoxicity, and
Oluwatomide Adeoye et al.
Pharmaceutical development and technology, 19(8), 901-910 (2013-10-05)
Novel multifunctional excipients were prepared by coprocessing tapioca starch with mannitol using two methods viz; co-grinding and co-fusion. The flow, packing and compaction properties of the native and novel excipients were evaluated by using density, Hausner's ratio, angle of repose
Jiawen Huang et al.
The Journal of biological chemistry, 290(31), 19044-19054 (2015-06-14)
G protein pathway suppressor 2 (GPS2) is a multifunctional protein involved in the regulation of a number of metabolic organs. First identified as part of the NCoR-SMRT corepressor complex, GPS2 is known to play an important role in the nucleus
Jian-ping Jia et al.
Chinese medical journal, 117(8), 1161-1164 (2004-09-14)
An important aspect of Alzheimer's disease (AD) is loss or impairment of cholinergic neurons. It is controversial whether there is a similar cholinergic impairment and cerebral deficit of acetylcholine (ACh) in the case of vascular dementia (VD). The purpose of
Anna Ermund et al.
Clinical and experimental pharmacology & physiology, 42(1), 69-75 (2014-10-15)
Hypertonic saline inhalation has become a cornerstone in the treatment of cystic fibrosis (CF), but its effect on CF mucus is still not understood. In CF, mucus stagnates in the airways, causing mucus plugging, and forming a substrate for bacterial
Ayşegül Karataş et al.
Acta poloniae pharmaceutica, 70(5), 883-897 (2013-10-24)
The aim of the study was to investigate the physical stability of the semi-solid dispersions into the hard gelatine capsules prepared with Gelucire 44/14, Labrasol and different additives such as microcrystalline cellulose (MCC), mannitol and lactose (alpha-monohydrate) used for enhancing
Patricia Bonin et al.
Environmental science and pollution research international, 22(20), 15347-15359 (2015-01-07)
The impact of petroleum contamination and of burrowing macrofauna on abundances of Marinobacter and denitrifiers was tested in marine sediment mesocoms after 3 months incubation. Quantification of this genus by qPCR with a new primer set showed that the main
Maliha Shaikh et al.
Clinica chimica acta; international journal of clinical chemistry, 442, 24-32 (2015-01-17)
Measurement of intestinal permeability is important in several diseases but currently several methods are employed. We sought to: (1) develop a new GC based method to measure urinary mannitol, lactulose and sucralose to assess regional and total gut permeability; (2)
Evangelia Daviskas et al.
Expert review of respiratory medicine, 7(1), 65-75 (2013-02-01)
Insufficient hydration at the airway surface can make mucus adherent and poorly cleared. Cough, the major mechanism of mucus clearance in disease, is ineffective when mucus is adhesive. Inhaled mannitol creates an osmotic drive for water to move into the
Ali Al-Khattawi et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 94, 1-10 (2015-05-12)
The importance of mannitol has increased recently as an emerging diluent for orodispersible dosage forms. The study aims to prepare spray dried mannitol retaining high porosity and mechanical strength for the development of orally disintegrating tablets (ODTs). Aqueous feed of
R Bergeron et al.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 46(11), 774-781 (2014-07-02)
Studies on normoglycemic ovariectomized Sprague-Dawley rats have provided insights about the effects of estrogen deficiency on insulin resistance in lean individuals. It is not completely clear if subjects with pre-established obesity and insulin resistance are at greater risk of developing
Da Jung Kim et al.
Amino acids, 46(10), 2333-2343 (2014-06-24)
Infected wounds cause delay in wound closure and impose significantly negative effects on patient care and recovery. Antimicrobial peptides (AMPs) with antimicrobial and wound closure activities, along with little opportunity for the development of resistance, represent one of the promising
M L Selley et al.
Neurobiology of aging, 23(3), 383-388 (2002-04-18)
There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease.
Rohit Seth et al.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 30, 59-65 (2014-12-04)
Previous studies have shown that zinc deficiency leads to apoptosis of neuronal precursor cells in vivo and in vitro. In addition to the role of p53 as a nuclear transcription factor in zinc deficient cultured human neuronal precursors (NT-2), we
Jing Yang et al.
