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Natalie A Wheeler et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(32), 11399-11414 (2015-08-14)
During development, oligodendrocytes (OLGs), the myelinating cells of the CNS, undergo a stepwise progression during which OLG progenitors, specified from neural stem/progenitor cells, differentiate into fully mature myelinating OLGs. This progression along the OLG lineage is characterized by well synchronized
David E A Kloet et al.
The Biochemical journal, 469(2), 289-298 (2015-05-21)
Activity of FOXO (forkhead box O) transcription factors is inhibited by growth factor-PI3K (phosphoinositide 3-kinase)-PKB (protein kinase B)/Akt signalling to control a variety of cellular processes including cell cycle progression. Through comparative analysis of a number of microarray datasets we
Mathieu Cayla et al.
PLoS pathogens, 10(9), e1004347-e1004347 (2014-09-19)
Protozoan pathogens of the genus Leishmania have evolved unique signaling mechanisms that can sense changes in the host environment and trigger adaptive stage differentiation essential for host cell infection. The signaling mechanisms underlying parasite development remain largely elusive even though
Summer Gul et al.
Cancer biomarkers : section A of Disease markers, 15(5), 551-557 (2015-09-26)
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor beta (TGF-β) super family, which are primarily known for their inherent role in osteogenesis and ontogenesis. Accumulating evidence suggests the regulatory role of BMP-4 in cellular proliferation, apoptosis, differentiation and
Yuki Konishi et al.
Analytical biochemistry, 484, 66-71 (2015-05-17)
Quantifying levels of DNA methylation in tumors is a useful approach for the identification of potential tumor suppressors and to find biomarkers that can be used as prognostic or therapeutic indicators. In the current study, we compared three methods commonly
Thorsten Langner et al.
Eukaryotic cell, 14(9), 846-857 (2015-05-03)
Chitin is an essential component of the fungal cell wall, providing rigidity and stability. Its degradation is mediated by chitinases and supposedly ensures the dynamic plasticity of the cell wall during growth and morphogenesis. Hence, chitinases should be particularly important
Ronghua Wu et al.
PloS one, 10(5), e0127940-e0127940 (2015-05-30)
The 27.8 kDa membrane protein from flounder (Paralichthys olivaceus) gill (FG) cells was previously identified as a putative cellular receptor involved in lymphocystis disease virus (LCDV) infection. In this paper, the expression of receptor-27.8 kDa (27.8R) and LCDV loads in
Bingkun K Chen et al.
Transfusion, 55(5), 1013-1020 (2014-11-22)
There are no effective treatments that slow the progression of neurodegenerative diseases. A major challenge of treatment in neurodegenerative diseases is appropriate delivery of pharmaceuticals into the cerebrospinal fluid (CSF) of affected individuals. Mesenchymal stromal cells (MSCs-either naïve or modified)
Shenghong Zhong et al.
Soft matter, 11(35), 6999-7004 (2015-08-05)
Here, we report the development of an experimental system based on liquid crystals (LCs) confined in microcapillaries for imaging interfacial phenomena. The inner surfaces of the microcapillaries were modified with octadecyltrichlorosilane to promote an escaped-radial configuration of LCs. We checked
Peifu Zhou et al.
Biochemical and biophysical research communications, 467(2), 421-426 (2015-09-30)
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), has inflicted about one third of mankind and claims millions of deaths worldwide annually. Signalling plays an important role in Mtb pathogenesis and persistence, and thus represents attractive resource for drug
Xuan Ye et al.
Human molecular genetics, 24(10), 2938-2951 (2015-02-14)
Accumulation of dysfunctional mitochondria is one of the hallmarks in Alzheimer's disease (AD). Mitophagy, a selective autophagy for eliminating damaged mitochondria, constitutes a key cellular pathway in mitochondrial quality control. Recent studies established that acute depolarization of mitochondrial membrane potential
Satoshi Ishii et al.
Applied and environmental microbiology, 80(24), 7505-7511 (2014-09-28)
To secure food and water safety, quantitative information on multiple pathogens is important. In this study, we developed a microfluidic quantitative PCR (MFQPCR) system to simultaneously quantify 11 major human viral pathogens, including adenovirus, Aichi virus, astrovirus, enterovirus, human norovirus
Carmela De Marco et al.
Oncotarget, 6(37), 39634-39650 (2015-06-09)
The hotspot E17K mutation in the pleckstrin homology domain of AKT1 occurs in approximately 0.6-2% of human lung cancers. In this manuscript, we sought to determine whether this AKT1 variant is a bona-fide activating mutation and plays a role in
Heather D Eshleman et al.
Journal of cell science, 127(Pt 22), 4974-4983 (2014-09-23)
Sister chromatid bi-orientation on the mitotic spindle is essential for proper chromosome segregation. Defects in bi-orientation are sensed and corrected to prevent chromosome mis-segregation and aneuploidy. This response depends on the adaptor protein Sgo1, which associates with pericentromeric chromatin in
Siriphat Ruengphayak et al.
