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M3262
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Tufan Mert et al.
Pharmacological reports : PR, 66(6), 1065-1072 (2014-12-03)
In this study, we investigated the effects of locally (intraplantar) applied remifentanil, a μ opioid receptor agonist, to the paws and tested whether locally N-methyl d-aspartate (NMDA) receptors agonist or antagonist can modify remifentanil-induced effects in diabetic rats. Effects of
Luyan Jiao et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(9), 12239-12254 (2020-10-02)
α-Synuclein (α-syn)-induced neurotoxicity has been generally accepted as a key step in the pathogenesis of Parkinson's disease (PD). Microtubule-associated protein tau, which is considered second only to α-syn, has been repeatedly linked with PD in association studies. However, the underlying
Xuan Zhou et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 42(8), 1142-1151 (2019-03-08)
Glutamatergic activity in the rostral ventrolateral medulla (RVLM), which is an important brain area where angiotensin II (Ang II) elicits its pressor effects, contributes to the onset of hypertension. The present study aimed to explore the effect of central Ang
Bharanidharan Shanmugasundaram et al.
Behavioural brain research, 289, 157-168 (2015-05-02)
Several neurotransmitter receptors have been proposed to be involved in memory formation. However, information on receptor complexes (RCs) in the radial arm maze (RAM) is missing. It was therefore the aim of this study to determine major neurotransmitter RCs levels
Eriko Someya et al.
European journal of pharmacology, 803, 124-129 (2017-03-28)
Opioids contribute to the regulation of cerebral vascular tone. The purpose of this study was to examine the effects of herkinorin, a non-opioid μ-opioid receptor agonist derived from salvinorin A, on blood vessels in the rat retina and to investigate
Dae Hwan Kim et al.
Frontiers in molecular neuroscience, 10, 295-295 (2017-10-06)
The importance of actin-binding proteins (ABPs) in the regulation of synapse morphology and plasticity has been well established. SH3 protein interacting with Nck, 90 kDa (SPIN90), an Nck-interacting protein highly expressed in synapses, is essential for actin remodeling and dendritic
Christoforos A Papasavvas et al.
eNeuro, 7(2) (2020-02-27)
Parvalbumin-expressing interneurons in cortical networks are coupled by gap junctions, forming a syncytium that supports propagating epileptiform discharges, induced by 4-aminopyridine. It remains unclear, however, whether these propagating events occur under more natural states, without pharmacological blockade. In particular, we
André Kougioumoutzakis et al.
Molecular brain, 13(1), 12-12 (2020-01-31)
Hippocampal GABAergic interneurons play key roles in regulating principal cell activity and plasticity. Interneurons located in stratum oriens/alveus (O/A INs) receive excitatory inputs from CA1 pyramidal cells and express a Hebbian form of long-term potentiation (LTP) at their excitatory input
Hitoshi Miyakawa et al.
PloS one, 10(3), e0121324-e0121324 (2015-03-24)
Phenotypic plasticity is the ability held in many organisms to produce different phenotypes with a given genome in response to environmental stimuli, such as temperature, nutrition and various biological interactions. It seems likely that environmental signals induce a variety of
Jung-Hwa Tao-Cheng et al.
Biochemical and biophysical research communications, 450(1), 808-811 (2014-06-22)
Shank is a specialized scaffold protein present in high abundance at the postsynaptic density (PSD). Using pre-embedding immunogold electron microscopy on cultured hippocampal neurons, we had previously demonstrated further accumulation of Shank at the PSD under excitatory conditions. Here, using
Hironori Kamii et al.
The European journal of neuroscience, 41(9), 1126-1138 (2015-02-26)
The laterodorsal tegmental nucleus (LDT) is a brainstem nucleus implicated in reward processing and is one of the main sources of cholinergic afferents to the ventral tegmental area (VTA). Neuroplasticity in this structure may affect the excitability of VTA dopamine
Lisa Kinnavane et al.
Behavioural brain research, 359, 536-549 (2018-10-12)
The rodent anterior thalamic nuclei (ATN) are vital for spatial memory. A consideration of their extensive frontal connections suggests that these nuclei may also subserve non-spatial functions. The current experiments explored the importance of the ATN for different aspects of
Spencer G Smith et al.
International journal of molecular sciences, 21(22) (2020-11-18)
Maintenance of long-term synaptic plasticity requires gene expression mediated by cAMP-responsive element binding protein (CREB). Gene expression driven by CREB can commence only if the inhibition by a transcriptional repressor activating transcription factor 4 (ATF4; also known as CREB2) is
Muhammad Sona Khan et al.
International journal of molecular sciences, 21(12) (2020-06-25)
Carbonic anhydrase (CA) is abundant in glial cells in the brain and CA type II isoform (CA II) activity in the hippocampus plays an important role in buffering extracellular pH transients produced by neural activity. Chronic ethanol exposure results in
Johanna Andrea Gutierrez-Vargas et al.
Journal of neuroscience research, 92(11), 1529-1548 (2014-06-19)
Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and
Tomomitsu Iida et al.
