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Inhibition of calmodulin activity by insect venom peptides
Barnette MS
Biochemical Pharmacology, 32, 2929-2933 (1983)
Lucilene Delazari dos Santos et al.
Proteomics, 12(17), 2682-2693 (2012-07-05)
It is well known that the activation of mast cells due to the binding of mastoparan to the G(α) subunit of trimeric G proteins involves exocytosis regulation. However, experimental evidence in the literature indicates that mastoparan can also activate certain
Chun-Hsien Lin et al.
Peptides, 32(10), 2027-2036 (2011-09-03)
Mastoparans, a family of small peptides, are isolated from the wasp venom. In this study, six mastoparans were identified in the venom of six Vespa species in Taiwan. The precursors of these mastoparans are composed of N-terminal signal sequence, prosequence
Hongkuan Fan et al.
Biochimica et biophysica acta, 1813(3), 466-472 (2011-01-25)
Previous studies have implicated a role of heterotrimeric Gα(i) proteins in lipopolysaccharide (LPS)-induced inflammatory responses. We hypothesized that Toll-like receptor (TLR) signaling regulates Gα(i) proteins, which are anti-inflammatory in endotoxemia and polymicrobial sepsis. RAW 264.7 cells were stimulated with LPS
Lauri Tõntson et al.
Archives of biochemistry and biophysics, 524(2), 93-98 (2012-06-05)
Recombinant heterotrimeric G-protein α(i1), α(i2) and α(i3) subunits were purified in GDP-depleting conditions by affinity chromatography using StrepII-tagged β₁γ₂ subunits. Real-time monitoring of fluorescence anisotropy of Bodipy-FL-GTPγS was used for characterization of nucleotide binding properties and inactivation of the purified
Randy S Sprague et al.
American journal of physiology. Heart and circulatory physiology, 301(6), H2466-H2472 (2011-10-04)
Erythrocytes, via release of ATP in areas of low oxygen (O(2)) tension, are components of a regulatory system for the distribution of perfusion in skeletal muscle ensuring optimal O(2) delivery to meet tissue needs. In type 2 diabetes (DM2), there
Marcia Perez dos Santos Cabrera et al.
Biochemistry, 51(24), 4898-4908 (2012-05-29)
This study shows that MP-1, a peptide from the venom of the Polybia paulista wasp, is more toxic to human leukemic T-lymphocytes than to human primary lymphocytes. By using model membranes and electrophysiology measurements to investigate the molecular mechanisms underlying
Effects of the amphiphilic peptides melittin and mastoparan on calcium influx, phosphoinositide breakdown and arachidonic acid release in rat pheochromocytoma PC12 cells.
Choi OH
Journal of Pharmacology and Experimental Therapeutics, 260, 369-375 (1992)
Sandro Capellmann et al.
Frontiers in immunology, 14, 1154416-1154416 (2023-04-18)
Mast cells (MCs) are immune cells of the myeloid lineage distributed in tissues throughout the body. Phenotypically, they are a heterogeneous group characterized by different protease repertoires stored in secretory granules and differential presence of receptors. To adequately address aspects
Zhenya P Yordanova et al.
Annals of botany, 111(2), 191-205 (2012-12-20)
Under stress-promoting conditions unicellular algae can undergo programmed cell death (PCD) but the mechanisms of algal cellular suicide are still poorly understood. In this work, the involvement of caspase-like proteases, DNA cleavage and the morphological occurrence of cell death in
The Peptide Mastoparan Is a Potent Facilitator of the Mitochondrial Permeability Transition
Pfeiffer DR
The Journal of Biological Chemistry, 270, 4923-4932 (1995)
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins).
Higashijima T
The Journal of Biological Chemistry, 263, 6491-6494 (1988)
Speranta Avram et al.
Molecular bioSystems, 8(2), 587-594 (2011-11-17)
Antimicrobial peptides are drugs used against a wide range of pathogens which present a great advantage: in contrast with antibiotics they do not develop resistance. The wide spectrum of antimicrobial peptides advertises them in the research and pharmaceutical industry as
Jacob C Nordman et al.
Journal of neurochemistry, 129(4), 649-662 (2013-12-20)
Cholinergic signaling plays an important role in regulating the growth and regeneration of axons in the nervous system. The α7 nicotinic receptor (α7) can drive synaptic development and plasticity in the hippocampus. Here, we show that activation of α7 significantly
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists
Kleene SJ
British Journal of Pharmacology, 111, 469-472 (1994)
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii.
Y Hirai et al.
Chemical & pharmaceutical bulletin, 27(8), 1942-1944 (1979-08-01)
Dimitris Petroutsos et al.
The Plant cell, 23(8), 2950-2963 (2011-08-23)
The plant-specific calcium binding protein CAS (calcium sensor) has been localized in chloroplast thylakoid membranes of vascular plants and green algae. To elucidate the function of CAS in Chlamydomonas reinhardtii, we generated and analyzed eight independent CAS knockdown C. reinhardtii
K M Clapp et al.
