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M8407
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Maxime Dougados et al.
Annals of the rheumatic diseases, 73(5), 803-809 (2014-01-30)
To assess the 1-year efficacy and safety of a regimen of tocilizumab plus methotrexate or placebo, which was augmented by a treat-to-target strategy from week 24. ACT-RAY was a double-blind, 3-year trial. Adults with active rheumatoid arthritis despite methotrexate were
[Rheumatoid arthritis: lower work loss during treatment with biologicals?--Modern treatment principles reduce work loss in rheumatoid arthritis].
Klaus Krüger
Deutsche medizinische Wochenschrift (1946), 138(44), 2236-2236 (2013-10-24)
Theodore Pincus et al.
Bulletin of the Hospital for Joint Disease (2013), 71 Suppl 1, S9-19 (2013-11-28)
Methotrexate has become the "anchor drug" for rheumatoid arthritis (RA), taken by many more patients than any other disease modifying anti-rheumatic drug (DMARD) or biological agent. Methotrexate has greater efficacy and effectiveness than any other non-biologic DMARD, and greater tolerability
Hua-Nian Zhang et al.
Pediatric blood & cancer, 61(12), 2203-2207 (2014-08-19)
Recent studies suggest that SLCO1B1 c.521T > C variant decreases the clearance of methotrexate (MTX) and elevates its plasma concentration, hence leucovorin doses may need to be adjusted. However, high leucovorin doses may affect the cure rate in childhood acute lymphoblastic leukemia
O A Bezborodova et al.
Eksperimental'naia i klinicheskaia farmakologiia, 76(5), 18-22 (2013-08-02)
We have experimentally investigated the detoxifying and modifying effects of remaxol in the framework of traditional and high-dose chemotherapy in mice with transplanted tumors. The influence of remaxol in comparison with heptral was studied on the toxic and therapeutic action
Vishal Patel et al.
The Cochrane database of systematic reviews, 8(8), CD006884-CD006884 (2014-08-27)
Safe and effective long-term treatments that reduce the need for corticosteroids are needed for Crohn's disease. Although purine antimetabolites are moderately effective for maintenance of remission patients often relapse despite treatment with these agents. Methotrexate may provide a safe and
Yuki Kojima et al.
Japanese journal of clinical oncology, 44(4), 318-323 (2014-02-22)
Acquired immunodeficiency syndrome-related non-Hodgkin lymphoma is treated similarly to non-acquired immunodeficiency syndrome lymphoma, but it is not clear whether highly intensive regimens are beneficial for acquired immunodeficiency syndrome-related Burkitt lymphoma. We conducted a multicenter retrospective survey to clarify the clinical
Yunqian Qiao et al.
Nature communications, 12(1), 6360-6360 (2021-11-06)
Expression of the cell surface receptor CD137 has been shown to enhance anti-cancer T cell function via engagement with its natural ligand 4-1BBL. CD137 ligation with engineered ligands has emerged as a cancer immunotherapy strategy, yet clinical development of agonists
Nilesh Chande et al.
The Cochrane database of systematic reviews, 8(8), CD006618-CD006618 (2014-08-28)
Ulcerative colitis (UC) is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy for steroid-refractory and steroid-dependent disease. Methotrexate is a medication that is effective for treating a variety
Using Hawthorne effects to improve adherence in clinical practice: lessons from clinical trials--reply.
Joel M Gelfand et al.
JAMA dermatology, 149(4), 491-491 (2013-05-30)
Seok Jin Kim et al.
Annals of hematology, 94(1), 71-78 (2014-08-02)
The aim of this study was to investigate the impact of the induction treatment with SMILE (dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide) chemotherapy and consolidation with upfront autologous stem cell transplantation (ASCT) on clinical outcomes of patients with stage IV
Christian A Waimann et al.
Arthritis and rheumatism, 65(6), 1421-1429 (2013-06-04)
To quantify adherence to oral therapies in ethnically diverse and economically disadvantaged patients with rheumatoid arthritis (RA), using electronic medication monitoring, and to evaluate the clinical consequences of low adherence. A total of 107 patients with RA enrolled in a
F M Huennekens
Advances in enzyme regulation, 34, 397-419 (1994-01-01)
Methotrexate (MTX), one of the earliest cancer chemotherapy agents, continues to be used extensively in the treatment of leukemia and a variety of other tumors. The efficacy of this drug results from its facile uptake by cells, rapid polyglutamylation and
Jeremy Hugh et al.
Journal of the American Academy of Dermatology, 70(1), 168-177 (2013-11-05)
Many studies have identified cardiovascular risk factors in patients with psoriasis. Some psoriasis therapies may increase cardiovascular disease (CVD) and others may decrease CVD. We reviewed the literature to define the impact of common psoriasis therapies on cardiovascular measures and
K M Lo et al.
Biochimica et biophysica acta, 1088(2), 217-224 (1991-02-16)
We have developed an inducible system for high level expression of heterologous genes in murine hybridoma cells. The rapid induction by methotrexate (MTX) does not involve gene amplification and is controlled at the level of mRNA accumulation. Transfection was achieved
Michael E Rytting et al.
