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显示 1-30 #N/A 137 条结果 关于 "M6035" 范围 论文
Zong Li et al.
Theranostics, 10(11), 5090-5106 (2020-04-21)
Meniscus deficiency, the most common and refractory disease in human knee joints, often progresses to osteoarthritis (OA) due to abnormal biomechanical distribution and articular cartilage abrasion. However, due to its anisotropic spatial architecture, complex biomechanical microenvironment, and limited vascularity, meniscus
Xin Sun et al.
Investigational new drugs, 39(1), 24-33 (2020-08-10)
T cells play crucial roles in the antitumour immune response. However, their dysfunction leads to inefficient tumour eradication. New members of the B7 family have moved to the fore of cancer research because of their involvement in T cell-mediated immune
Yunfei Zhang et al.
Macromolecular bioscience, 21(1), e2000194-e2000194 (2020-10-15)
Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on-demand antibacterial effects. In this study, a
Maria W Smith et al.
PloS one, 9(5), e97826-e97826 (2014-05-17)
PCR multiplexing has proven to be challenging, and thus has provided limited means for pathogen genotyping. We developed a new approach for analysis of PCR amplicons based on restriction endonuclease digestion. The first stage of the restriction enzyme assay is
Lanfang Zhang et al.
Journal of immunology research, 2015, 129682-129682 (2015-08-11)
In this study, we have evaluated our recently developed method for antigen-cell coupling using sulfosuccinimidyl-4-[N-maleimidomethyl]cyclohexane-1-carboxylate (sulfo-SMCC) heterobifunctional crosslinker in prevention and reversal of experimental autoimmune encephalomyelitis (EAE). We demonstrate that infusion of MOG35-55-coupled spleen cells (MOG-SP) significantly prevents and reverses
Catherine A Bessell et al.
JCI insight, 5(8) (2020-04-24)
Recent studies show gut microbiota modulate antitumor immune responses; one proposed mechanism is cross-reactivity between antigens expressed in commensal bacteria and neoepitopes. We found that T cells targeting an epitope called SVYRYYGL (SVY), expressed in the commensal bacterium Bifidobacterium breve
Adam A Walters et al.
Journal of controlled release : official journal of the Controlled Release Society, 322, 519-529 (2020-04-04)
Apoptotic cells and cell fragments, especially those produced as a result of immunogenic cell death (ICD), are known to be a potential source of cancer vaccine immunogen. However, due to variation between tumours and between individuals, methods to generate such
Qingyang Meng et al.
Scientific reports, 5, 17802-17802 (2015-12-04)
Articular cartilage injury is still a significant challenge because of the poor intrinsic healing potential of cartilage. Stem cell-based tissue engineering is a promising technique for cartilage repair. As cartilage defects are usually irregular in clinical settings, scaffolds with moldability
Wenshi Li et al.
Bioanalysis, 11(9), 825-935 (2019-05-30)
Aim: A low-fouling and highly sensitive fluorescence immunoassay for protein detection in serum was proposed, and IgG was used as a model protein. Materials & methods: SH-PEG-NH2 serving as antifouling coating was conjugated with carboxyl Fe3O4 nanoparticles, and then, the thiol
Viktoriya Sokolova et al.
Acta biomaterialia, 64, 401-410 (2017-10-01)
The selective activation of the immune system is a concurrent problem in the treatment of persistent diseases like viral infections (e.g. hepatitis). For the delivery of the toll-like receptor ligand poly(I:C), an immunostimulatory action was discovered earlier by hydrodynamic injection.
Wolfgang Ott et al.
ACS nano, 11(6), 6346-6354 (2017-06-08)
Single-molecule force spectroscopy (SMFS) is by now well established as a standard technique in biophysics and mechanobiology. In recent years, the technique has benefitted greatly from new approaches to bioconjugation of proteins to surfaces. Indeed, optimized immobilization strategies for biomolecules
Donna Grace Karp et al.
Scientific reports, 10(1), 20188-20188 (2020-11-21)
Accurate surveillance of coronavirus disease 2019 (COVID-19) incidence requires large-scale testing of the population. Current testing methods require in-person collection of biospecimens by a healthcare worker, limiting access of individuals who do not have access to testing facilities while placing
Pubudu M Peiris et al.
Cancer research, 75(7), 1356-1365 (2015-01-30)
Glioblastoma multiforme is generally recalcitrant to current surgical and local radiotherapeutic approaches. Moreover, systemic chemotherapeutic approaches are impeded by the blood-tumor barrier. To circumvent limitations in the latter area, we developed a multicomponent, chain-like nanoparticle that can penetrate brain tumors
Lingwen Zeng et al.
Talanta, 198, 412-416 (2019-03-17)
As an ubiquitous heavy metal pollutant, cadmium ion (Cd2+) is detrimental to food and human health even at low concentrations. Conventional methods require costly instruments and cannot meet the requirements of on-site analysis. Here we report the use of a
Ziyi Wang et al.
International journal of pharmaceutics, 577, 119047-119047 (2020-01-27)
Rheumatoid arthritis (RA) is an autoimmune disease featured with chronic joint inflammation. Suppression of inflammation is critical to RA treatment and joint protection. In this study, DNA nanodrugs are prepared via the conjugation of NF-κB decoy oligodeoxynucleotides (dODNs) and VCAM-1
Protein labeling with the labeling precursor [(18)F]SiFA-SH for positron emission tomography.