American journal of physiology. Heart and circulatory physiology, 304(5), H660-H666 (2013-01-22)
Statin drugs inhibit 3-hydroxy-3-methylglutaryl CoA reductase, which reduces the synthesis of both cholesterol and isoprenoids (geranylgeranyl pyrophosphate and farnesyl pyrophosphate), with the latter being lipid molecules responsible for the posttranslational modification of small GTP-binding proteins such as Rho. Effects of
Marcia P dos Santos Cabrera et al.
Langmuir : the ACS journal of surfaces and colloids, 27(17), 10805-10813 (2011-07-30)
Antimicrobial peptides of the mastoparans family exert their bactericidal activity by binding to lipid membranes, inducing pores or defects and leaking the internal contents of vesicles and cells. However, this does not seem to be the only mechanism at play
Yoshiteru Yamada et al.
Biochemistry, 51(19), 3963-3970 (2012-05-03)
Calmodulin undergoes characteristic conformational changes by binding Ca(2+), which allows it to bind to more than 300 target proteins and regulate numerous intracellular processes in all eukaryotic cells. We measured the conformational changes of calmodulin upon Ca(2+) and mastoparan binding
Ming-Yu Guo et al.
Biomedical research (Tokyo, Japan), 31(5), 293-299 (2010-11-17)
In parotid acinar cells, the activation of β-adrenergic receptors induces the accumulation of intracellular cAMP, and consequently provokes the exocytotic release of amylase, a digestive enzyme. The cellular redox status plays a pivotal role in regulating various cellular functions. Cellular
Sarah Jones et al.
Bioconjugate chemistry, 23(1), 47-56 (2011-12-14)
Retro-inverso transformation has commonly been employed as a strategy both for the synthesis of proteolytically stable peptide analogues and for the detailed investigation of structure activity relationships. Herein, we adopted a similar strategy to probe the structure activity relationships of
Teresa M Brophy et al.
The Journal of biological chemistry, 288(15), 10628-10639 (2013-03-07)
TGF-β1 is a disulfide-bonded homodimeric protein produced by platelets and other cells that plays a role in many physiologic and pathologic processes. TGF-β1 is secreted as an inactive large latent complex (LLC) comprised of TGF-β1, latency-associated peptide, and latent TGF-β
Jelena Dinic et al.
Biochimica et biophysica acta, 1808(1), 298-306 (2010-10-13)
Laurdan and di-4-ANEPPDHQ are used as probes for membrane order, with a blue shift in emission for membranes in liquid-ordered (lo) phase relative to membranes in liquid-disordered (ld) phase. Their use as membrane order probes requires that their spectral shifts
Helen J Whalley et al.
The Plant cell, 23(11), 4079-4095 (2011-11-17)
Increases in intracellular calcium concentration ([Ca(2+)](c)) mediate plant responses to stress by regulating the expression of genes encoding proteins that confer tolerance. Several plant stress genes have previously been shown to be calcium-regulated, and in one case, a specific promoter
Hirofumi Nishikawa et al.
Journal of biochemical and molecular toxicology, 25(3), 158-168 (2011-06-15)
Antihistamine, the most important drug for Hymenoptera stinging, cannot attenuate cytotoxicity and mast cell direct activation by mastoparan that is the most abundant polypeptides in the venoms of social wasps. The aim of this study was to investigate whether gangliosides
Juan D Chavez et al.
Journal of proteome research, 10(4), 1528-1537 (2011-01-13)
Chemical cross-linking in combination with mass spectrometry has largely been used to study protein structures and protein-protein interactions. Typically, it is used in a qualitative manner to identify cross-linked sites and provide a low-resolution topological map of the interacting regions
X Vila-Farres et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 18(4), 383-387 (2011-06-16)
At present, colistin is among the few antibiotics effective against Acinetobacter baumannii clinical isolates. However, in the last few years, colistin-resistant A. baumannii strains have been isolated. Therefore, antibiotics effective against these usually pan-resistant colistin-resistant A. baumannii strains are required.
Asha Amritraj et al.
Endocrinology, 153(10), 4784-4798 (2012-08-21)
The IGF-II/mannose 6-phosphate (M6P) receptor is a single-transmembrane domain glycoprotein that plays an important role in the intracellular trafficking of lysosomal enzymes and endocytosis-mediated degradation of IGF-II. The receptor may also mediate certain biological effects in response to IGF-II binding
T Yajima et al.
Acta physiologica (Oxford, England), 203(3), 381-389 (2011-06-09)
Short-chain fatty acids (SCFA) stimulate colonic contraction and secretion, which are mediated by an enteric reflex via a mucosal sensing and cholinergic mechanisms. The involvement of G-protein signal transduction was examined in the secretory response to luminal propionate sensing in
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