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关键词:'M2133'
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beta-N-Acetylhexosaminidases HEXO1 and HEXO3 are responsible for the formation of paucimannosidic N-glycans in Arabidopsis thaliana
Liebminger E, et al.
Test, 286(12), 10793-10802 (2011)
M O'Brien et al.
Applied and environmental microbiology, 53(7), 1718-1720 (1987-07-01)
A total of 101 strains of bacteria from environmental and clinical sources, most of which were gram negative, were tested for chitobiase activity by using a filter paper spot test with 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide as the substrate. The results were compared with
Gianluca Scerra et al.
iScience, 24(7), 102707-102707 (2021-07-15)
Lysosome functions mainly rely on their ability to either degrade substrates or release them into the extracellular space. Lysosomal storage disorders (LSDs) are commonly characterized by a chronic lysosomal accumulation of different substrates, thereby causing lysosomal dysfunctions and secretion defects.
Considerations in the storage of soil samples for enzyme activity analysis
Peoples MS and Koide RT
Applied soil ecology : a section of Agriculture, Ecosystems & Environment, 62(1), 98-102 (2012)
Purification and characterization of beta-N-acetylhexosaminidase I2 from human liver
Dewji NN, et al.
The Biochemical Journal, 234(1), 157-162 (1986)
Charles S Ferranti et al.
The Journal of cell biology, 219(4) (2020-04-25)
Diverse stresses, including reactive oxygen species (ROS), ionizing radiation, and chemotherapies, activate acid sphingomyelinase (ASMase) and generate the second messenger ceramide at plasma membranes, triggering apoptosis in specific cells, such as hematopoietic cells and endothelium. Ceramide elevation drives local bilayer
Quantification of Chitinase Activity in Fusarium oxysporum
Ruiz-Roldan, Carmen and Roncero, M Isabel G
Bio-protocol, 6(15), 98-102 (2016)
Natália Fernanda Couto et al.
Biochimica et biophysica acta. Biomembranes, 1862(3), 183139-183139 (2019-12-10)
Plasma membrane repair (PMR) is an important process for cell homeostasis, especially for cells under constant physical stress. Repair involves a sequence of Ca2+-dependent events, including lysosomal exocytosis and subsequent compensatory endocytosis. Cholesterol sequestration from plasma membrane causes actin cytoskeleton
Yi Cui et al.
The Journal of cell biology, 218(2), 615-631 (2018-12-19)
Retromer is a peripheral membrane protein complex that coordinates multiple vesicular trafficking events within the endolysosomal system. Here, we demonstrate that retromer is required for the maintenance of normal lysosomal morphology and function. The knockout of retromer subunit Vps35 causes
Li Ou et al.
Gene therapy, 27(5), 226-236 (2020-01-04)
The GM2-gangliosidoses are neurological diseases causing premature death, thus developing effective treatment protocols is urgent. GM2-gangliosidoses result from deficiency of a lysosomal enzyme β-hexosaminidase (Hex) and subsequent accumulation of GM2 gangliosides. Genetic changes in HEXA, encoding the Hex α subunit
Christian Hinderer et al.
Human gene therapy, 31(21-22), 1169-1177 (2020-10-14)
GM1 gangliosidosis is a rare neurodegenerative lysosomal storage disease caused by loss-of-function mutations in the gene encoding beta-galactosidase (β-gal). There are no approved treatments for GM1 gangliosidosis. Previous studies in animal models have demonstrated that adeno-associated viral (AAV) vector-mediated gene
Matt Lloyd Jones et al.
eLife, 10 (2021-10-19)
Common garden experiments that inoculate a standardised growth medium with synthetic microbial communities (i.e. constructed from individual isolates or using dilution cultures) suggest that the ability of the community to resist invasions by additional microbial taxa can be predicted by
Tri M Tran et al.
Apoptosis : an international journal on programmed cell death, 14(3), 320-332 (2009-01-20)
Macrophages are the principal source of TNFalpha, yet they are highly resistant to TNFalpha-mediated cell death. Previously, employing in vitro differentiated human macrophages, we showed that following the inhibition of NF-kappaB, TNFalpha-induced caspase-8 activation contributes to DNA fragmentation but is
4-MUF-NAG for fungal biomass determination: Scope and limitations in the context of biodeteriorationstudies
Sequeira S, et al.
Journal of cultural heritage, 22, 992-998 (2016)
Jinzhong Zhang et al.
Autophagy, 15(10), 1738-1756 (2019-03-21)
Several lines of evidence support the occurrence of cross-regulation between the endocytic pathway and autophagy, but the molecular mechanisms regulating this process are not well-understood. Here, we show that the calcium sensor UNC13D regulates the molecular mechanism of late endosomal
Xiaohai Wang et al.
The Journal of pharmacology and experimental therapeutics, 374(2), 252-263 (2020-06-05)
Deposition of hyperphosphorylated and aggregated tau protein in the central nervous system is characteristic of Alzheimer disease and other tauopathies. Tau is subject to O-linked N-acetylglucosamine (O-GlcNAc) modification, and O-GlcNAcylation of tau has been shown to influence tau phosphorylation and
Sreeja V Nair et al.
Journal of cell science, 133(11) (2020-05-16)
Lysosomal exocytosis and resealing of damaged plasma membrane are essential for cellular homeostasis and tumor invasion. However, very little is known of the molecular machinery that regulates these physiological processes. Moreover, no mutations in any of the known regulators of
Raed Ibraheim et al.
Nature communications, 12(1), 6267-6267 (2021-11-03)
Adeno-associated virus (AAV) vectors are important delivery platforms for therapeutic genome editing but are severely constrained by cargo limits. Simultaneous delivery of multiple vectors can limit dose and efficacy and increase safety risks. Here, we describe single-vector, ~4.8-kb AAV platforms
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