CN
Search Within
M4880
应用筛选条件
关键词:'M4880'
显示 1-30 共 3888 条结果 关于 "M4880" 范围 论文
Brennan S Dirk et al.
PloS one, 10(4), e0125619-e0125619 (2015-04-29)
The Human Immunodeficiency Virus type 1 (HIV-1) accessory protein Nef interacts with a multitude of cellular proteins, manipulating the host membrane trafficking machinery to evade immune surveillance. Nef interactions have been analyzed using various in vitro assays, co-immunoprecipitation studies, and
Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Ayaka Yatsu et al.
Biology open, 4(3), 267-275 (2015-02-11)
Varp (VPS9-ankyrin repeat protein) was originally identified as an activator of small GTPase Rab21 through its VPS9 domain, but it has subsequently been shown to function as a Rab32/38 effector through its first ANKR1 domain. Although these functions of Varp
Sabu Abraham et al.
Nature communications, 6, 7286-7286 (2015-07-02)
During angiogenesis, Rho-GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenesis
Sumei Wang et al.
Molecular cancer therapeutics, 13(12), 3163-3174 (2014-10-17)
Nasopharyngeal carcinoma (NPC) is a malignant tumor originating in the epithelium. Radiotherapy is the standard therapy, but tumor resistance to this treatment reduces the 5-year patient survival rate dramatically. Studies are urgently needed to elucidate the mechanism of NPC radioresistance.
Maksym O Chekanov et al.
Journal of enzyme inhibition and medicinal chemistry, 29(5), 639-646 (2013-10-05)
In order to find the new potent CK2 inhibitors the 60 derivatives of 2-aminopyrimidinone and their 6-aza-substituted analogs were synthesized and tested in vitro. Among them, the most efficient inhibitor 2-hydroxy-5-[4-(4-methoxyphehyl)-6-oxo-1,6-dihydropyrimidin-2-ylamino] benzoic acid was identified (IC50 = 1.1 μM). The structure--activity relationship study
Jason M Wolfs et al.
Nucleic acids research, 42(13), 8816-8829 (2014-07-12)
Targeting gene disruptions in complex genomes relies on imprecise repair by the non-homologous end-joining DNA pathway, creating mutagenic insertions or deletions (indels) at the break point. DNA end-processing enzymes are often co-expressed with genome-editing nucleases to enhance the frequency of
Annelies Geirnaert et al.
FEMS microbiology ecology, 91(6) (2015-05-23)
Butyrate-producing bacteria are promising probiotic candidates to target microbial dysbiosis in gastrointestinal disorders like inflammatory bowel diseases. Butyricicoccus pullicaecorum 25-3(T), a butyrate-producing clostridial cluster IV strain, is such a candidate. Little is known about its abundance in the colon microbiota
Tian Wang et al.
Toxicology mechanisms and methods, 24(8), 560-566 (2014-08-20)
Escin, a natural mixture of triterpenoid saponin isolated from the seed of the horse chestnut, is reported to have a potent antiulcer activity against ethanol-induced gastric mucosal lesions. This study investigated the possible mechanisms underlying the gastroprotective effect of escin
Khosrow Chehri et al.
Microbial ecology, 69(3), 457-471 (2014-09-23)
Members of Fusarium solani species complex (FSSC) have been known as plant, animal, and human pathogens. Nevertheless, the taxonomic status of such an important group of fungi is still very confusing and many new species as well as lineages have
Marika Comegna et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3720-3733 (2014-05-16)
Cellular senescence is a permanent cell cycle arrest triggered by different stimuli. We recently identified up-regulation of microRNA (miR)-494 as a component of the genetic program leading to senescence of human diploid IMR90 fibroblasts. Here, we used 2-dimensional differential gel
Rajesh Kumar G et al.
PloS one, 10(3), e0120359-e0120359 (2015-03-31)
Coronary Artery Disease (CAD) is clearly a multifactorial disease that develops from childhood and ultimately leads to death. Several reports revealed having a First Degree Relatives (FDRS) with premature CAD is a significant autonomous risk factor for CAD development. C
Bjoern Traenkle et al.
Molecular & cellular proteomics : MCP, 14(3), 707-723 (2015-01-18)
β-catenin is the key component of the canonical Wnt pathway and plays a crucial role in a multitude of developmental and homeostatic processes. The different tasks of β-catenin are orchestrated by its subcellular localization and participation in multiprotein complexes. To
S C Salvage et al.
Acta physiologica (Oxford, England), 214(3), 361-375 (2015-04-09)
Cardiac ryanodine receptor mutations are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT), and some, including RyR2-P2328S, also predispose to atrial fibrillation. Recent work associates reduced atrial Nav 1.5 currents in homozygous RyR2-P2328S (RyR2(S/S) ) mice with slowed conduction and increased
Giuseppe Mancuso et al.
Molecules (Basel, Switzerland), 20(10), 18907-18922 (2015-10-27)
Ruta graveolens (rue) is a spontaneous plant in the Mediterranean area with a strong aroma and a very intense bitter taste, used in gastronomy and in folk medicine. From the leaves, stems and fruits of rue, we isolated rutin, rutamarin
Joydeep Roy et al.
