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显示 1-30 共 137 条结果 关于 "M6035" 范围 论文
Wouter Engelen et al.
Nature communications, 8, 14473-14473 (2017-02-18)
DNA-based molecular circuits allow autonomous signal processing, but their actuation has relied mostly on RNA/DNA-based inputs, limiting their application in synthetic biology, biomedicine and molecular diagnostics. Here we introduce a generic method to translate the presence of an antibody into
Ahmed A H Abdellatif
Drug development and industrial pharmacy, 46(5), 744-750 (2020-04-07)
Even so, the metal nanoparticles (metal NPs) have attractive optical and biomedical applications, the translation of metal NPs into the clinical practice remains a challenge due to their severe accumulation in the body. Active targeting to renal podocytes opens the
Heini Ijäs et al.
ACS nano, 13(5), 5959-5967 (2019-04-17)
DNA nanotechnology provides a toolbox for creating custom and precise nanostructures with nanometer-level accuracy. These nano-objects are often static by nature and serve as versatile templates for assembling various molecular components in a user-defined way. In addition to the static
Hyeong Jun Byeon et al.
Journal of controlled release : official journal of the Controlled Release Society, 225, 301-313 (2016-01-31)
Albumin nanoparticles have been increasingly viewed as an effective way of delivering chemotherapeutics to solid tumors. Here, we report the one-pot development of a unique prototype of doxorubicin-loaded nanoparticles (NPs) made of naïve albumin (HSA) plus cationic- (c-HSA) or mannose-modified-albumin
Jason R Potas et al.
Journal of immunological methods, 420, 38-49 (2015-04-04)
Macrophages play a key role in tissue regeneration following peripheral nerve injury by preparing the surrounding parenchyma for regeneration, however, they can be damaging if the response is excessive. Interleukin 10 (IL-10) is a cytokine that promotes macrophages toward an
Jun Xi et al.
International journal of biological macromolecules, 141, 1287-1292 (2019-09-10)
β-conglycinin is one of the most allergenic proteins, and its constituent subunits α', α, and β are all potential allergens to humans. In the present study, we concentrated on the destructed antigenic sites of β subunit of β-conglycinin after high
Valérie Rodrigues et al.
Cytometry. Part A : the journal of the International Society for Analytical Cytology, 91(9), 901-907 (2017-07-13)
Quantifying cytokines is extremely important in studies of host-pathogen interactions. Multiplex assays are commercially available but only for human and mouse cytokines. Here a method for the simultaneous quantification of five important bovine cytokines IFNγ, IL-4, IL-10, IL-12, and TNFα
Fengchun Zhao et al.
Talanta, 195, 55-61 (2019-01-11)
Mimotopes could replace mycotoxins and their conjugates to develop immunoassay methods. The mimotopes obtained by phage display technology were mainly using monoclonal antibodies or polyclonal antibodies as targets. However, the mimotope of recombinant antibody has not been selected and applied
Silica-coated CdTe quantum dots functionalized with thiols for bioconjugation to IgG proteins.
Wolcott A, et. al.
The Journal of Physical Chemistry B, 110, 5779-5779 (2006)
A C Marques et al.
Journal of controlled release : official journal of the Controlled Release Society, 320, 180-200 (2020-01-25)
Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic options for cancer due to major potential for selective targeting and controlled drug release.
Julia Volckmar et al.
Scientific reports, 7, 43985-43985 (2017-03-08)
Hepatotropic viruses such as hepatitis C virus cause life-threatening chronic liver infections in millions of people worldwide. Targeted in vivo antigen-delivery to cross-presenting dendritic cells (DCs) has proven to be extraordinarily efficient in stimulating antigen-specific T cell responses. To determine
Danyu Wu et al.
Journal of the American Heart Association, 9(1), e014358-e014358 (2019-12-25)
Background Defects in the renal fatty acid β-oxidation pathway have been implicated in the development of renal fibrosis. Our group has developed a therapeutic vaccine targeting PCSK9 (proprotein convertase subtilisin/kexin type 9), named PCSK9Qβ-003. In this study, we investigated the
Noah R Sundah et al.
Science advances, 7(12) (2021-03-19)
Despite the importance of nucleic acid testing in managing the COVID-19 pandemic, current detection approaches remain limited due to their high complexity and extensive processing. Here, we describe a molecular nanotechnology that enables direct and sensitive detection of viral RNA
Noah R Sundah et al.
Nature biomedical engineering, 3(9), 684-694 (2019-07-10)
Massively parallel DNA sequencing is established, yet high-throughput protein profiling remains challenging. Here, we report a barcoding approach that leverages the combinatorial sequence content and the configurational programmability of DNA nanostructures for high-throughput multiplexed profiling of the subcellular expression and
Jun Ishihara et al.
Science translational medicine, 11(487) (2019-04-12)
Cancer immunotherapy with immune checkpoint inhibitors (CPIs) and interleukin-2 (IL-2) has demonstrated clinical efficacy but is frequently accompanied with severe adverse events caused by excessive and systemic immune system activation. Here, we addressed this need by targeting both the CPI
Run Lin et al.
