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Robert H Dods et al.
Journal of molecular biology, 425(22), 4379-4387 (2013-07-23)
The generality of acyl transfer from phospholipids to membrane-active peptides has been probed using liquid chromatography-mass spectrometry analysis of peptide-lipid mixtures. The peptides examined include melittin, magainin II, PGLa, LAK1, LAK3 and penetratin. Peptides were added to liposomes with membrane
Bin Chen et al.
Journal of natural products, 69(1), 23-28 (2006-01-31)
Cycloviolacin H4, a new macrocyclic miniprotein comprising 30 amino acid residues, was isolated from the underground parts of the Australian native violet Viola hederaceae. Its sequence, cyclo-(CAESCVWIPCTVTALLGCSCSNNVCYNGIP), was determined by nanospray tandem mass spectrometry and quantitative amino acid analysis. A
Structural and Dynamic Insights into S100B Protein Activity Inhibition by Melittin for the Treatment of Epilepsy
Verma N
International Journal of Computer Applications, 55-60 (2013)
C E Dempsey
Biochimica et biophysica acta, 1031(2), 143-161 (1990-05-07)
The molecular mechanisms underlying the various effects of melittin on membranes have not been completely defined and much of the evidence described indicates that different molecular mechanisms may underlie different actions of the peptide. Ideas about the formation of transbilayer
Burcin Altinbas et al.
Prostaglandins, leukotrienes, and essential fatty acids, 87(4-5), 153-158 (2012-09-22)
Melittin is a polypeptide component of bee venom that leads to an increase in arachidonic acid release and subsequently in prostaglandin synthesis by activating phospholipase A(2). Recently we demonstrated that centrally or peripherally administrated melittin caused pressor effect and central
Kirk K Hou et al.
Biomaterials, 34(12), 3110-3119 (2013-02-06)
Traditional transfection agents including cationic lipids and polymers have high efficiency but cause cytotoxicity. While cell penetrating peptide based transfection agents exhibit improved cytotoxicity profiles, they do not have the efficiency of existing lipidic agents due to endosomal trapping. As
Laura M Thoma et al.
Biomacromolecules, 15(8), 2933-2943 (2014-07-11)
The in vitro and in vivo antimicrobial activity of primary ammonium ethyl methacrylate homopolymers (AEMPs) was investigated. AEMPs with different degrees of polymerization (DP = 7.7-12) were prepared by reversible addition-fragmentation chain-transfer (RAFT) polymerization. The AEMPs showed higher inhibitory effects
Yao-Qing Yu et al.
Neuromolecular medicine, 15(1), 209-217 (2012-12-25)
Tetrodotoxin-resistant (TTX-R) sodium channels NaV1.8 and NaV1.9 in dorsal root ganglion (DRG) neurons play important roles in pathological pain. We recently reported that melittin, the major toxin of whole bee venom, induced action potential firings in DRG neurons even in
Hongyan Liu et al.
Applied microbiology and biotechnology, 97(7), 2877-2884 (2012-11-15)
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), as an anticancer protein with tumor-selective apoptotic activity, has been examined for use in clinical application. Melittin, an antibacterial peptide isolated from the bee Apis mellifera, has shown strong cytotoxicity to both tumor and
S Yang et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 18(1), 3-5 (1997-01-01)
Extensive work with melittin has shown that the venom has multiple effects, probably, as a result of its interaction with negatively changed phospholipids. It inhibits well known transport pumps such as the Na(+)-K(+)-ATPase and the H(+)-K(+)-ATPase. Melittin increases the permeability
Ya-Qin Zhao et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 18(1), 123-136 (2012-11-28)
Centrin is a member of the EF-hand superfamily that is phosphorylated during mitosis and is associated with alterations of contractile fibers. To obtain insight into the structural basis for the functional effects of phosphorylation, we found that the serine residue
Chun-Jen Su et al.
Biochimica et biophysica acta, 1828(2), 528-534 (2012-11-06)
We have studied the bilayer thinning structure of unilamellar vesicles (ULV) of a phospholipid 1,2-dierucoyl-sn-glycero-3-phosphocholine (di22:1PC) upon binding of melittin, a water-soluble amphipathic peptide. Successive thinning of the ULV bilayers with increasing peptide concentration was monitored via small-angle X-ray scattering
Mingjun Liu et al.
Cancer immunology, immunotherapy : CII, 62(5), 889-895 (2013-02-28)
In the current study, we produced a novel fusion protein (melittin-mutant human interleukin 2, melittin-MhIL-2) comprising a mutant human interleukin 2 (Arg88/Ala125) genetically linked to melittin. The plasmid pET15b-melittin-MhIL-2 (Arg88/Ala125) was transformed into E. coli for protein expression. The expressed
Joshua L Hood et al.
Antiviral therapy, 18(1), 95-103 (2012-09-08)
We investigated whether cytolytic melittin peptides could inhibit HIV-1 infectivity when carried in a nanoparticle construct that might be used as a topical vaginal virucide. Free melittin and melittin-loaded nanoparticles were prepared and compared for cytotoxicity and their ability to
Kent R Thurber et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 226, 100-106 (2012-12-15)
We describe an apparatus for solid state nuclear magnetic resonance (NMR) with dynamic nuclear polarization (DNP) and magic-angle spinning (MAS) at 20-25 K and 9.4 Tesla. The MAS NMR probe uses helium to cool the sample space and nitrogen gas
J E Fletcher et al.