Cell cycle (Georgetown, Tex.), 14(20), 3318-3330 (2015-09-18)
Fibroblast growth factors (FGF1, FGF2 and FGF4) and fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3 and FGFR4) have been reported to be expressed in preimplantation embryos and be required for their development. However, the functions of these molecules in trophectoderm
Soraya Cherifi et al.
Annals of clinical microbiology and antimicrobials, 13, 20-20 (2014-06-06)
Staphylococcus epidermidis is a pathogen that is frequently encountered in the hospital environment. Healthcare workers (HCWs) can serve as a reservoir for the transmission of S. epidermidis to patients. The aim of this study was to compare and identify differences
Valerio Leoni et al.
Clinical chemistry and laboratory medicine, 42(2), 186-191 (2004-04-06)
24S-Hydroxycholesterol (24OHC) and 27-hydroxycholesterol (27OHC) are two structurally similar oxysterols of different origins--the former almost exclusively formed in the brain and the latter formed to a lesser extent in the brain than in most other organs. HYPOTHESIS TO BE TESTED:
J-S Song et al.
Allergy, 70(6), 674-681 (2015-02-24)
Periostin is a matricellular protein, and its synthesis in airway epithelial cells and lung fibroblasts is induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of TH 2-induced airway inflammation, and (importantly) as a measure of
Reiko Ban-Ishihara et al.
FEBS letters, 589(20 Pt B), 3126-3132 (2015-09-12)
Mitochondria are dynamic organelles that alter their morphology in response to cellular signaling and differentiation through balanced fusion and fission. In this study, we found that the mitochondrial inner membrane ATPase ATAD3A interacted with ccdc56/MITRAC12/COA3, a subunit of the cytochrome
Linjie Qi et al.
Plant physiology and biochemistry : PPB, 94, 235-243 (2015-06-27)
MYB proteins are involved in many significant physiological and biochemical processes, including regulation of primary and secondary metabolism, flavonoid biosynthesis, response to various biotic and abiotic stresses, hormone synthesis and signal transduction. The functions of R2R3-MYB proteins in Scutellaria baicalensis
A Kiyoshima et al.
Journal of chromatography. B, Biomedical sciences and applications, 758(1), 103-108 (2001-08-03)
A simple, reliable and sensitive gas chromatographic-mass spectrometric method was devised to determine the level of mannitol in various human brain tissues obtained at autopsy. Mannitol was extracted with 10% trichloroacetic acid solution which effectively precipitated brain tissues. The supernatant
J-M Serot et al.
Journal of neurology, neurosurgery, and psychiatry, 76(11), 1585-1587 (2005-10-18)
Homocysteine may be involved in the pathogenesis of late onset Alzheimer's disease. It is implicated in the metabolism of several important pathways in the brain. Methylmalonic acid (MMA) is related to the metabolism of branched chained amino acids and fatty
Kuen-Bao Chen et al.
Neuroreport, 24(6), 303-307 (2013-02-22)
Intravenous mannitol (IV-M) is widely administered in the clinic to lower intracranial pressure in patients with brain trauma and stroke. However, intracarotid arterial mannitol (ICA-M) is known to potently open the blood-brain barrier (BBB) to serum protein tracers such as
Emil Meng-Lund et al.
Journal of pharmaceutical sciences, 103(7), 2053-2061 (2014-05-16)
The pH partition theory proposes a correlation between fraction of unionized drug substance and permeability. The aim of this study was to compare the permeability of metoprolol and mannitol in ex vivo human and porcine buccal mucosa models at varying
M Diop et al.
International journal of pharmaceutics, 491(1-2), 402-408 (2015-06-07)
Insulin delivery by oral route would be ideal, but has no effect, due to the harsh conditions of the gastrointestinal tract. Protection of insulin using encapsulation in self-assembled particles is a promising approach. However, the lack of stability of this
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Ivana R Sequeira et al.
PloS one, 9(6), e99256-e99256 (2014-06-06)
Lactulose mannitol ratio tests are clinically useful for assessing disorders characterised by changes in gut permeability and for assessing mixing in the intestinal lumen. Variations between currently used test protocols preclude meaningful comparisons between studies. We determined the optimal sampling
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