Cancer, 120(23), 3660-3668 (2014-07-22)
Various trials have reported improved outcomes for adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL) who received treatment with pediatric-based regimens. Those reports prompted the current investigation of the pediatric augmented Berlin-Frankfurt-Münster (ABFM) regimen in AYA patients. The
Isabel Castrejón et al.
Bulletin of the Hospital for Joint Disease (2013), 71 Suppl 1, S20-S28 (2013-11-28)
Methotrexate (MTX) is well-established as the "anchor drug" for patients with rheumatoid arthritis (RA), to be used early and aggressively, with higher long-term effectiveness, tolerability, and safety than any other disease-modifying antirheumatic drug (DMARD). However, about 20% to 40% of
Eric M Ruderman
Bulletin of the Hospital for Joint Disease (2013), 71 Suppl 1, S29-S32 (2013-11-28)
From the first use of biologic therapy for the management of rheumatoid arthritis, methotrexate (MTX) has been commonly used as co-therapy. There are a number of mechanistic reasons why MTX may improve the efficacy of biologics, including reduced antigenicity as
Kazuhisa Katayama et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(5), 655-658 (2013-07-19)
Carcinomatous peritonitis may develop after operation for gastric cancer. As ascites are difficult to control, especially for gastric cancer postoperative carcinomatous peritonitis, many cases are difficult to treat. The present case was a female patient with carcinomatous peritonitis that occurred
Sivakumar R Rathinam et al.
Ophthalmology, 121(10), 1863-1870 (2014-06-12)
To compare the relative effectiveness of methotrexate and mycophenolate mofetil for noninfectious intermediate uveitis, posterior uveitis, or panuveitis. Multicenter, block-randomized, observer-masked clinical trial. Eighty patients with noninfectious intermediate, posterior, or panuveitis requiring corticosteroid-sparing therapy at Aravind Eye Hospitals in Madurai
Resolution of methotrexate-induced Epstein-Barr virus-associated mucocutaneous ulcer.
Nandini Sadasivam et al.
British journal of haematology, 165(5), 584-584 (2014-01-25)
Matthew Trendowski et al.
Anticancer research, 35(1), 65-76 (2015-01-01)
Cytochalasin B is a mycogenic toxin that preferentially damages malignant cells through multiple mechanisms. The microfilament-disrupting agent inhibits cytokinesis, producing enlarged and multinucleated neoplastic cells without enlarging or producing multinucleated normal cells. In addition, cytochalasin B has been shown to
Delwar Hossain
Leprosy review, 84(1), 105-112 (2013-06-08)
Erythema nodosum leprosum (ENL) is a chronic recurrent systemic complication of multi-bacillary leprosy frequently associated with the development of neuritis, iritis, orchitis, arthritis and dactylitis. It is well managed by thalidomide, but thalidomide is not available in Bangladesh. The World
Diego R Perinelli et al.
Pharmaceutical research, 32(3), 1094-1104 (2014-09-23)
This work investigated the influence of a model protein, bovine serum albumin (BSA), on the properties of a thermogelling formulation intended for administration inside body compartments where there is high albumin content, as in the case of inflamed joints; it
Daniel Nowak et al.
Experimental hematology, 43(1), 32-43 (2014-12-03)
The use of genome-wide copy-number analysis and massive parallel sequencing has revolutionized the understanding of the clonal architecture of pediatric acute lymphoblastic leukemia (ALL) by demonstrating that this disease is composed of highly variable clonal ancestries following the rules of
Using Hawthorne effects to improve adherence in clinical practice: lessons from clinical trials.
Scott A Davis et al.
JAMA dermatology, 149(4), 490-491 (2013-05-30)
Reticulated hyperpigmentation following chemotherapy for radiation-induced osteosarcoma.
Catherine A Necessary et al.
Journal of the American Academy of Dermatology, 71(1), e23-e24 (2014-06-21)
John W D McDonald et al.
The Cochrane database of systematic reviews, 8(8), CD003459-CD003459 (2014-08-08)
Although corticosteroids are effective for induction of remission of Crohn's disease, many patients relapse when steroids are withdrawn or become steroid dependent. Furthermore, corticosteroids exhibit significant adverse effects. The success of methotrexate as a treatment for rheumatoid arthritis led to
Diagnostic criteria for primary ocular lymphoma.
Cheryl A Arcinue et al.
Ophthalmology, 120(3), 646-646 (2013-05-30)
P Verschueren et al.
Annals of the rheumatic diseases, 74(1), 27-34 (2014-11-02)
To compare the efficacy and safety of intensive combination strategies with glucocorticoids (GCs) in the first 16 weeks (W) of early rheumatoid arthritis (eRA) treatment, focusing on high-risk patients, in the Care in early RA trial. 400 disease-modifying antirheumatic drugs (DMARD)-naive
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