Wangler B
Nature Protocols, 7, 1964-1964 (2012)
Wei Li et al.
Colloids and surfaces. B, Biointerfaces, 192, 111040-111040 (2020-04-25)
Electrospinning is a common technology to construct tissue engineering scaffolds for bone regeneration. However, pure electrospun scaffolds do not enrich seed cells or promote their osteogenic differentiation. Biological functionalization of tissue engineering scaffolds is currently a hot research topic. Therefore
Kai Cheng et al.
ACS nano, 11(12), 12276-12291 (2017-12-05)
Our development of multifunctional dual-modal imaging probes aims to integrate the benefits from both second near-infrared (NIR-II) fluorescence (1000-1700 nm) and photoacoustic imaging with an ultimate goal of improving overall cancer diagnosis efficacy. Herein we designed a donor-acceptor chromophore based
Galina Nifontova et al.
Frontiers in chemistry, 7, 34-34 (2019-02-15)
Imaging agents and drug carriers are commonly targeted toward cancer cell through functionalization with specific recognition molecules. Quantum dots (QDs) are fluorescent semiconductor nanocrystals whose extraordinary brightness and photostability make them attractive for direct fluorescent labeling of biomolecules or optical
Denise Bamberger et al.
Molecular pharmaceutics, 14(12), 4403-4416 (2017-10-25)
Surface modifications of nanoparticles can alter their physical and biological properties significantly. They effect particle aggregation, circulation times, and cellular uptake. This is particularly critical for the interaction with primary immune cells due to their important role in particle processing.
Fenglin Liu et al.
Biochemical and biophysical research communications, 508(3), 953-958 (2018-12-14)
RNA-binding proteins (RBPs) are proteins that bind to the RNA and participate in forming ribonucleoprotein complexes. They have crucial roles in various biological processes such as RNA splicing, editing, transport, maintenance, degradation, intracellular localization and translation. The RBPs bind RNA
Danyu Wu et al.
Cardiovascular drugs and therapy, 35(1), 141-151 (2020-07-30)
Our group has developed a therapeutic vaccine targeting proprotein convertase subtilisin/kexin type 9 (PCSK9), named PCSK9Qβ-003. In this study, we investigated the potential effectiveness of the PCSK9Qβ-003 vaccine on atherosclerosis. Male ApoE-/- mice were randomly assigned to three groups: a
Ahmed A H Abdellatif et al.
Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 26(8), 1162-1169 (2018-12-12)
Cancer may be difficult to target, however, if cancer targeted this provides the chance for a better and more effective treatment. Quantum dots (Qdots) coated vapreotide (VAP) as a somatostatin receptors (SSTRs) agonist can be efficient targeting issue since may
Jiafu Shi et al.
Chemical Society reviews, 47(12), 4295-4313 (2018-05-09)
Enzyme catalysis, as a green, efficient process, displays exceptional functionality, adaptivity and sustainability. Multi-enzyme catalysis, which can accomplish the tandem synthesis of valuable materials/chemicals from renewable feedstocks, establishes a bridge between single-enzyme catalysis and whole-cell catalysis. Multi-enzyme catalysis occupies a
Vladimir V Temchura et al.
Biomaterials, 35(23), 6098-6105 (2014-04-30)
Cross-linking of the B-cell receptors of an antigen-specific B-cell is the initial signal for B-cell activation, proliferation, and differentiation into antibody secreting plasma cells. Since multivalent particulate structures are efficient activators of antigen-specific B-cells, we developed biodegradable calcium phosphate nanoparticles
Kai Cai et al.
Structure (London, England : 1993), 26(8), 1127-1136 (2018-07-10)
Cysteine desulfurase plays a central role in mitochondrial iron-sulfur cluster biogenesis by generating sulfur through the conversion of L-cysteine to L-alanine and by serving as the platform for assembling other components of the biosynthetic machinery, including ISCU, frataxin, and ferredoxin.
Sebastian Bäumer et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 21(6), 1383-1394 (2015-01-16)
KRAS mutations are frequent driver mutations in multiple cancers. KRAS mutations also induce anti-EGFR antibody resistance in adenocarcinoma such as colon cancer. The aim of this study was to overcome anti-EGFR antibody resistance by coupling the antibody to KRAS-specific siRNA.
Robert K Strother et al.
Journal of immunology (Baltimore, Md. : 1950), 197(11), 4301-4311 (2016-11-01)
Patients surviving acute stages of sepsis often display impaired adaptive-immune responses. Using the cecal ligation and puncture model, we demonstrated that sepsis leads to substantial and long-lasting changes in the naive CD8 T cell repertoire, affecting the capacity of the
Suping Li et al.
Nature biomedical engineering, 4(7), 732-742 (2020-06-24)
Drugs that induce thrombosis in the tumour vasculature have not resulted in long-term tumour eradication owing to tumour regrowth from tissue in the surviving rim of the tumour, where tumour cells can derive nutrients from adjacent non-tumoral blood vessels and
Ying-Pei Hsu et al.
Biosensors & bioelectronics, 151, 111960-111960 (2020-01-31)
Zika virus (ZIKV) is a mosquito-borne flavivirus (FLAV) that emerged in Brazil in 2015 and has rapidly spread to more than 50 countries worldwide. However, early, accurate, and specific point-of-care (POC) diagnosis of ZIKV is very difficult because most infected
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