Toxicon : official journal of the International Society on Toxinology, 31(6), 669-695 (1993-06-01)
Cobra snake venom cardiotoxins and bee venom melittin share a number of pharmacological properties in intact tissues including hemolysis, cytolysis, contractures of muscle, membrane depolarization and activation of tissue phospholipase C and, to a far lesser extent, an arachidonic acid-associated
Woo-Ram Lee et al.
The Journal of investigative dermatology, 134(7), 1922-1930 (2014-02-06)
Melittin is the main component in the venom of the honey bee (Apis mellifera). It has multiple effects including antibacterial, antiviral, and anti-inflammatory activities in various cell types. However, the anti-inflammatory mechanisms of melittin have not been elucidated in Propionibactierium
Yukun Wang et al.
Biochimica et biophysica acta, 1838(9), 2280-2288 (2014-04-22)
Membrane-active antimicrobial peptides (AMPs) are challenging to study experimentally, but relatively easy to investigate using molecular dynamics (MD) computer simulations. For this reason, a large number of MD studies of AMPs have been reported over recent years. Yet relatively little
Ignacio López-Peña et al.
Biochemistry, 54(31), 4770-4783 (2015-07-30)
Raman spectroscopy is a form of vibrational spectroscopy based on inelastic scattering of light. In resonance Raman spectroscopy, the wavelength of the incident light falls within an absorption band of a chromophore, and this overlap of excitation and absorption energy
Famke Aeffner et al.
PloS one, 7(10), e46660-e46660 (2012-10-12)
Each year, approximately 20% of asthmatics in the United States experience acute symptom exacerbations, which commonly result from pulmonary viral infections. The majority of asthma exacerbations in very young children follow infection with respiratory syncytial virus (RSV). However, pathogenic mechanisms
Melissa A Patterson et al.
The Journal of biological chemistry, 290(48), 28944-28952 (2015-08-09)
Transmembrane topology of polytopic membrane proteins (PMPs) is established in the endoplasmic reticulum (ER) by the ribosome Sec61-translocon complex (RTC) through iterative cycles of translocation initiation and termination. It remains unknown, however, whether tertiary folding of transmembrane domains begins after
Raquel F Epand et al.
Antimicrobial agents and chemotherapy, 54(9), 3708-3713 (2010-06-30)
Ceragenins are cholic acid-derived antimicrobial agents that mimic the activity of endogenous antimicrobial peptides. Ceragenins target bacterial membranes, yet the consequences of these interactions have not been fully elucidated. The role of the outer membrane in allowing access of the
Sung-Min Kim et al.
Bioorganic & medicinal chemistry letters, 19(19), 5627-5631 (2009-08-26)
We synthesized antibacterial pseudopeptides with less hemolytic activity by incorporation of reduced amide bond psi[CH2NH] into alpha helical antibacterial peptide with hemolytic activity. As the pKa value of reduced amide bond is 7-8, it is protonated depending on the pH.
Sunithi Gunasekera et al.
Journal of medicinal chemistry, 51(24), 7697-7704 (2008-12-05)
Cyclotides are plant derived mini-proteins with compact folded structures and exceptional stability. Their stability derives from a head-to-tail cyclized backbone coupled with a cystine knot arrangement of three-conserved disulfide bonds. Taking advantage of this stable framework we developed novel VEGF-A
Lili Qu et al.
Journal of biomedical nanotechnology, 10(4), 695-706 (2014-04-17)
Hepatic resection and orthotopic liver transplantation are the only potentially curative treatments for hepatocellular carcinoma (HCC) but are indicated only in a minority of patients. Biosynthetic nanoscale peptide Melittin (Mel) is postulated to disrupt microbial phospholipid membranes by formation of
Woong Sik Jang et al.
Antimicrobial agents and chemotherapy, 51(11), 4148-4156 (2007-09-12)
Halocidin is an antimicrobial peptide found in the tunicate. A series of experiments were previously conducted in an attempt to develop a novel antibiotic derived from halocidin, as the peptide was determined to evidence profound antimicrobial activity against a variety
Babak Y Moghadam et al.
Langmuir : the ACS journal of surfaces and colloids, 28(47), 16318-16326 (2012-08-28)
Lipid bilayers are biomembranes common to cellular life and constitute a continuous barrier between cells and their environment. Understanding the interaction of engineered nanomaterials (ENMs) with lipid bilayers is an important step toward predicting subsequent biological effects. In this study
Honey Bee Venom (Apis mellifera) Contains Anticoagulation Factors and Increases the Blood-clotting Time.
Zolfagharian H
Journal of pharmacopuncture, 18(4), 7-11 (2015)
Stephanie Gross et al.
Biological chemistry, 393(8), 817-827 (2012-09-05)
Some antimicrobial peptides have emerged as potential anticancer agents. In contrast to chemotherapeutics, they act primarily by physical disruption of the cancer cell membrane. Selective targeting of these cationic peptides still remains elusive. We focus on the interaction of α-helical
Santosh K Misra et al.
PloS one, 10(6), e0125908-e0125908 (2015-06-02)
We present an in-silico-to-in-vitro approach to develop well-defined, self-assembled, rigid-cored polymeric (Polybee) nano-architecture for controlled delivery of a key component of bee venom, melittin. A competitive formulation with lipid-encapsulated (Lipobee) rigid cored micelle is also synthesized. In a series of
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