Molecular biology of the cell, 26(9), 1583-1600 (2015-03-06)
Hsp70 aids in protein folding and directs misfolded proteins to the cellular degradation machinery. We describe discrete roles of Hsp70,SSA1 as an important quality-control machinery that switches functions to ameliorate the cellular environment. SSA1 facilitates folding/maturation of newly synthesized protein
Michelle M Leger et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(33), 10239-10246 (2015-04-02)
Bacterial division initiates at the site of a contractile Z-ring composed of polymerized FtsZ. The location of the Z-ring in the cell is controlled by a system of three mutually antagonistic proteins, MinC, MinD, and MinE. Plastid division is also
Andrea A Baccarelli et al.
Clinical epigenetics, 7, 44-44 (2015-04-23)
Platelets are critical in the etiology of cardiovascular disease (CVD), and the mitochondria in these cells serve as an energy source for platelet function. Epigenetic factors, especially DNA methylation, have been employed as markers of CVD. Unlike nuclear DNA methylation
M G Desimio et al.
Cell cycle (Georgetown, Tex.), 14(7), 1036-1045 (2015-01-21)
As the name implies, Stimulated by Retinoic Acid 8 is an early retinoic acid (RA) responsive gene pivotal for the beginning of meiosis in female and male germ cells. Its expression is strictly time-dependent and cell-specific (pre-meiotic germ cells) and
Wei Dang et al.
Journal of molecular neuroscience : MN, 54(4), 811-819 (2014-11-16)
The single-nucleotide polymorphisms (SNP) rs6943555 in autism susceptibility candidate 2 (AUTS2) has been reported to be significantly associated with alcohol consumption in Europeans. In this study, we identified the SNP in AUTS2 contributing to the genetic susceptibility to heroin dependence.
Yingyi Wang et al.
Gene, 556(2), 127-131 (2014-11-30)
Growing evidence suggests that genetic variants of X-ray repair cross-complementing group 1 proteins (XRCC1) contribute to genetic effects on the development of lung cancer. This case-control study aims to evaluate the genetic effects of XRCC1 c.482C>T and c.1686C>G single nucleotide
S K Brown et al.
Heredity, 115(6), 488-495 (2015-06-25)
Throughout most of the Americas, post-colonial dogs largely erased the genetic signatures of pre-historical dogs. However, the North American Arctic harbors dogs that are potentially descended from pre-historical ancestors, as well as those affected by post-colonial translocations and admixtures. In
J L Barr et al.
British journal of pharmacology, 172(22), 5414-5424 (2015-09-17)
Ceftriaxone is a β-lactam antibiotic and glutamate transporter activator that reduces the reinforcing effects of psychostimulants. Ceftriaxone also reduces locomotor activation following acute psychostimulant exposure, suggesting that alterations in dopamine transmission in the nucleus accumbens contribute to its mechanism of
Carlos Moreno-Yruela et al.
STAR protocols, 2(1), 100313-100313 (2021-03-05)
Histone deacetylases (HDACs) are ubiquitous enzymes that cleave post-translational ε-N-acyllysine modifications. The continued identification of diverse acyl modifications at lysine residues in proteins has resulted in discovery of new insight into the biological roles of these enzymes. Here, we describe
S C Zainathan et al.
Journal of fish diseases, 38(8), 739-754 (2014-08-19)
Molecular (PCR) diagnostic tests for the detection and identification of aquareovirus in general, and Tasmanian Atlantic salmon reovirus (TSRV) specifically, were developed, and their diagnostic sensitivity and specificity were determined and compared with virus isolation in cell culture. Intralaboratory and
Binbin Yang et al.
Current neurovascular research, 12(1), 63-72 (2015-01-06)
Heat shock protein B8 (HspB8) is a chaperone protein that is highly and constitutively expressed in the brain, cardiac tissue and many other organs. Recently, it has been shown that HspB8 can enhance cardiac function and render cardioprotection. However, the
Carla Ritagliati et al.
PLoS neglected tropical diseases, 9(4), e0003725-e0003725 (2015-04-16)
Trypanosoma cruzi is a protozoan pathogen responsible for Chagas disease. Current therapies are inadequate because of their severe host toxicity and numerous side effects. The identification of new biotargets is essential for the development of more efficient therapeutic alternatives. Inhibition
P S S Rao et al.
Psychopharmacology, 232(13), 2333-2342 (2015-01-27)
Several studies have demonstrated a correlation between extracellular glutamate concentration in the mesolimbic reward pathway and alcohol craving. Extracellular glutamate concentration is regulated by several glutamate transporters. Glial glutamate transporter 1 (GLT1) is one of them that regulates the majority
Agnieszka Paradowska-Gorycka et al.
The Journal of rheumatology, 42(2), 170-180 (2014-12-03)
The aim of the study was to identify 2 polymorphic variants in the promoter region of the Foxp3 gene and their possible association with susceptibility to and severity of rheumatoid arthritis (RA). The association between genetic factors and pathogenesis suggests
Martin Holzer et al.
Journal of applied toxicology : JAT, 34(11), 1167-1176 (2014-02-18)
Although carbon-based nanomaterials (CBNs) have been shown to exert prothrombotic effects in microvessels, it is poorly understood whether CBNs also have the potential to interfere with the process of leukocyte-endothelial cell interactions and whether the shape of CBNs plays a
Capucine Hyon et al.
American journal of medical genetics. Part A, 167A(8), 1851-1858 (2015-04-23)
Disorders of Sex Development (DSD) are a heterogeneous group of disorders affecting gonad and/or genito-urinary tract development and usually the endocrine-reproductive system. A genetic diagnosis is made in only around 20% of these cases. The genetic causes of 46,XX-SRY negative
1/130