Colloids and surfaces. B, Biointerfaces, 150, 261-270 (2016-12-29)
Detecting circulating tumor cells (CTCs) with high sensitivity and specificity is critical to management of metastatic cancers. Although immuno-magnetic technology for in vitro detection of CTCs has shown promising potential for clinical applications, the biofouling effect, i.e., non-specific adhesion of
Min Jiang et al.
Applied microbiology and biotechnology, 104(14), 6223-6234 (2020-05-24)
Porcine circovirus type 3 (PCV3) is an emerging swine pathogen associated with acute porcine dermatitis and nephropathy syndrome (PDNS)-like clinical signs, reproductive failure, and multisystemic inflammation. Current evidence shows that PCV3 is spread worldwide, and its high incidence may pose
Wanru Ma et al.
Journal of Cancer, 10(21), 5153-5161 (2019-10-12)
To investigate whether CD155 is an attractive target for T cell-mediated immunotherapy against human bladder cancer, we examined the novel bispecific antibody anti-CD3 x anti-CD155 (CD155Bi-Ab) for its ability to redirect activated T cells (ATCs) to target bladder cancer cells
Yan Du et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 22(8), 1305-1316 (2017-10-27)
A multifunctional nanobiomaterial has been developed by deliberately combining functions of superparamagnetism, fluorescence, and axonal tracing into one material. Superparamagnetic iron oxide nanoparticles were first synthesized and coated with a silica layer to prevent emission quenching through core-dye interactions; a
Cheng-Yu Li et al.
Biosensors & bioelectronics, 90, 146-152 (2016-11-26)
Direct analysis of biomolecules in complex biological samples remains a major challenge for fluorescence-based approaches due to the interference of background signals. Herein, we report an analytical methodology by exploiting a single low-cost near-infrared sub-nanosecond pulse laser to synchronously actualize
Lilin Ge et al.
Biosensors & bioelectronics, 132, 210-216 (2019-03-16)
A simple and feasible electrochemical immunosensing protocol with glucometer readout was designed for the detection of low-abundance disease-related biomarker (alpha-fetoprotein; AFP) on the basis of backfilling rolling cycle amplification (RCA) with invertase-DNA2 conjugates on the detection antibody. The assay consisted
Krupa Arun Navalkar et al.
Journal of immunological methods, 417, 10-21 (2014-12-17)
Diagnostics using peptide ligands have been available for decades. However, their adoption in diagnostics has been limited, not because of poor sensitivity but in many cases due to diminished specificity. Numerous reports suggest that protein-based rather than peptide-based disease detection
Glenn A O Cremers et al.
Bioconjugate chemistry, 30(9), 2384-2392 (2019-08-24)
The combination of the specificity of antibodies and the programmability of DNA nanotechnology has provided the scientific community with a powerful tool to label and unambiguously distinguish a large number of subcellular targets using fluorescence-based read-out methods. Whereas primary antibodies
Jianpei Xu et al.
ACS nano, 13(8), 8577-8588 (2019-07-25)
Ischemic stroke caused by a thrombus clog and ischemia is one of the most lethal and disabling cerebrovascular diseases. A sequentially targeted delivery system is highly desired to deliver thrombolytics and neuroprotectant to the site of the thrombus and ischemic
Gary A Clawson et al.
Nucleic acid therapeutics, 27(1), 23-35 (2016-10-19)
Pancreatic ductal adenocarcinomas (PDACs) constitutively express the G-protein-coupled cholecystokinin B receptor (CCKBR). In this study, we identified DNA aptamers (APs) that bind to the CCKBR and describe their characterization and targeting efficacy. Using dual SELEX selection against "exposed" CCKBR peptides
Junsung Lee et al.
Molecular pharmaceutics, 14(2), 423-430 (2016-12-13)
Efficient delivery of drugs to the retina is critical but difficult to achieve with current methods. There have been a number of attempts to use intravitreal injection of liposomes, artificial vesicles composed of a phospholipid bilayer, to overcome the limitations
Marzieh Ghanemi et al.
Current cancer drug targets, 19(1), 65-73 (2017-05-04)
Expression of human epidermal growth factor receptor type 2 (HER2) in head and neck squamous cell carcinoma (HNSCC) cell line HN5 can be employed with great opportunities of success for specific targeting of anti-cancer chemotherapeutic agents. In the current study
Joshua M Jackson et al.
The Analyst, 141(2), 640-651 (2015-11-03)
We report a highly sensitive microfluidic assay to detect minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) that samples peripheral blood to search for circulating leukemic cells (CLCs). Antibodies immobilized within three separate microfluidic devices affinity-selected CLC
Max Sauter et al.
Journal of controlled release : official journal of the Controlled Release Society, 322, 200-208 (2020-03-19)
Monoclonal antibodies (mAbs) are increasingly exploited as vehicles for the targeted delivery of cytotoxic drugs. In antibody-drug conjugates (ADCs) antibodies specifically deliver cytotoxic compounds to cancer cells. Here, we present a technology for elevating the intracellular delivery of antibodies by
Robert Hennig et al.
Journal of drug targeting, 24(10), 952-959 (2016-03-15)
The major risk factor for primary open-angle glaucoma is increased intraocular pressure stemming from elevated outflow resistance in the trabecular meshwork (TM) region. Integrins play a pivotal role in the TM by influencing its biological properties and growth factor signaling.
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