Rice (New York, N.Y.), 8, 7-7 (2015-04-07)
Pyramiding multiple genes into a desirable genetic background can take years to accomplish. In this paper, a pseudo-backcrossing scheme was designed to shorten the backcrossing cycle needed. PinK3, an aromatic and potentially high-yielding rice variety-although one that is intolerant to
Meredith E Jackrel et al.
Disease models & mechanisms, 7(10), 1175-1184 (2014-07-27)
Protein misfolding is implicated in numerous lethal neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD). There are no therapies that reverse these protein-misfolding events. We aim to apply Hsp104, a hexameric AAA+ protein from yeast, to target
Muhammad Imran et al.
Viral immunology, 27(8), 404-411 (2014-09-10)
The adaptive immune system plays an important role in response to interferon plus ribavirin treatment of hepatitis C virus (HCV) infection. Cytokines play a significant role in the adaptive immune system. The production of cytokines may be regulated by single
Jennifer I Luebke et al.
Cerebral cortex (New York, N.Y. : 1991), 25(6), 1454-1468 (2013-12-11)
The effects of normal aging on morphologic and electrophysiologic properties of layer 3 pyramidal neurons in rhesus monkey primary visual cortex (V1) were assessed with whole-cell, patch-clamp recordings in in vitro slices. In another cohort of monkeys, the ultrastructure of
Yoojung Kwon et al.
The Journal of biological chemistry, 290(22), 14245-14266 (2015-04-25)
Cyclooxgenase-2 (COX-2) knock-out mouse experiments showed that COX-2 was necessary for in vivo allergic inflammation, such as passive cutaneous anaphylaxis, passive systemic anaphylaxis, and triphasic cutaneous allergic reaction. TargetScan analysis predicted COX-2 as a target of miR-26a and miR-26b. miR-26a/-26b
Minyoung Lee et al.
Foodborne pathogens and disease, 11(12), 988-997 (2014-10-11)
From July 2006 to June 2008, a total of 3876 Escherichia coli strains were collected from 1014 porcine intestinal contents to investigate antimicrobial resistance and related gene patterns. Average resistance rates of porcine E. coli isolates were 93.2% for tetracycline
Bi-Tzen Juang et al.
Human molecular genetics, 23(18), 4945-4959 (2014-05-14)
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a severe neurodegenerative disorder that affects carriers of premutation CGG-repeat expansion alleles of the fragile X mental retardation 1 (FMR1) gene; current evidence supports a causal role of the expanded CGG repeat within the
Bianca Dauber et al.
Journal of virology, 88(17), 9624-9632 (2014-06-13)
We recently demonstrated that the virion host shutoff (vhs) protein, an mRNA-specific endonuclease, is required for efficient herpes simplex virus 1 (HSV-1) replication and translation of viral true-late mRNAs, but not other viral and cellular mRNAs, in many cell types
Frank Yang et al.
Biomedical engineering online, 14, 109-109 (2015-11-28)
Microelectrode array (MEA) devices are frequently used in neural circuit studies, especially in retinal prosthesis. For a high throughput stimulation and recording paradigm, it is desirable to obtain the responses of multiple surface RGCs initiated from the electrical signals delivered
Carla B Mellough et al.
Stem cells (Dayton, Ohio), 33(8), 2416-2430 (2015-04-02)
We and others have previously demonstrated that retinal cells can be derived from human embryonic stem cells (hESCs) and induced pluripotent stem cells under defined culture conditions. While both cell types can give rise to retinal derivatives in the absence
Sascha Rother et al.
PloS one, 10(8), e0135682-e0135682 (2015-08-27)
Studying genetic diversity of immunologically relevant molecules can improve our knowledge on their functional spectrum in normal immune responses and may also uncover a possible role of different variants in diseases. We characterized the c.503T>C polymorphism in the human KLRB1
Anna Fiust et al.
Journal of applied genetics, 56(3), 299-309 (2015-02-27)
The tolerance of spring barley (Hordeum vulgare L.) cultivars to spring drought is an important agronomic trait affecting crop yield and quality in Poland. Therefore, breeders require new molecular markers to select plants with lower spring drought susceptibility. With the
Tuyen Thi Ngoc Tran et al.
Bioorganic & medicinal chemistry, 22(18), 5110-5116 (2014-02-18)
Natural products represent compound classes with high chemical and structural diversity and various biological activities. Libraries based on natural products are valuable starting point in the search for novel biologically active substances. Here we report on the identification of the
Harindranath Kadavath et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(24), 7501-7506 (2015-06-03)
The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and several other neurodegenerative diseases. Here
Kinyas Kartal et al.
BMC cancer, 15, 824-824 (2015-11-01)
The role of methylation status of the thyroid stimulating hormone receptor gene (TSHr) in the discrimination of benign and malignant thyroid nodules has already been studied using paraffin blocks and cell lines. As cytological sampling plays an important role in
Gowri Nayak et al.
Human genetics, 134(4), 423-437 (2015-02-11)
Pathogenic mutations of MARVELD2, encoding tricellulin, a tricelluar tight junction protein, cause autosomal recessive non-syndromic hearing loss (DFNB49) in families of Pakistan and Czech Roma origin. In fact, they are a significant cause of prelingual hearing loss in the Czech
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