Biochemical and biophysical research communications, 488(3), 534-540 (2017-05-21)
Brain histamine acts as a neurotransmitter and regulates various physiological functions, such as learning and memory, sleep-wake cycles, and appetite regulation. We have recently shown that histamine H3 receptor (H3R) is expressed in primary mouse microglia and has a strong
Shravan Chintala et al.
PloS one, 10(5), e0127776-e0127776 (2015-05-29)
The intrinsic mechanisms that promote the degeneration of retinal ganglion cells (RGCs) following the activation of N-Methyl-D-aspartic acid-type glutamate receptors (NMDARs) are unclear. In this study, we have investigated the role of downstream regulatory element antagonist modulator (DREAM) in NMDA-mediated
Timal S Kannangara et al.
Cerebral cortex (New York, N.Y. : 1991), 25(8), 2102-2113 (2014-02-21)
The different secondary subunits of the N-methyl-d-aspartate (NMDA) receptor each convey unique biophysical properties to the receptor complex, and may be key in determining the functional role played by NMDA receptors. In the hippocampus, the GluN2A and GluN2B subunits are
Laura Anselmi et al.
Gastroenterology, 153(6), 1581-1593 (2017-09-16)
In most patients with Parkinson's disease, gastrointestinal (GI) dysfunctions, such as gastroparesis and constipation, are prodromal to the cardinal motor symptoms of the disease. Sporadic Parkinson's disease has been proposed to develop after ingestion of neurotoxicants that affect the brain-gut
Julius Baya Mdzomba et al.
Cell death & disease, 9(7), 727-727 (2018-06-29)
Myelin-associated proteins such as Nogo-A are major inhibitors of neuronal plasticity that contribute to permanent neurological impairments in the injured CNS. In the present study, we investigated the influence of Nogo-A on visual recovery after retinal injuries in mice. Different
Hiram Luna-Munguia et al.
The Journal of pharmacology and experimental therapeutics, 352(2), 368-378 (2014-12-17)
As a member of the multidrug-resistance associated protein (MRP) family, MRP2 affects the brain entry of different endogenous and exogenous compounds. Considering the role of this transporter at the blood-brain barrier, the regulation is of particular interest. However, there is
Bao Fu et al.
BMC anesthesiology, 17(1), 111-111 (2017-08-25)
Ketamine is a frequently used intravenous anesthetic, which can reversibly induce loss of consciousness (LOC). Previous studies have demonstrated that thalamocortical system is critical for information transmission and integration in the brain. The ventral posteromedial nucleus (VPM) is a critical
Xiaoling Chen et al.
Acta pharmaceutica Sinica. B, 10(9), 1634-1645 (2020-10-23)
Systematic administration of anti-inflammatory cytokine interleukin 4 (IL-4) has been shown to improve recovery after cerebral ischemic stroke. However, whether IL-4 affects neuronal excitability and how IL-4 improves ischemic injury remain largely unknown. Here we report the neuroprotective role of
K Ogita
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 105(1), 23-33 (1995-01-01)
A series of investigations has been made to analyze the receptive mechanisms for signals mediated by an N-methyl-D-aspartic acid (NMDA)-sensitive subclass of brain excitatory amino acid receptors. Treatment of synaptic membranes with a low concentration of Triton X-100 induced a
Kolter B Grigsby et al.
Neuroscience letters, 671, 50-55 (2018-02-10)
The extent to which N-Methyl-d-aspartate (NMDA) receptors facilitate the motivation to voluntarily wheel-run in rodents has yet to be determined. In so, we utilized female Wistar rats selectively bred to voluntarily run high (HVR) and low (LVR) nightly distances in
Jiejie Wang et al.
Nature communications, 9(1), 2267-2267 (2018-06-13)
NMDA receptors (NMDARs) are crucial for excitatory synaptic transmission and synaptic plasticity. The number and subunit composition of synaptic NMDARs are tightly controlled by neuronal activity and sensory experience, but the molecular mechanism mediating NMDAR trafficking remains poorly understood. Here
Armita Kakavand Hamidi et al.
Psychoneuroendocrinology, 104, 243-248 (2019-03-25)
Type 2 diabetes mellitus (T2DM) is a continuous metabolic disease linked with increased rate of mortality and morbidity. High levels of glucose can damage organs including kidneys, eyes, and the nervous system. Individuals with T2DM have a high prevalence of
Ana Mendanha Falcão et al.
Cell reports, 27(4), 1090-1102 (2019-04-25)
Citrullination, the deimination of peptidylarginine residues into peptidylcitrulline, has been implicated in the etiology of several diseases. In multiple sclerosis, citrullination is thought to be a major driver of pathology through hypercitrullination and destabilization of myelin. As such, inhibition of
Luciana Luchelli et al.
Journal of cell science, 128(8), 1542-1554 (2015-03-05)
Repression of mRNA translation is linked to the formation of specific cytosolic foci such as stress granules and processing bodies, which store or degrade mRNAs. In neurons, synaptic activity regulates translation at the post-synapse and this is important for plasticity.
Nirnath Sah et al.
Scientific reports, 7(1), 10903-10903 (2017-09-09)
Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing
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